We report a 50-year-old woman who presented with an acute herniated disc syndrome secondary to an intraspinal inflammatory calcium pyrophosphate deposition disease mass at the level of the L4-L5 interspace. [ncbi.nlm.nih.gov]

Patients can present with fever and... References: McCarty DJ, Hollander JL. Identification of urate crystals in gouty synovial fluid. Ann Intern Med 1961; 54:452-460. McCarty DJ, Kohn NN, Faires JS. [posterng.netkey.at]

The presenting symptoms are similar to both gout and septic arthritis but may be treated differently. This article describes a typical patient presentation and management from an emergency medicine and orthopedic surgery standpoint. [journals.lww.com]

CPPD disease, however, can mimic rheumatoid arthritis or polymyalgia rheumatica, and patients may present with symmetrical joint involvement. [bpac.org.nz]

Articular synovial calcification is common and may be due to calcium hydroxyapatite, as well as CPPD, particularly if advanced degenerative changes are present. [pubs.rsna.org]

• Parotid Swelling

  A patient presented with a parotid swelling, which initially was suspected to be malignant because of the following findings: radiodensity, progression into the joint, osseous destruction of the major ala of the sphenoid and a fine needle aspirate with [cambridge.org]

• Bruxism

  Acute temporomandibular arthritis in a patient with bruxism and calcium pyrophosphate deposition disease. Arthritis Rheum 1982 ; 25 : 353 –355 Zemplenyi J, Caltcaterra TC. Chondrocalcinosis of the temporomandibular joint: a parotid pseudotumor. [ajnr.org]

• Jaw Pain

  Splint therapy during sleep was very effective in reducing jaw pain on movement. Because synovial chondromatosis of the left TMJ wassuspected, total extirpation of the calcified masses was performed via a preauricular approach. [ci.nii.ac.jp]

• Arthralgia

  In addition, induction of transient arthralgias in some patients is a well-recognized adverse effect of MTX [18], which could have further obscured a potential beneficial effect. [arthritis-research.biomedcentral.com]

  The most frequently reported adverse effects are diarrhea, back pain, headaches, and arthralgias. Also, patients should be monitored for thromboembolic events and increased hepatic transaminases. [clevelandclinicmeded.com]

Septic arthritis workup. Medscape Reference. Available online at . Accessed 9/9/2016. Sofronescu, A. (Updated 2016 April 13). Joint fluid interpretation. Medscape Reference. Available online at . Accessed 9/9/2016. Fisher, M. and Genzen, J. R. [labtestsonline.it]

Subsequent workup showed normal parathyroid hormone, normal calcium and phosphorous levels, and normal magnesium and alkaline phosphatase. [err.eg.net]

(See Etiology, Presentation, and Workup.) Calcium pyrophosphate deposition disease. Radiograph of the knee showing chondrocalcinosis involving the meniscal cartilage, as well as evidence of osteoarthritis. Calcium pyrophosphate deposition disease. [emedicine.medscape.com]

Gout or hyperuricemia in an adolescent or child is rare but invariably a manifestation of an underlying metabolic or inherited enzyme deficiency warranting a workup for these diseases. Postmenopausal women. [clevelandclinicmeded.com]

• Nephrolithiasis

  Ectopic calcifications in 70 individuals from 12 families * Family 1 1/F ASY 42 – – 2/F 32 42 Osteopoikilosis, nephrolithiasis – 3/M 40 74 Osteopoikilosis – 4/M ASY 46 Osteopoikilosis, nephrolithiasis – Family 2 1/M 42 64 Nephrolithiasis 2/M 41 53 Nephrolithiasis [onlinelibrary.wiley.com]

  Hyperuricemia can cause uric acid nephrolithiasis and, possibly, nephropathy, if uric acid accumulates in the renal interstitium and tubules. [clevelandclinicmeded.com]

Recommendations for the management of CPPD disease tend to be based on expert opinion or extrapolated from research on the treatment of gout.15 Treatment of an acute attack Treatments to reduce the pain and swelling associated with an acute attack of [bpac.org.nz]

CPPD with OA should be managed as primary OA, by a combination of non-pharmacological and pharmacological treatments (analgesics, NSAIDs). To date, there are no effective treatments capable of dissolving calcium deposits. [orpha.net]

Calcium pyrophosphate crystal deposition disease: diagnosis and treatment. Open Access Rheumatology : Research and Reviews. 2014;6:39-47. doi:10.2147/OARRR.S39039 MacMullan P, McCarthy G. [rarediseases.org]

Treatment of pseudogout attacks is with intra-articular corticosteroids or oral glucocorticoids, NSAIDs, or colchicine. [merckmanuals.com]

