Presentation
Case 1 A 42 year old woman presented with “recurrent vaginal thrush” since the age of 19. [sti.bmj.com]
C. glabrata and C. parapsilosis belong to two different Candida clades, presenting differences at genomic and pathogenic level. [ediss.uni-goettingen.de]
The only finding in that study which matches with the present study is that broad spectrum antibiotics at the time of diagnosis acted as important predisposing factors. [atmph.org]
Our patient presented with these symptoms on multiple occasions and was repeatedly treated empirically with fluconazole with improvement of her symptoms. [cureus.com]
Data are presented as absolute numbers (%) unless otherwise indicated for normally distributed variables or median numbers (25th–75th percentile) for variables that were not normally distributed. [medscape.com]
Workup
Following laboratory workup, 71 specimens were positive for genus Candida (30.6%). Further speciation showed 32.4% as Candida albicans, 45.07% Candida parapsilosis and 22.53% of Candida glabrata. [ijpmonline.org]
Serum
- Lymphopenia
[…] the day of candidemia) drug exposures Chemotherapy 69 (47.26) Any corticosteroids 85 (58.21) Antibacterial drugs 144 (98.63) Azoles 44 (30.13) Echinocandins 32 (21.91) Laboratory findings Neutropenia, cells/μL 28 (19.17) 100–500 9 (6.16) 19 (13.14) Lymphopenia [medscape.com]
Treatment
Adverse effects Treatment-emergent adverse events were defined as those occurring after receiving the first dose of treatment. [care.diabetesjournals.org]
This treatment was well tolerated in all patients with no or minimal side effects. [sti.bmj.com]
Combined oral contraceptive treatment was therefore discontinued which worsened her AUB/HMB. [cureus.com]
A first-line treatment for vaginal infections may be the use of terconazole 7-day cream. Several courses may be needed. The cure-rate for this treatment is approximately 40%. [en.wikipedia.org]
Next we’ll look at causes, symptoms, and treatment of the most common types of Candida infection. [healthline.com]
Prognosis
Potential of salivary protein as a biomarker in prognosis of diabetes mellitus. J Pharm Res 2011;4:2228-9. 14. Sashikumar R, Kannan R. Salivary glucose levels and oral candidal carriage in type II diabetics. [ijabmr.org]
Etiology
Frequency and etiology of vulvovaginal candidiasis in women reffered to gynaecological center in Babol, Iran. Int J Fertil Steril 2009;3:74-7. 11. Ahmad A, Khan AU. [ijpmonline.org]
Current status of the etiology of candidiasis in Mexico. Rev Iberoam Micol. 2017;34:203-10. [ Links ] 4. Alcoba-Flórez J, Méndez-Álvarez S, Cano J, Guarro J, Pérez-Roth E, del Pilar Arévalo M. [scielo.br]
[…] species, but only a minority are associated to human candidosis, as 65% of Candida species are unable to grow at a temperature of 37°C thus prevent them from being pathogenic to the human [3-5] and more than 17 different Candida species reported to be etiological [oatext.com]
Epidemiology
We now need to have more studies and more tools; specially molecular tools to study the epidemiology of this emerging pathogen. [atmph.org]
Nosocomial Candida glabrata colonization: an epidemiologic study. J Clin Microbiol 1998;36 (2) 421- 426 PubMed Google Scholar 28. [jamanetwork.com]
Jundishapur J Microbiol 9: 1-7. [ Crossref ] Pfaller MA, and Diekema DJ (2007) Epidemiology of Invasive Candidiasis: A Persistent Public Health Problem. [oatext.com]
Snydman DR (2003) Shifting patterns in the epidemiology of nosocomial Candida infections. Chest123(5 Suppl):500S-3S. [gynecology-obstetrics.imedpub.com]
Clin Microbiol Rev. 1999, 12:80-96. 10.1128/CMR.12.1.80 Pfaller MA, Diekema DJ: Epidemiology of invasive candidiasis: a persistent public health problem. [cureus.com]
Pathophysiology
Pathophysiology/Complications Abstract OBJECTIVE —A large proportion of vulvovaginal candidiasis (VVC) in diabetes is due to non– albicans Candida species such as C. glabrata and C. tropicalis. [care.diabetesjournals.org]
Prevention
Thus, one key to preventing fungal infections in cancer patients is careful and appropriate use of antifungal drugs. READ FULL ARTICLE From Medical News Today Topics: Cancer [oncologynurseadvisor.com]
Understanding more about the life cycle and transmission routes of C. glabrata could also help to pinpoint new ways to treat or prevent the condition. But Gabaldón's study raises a cautionary note for scientists working in the field. [eurekalert.org]
Some have advised that prescribing these medications should be done more judiciously to prevent increasing resistance [14]. [cureus.com]
Practicing good hygiene may make the biggest difference in prevention. [healthline.com]