Presentation
We present a case of a 56-year-old renal transplant recipient who presented with brief diarrheal illness followed by Campylobacter jejuni bacteremia. She remained asymptomatic for 5 days after initial presentation despite positive blood cultures. [ncbi.nlm.nih.gov]
Entire Body System
- Inflammation
However, much work remains to be done to fully understand the implications of immune-mediated inflammation and its potential role in diseases such as environmental enteric dysfunction. [ncbi.nlm.nih.gov]
- Malaise
Campylobacter jejuni food poisoning is characterised by a prodromal malaise, abdominal pain, diarrhoea, with vomiting being uncommon. [gpnotebook.co.uk]
This syndrome has an insidious onset of malaise, fever, abdominal pain, and bradycardia. Diarrhea and rash (rose spots) appear after 1 week of symptoms. [emedicine.medscape.com]
Systemic upset is common with fever [and febrile convulsions in vulnerable children (92) ], malaise, and headache. These symptoms sometimes precede the onset of abdominal symptoms. Vomiting also may occur. Symptoms usually resolve within a week. [doi.org]
- Fishing
RNA-FISH reveals that flaA mRNA is expressed and localized at the poles of elongating cells. Polar flaA mRNA localization is translation dependent and is post-transcriptionally regulated by the CsrA-FliW network. [ncbi.nlm.nih.gov]
Duration of symptoms: 7-10 days Control: Thoroughly cook meat, poultry and fish. Proper sanitation of food contact surfaces and utensils. Proper hand washing after handling raw meat, poultry and seafood. Use pasteurized milk. Use a safe water supply. [food.unl.edu]
Poisonings: food, fish, shellfish. Emerg Med Clin North Am. 1997 Feb. 15(1):157-77. [Medline]. Nataro JP, Steiner T, Guerrant RL. Enteroaggregative Escherichia coli. Emerg Infect Dis. 1998 Apr-Jun. 4(2):251-61. [Medline]. Paterson DL. [emedicine.medscape.com]
Gastrointestinal
- Chronic Diarrhea
Ingestion of particular foods Exposure to water Exposure to animals Travel to particular countries Preexisting conditions Physical findings may include the following: Dehydration (primary cause of morbidity and mortality) Malnutrition (typically a sign of a chronic [emedicine.medscape.com]
Neurologic
- Headache
Nausea, vomiting, headache, and myalgias may also be present. Tenesmus is a common feature. [ncbi.nlm.nih.gov]
Symptoms include: Abdominal cramps Diarrhea Headache Watery and occasionally bloody stools Fever Onset time: 2-3 days Infective Dose: 400-500 cells need to be consumed for some to become ill; Higher numbers of cells are needed for others. [food.unl.edu]
Between 12 to 24 hours before the onset of enteric symptoms, early symptoms include headache, fever, fatigue, abdominal, muscle and joint pain. Diarrhoea is often characterised by mushy to watery stools, which can occasionally be bloody. [hygiene-in-practice.com]
Systemic upset is common with fever [and febrile convulsions in vulnerable children (92) ], malaise, and headache. These symptoms sometimes precede the onset of abdominal symptoms. Vomiting also may occur. Symptoms usually resolve within a week. [doi.org]
Workup
Extensive workup revealed no signs of skin or joint disease, thus excluding Henoch-Schönlein purpura. [ncbi.nlm.nih.gov]
(See Etiology, Presentation, Workup, and Treatment .) Bacterial gastroenteritis is usually self-limited, but improper management of an acute infection can lead to a protracted course. By far, the most common complication is dehydration. [emedicine.medscape.com]
Microbiology
- Helicobacter Pylori
Campylobacter jejuni, from the delta-epsilon group of proteobacteria, is a microaerophilic, Gram-negative, flagellate, spiral bacterium-properties it shares with the related gastric pathogen Helicobacter pylori. [ncbi.nlm.nih.gov]
The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539– 547 (1997). 16 Konkel, M. E., Kim, B. J., Rivera-Amill, V. & Garvis, S. G. [nature.com]
- Giardia Lamblia
Escherichia coli Salmonella typhi Giardia lamblia Vibrio cholerae [museumofhealthcare.ca]
Colonoscopy
- Colitis
Community-acquired colitis may be caused by C. jejuni or other enteric pathogens, for example, Shigella, Entamoeba, Yersinia, Escherichia coli 0157:H7, Clostridium difficile colitis, ischemic colitis, or idiopathic ulcerative colitis. [ncbi.nlm.nih.gov]
Treatment
Intraperitoneal cefepime treatment was started. Campylobacter jejuni was isolated from peritoneal dialysis fluid culture and oral clarithromycin was added to the treatment. At the end of therapy, peritoneal fluid culture was negative. [ncbi.nlm.nih.gov]
Prognosis
However, long-term prognosis remains unclear. In addition to the case report, we conducted a review of the literature with results underlining Campylobacter jejuni's potential to trigger various types of immune mediated kidney diseases. [ncbi.nlm.nih.gov]
With proper management, the prognosis for bacterial gastroenteritis is very good, especially in industrialized countries. [emedicine.medscape.com]
In addition, all patients were followed for one year to determine the effect of C. jejuni infection on prognosis. [doi.org]
Etiology
Although C. jejuni peritonitis is rarely encountered in children, it should be considered as an etiologic factor for peritonitis. [ncbi.nlm.nih.gov]
The thermophilic campylobacteria that are etiological agents of human enteritis now include three species, C. jejuni, C. coli, and C. laridis. [doi.org]
Epidemiology
Ultimately, the data generated from this study will help to better understand the molecular epidemiology of C. jejuni infection. Copyright © 2018. Published by Elsevier B.V. [ncbi.nlm.nih.gov]
Epidemiology of Campylobacter jejuni infections in the United States and other industrialized nations. In Campylobacter (2 ed., Vol. II/6, pp. 121-138). Washington, USA: ASM International. [orbit.dtu.dk]
Pathophysiology
With treatment, the prognosis of full recovery is good but several questions remain to be answered regarding the pathophysiology and the male preponderance of the condition. [ncbi.nlm.nih.gov]
Pathophysiology of Campylobacter enteritis. Microbiol Rev. 1986 Mar. 50(1):81-94. [Medline]. Wassenaar TM, Blaser MJ. Pathophysiology of Campylobacter jejuni infections of humans. Microbes Infect. 1999 Oct. 1(12):1023-33. [Medline]. [emedicine.medscape.com]
These features are consistent with the unique niche of H. pylori in the stomach, and its pathophysiology and propensity for chronic infection. [nature.com]
Prevention
Rome, Italy. 4 4 Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy. 5 5 European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden. [ncbi.nlm.nih.gov]