Patients can present with fever and... References: McCarty DJ, Hollander JL. Identification of urate crystals in gouty synovial fluid. Ann Intern Med 1961; 54:452-460. McCarty DJ, Kohn NN, Faires JS. [posterng.netkey.at]

The presenting symptoms are similar to both gout and septic arthritis but may be treated differently. This article describes a typical patient presentation and management from an emergency medicine and orthopedic surgery standpoint. [journals.lww.com]

Acute CPPD crystal arthritis (pseudogout) presents with severe acute or subacute pain, swelling, erythema, and warmth, of one or more joints and is usually self-limited. The presentation classically resembles an acute gout attack. [radiopaedia.org]

We report a 50-year-old woman who presented with an acute herniated disc syndrome secondary to an intraspinal inflammatory calcium pyrophosphate deposition disease mass at the level of the L4-L5 interspace. [ncbi.nlm.nih.gov]

• Neuropathic Arthropathy

  A Hematologic and Malignant Disorders 470 25 Less Common Arthropathies B Rheumatic Disease and Endocrinopathies 479 25 Less Common Arthropathies C Hyperlipoproteinemia and Arthritis 484 25 Less Common Arthropathies D Neuropathic Arthropathy 488 25 Less [books.google.de]

  Pseudo-neuropathic Arthropathy Pseudo-neuropathic arthropathy is an unusual subtype of CPPD-related arthropathy, which is not fully understood yet. [cureus.com]

  Severe joint degeneration : Neuropathic arthropathy is characterized by severe joint degeneration and disruption occurring in the course of neurologic disorders leading to joint denervation; the affected joint is often called a Charcot joint. [wikidoc.org]

  Pseudo-neuropathic arthropathy: Some patients with CPPD disease have a dramatic destructive monoarthritis similar to that seen in neuropathic joints. [rheumatologyadvisor.com]

• Arthralgia

  In addition, induction of transient arthralgias in some patients is a well-recognized adverse effect of MTX [18], which could have further obscured a potential beneficial effect. [arthritis-research.biomedcentral.com]

  The most frequently reported adverse effects are diarrhea, back pain, headaches, and arthralgias. Also, patients should be monitored for thromboembolic events and increased hepatic transaminases. [clevelandclinicmeded.com]

• Flexion Contracture

  Signs: Pseudo-Rheumatoid (5% of CPPD Deposition Disease) Symmetric Polyarthritis with low grade inflammation Synovial thickening Flexion contractures Morning Stiffness Fatigue VI. [fpnotebook.com]

• Myelopathy

  Affected patients may present with a myelopathy. Preferential deposition of CPP crystals in ligamentum flavum at C3-C6 remains unexplained, but corresponds to the level of greatest mobility. [rheumatologyadvisor.com]

  […] patients with suspected CPPD.14 Therefore, plain X-ray film has shown greater sensitivity than MRI in the diagnosis of CPP arthropathy of the knee.24 CPP crystals may be deposited in both ligamentum flavum and posterior longitudinal ligament, leading to myelopathy [dovepress.com]

• Seizure

  Very rarely, familial CPPD can be associated with non rheumatological features, such as recurrent infantile seizures as was the case in a British family with CPPD and polyarticular chondrocalcinosis but without structural arthropathy. [orpha.net]

Septic arthritis workup. Medscape Reference. Available online at http://emedicine.medscape.com/article/236299-workup#c8. Accessed 9/9/2016. Sofronescu, A. (Updated 2016 April 13). Joint fluid interpretation. Medscape Reference. [labtestsonline.it]

Subsequent workup showed normal parathyroid hormone, normal calcium and phosphorous levels, and normal magnesium and alkaline phosphatase. [err.eg.net]

(See Etiology, Presentation, and Workup.) Calcium pyrophosphate deposition disease. Radiograph of the knee showing chondrocalcinosis involving the meniscal cartilage, as well as evidence of osteoarthritis. Calcium pyrophosphate deposition disease. [emedicine.medscape.com]

Gout or hyperuricemia in an adolescent or child is rare but invariably a manifestation of an underlying metabolic or inherited enzyme deficiency warranting a workup for these diseases. Postmenopausal women. [clevelandclinicmeded.com]

• Nephrolithiasis

  – 5/M 55 82 + + + + − − + + – – 6/F 42 46 + − − + + + + − Shoulder calcification – 7/F 45 59 + + − + + + + − Nephrolithiasis + 8/M 22 57 + + − + − + + − Nephrolithiasis, Osgood-Schlatter disease – 9/M 18 79 + + + + + + + + Nephrolithiasis – 10/M 40 75 [onlinelibrary.wiley.com]

