Presentation
The patient died of pneumonia 2 years after presentation. [ncbi.nlm.nih.gov]
Entire Body System
-
Collapse
Some authors caution that readministration of intravitreal steroid for recurrent CME in npAIR and CAR is best done early when cystic changes are just starting to recur to avoid cycles of retinal cyst expansion and collapse which may cause retinal damage [joii-journal.springeropen.com]
Eyes
-
Retinal Cyst
Some authors caution that readministration of intravitreal steroid for recurrent CME in npAIR and CAR is best done early when cystic changes are just starting to recur to avoid cycles of retinal cyst expansion and collapse which may cause retinal damage [joii-journal.springeropen.com]
Musculoskeletal
-
Short Arm
Using a 7 kb subclone of the human recoverin gene, a positive fluorescence in situ hybridization signal was demonstrated near the terminus of the short arm of chromosome 17 at position p13.1. [ncbi.nlm.nih.gov]
Psychiatrical
-
Suggestibility
This strongly suggested that the 23-kDa antigen and recoverin are identical proteins. [ncbi.nlm.nih.gov]
Workup
In a patient with suspected CAR and no known history of malignancy, appropriate workup includes a detailed history and physical examination, and chest X-ray. 31 Additional imaging studies may be warranted depending on findings of the initial workup. [reviewofophthalmology.com]
The initial workup should include a full assessment of the patient's visual function, including color vision and visual field testing. [emedicine.medscape.com]
Treatment
During treatment, there was progressive improvement in symptoms and the ERG normalized. Serology confirmed complete clearance of autoantibodies. [ncbi.nlm.nih.gov]
Prognosis
Taken together, our present data suggest that peripheral activation of recoverin-specific antitumor CTL is likely to contribute to the preferable prognosis of CAR( ) cancer patients. [ncbi.nlm.nih.gov]
Prognosis The ophthalmological prognosis varies depending on the clinical course of CAR, ranging from progressive visual loss to blindness. The overall prognosis varies depending on the type of cancer present. [orpha.net]
Etiology
Etiology The exact etiology remains unknown but an autoimmune mechanism may contribute to the development of retinal degeneration. No known genetic association has been reported. [orpha.net]
CONCLUSIONS AND CLINICAL RELEVANCE: The etiology of SARDS in dogs does not appear to be similar to cancer-associated retinopathy in humans on the basis of absence of differential antibody activity against retinal proteins. [ncbi.nlm.nih.gov]
274 1541 Myohistological Investigations 275 155 Treatment 276 1552 Symptomatic Treatment 277 156 Differential Diagnosis 278 1563 Congenital Fibrosis of the Extraocular Muscles 279 Treatment of Specific Types of Nystagmus 283 161 Introduction 284 16211 Etiology [books.google.com]
Etiology There has been different antibodies isolated against many specific retinal proteins: Recoverin Carbonic anhydrase II Transducin B [Alpha]-enolase TULP1 [Tubby-like Protein 1] PNR photoreceptor cell-specific nuclear receptor Heat shock cognate [eyewiki.aao.org]
Epidemiology
Summary Epidemiology The prevalence is unknown but around 100 cases have been reported in the literature. [orpha.net]
Plasma exchange Ataxia with antibodies to CARP 8 10 Epidemiology: 1 patient; 77 year old female Clinical: Pure cerebellar syndrome Onset: 3 years after neoplasm Ataxia: Limb; Truncal; Gait; Dysarthria Ocular: Horizontal nystagmus Mental status: Normal [neuromuscular.wustl.edu]
Diagnosis : Interferon-associated Retinopathy Epidemiology: No age/gender predilection Pre-existing arteriosclerosis that affects microcirculation may promote development of retinopathy Signs: Cotton wool spots especially around the optic nerve Retinal [webeye.ophth.uiowa.edu]
Epidemiology In general, PR and AR are uncommon disorders; their exact prevalence, however, is unknown. They usually affect older adults, but patients as young as 3 years have been described, [13] with no sex predilection. [emedicine.medscape.com]
Pathophysiology
We discuss the typical clinical symptoms as well as the pathophysiology of this uncommon disorder. [ncbi.nlm.nih.gov]
Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. [books.google.com]
Pathophysiology Keltner et al developed an autoimmune theory in 1983 when he found antibodies against retinal photoreceptors in patient with lymphoma who developed acute vision loss and retinal degeneration. [eyewiki.aao.org]
[…] affected patients' serum with the inner segments and nuclei of rods and cones and the outer plexiform layer of the retina, in MAR, affected patients' serum reacts with the bipolar cell layer of the retina.2 Two mechanisms have been postulated as the pathophysiologic [ispub.com]
Prevention
Corticosteroid therapy failed to prevent visual loss. She was found to possess antibodies against retinal 45 kd protein. This led to a diagnosis of cancer-associated retinopathy with atypical protein profile. [ncbi.nlm.nih.gov]
Funding and Disclosures Supported by grants from Research to Prevent Blindness, Fight for Sight, the National Society for the Prevention of Blindness, and Retinitis Pigmentosa International. [nejm.org]
The study was fund in part by the grant from National Eye Institute EY13053 (GA), EY10572 (DC), and unrestricted grant to Casey Eye Institute from the Foundation to Prevent Blindness. [omicsonline.org]
Interdisciplinary Center of Ophthalmic Preventive Medicine and Imaging, Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Deutschland ICD10-Code: H35.0, D05.7 Path: Retina - Aquired Macular Diseases - Cancer-associated Retinopathy [atlas-1-elastic.atlasoph.com]