A 55-year-old male presented with fissured, foul smelling, fungating growth over prepuce with ph… PMC Free Full TextPMC Free PDF Cutaneous metastases of rectal mucinous adenocarcinoma mimicking granuloma inguinale. [unboundmedicine.com]

Thiswide range is probably multifactorial andmay reflect either late presentation anddenial or non-sexual transmission. [fr.slideshare.net]

Clinical Presentation of Donovanosis The incubation period of Klebsiella granulomatis is usually more than one month. [lecturio.com]

Numerous electron dense granules were present within the cytoplasm. [ncbi.nlm.nih.gov]

Confirmatory test: demonstration of Donovan bodies in biopsies and/or smears from lesions PCR: if Donovan bodies or not present and to differentiate K. granulomatis from other Klebsiella species K. granulomatis cannot be cultured. [amboss.com]

• Cervical Lymphadenopathy

  Donovanosis causing cervical lymphadenopathy in a five-month old boy. Paed Infect Dis J 2000 ; 19: 167 – 169. Google Scholar | Crossref | Medline | ISI [journals.sagepub.com]

Without treatment: Severe genital disfigurement Pseudoelephantiasis Dissemination to liver & bone Diagnostic Workup for Donovanosis Isolation and culture of the organism are not easy or straightforward; therefore, the best way to diagnose donovanosis [lecturio.com]

Granuloma inguinale (donovanosis): Workup: Laboratory studies. Medscape. http://emedicine.medscape.com/article/1052617-workup [10] Satter, E.K. 2015. Granuloma inguinale (donovanosis): Treatment: Medical care. [microbewiki.kenyon.edu]

• Chlamydia Trachomatis

  Lymphogranuloma venereum is caused by Chlamydia trachomatis and begins with a frequently unnoticed bump on the genitals. Later, lymph…Read More [britannica.com]

  trachomatis serotype L1–L3), which is commonly known as lymphogranuloma venereum! [amboss.com]

  Three subjects were positive for Chlamydia trachomatis and T. pallidum; 2 subjects were positive for C. trachomatis and Neisseria gonorrhoeae; 2 subjects were positive for T. pallidum and HSV-2; and 1 subject was positive for T. pallidum and N. gonorrhoeae [academic.oup.com]

• Candida

  Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, E. coli, Escherichia fergunosii, Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Salmonella species, Streptococcus species, Serratia species, Saccharomyces cerevisiae, Candida [academic.oup.com]

Drug treatment There is a dilemma in recommending optimal treatment for donovanosis depending upon whether or not strict syndromic guidelines for GUD are recommended and adhered to. [doi.org]

A treatment failure with ampicillin was reported by Johnson in 1991 (22). On the strength of available evidence ampicillin cannot be recommended as first line treatment. [antimicrobe.org]

Terramycin in the treatment of granuloma inguinale. J Vener Dis Inf 1951 ; 32: 113 – 115. Google Scholar | Medline 18. Robinson, HM, Cohen, MM. Treatment of granuloma inguinale with erythromycin. J Invest Dermatol 1953 ; 20: 407 – 409. [journals.sagepub.com]

Treatment Complications References:[1] We list the most important complications. The selection is not exhaustive. Granuloma inguinale Summary Epidemiology Etiology Clinical features Diagnostics Differential diagnoses Treatment Complications [amboss.com]

Donovanosis Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Classification Differentiating Donovanosis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis [wikidoc.org]

Prognosis Relapse may occur up to 18 months after treatment. If untreated, the lesions may continue to expand for years. If granuloma inguinale remains untreated, secondary infections and lymphedema/elephantiasis may occur. [emedicine.medscape.com]

Any patient found to have a sexually transmitted disease should be considered for HIV testing.[3] Prognosis The prognosis for uncomplicated donovanosis is positive with appropriate treatment. [statpearls.com]

Prognosis If untreated the lesions may continue to increase in size and despite treatment, recurrent donovanosis is common. Relapse may occur up to 18 months after treatment. Healing of donovanosis ulcers can leave scars or hypertrophic lesions. [lecturio.com]