  Hyperuricemia can cause uric acid nephrolithiasis and, possibly, nephropathy, if uric acid accumulates in the renal interstitium and tubules. [clevelandclinicmeded.com]

Recommendations for the management of CPPD disease tend to be based on expert opinion or extrapolated from research on the treatment of gout.15 Treatment of an acute attack Treatments to reduce the pain and swelling associated with an acute attack of [bpac.org.nz]

Treatment may involve removing fluid to relieve pressure in the joint. [healthing.ca]

Treatment of pseudogout attacks is with intra-articular corticosteroids or oral glucocorticoids, NSAIDs, or colchicine. [merckmanuals.com]

Prognosis The prognosis for individual attacks of acute calcium pyrophosphate arthritis is usually excellent. [merckmanuals.com]

Prognosis Some forms may be severe and result in considerable pain and disability. The documents contained in this web site are presented for information purposes only. [orpha.net]

[…] synovial fluid leading to a synovitis Associated conditions hemochromatosis hyperparathyroidism hypomagnesemia can be seen in Gitelman and Bartter syndrome joint trauma, surgery, and severe medical illness these conditions can provoke an acute attack Prognosis [medbullets.com]

The most likely etiology of the patient's knee pain is characterized by which finding? Review Topic QID: 1398 [orthobullets.com]

Prevalence Widespread in older population M:F = 3:2 Clinical findings Intermittent attacks May be mono-articular or polyarticular (more often) Pain Redness Swelling Types Frequently occurs in association with osteoarthritis Aging process with no known etiology [learningradiology.com]

Etiology The cause of calcium pyrophosphate arthritis is unknown. [merckmanuals.com]

Etiology Although the exact mechanism for the development of CPDD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. [emedicine.medscape.com]

[…] forearm) 712.24 (hand) 712.25 (pelvic region and thigh) 712.26 (leg) 712.27 (ankle and foot) 712.28 (other specified site) 727.82 (calcium deposites in tendon and bursa) 712.3 Chondrocalcinosis, unspecified 275.4 Disorders fo calcium metabolism Pseudogout Etiology [eorif.com]

His research is focused on a number of key elements in OA including (but not limited to) the epidemiology of osteoarthritis, the application of imaging to better understand structure and function with application to both epidemiologic research and clinical [books.google.de]

Epidemiology Autosomal Dominant inheritance and sporadic cases III. Associated Conditions IV. [fpnotebook.com]

Richette P, Bardin T, Doherty M; An update on the epidemiology of calcium pyrophosphate dihydrate crystal deposition disease. Rheumatology (Oxford). 2009 Jul48(7):711-5. Epub 2009 Apr 27. [patient.info]

[…] hand) 712.25 (pelvic region and thigh) 712.26 (leg) 712.27 (ankle and foot) 712.28 (other specified site) 727.82 (calcium deposites in tendon and bursa) 712.3 Chondrocalcinosis, unspecified 275.4 Disorders fo calcium metabolism Pseudogout Etiology / Epidemiology [eorif.com]

Neoplasms of the Joint 543 31 Heritable Disorders of Connective Tissue 549 32 Bone and Joint Dysplasias 559 33 Osteonecrosis 565 34 Pagets Disease of Bone 573 35 Osteoporosis A Epidemiology and Clinical Assessment 576 35 Osteoporosis B Pathology and Pathophysiology [books.google.de]

To learn the pathophysiology of this disorder. To understand the clinical manifestations of this disorder. To learn the radiographic distribution and appearance using example radiographs and the target approach to radiographic diagnosis. [posterng.netkey.at]

Definition / general Also called pseudogout, chondrocalcinosis Common finding in arthritic joints Pathophysiology Calcium pyrophosphate dehydrate (CPPD) crystals develop first in menisci and intervertebral discs, may seed the joint and elicit neutrophilic [pathologyoutlines.com]

"Crystal Arthritides: Gout and Calcium Pyrophosphate Arthritis/Part 1: Epidemiology and Pathophysiology." Z Gerontol Geriatr. 2017. DOI: 10.1007/s00391-017-1197-3. [verywellhealth.com]

Terkeltaub RA (2001) Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 281: C1–C11 Google Scholar 16. Zemplenyi J, Calcaterra TC (1985) Chondrocalcinosis of the temporomandibular joint. [link.springer.com]

Prevention There is no known way to prevent this disorder. However, treating other problems that may cause CPPD arthritis may make the condition less severe. Regular follow-up visits may help prevent permanent damage of the affected joints. [baptistjax.com]

They act in vasospastic angina to relax and prevent coronary artery spasm. [medical-dictionary.thefreedictionary.com]

Experts do not know how to prevent these crystals. If CPPD is due to some other medical problem, treatment of that condition may sometimes prevent CPPD from getting worse. [rheumatology.org]