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2.1
Calcium Gluconate
CALGLUC

Images

WIKIDATA, Public Domain
WIKIDATA, CC0 1.0
WIKIDATA, CC BY 3.0

Presentation

It was also noted that calcium gluconate was more effective in patients who presented 3 hours of more after they were bitten. Antivenom may be necessary in those who present with symptoms in less than 3 hours. [ncbi.nlm.nih.gov]

Entire Body System

  • Asymptomatic

    Treatment of asymptomatic neonatal hypocalcaemia is controversial. [adhb.govt.nz]

    Asymptomatic patient: 1 gram calcium gluconate IV q6-12h with careful monitoring of Ca++ levels. [globalrph.com]

    Hypocalcemia Hypocalcemia’s manifestations range from asymptomatic to life threatening. [epmonthly.com]

    […] rarely produced by administration of calcium alone, but may occur with large doses in patients with chronic renal failure. b Avoid overtreatment of hypocalcemia since hypercalcemia may be more dangerous than hypocalcemia. b Mild hypercalcemia may be asymptomatic [drugs.com]

  • Intravenous Administration

    Abstract Nine infants who had severe local manifestations following intravenous administration of calcium gluconate are presented. [ncbi.nlm.nih.gov]

    Intravenous calcium should be restricted to acute symptomatic patients that require prompt therapy. " Treatment of Hypocalcemia : Treatment of hypocalcemia requires administration of calcium. [globalrph.com]

    DOSAGE AND ADMINISTRATION Calcium Gluconate should be administered intravenously either directly or by infusion. The dose is dependent upon the individual requirements of the patient. [rxlist.com]

    Learn more Absorption Following intravenous administration of 500mg nafcillin, the mean plasma concentration was approximately 30 µg/mL. This value was reached after 5 minutes of injection Label. [drugbank.ca]

  • Fishing

    Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers, and fatty fish. Vitamin D is also made by the body as a result of exposure to the sun. Keep all regular medical and laboratory appointments. [webmd.com]

Gastrointestinal

  • Constipation

    Calcium gluconate side effects include nausea, constipation, and upset stomach. [en.wikipedia.org]

    Potential side effects of calcium gluconate use include allergic reactions, constipation, increased thirst, dry mouth, nausea, vomiting and frequent urination. [livestrong.com]

    Common side effects may include: upset stomach, gas; or constipation. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. [drugs.com]

    […] it does not have an effect on potassium levels in the blood, it reduces the excitability of cardiomyocytes thus lowering the likelihood of developing cardiac arrhythmias. [5 ] [ edit ] Side Effects Edit Calcium gluconate side effects include nausea, constipation [house.wikia.com]

  • Diarrhea

    Nausea, vomiting, diarrhea, sensations of heat and sweating; arrhythmias, hypotension, circulatory collapse. Treatment: The patient should be in the horizontal position. Treat shock in the usual fashion. [rxmed.com]

    Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses. [drugbank.ca]

    […] therapy) Calcium salts are used as a source of calcium cation for the treatment or prevention of calcium depletion when dietary measures are inadequate. b Conditions associated with calcium deficiency include hypoparathyroidism, achlorhydria, chronic diarrhea [drugs.com]

Cardiovascular

  • Hypotension

    Hypotension and bradycardia due to calcium channel blocker or beta blocker overdose. [iwkpoisoncentre.ca]

    Hypotension and citrate toxicity were seen in Copyright 2007 Wiley-Liss, Inc. [ncbi.nlm.nih.gov]

    To the Editor: Intoxication with verapamil is a serious and often fatal condition, complicated by severe hypotension and cardiac-conduction abnormalities 1 4. [nejm.org]

    […] temperature Do not mix in same bag or line with carbonates, phosphates, sulfates, and tartrates, because of precipitation IV Administration May administer IV push at rate of 50-100 mg/min (0.5-1 mL/min); rapid IV administration may produce arrhythmias, hypotension [reference.medscape.com]

    List the contraindications for Calcium Gluconate V-fib, digitalis toxicity, hypercalcemia List the adverse reactions/side effects for Calcium Gluconate Syncope, cardiac arrest, dysrhythmia, bradycardia, hypotension, asystole, peripheral vasodilation, [quizlet.com]

  • Heart Disease

    You should not be given Calcium Gluconate Injection if you have severe heart disease. You should not be given Calcium Gluconate Injection if you have severe kidney disease. [nps.org.au]

Neurologic

  • Irritability

    Abstract Calcium gluconate is irritating to soft tissues and can produce tissue necrosis and slough; Radiographs of the part following extravasation initially show only soft tissue swelling. [ncbi.nlm.nih.gov]

    The gluconate salt is not irritating to the veins but has been reported to cause skin necrosis and sloughing in infants. The i.m. route should not be used because it is irritating, painful, and may cause abscess formation. [rxmed.com]

    Carefully monitor infants of hypocalcemic mothers for abnormal calcium levels; signs include neuromuscular irritability, apnea, cyanosis, and cardiac arrhythmias. [drugs.com]

    Gastric irritation and diarrhoea may occur during oral therapy. Avoid intra-arterial and subcutaneous administration. Never give intramuscularly. Adjust dose in renal failure. [adhb.govt.nz]

