Conclusions: CAR can present with periphlebitis and a negative-type ERG. [jhu.pure.elsevier.com]

The 40 kD antigen doublet was most abundant in retinal extract but was also present in lung and spleen extracts. The 35 kD antigen showed little tissue specificity and was present in all tissues tested. [ncbi.nlm.nih.gov]

• Short Arm

  Using a 7 kb subclone of the human recoverin gene, a positive fluorescence in situ hybridization signal was demonstrated near the terminus of the short arm of chromosome 17 at position p13.1. [ncbi.nlm.nih.gov]

• Suggestibility

  This strongly suggested that the 23-kDa antigen and recoverin are identical proteins. [ncbi.nlm.nih.gov]

In a patient with suspected CAR and no known history of malignancy, appropriate workup includes a detailed history and physical examination, and chest X-ray. 31 Additional imaging studies may be warranted depending on findings of the initial workup. [reviewofophthalmology.com]

The initial workup should include a full assessment of the patient's visual function, including color vision and visual field testing. [emedicine.medscape.com]

The role of alemtuzumab in the treatment of paraneoplastic retinopathy and optic neuropathy should be studied in future larger-scale studies. [iovs.arvojournals.org]

During treatment, there was progressive improvement in symptoms and the ERG normalized. Serology confirmed complete clearance of autoantibodies. [ncbi.nlm.nih.gov]

[…] sensitivity of acute lymphoblastic leukemia cells carrying the t(12;21) translocation to campath-1H-mediated cell lysis Golay, J; Cortiana, C; Manganini, M Mature T-cell leukemias Ravandi, F; Kantarjian, H; Jones, D; Dearden, C; Keating, M; O’Brien, S Treatment [deepdyve.com]

The CAR syndrome relapsed at 32 month of treatment without cancer relapse, and required to re-increase corticosteroid treatment. [erj.ersjournals.com]

The treatment of CAR is often challenging. Treatment of the underlying malignancy alone does not alter the course of the ocular disease. [joii-journal.springeropen.com]

Taken together, our present data suggest that peripheral activation of recoverin-specific antitumor CTL is likely to contribute to the preferable prognosis of CAR(+) cancer patients. [ncbi.nlm.nih.gov]

Prognosis The ophthalmological prognosis varies depending on the clinical course of CAR, ranging from progressive visual loss to blindness. The overall prognosis varies depending on the type of cancer present. [orpha.net]

Etiology The exact etiology remains unknown but an autoimmune mechanism may contribute to the development of retinal degeneration. No known genetic association has been reported. [orpha.net]

274 1541 Myohistological Investigations 275 155 Treatment 276 1552 Symptomatic Treatment 277 156 Differential Diagnosis 278 1563 Congenital Fibrosis of the Extraocular Muscles 279 Treatment of Specific Types of Nystagmus 283 161 Introduction 284 16211 Etiology [books.google.com]

Etiology There has been different antibodies isolated against many specific retinal proteins: Recoverin Carbonic anhydrase II Transducin B [Alpha]-enolase TULP1 [Tubby-like Protein 1] PNR photoreceptor cell-specific nuclear receptor Heat shock cognate [eyewiki.aao.org]

Clinical course, genetic etiology, and visual outcome in cone and cone-rod dystrophy. Ophthalmology. 2012;119(4):819-826. Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. [retinalphysician.com]

Summary Epidemiology The prevalence is unknown but around 100 cases have been reported in the literature. [orpha.net]

Plasma exchange Ataxia with antibodies to CARP 8 10 Epidemiology: 1 patient; 77 year old female Clinical: Pure cerebellar syndrome Onset: 3 years after neoplasm Ataxia: Limb; Truncal; Gait; Dysarthria Ocular: Horizontal nystagmus Mental status: Normal [neuromuscular.wustl.edu]

Diagnosis : Interferon-associated Retinopathy Epidemiology: No age/gender predilection Pre-existing arteriosclerosis that affects microcirculation may promote development of retinopathy Signs: Cotton wool spots especially around the optic nerve Retinal [webeye.ophth.uiowa.edu]

Epidemiology In general, PR and AR are uncommon disorders; their exact prevalence, however, is unknown. They usually affect older adults, but patients as young as 3 years have been described, [13] with no sex predilection. [emedicine.medscape.com]

We discuss the typical clinical symptoms as well as the pathophysiology of this uncommon disorder. [ncbi.nlm.nih.gov]

Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. [books.google.com]

Pathophysiology Keltner et al developed an autoimmune theory in 1983 when he found antibodies against retinal photoreceptors in patient with lymphoma who developed acute vision loss and retinal degeneration. [eyewiki.aao.org]

[…] affected patients' serum with the inner segments and nuclei of rods and cones and the outer plexiform layer of the retina, in MAR, affected patients' serum reacts with the bipolar cell layer of the retina.2 Two mechanisms have been postulated as the pathophysiologic [ispub.com]

Corticosteroid therapy failed to prevent visual loss. She was found to possess antibodies against retinal 45 kd protein. This led to a diagnosis of cancer-associated retinopathy with atypical protein profile. [ncbi.nlm.nih.gov]

Funding and Disclosures Supported by grants from Research to Prevent Blindness, Fight for Sight, the National Society for the Prevention of Blindness, and Retinitis Pigmentosa International. [nejm.org]

Dr. med., Interdisciplinary Center of Ophthalmic Preventive Medicine and Imaging, Department of Ophthalmology, Friedrich-Alexander-University, Erlangen, Deutschland ICD10-Code: H35.0, D05.7 Path: Retina -> Aquired Macular Diseases -> Cancer-associated [atlas-1-elastic.atlasoph.com]