Presentation
We present the case of a preterm neonate who was born with respiratory distress and a papulovesicular rash that was diagnosed as congenital candidiasis (CC). The mother was asymptomatic. [ncbi.nlm.nih.gov]
Entire Body System
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Candidiasis
candidiasis fungal infection due to any type of Candida Disseminated candidiasis systemic candidiasis thrush Candidiasis Candidiasis, thrush Candida infection Candidosis infections, Candida Candida Infection Statements Identifiers Sitelinks Wikipedia [wikidata.org]
Systemic candidiasis Systemic candidiasis can be divided into 2 primary syndromes: candidemia and disseminated candidiasis (organ infection by Candida species). [emedicine.medscape.com]
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Splenectomy
Case 3 illustrates treatment challenges, with ongoing dissemination and insufficient source control despite months of antifungal therapy, eventually resulting in a splenectomy. [ncbi.nlm.nih.gov]
Gastrointestinal
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Dysphagia
Referral Admit to hospital if there are systemic symptoms, the patient is unwell or if there are oesophageal symptoms (dysphagia or retrosternal pain) - particularly if there is immunocompromise. [patient.info]
[…] mellitus Steroids Chemotherapy Radiotherapy Diseases which cause delayed esophageal emptying Scleroderma Strictures Achalasia S/P fundoplication Rarely may occur in otherwise healthy individuals Produces whitish slightly raised plaques Clinical Findings Dysphagia [learningradiology.com]
However, some of the symptoms may include the following: Sore and painful mouth Burning mouth or tongue Dysphagia Whitish thick patches on the oral mucosa Physical examination reveals a diffuse erythema and white patches that appear on the surfaces of [emedicine.medscape.com]
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Pruritus Ani
Amir Bastawrous and Vivek Chaudhry, Specific pruritus ani, Seminars in Colon and Rectal Surgery, 14, 4, (203), (2003). [doi.org]
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Absent Bowel Sounds
Physical examination may reveal the following: Fever Abdominal distention Abdominal pain Absent bowel sounds Rebound tenderness Localized mass Candida splenic abscess and hypersplenism Both are manifestations of disseminated candidiasis and are usually [emedicine.medscape.com]
Physical examination may reveal the following: Fever Abdominal distention Abdominal pain Absent bowel sounds Rebound tenderness Localized mass Candida splenic abscess and hypersplenism: Both are manifestations of disseminated candidiasis and are usually [web.archive.org]
Skin
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Erythema
The presenting signs and symptoms include chronic erythema and edema of the portion of the palate that comes into contact with dentures. [emedicine.medscape.com]
A minority of male sex partners may have balanitis, which is characterised by erythema (redness) of the glans penis. [apps.who.int]
[…] foreskin, may or may not be itchy White ‘curd like’ vaginal discharge although discharge can appear normal Swelling of foreskin if severe Genital/vulval itch, discomfort Fissures Superficial erosions Superficial dysparuenia External dysuria Excoriation, erythema [sti.guidelines.org.au]
All of them reported improvement of their vaginal symptoms and were found to have reduced vaginal erythema and discharge during clinical examination. [doi.org]
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Pruritus
The patient has a history of generalized pruritus, with increased severity in the genitocrural folds, anal region, axillae, hands, and feet. [emedicine.medscape.com]
Intense itching in the external genitalia in women (pruritus vulvae) may be due to candidiasis (yeast), hormonal changes, or the use of certain spermicides or vaginal suppositories, ointments, or deodorants. [yourdictionary.com]
Amir Bastawrous and Vivek Chaudhry, Specific pruritus ani, Seminars in Colon and Rectal Surgery, 14, 4, (203), (2003). [doi.org]
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Eczema
Abeck, The therapeutic concept of “patient management” in atopic eczema, Allergy, 51, 4, (206-215), (2007). [doi.org]
In 38 patients, a cause was established; specifically, 63% had candidiasis, 16% had irritant dermatitis, 11% had eczema, and 11% had psoriasis. Of these patients, 37 were treated and 73% were cured after 8 weeks of treatment. [emedicine.medscape.com]