Heritable Disorders of Connective Tissue 549 32 Bone and Joint Dysplasias 559 33 Osteonecrosis 565 34 Pagets Disease of Bone 573 35 Osteoporosis A Epidemiology and Clinical Assessment 576 35 Osteoporosis B Pathology and Pathophysiology 584 35 Osteoporosis C Treatment [books.google.de]

Prognosis The prognosis for individual attacks of acute calcium pyrophosphate arthritis is usually excellent. [merckmanuals.com]

Prognosis Some forms may be severe and result in considerable pain and disability. The documents contained in this web site are presented for information purposes only. [orpha.net]

[…] synovial fluid leading to a synovitis Associated conditions hemochromatosis hyperparathyroidism hypomagnesemia can be seen in Gitelman and Bartter syndrome joint trauma, surgery, and severe medical illness these conditions can provoke an acute attack Prognosis [medbullets.com]

Etiology Mutations in the ANKH gene (human homologue of progressive ankylosis; 5p15.2), encoding a protein involved in cellular inorganic pyrophosphate transport, were identified in some cases of familial CPPD. [orpha.net]

Etiology The cause of calcium pyrophosphate arthritis is unknown. [merckmanuals.com]

The most likely etiology of the patient's knee pain is characterized by which finding? Review Topic QID: 1398 [orthobullets.com]

Prevalence Widespread in older population M:F 3:2 Clinical findings Intermittent attacks May be mono-articular or polyarticular (more often) Pain Redness Swelling Types Frequently occurs in association with osteoarthritis Aging process with no known etiology [learningradiology.com]

[…] forearm) 712.24 (hand) 712.25 (pelvic region and thigh) 712.26 (leg) 712.27 (ankle and foot) 712.28 (other specified site) 727.82 (calcium deposites in tendon and bursa) 712.3 Chondrocalcinosis, unspecified 275.4 Disorders fo calcium metabolism Pseudogout Etiology [eorif.com]

His research is focused on a number of key elements in OA including (but not limited to) the epidemiology of osteoarthritis, the application of imaging to better understand structure and function with application to both epidemiologic research and clinical [books.google.de]

Summary Epidemiology Its prevalence is unknown. About 100 affected families have been identified to date. Clinical description Familial CPPD manifests in early adulthood (20-40 years old) and has a variable clinical phenotype. [orpha.net]

[…] revealed by chondrocalcinosis. 61 Volpe A...Furlani L 19467900 2009 48 An idiopathic case of calcium pyrophosphate dihydrate crystal deposition disease with crowned dens syndrome in a young patient. 61 Unlu Z...Ozmen EM 19668044 2009 49 An update on the epidemiology [malacards.org]

[…] already occurring, higher doses are administered.[3] If nothing else works, hydroxychloroquine or methotrexate may provide relief.[12] Research into surgical removal of calcifications is underway, however this still remains an experimental procedure.[3] Epidemiology [en.wikipedia.org]

Neoplasms of the Joint 543 31 Heritable Disorders of Connective Tissue 549 32 Bone and Joint Dysplasias 559 33 Osteonecrosis 565 34 Pagets Disease of Bone 573 35 Osteoporosis A Epidemiology and Clinical Assessment 576 35 Osteoporosis B Pathology and Pathophysiology [books.google.de]

To learn the pathophysiology of this disorder. To understand the clinical manifestations of this disorder. To learn the radiographic distribution and appearance using example radiographs and the target approach to radiographic diagnosis. [posterng.netkey.at]

Definition / general Also called pseudogout, chondrocalcinosis Common finding in arthritic joints Pathophysiology Calcium pyrophosphate dehydrate (CPPD) crystals develop first in menisci and intervertebral discs, may seed the joint and elicit neutrophilic [pathologyoutlines.com]

"Crystal Arthritides: Gout and Calcium Pyrophosphate Arthritis/Part 1: Epidemiology and Pathophysiology." Z Gerontol Geriatr. 2017. DOI: 10.1007/s00391-017-1197-3. [verywellhealth.com]

Terkeltaub RA (2001) Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 281: C1–C11 Google Scholar 16. Zemplenyi J, Calcaterra TC (1985) Chondrocalcinosis of the temporomandibular joint. [link.springer.com]

With coverage of the latest therapies, preventions, and imaging studies, along with access to the fully searchable text online at www.expertconsult.com, this comprehensive resource is ideal for any physician who diagnoses, treats, and manages gout and [books.google.de]

They act in vasospastic angina to relax and prevent coronary artery spasm. [medical-dictionary.thefreedictionary.com]

Experts do not know how to prevent these crystals. If CPPD is due to some other medical problem, treatment of that condition may sometimes prevent CPPD from getting worse. [rheumatology.org]

Prevention There is no known way to prevent this disorder. However, treating other problems that may cause CPPD arthritis may make the condition less severe. Regular follow-up visits may help prevent permanent damage of the affected joints. [baptistjax.com]