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Campylobacter Jejuni


Presentation

  • We present a case of a 56-year-old renal transplant recipient who presented with brief diarrheal illness followed by Campylobacter jejuni bacteremia. She remained asymptomatic for 5 days after initial presentation despite positive blood cultures.[ncbi.nlm.nih.gov]
  • We present the case of a 24-year-old male with Noonan syndrome who presented with a diarrhoeal pro-dromal illness, acute onset chest pain, elevated cardiac biomarkers and an abnormal ECG with ST elevation in the absence of obstructive coronary artery[ncbi.nlm.nih.gov]
  • The present case findings suggest that CD should be considered in the differential diagnosis of persistent IBS-like symptoms after an episode of infectious gastroenteritis.[ncbi.nlm.nih.gov]
  • The rapid diagnosis and subtyping of influenza is particularly important in areas where avian influenza (H5N1) is present. The ability to recognise both typical and atypical presentations of influenza is also critical in such settings.[ncbi.nlm.nih.gov]
  • In both cases, the diagnosis of C jejuni-associated perimyocarditis was set based on the typical presentation and positive stool cultures with identical strains.[ncbi.nlm.nih.gov]
Chest Discomfort
  • A 73-year-old female hemodialysis patient experienced fever, shortness of breath on effort, and chest discomfort.[ncbi.nlm.nih.gov]
Developmental Disabilities
  • We hypothesize that the inflammation mediated by C. jejuni infection causes environmental enteric dysfunction, and with contribution from diet and the host, microbiome may be responsible for growth faltering in children and developmental disability.[ncbi.nlm.nih.gov]
Nasal Voice
  • A 29-year-old man developed dysphagia and nasal voice without limb weakness, ataxia, or areflexia. High titres of serum anti-GT1a and anti-Campylobacter jejuni IgG antibodies were detected.[ncbi.nlm.nih.gov]
Pleural Effusion
  • A decrease in breath sounds in the right lung field, leukocytosis, elevated CRP level, and a right massive pleural effusion were observed.[ncbi.nlm.nih.gov]
Dysphagia
  • A 29-year-old man developed dysphagia and nasal voice without limb weakness, ataxia, or areflexia. High titres of serum anti-GT1a and anti-Campylobacter jejuni IgG antibodies were detected.[ncbi.nlm.nih.gov]
Left Ventricular Dysfunction
  • Severe left ventricular dysfunction complicated only two cases of C. jejuni myocarditis. We report here a young male with Campylobacter myopericarditis.[ncbi.nlm.nih.gov]
Abnormal Reflex
  • He showed exaggerated tendon reflexes with abnormal reflex spread to other segments, and was initially diagnosed as having post-infectious myelitis.[ncbi.nlm.nih.gov]
Excitement
  • This case provides further evidence that patients with AMAN can develop increased motor neuron excitability, and possible mechanisms for the hyperreflexia are discussed.[ncbi.nlm.nih.gov]
Hyperreflexia
  • Hyperreflexia was still present 12 months after onset when muscle strength was completely normal.[ncbi.nlm.nih.gov]

Workup

  • Extensive workup revealed no signs of skin or joint disease, thus excluding Henoch-Schönlein purpura.[ncbi.nlm.nih.gov]
  • (See Etiology, Presentation, Workup, and Treatment .) Bacterial gastroenteritis is usually self-limited, but improper management of an acute infection can lead to a protracted course. By far, the most common complication is dehydration.[emedicine.medscape.com]
Cytopenia
  • Cytopenias were mild, transient, and not associated with prolonged hospital stay or complications.[ncbi.nlm.nih.gov]
Escherichia Coli 0157:H7
  • Community-acquired colitis may be caused by C. jejuni or other enteric pathogens, for example, Shigella, Entamoeba, Yersinia, Escherichia coli 0157:H7, Clostridium difficile colitis, ischemic colitis, or idiopathic ulcerative colitis.[ncbi.nlm.nih.gov]
Abnormal ECG
  • We present the case of a 24-year-old male with Noonan syndrome who presented with a diarrhoeal pro-dromal illness, acute onset chest pain, elevated cardiac biomarkers and an abnormal ECG with ST elevation in the absence of obstructive coronary artery[ncbi.nlm.nih.gov]
HLA-DR8
  • The patient shared the HLA-B35 and HLA-DR8 antigens, which have been found to be increased in GBS patients with previous C. jejuni infection.[ncbi.nlm.nih.gov]
Pleural Effusion
  • A decrease in breath sounds in the right lung field, leukocytosis, elevated CRP level, and a right massive pleural effusion were observed.[ncbi.nlm.nih.gov]

