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Candida Albicans


Presentation

  • The patient also presented with a local fistula. The iliac crest was the only bone affected and local pain was the only symptom present in our case. Diagnosis was made by multiple-specimen biopsy obtained by surgery.[ncbi.nlm.nih.gov]
  • C. albicans eyelid abscess may be the presenting sign of systemic immunodeficiency.[ncbi.nlm.nih.gov]
  • Here, we present the case report of a woman, aged 64, who presented with type II diabetes mellitus and psoriasis, on chronic treatment with cyclosporin A and with endoscopic evidence of an ulcerated, vegetating gastric lesion secondary to Candida albicans[ncbi.nlm.nih.gov]
  • He most likely developed C. albicans arthritis and osteomyelitis during the neonatal period with a subsequent indolent and subacute presentation.[ncbi.nlm.nih.gov]
  • All of the clinical isolates presented a high adhesion capacity on SiHa cells.[ncbi.nlm.nih.gov]
Turkish
  • A 4-year-old Turkish girl of consanguineous parents was hospitalized for the evaluation of headaches and recurrent febrile episodes of unknown origin. Her medical history was unremarkable except for a few episodes of uncomplicated oral thrush.[ncbi.nlm.nih.gov]
Splenectomy
  • Neither patient responded to standard ITP therapy including splenectomy. Appropriate antifungal treatment of the C. albicans infection was followed by sustained improvement in platelet count in both patients.[ncbi.nlm.nih.gov]
Heart Failure
  • A 60-year-old woman with past medical history of heart failure with reduced ejection fraction, implantable cardioverter-defibrillator (ICD) placement, sarcoidosis and diabetes presented with fevers and atypical pleuritic chest pain.[ncbi.nlm.nih.gov]
Periodontitis
  • Porphyromonas gingivalis, an anaerobic Gram-negative bacterium critically involved in the development of human periodontitis, belongs to the late colonizers of the oral cavity.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • This case widens our knowledge on the C. albicans infections both in terms of host susceptibility and cutaneous manifestations.[ncbi.nlm.nih.gov]
Limb Weakness
  • A 42-year-old woman was admitted to our hospital because of fever, abdominal pain, headache, and right limb weakness.[ncbi.nlm.nih.gov]

Workup

  • Additional workup revealed severe neutropenia with an absolute neutrophil count of 0.18 k/μl (1.19-7.21 k/μl). The abscess resolved after 2 weeks of oral fluconazole. C. albicans eyelid abscess may be the presenting sign of systemic immunodeficiency.[ncbi.nlm.nih.gov]
  • Neuroimaging studies should be included in diagnostic workup of patients with systemic fungal infection. Improved neuroimaging techniques such as MRI may lead to earlier diagnosis of cerebral abscesses.[ncbi.nlm.nih.gov]
  • On further workup he was found to have infective endocarditis with a large vegetation across the pulmonary valve. No other valves were involved. He was treated with intravenous antifungal therapy for eight weeks. Valvular surgery was not performed.[ncbi.nlm.nih.gov]
  • Immunologic workup excluded predisposing B-cell and T-cell defects. In addition, T cells producing interleukin-17 were repeatedly measured within the normal range.[ncbi.nlm.nih.gov]
  • Genitourinary candidiasis - A urinalysis should be performed; evidence of white blood cells (WBCs), red blood cells (RBCs), protein, and yeast cells is common; urine fungal cultures are useful Gastrointestinal candidiasis - Endoscopy with or without biopsy See Workup[emedicine.medscape.com]