Any patient found to have a sexually transmitted disease should be considered for HIV testing. [3] Prognosis The prognosis for uncomplicated donovanosis is positive with appropriate treatment. [ncbi.nlm.nih.gov]

Granuloma inguinale Summary Epidemiology Etiology Clinical features Diagnostics Differential diagnoses Treatment Complications [amboss.com]

Etiology Pathogen of granuloma inguinale is gram-negative and intracellular Calymmatobacterium granulomatis. Signs and Symptoms Granuloma inguinale presents with progressive painless genital ulcers without inguinal lymphadenopathy. [urology-textbook.com]

Etiology: C.granulomatis is a capsulated gram negative bacillus which is non-motile, pleomorphic, non-sporing and displays bipolar staining. The safety pin appearance is due to single or bipolar condensation of chromatin. [microrao.com]

[…] including India, Guyana, New Guinea, central Australia, southern Africa Rare in USA and Europe Sites Anogenital skin, rarely oral mucosa or pharynx In females, vulva and perianal area are frequent sites; only rarely affects uterus, fallopian tubes, ovaries Etiology [pathologyoutlines.com]

However, DNA sequencing of 16S rRNA and phoE genes revealed similarity to Klebsiella.[1] There is 99% homology between the etiologic agent of donovanosis and members of Klebsiella.[2] A proposal has been put forth to reclassify the bacteria to Klebsiella [wikidoc.org]

Epidemiology Prevalence: endemic to tropical and subtropical countries Incidence: < 100 cases annually in the US Age range: 20–40 years References:[1] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Recurrence is said to occur despite good initial responses. 58 Epidemiological treatment can be considered in the absence of signs and symptoms in sexual partners of index cases. [doi.org]

Recurrence is said to occur despite good initial responses.58 Epidemiological treatment can be considered in the absence of signs and symptoms in sexual partners of index cases. [sti.bmj.com]

Definition Sexually transmitted disease with Calymmatobacterium granulomatis leading to progressive painless genital ulcers Epidemiology Granuloma inguinale occurs mainly in tropical countries. [urology-textbook.com]

Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011 Jul 1. 53(1):60-7. [Medline]. van Duin D, Bonomo RA. [medscape.com]

Donovanosis Microchapters Home Patient Information Overview Historical Perspective Pathophysiology Causes Classification Differentiating Donovanosis from other Diseases Epidemiology and Demographics Risk Factors Natural History, Complications and Prognosis [wikidoc.org]

Pathophysiology The intracellular organism responsible for granuloma inguinale was initially described by Donovan over a century ago, and subsequently, the bacterium was classified in 1913 as Calymmatobacterium granulomatis. [emedicine.medscape.com]

Pathophysiology of Donovanosis Once the patient acquires the causative organism Klebsiella granulomatis, repeated exposure is important in order for them to develop clinical symptoms. [lecturio.com]

In general, the incubation period is recorded as 1 to 365 days due to lack of data.[4] Pathophysiology Donovanosis is a sexually transmitted infection that can rarely have non-sexual modes of transmission. [statpearls.com]

In general, the incubation period is recorded as 1 to 365 days due to lack of data. [4] Pathophysiology Donovanosis is a sexually transmitted infection that can rarely have non-sexual modes of transmission. [ncbi.nlm.nih.gov]

Safe- sex practices will prevent the spread of granuloma inguinale as well as other sexually transmitted diseases. [dermnetnz.org]

Control measures for donovanosis Preventive measures Preventive measures include education about safe sex practices, including use of condoms when having vaginal or anal sex, and early detection of infection by testing of people at risk. [www2.health.vic.gov.au]

Index: 1–9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z References Center for Disease Control and Prevention.: Sexually transmitted diseases treatment guidelines 2006. in: MMWR 2006; 55 (No. RR-11): 1–93. [urology-textbook.com]

You might guess that it’s chlamydia or gonorrhea, but according to the Centers for Disease Control and Prevention, it’s trichomoniasis (also known as trich, pronounced “trick”). [advocatesaz.org]

Source: Wikipedia, Wikipedia LP6429-7 Organism specific culture An organism-specific culture contains nutrients that optimize the growth of a specific organism and inhibitors that prevent the growth of competing organisms. [loinc.org]