Treatment

  • After chemotherapeutic treatment, the patient experienced fever associated with severe neutropenia and thrombocytopenia without hemodynamic instability, abdominal pain, and diarrhea.[ncbi.nlm.nih.gov]
  • Recrudescent Campylobacter infections after treatment may be more common than has previously been appreciated.[ncbi.nlm.nih.gov]
  • Intraperitoneal cefepime treatment was started. Campylobacter jejuni was isolated from peritoneal dialysis fluid culture and oral clarithromycin was added to the treatment. At the end of therapy, peritoneal fluid culture was negative.[ncbi.nlm.nih.gov]
  • After 2 weeks of treatment with meropenem and erythromycin for 4 weeks, the patient developed a relapse of bacteremia 10 months later with a high level erythromycin resistant C. jejuni.[ncbi.nlm.nih.gov]
  • KEYWORDS: Antimicrobial treatment; Campylobacter jejuni; Postharvest poultry; β-Resorcylic acid[ncbi.nlm.nih.gov]

Prognosis

  • However, long-term prognosis remains unclear. In addition to the case report, we conducted a review of the literature with results underlining Campylobacter jejuni's potential to trigger various types of immune mediated kidney diseases.[ncbi.nlm.nih.gov]
  • With treatment, the prognosis of full recovery is good but several questions remain to be answered regarding the pathophysiology and the male preponderance of the condition.[ncbi.nlm.nih.gov]
  • With proper management, the prognosis for bacterial gastroenteritis is very good, especially in industrialized countries.[emedicine.medscape.com]
  • In addition, all patients were followed for one year to determine the effect of C. jejuni infection on prognosis.[doi.org]

Etiology

  • Although C. jejuni peritonitis is rarely encountered in children, it should be considered as an etiologic factor for peritonitis.[ncbi.nlm.nih.gov]
  • Unfortunately, corticosteroids (necessary for the treatment of inflammatory bowel disease) may exacerbate infectious etiologies.[ncbi.nlm.nih.gov]
  • Identifying the etiology of myocarditis as bacterial will ensure that appropriate treatment with antibiotics occurs in addition to any cardiology medications needed for supportive care.[ncbi.nlm.nih.gov]
  • The thermophilic campylobacteria that are etiological agents of human enteritis now include three species, C. jejuni, C. coli, and C. laridis.[doi.org]

Epidemiology

  • Ultimately, the data generated from this study will help to better understand the molecular epidemiology of C. jejuni infection. Copyright 2018. Published by Elsevier B.V.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Infectious Disease Epidemiology,Statens Serum Institut,Copenhagen,Denmark. 2 Department for Infectious Disease Epidemiology,Robert Koch Institute,Berlin,Germany. 3 Department of Microbiological Diagnostics and Virology[ncbi.nlm.nih.gov]
  • KEYWORDS: Campylobacter jejuni; genomic epidemiology; monomorphic clones; whole-genome sequencing[ncbi.nlm.nih.gov]
  • The aim of this study was to determine the genetic and epidemiological degree of clustering among Campylobacter jejuni isolates from Danish patients.[ncbi.nlm.nih.gov]
  • We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • With treatment, the prognosis of full recovery is good but several questions remain to be answered regarding the pathophysiology and the male preponderance of the condition.[ncbi.nlm.nih.gov]
  • Pathophysiology of Campylobacter enteritis. Microbiol Rev. 1986 Mar. 50(1):81-94. [Medline]. Wassenaar TM, Blaser MJ. Pathophysiology of Campylobacter jejuni infections of humans. Microbes Infect. 1999 Oct. 1(12):1023-33. [Medline].[emedicine.medscape.com]
  • These features are consistent with the unique niche of H. pylori in the stomach, and its pathophysiology and propensity for chronic infection.[dx.doi.org]

Prevention

  • The other immunoglobulin classes act on bacteria entering the blood stream, thus preventing bacteraemia. C. jejuni can also stimulate the cellular immune system, but this seems to play only a small role in preventing infection.[ncbi.nlm.nih.gov]
  • Further studies to establish appropriate antibiotic therapy for eradicating colonized C. jejuni and preventing recurrent infection are needed.[ncbi.nlm.nih.gov]
  • This review article summarizes the current literature on the role of poly P in C. jejuni stress survival and virulence and discusses on how poly P-related enzymes can be exploited for therapeutic/prevention purposes.[ncbi.nlm.nih.gov]
  • Bergamo , Rome, Italy . 4 4 Azienda Ospedaliera Papa Giovanni XXIII , Bergamo, Italy . 5 5 European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC) , Stockholm, Sweden .[ncbi.nlm.nih.gov]
  • Author information 1 Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011; 2 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074; Genome Institute[ncbi.nlm.nih.gov]

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