Treatment

  • She was prescribed corticosteroid treatment for endothelial rejection by another ophthalmologist because of misdiagnosis, but suffered a recurrence of symptoms after reduction of the corticosteroid treatment.[ncbi.nlm.nih.gov]
  • Photodynamic therapy (PDT) utilizing curcumin and blue light was tested as an independent therapy and in combination with fluconazole treatment. Viability assays and morphology analysis were used to assess the effectiveness of C. albicans treatment.[ncbi.nlm.nih.gov]
  • Endovascular stent-graft placement has emerged as a minimally invasive alternative to open surgery for the treatment of aortic aneurysms and dissections.[ncbi.nlm.nih.gov]
  • These results clearly indicate that the combination of PDI and antifungal agents could be a promising treatment against C. albicans infections.[ncbi.nlm.nih.gov]
  • Surgical debridement has to be considered, following antimycotic regime recommendations vary in pharmaceutical agents and treatment duration.[ncbi.nlm.nih.gov]

Prognosis

  • This situation can be considered as a one-stage exchange for fungal peri-prosthetic infection without preoperative identification of the responsible organism, which is considered as having a poor prognosis.[ncbi.nlm.nih.gov]
  • Therefore, the course of this patient's disease care will be a useful adjunct to the current literature for determining treatment and prognosis in similar cases.[ncbi.nlm.nih.gov]
  • Discussion Polymicrobial infections are increasingly recognized as a clinically important entities due to altered patient prognosis that results in increased hospital stays and decreased antimicrobial efficacy ( Sancho et al., 2012 ).[frontiersin.org]

Etiology

  • The authors discuss the unusual site of the disease and the singular clinical features related to the fungal etiology and put forward considerations on the pathogenic role of common microorganisms.[ncbi.nlm.nih.gov]
  • Candida biofilms adhere to the internal surface of removable dentures, which is an etiological factor in the pathogenesis of denture stomatitis (DS).[ncbi.nlm.nih.gov]
  • The present review highlights the etiology, epidemiology, molecular typing, commensalism and virulence factors, along with the appropriate prevention and control strategies regarding this widespread pathogen.[ncbi.nlm.nih.gov]
  • Candida species and coagulase-negative staphylococci (CoNS) are common etiologies of hospital acquired bloodstream infection in the neonatal intensive care unit (NICU).[ncbi.nlm.nih.gov]
  • Candida species have emerged as the most prevalent etiologic agents of brain abscesses in autopsy studies.[ncbi.nlm.nih.gov]

Epidemiology

  • The efficacy of antifungal treatment against candidiasis has been evaluated and discussed in the context of large epidemiological studies.[ncbi.nlm.nih.gov]
  • It could be integrated into routine clinical laboratories and as a reliable identification tool and has the potential to be implemented into epidemiological studies to broaden the limited knowledge of cryptic species complexes.[ncbi.nlm.nih.gov]
  • Epidemiological cutoff values (ECVs) published in the Clinical and Laboratory Standards Institute (CLSI) M59 document were applied for species with no clinical breakpoints.[ncbi.nlm.nih.gov]
  • Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.[books.google.es]
  • "Epidemiology and risk factors for invasive candidiasis" . Dovepress . 10 : 95–105. doi : 10.2147/TCRM.S40160 . PMC 3928396 . PMID 24611015 . “Fungal Diseases.”[en.wikipedia.org]
Sex distribution
Age distribution

Pathophysiology

  • The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain[ncbi.nlm.nih.gov]
  • Pathophysiology Candida species are yeastlike fungi that can form true hyphae and pseudohyphae.[emedicine.medscape.com]

Prevention

  • Therefore, when these extracts were combined with COREGA , they played a collaborative and innovative role in biofilm control and can be considered alternatives for temporary use in the treatment and/or prevention of DS.[ncbi.nlm.nih.gov]
  • In conclusion, invasive Candida infections may occur in patients with CF, and preventive measures might be considered in patients at risk.[ncbi.nlm.nih.gov]
  • As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites.[ncbi.nlm.nih.gov]
  • We recommend a close follow-up and a timely intervention to prevent the need for more invasive treatment such as penetrating keratoplasty.[ncbi.nlm.nih.gov]
  • Therefore, leading proxyphylline derivatives can be employed to prevent cancer-associated biofilm Candida infections.[ncbi.nlm.nih.gov]

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