  • Seizure

    Monitor: plasma calcium Late hypocalcaemia (4-10 days after birth) is usually associated with increased tone, jitteriness, and multiofcal seizures in an otherwise well infant. Seizures are usually associated with serum Ca 2+ 2+ 2+ c >0.2 sec). [adhb.govt.nz]

    Infants of mothers with hypocalcemia may have neonatal hyperparathyroidism, which may lead to fetal and neonatal skeletal demineralization, subperiosteal bone resorption, osteitis fibrosa cystica, and seizures. [drugs.com]

    […] is acute and severe, calcium chloride is given instead. [ edit ] Magnesium sulfate overdose Edit It is also used to counteract an overdose of magnesium sulfate, [2 ] which is often administered to pregnant women in order to prophylactically prevent seizures [house.wikia.com]

    It is also used to counteract an overdose of Epsom salts magnesium sulfate, which is often administered to pregnant women in order to prophylactically prevent seizures (as in a patient experiencing preeclampsia). [en.wikipedia.org]

    Clinical Scenario A 22 year old woman with a history of hypoparathyroidism presents to the emergency department with recurrent grand mal seizures. Her ionized calcium level is 0.7 mmol/L (2.8 mg/dL). [bestbets.org]

  • Excitement

    Despite exciting preclinical data with various approaches, there are only a few examples of clear efficacy in clinical trials. [ncbi.nlm.nih.gov]

    Though it does not have an effect on potassium levels in the blood, it reduces the excitability of cardiomyocytes thus lowering the likelihood of developing cardiac arrhythmias. [5 ] [ edit ] Side Effects Edit Calcium gluconate side effects include nausea [house.wikia.com]

    It is recommended when the potassium levels are high (>6.5 mmol/l) or when the electrocardiogram (ECG) shows changes due to high blood potassium.Though it does not have an effect on potassium levels in the blood, it reduces the excitability of cardiomyocytes [en.wikipedia.org]

    The use of calcium does not reduce the serum potassium level, but counteracts the effects of hyperkalemia on cardiac excitability. [gmedication.com]

  • Hyporeflexia

    Excess magnesium sulfate results in magnesium sulfate toxicity, which results in both respiratory depression and a loss of deep tendon reflexes ( hyporeflexia ). [house.wikia.com]

    Excess magnesium sulfate results in magnesium sulfate toxicity, which results in both respiratory depression and a loss of deep tendon reflexes (hyporeflexia). Gel preparations of calcium gluconate are used to treat hydrofluoric acid burns. [en.wikipedia.org]

  • Burning Sensation

    WARNINGS Calcium gluconate should be injected into a large vein very slowly, as it may cause peripheral vasodilatation and a cutaneous burning sensation (it is preferable to administer it centrally if the patient has a central line) Avoid IV calcium in [drug.wellingtonicu.com]

    When administering the Calcium Gluconate injection, watch out for peripheral vasodilation (marked by a fall in BP) and reports of a ‘burning’ sensation. Throughout therapy, you should observe the patient for signs of hypocalcemia or hypercalcemia. [nclexpreceptor.com]

Workup

Serum

  • Calcium Increased

    Total and ionized serum calcium increased 3 to 6 hours following the calcium, but not the placebo, infusion. [ncbi.nlm.nih.gov]

    Intramuscular injections may lead to local necrosis and abscess formation. [6 ] It is also reported that this form of calcium increases renal plasma flow, diuresis, natriuresis, [7 ] [8 ] glomerular filtration rate, [9 ] and prostaglandin E2 and F1-alpha [house.wikia.com]

    Intramuscular injections may lead to local necrosis and abscess formation.It is also reported that this form of calcium increases renal plasma flow, diuresis, natriuresis, glomerular filtration rate, and prostaglandin E2 and F1-alpha levels. [en.wikipedia.org]

Treatment

Citrate reactions occurred in 35.6% of Group A and 29.4% of Group B treatments (P = 0.3), but in only 8.6% of Group C treatments (P < 0.0001). [ncbi.nlm.nih.gov]

Epidemiology

The aim of this study is to present a number of cases of calcium gluconate extravasation, which have occurred in our hospital, and to carry out a review of those clinical cases published in the literature to obtain relevant epidemiological data. [ncbi.nlm.nih.gov]

Pathophysiology

And also it presented pathophysiologic mechanism underlying severe hypokalemia as well as suggestions for clinical practice regarding combination use of dexamethasone and calcium gluconate. [ncbi.nlm.nih.gov]

Prevention

Abstract We have examined the effectiveness of intravenous calcium gluconate infusion in the prevention of citrate reactions during therapeutic plasma exchange. [ncbi.nlm.nih.gov]

They may also be used for the prevention of hypocalcaemia in exchange transfusions, and in long term electrolyte replacement therapy. [healthdirect.gov.au]

RATIONALE: Chemoprotective drugs, such as calcium gluconate and magnesium sulfate, may prevent neurotoxicity caused by oxaliplatin. [clinicaltrials.gov]

Supplementation may be done to treat or prevent osteoporosis or rickets. [en.wikipedia.org]

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