Other conditions that may resemble candidiasis of the skin include: ringworm hives herpes diabetes-related skin conditions contact dermatitis seborrheic dermatitis eczema psoriasis Candidiasis of the skin develops when the skin becomes infected with Candida [healthline.com]
[…] over-proliferates in the body, though, the symptoms can be debilitating: • Painful and persistent gas and bloating • Recurrent yeast infections in women • Constipation, or diarrhea • Migraines • Weight gain • Depression and brain fog • Skin issues like eczema [huffpost.com]
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Skin Fissure
There may be severe redness, swelling, and itching, leading to skin fissures or sores. [medicalnewstoday.com]
Urogenital
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Genital Lesions
In HIV negative person, both the leucocytes infiltration and genital lesions induced by trichomonas vaginalis may enlarge the portal of entry for HIV, by increasing the number of target cells for the virus and allowing direct viral access to the bloodstream [grin.com]
Workup
Genitourinary candidiasis - A urinalysis should be performed; evidence of white blood cells (WBCs), red blood cells (RBCs), protein, and yeast cells is common; urine fungal cultures are useful Gastrointestinal candidiasis - Endoscopy with or without biopsy See Workup [emedicine.medscape.com]
Treatment
Other management strategies and second-line treatments: Voriconazole (may be an alternative or a step-down treatment). [patient.info]
Treatment Regimens Table 1. Table 1. [doi.org]
Short-course treatments should not be used for recurrent or resistant infections. Are Over-the-Counter Treatments Safe to Use? Over-the-counter treatments for VVC are available. As a result, more women are diagnosing and treating themselves. [web.archive.org]
Utilize este identificador para referenciar este registo: Título: Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment Autor: Ferreira, Isabel C.F.R. [hdl.handle.net]
Prognosis
What is the prognosis of thrush? The prognosis of candidiasis and how long it will last depends on the severity of the infection and the status of the immune system of the patient. [medicinenet.com]
Prognosis of vaginal thrush The prognosis is good and most women with thrush will respond to antifungal treatment. [myvmc.com]
Prognosis Typically, in otherwise healthy people with superficial candidiasis, a properly treated infection goes away without leaving permanent damage. [drugs.com]
It is a very serious symptom, most of the time with a poor prognosis. Due to the weakness of the patient, the fungus spreads very quickly and can become fatal. Therefore, it’s key to be very alert to the early symptoms. [steptohealth.com]
Etiology
Etiology Pathogen Most common: Candida albicans (C. albicans) C. albicans is a type of oval, budding yeast (see general mycology) Forms hyphae and long pseudohyphae Ubiquitous on healthy skin, as well as in the oropharyngeal cavity, gastrointestinal tract [amboss.com]
Etiology Candidal vulvovaginitis is caused by inflammatory changes in the vaginal and vulvar epithelium secondary to infection with Candida species, most commonly Candida albicans. [ncbi.nlm.nih.gov]
In 20 cases of balanitis and balanoposthitis, the most common etiologic agent was C. albicans, followed by C. glabrata complex. [elsevier.es]
3 Department of Medical Laboratory, School of Health Technology, Tsafe, Zamfara State, Nigeria Background: Candida spp. are normal flora of the vagina that eventually become pathogenic under some prevailing conditions, and thus present as a common etiology [dovepress.com]
Epidemiology
The changing landscape of invasive fungal infections: epidemiology, diagnosis, and pharmacologic options. Clin Infect Dis. 2006. 43:S1-2. Kaufman DA. [emedicine.medscape.com]
Epidemiology of candidemia in Brazil: a nationwide sentinel surveillance of candidemia in eleven medical centers. J Clin Microbiol. 2006 Aug. 44(8):2816-23. [Medline]. Maródi L, Johnston RB Jr. [web.archive.org]
Pathophysiology
References:[1][2][3][4][5][6] Pathophysiology Clinical features Local mucocutaneous Oropharyngeal (oral thrush) Pseudomembranous candidiasis White plaque in the oral cavity that can be scraped off, giving way to red, inflamed, or bleeding areas. [amboss.com]
Pathophysiology Thrush represents an overgrowth of yeast when either normal host immunity or normal host flora has been disrupted. Yeast overgrowth on the oral mucosa causes the epithelial cells to desquamate. [pedclerk.bsd.uchicago.edu]
Pathophysiology Candidal vulvovaginitis occurs when Candida species superficially penetrate the mucosal lining of the vagina and cause an inflammatory response. The dominant inflammatory cells are typically polymorphonuclear cells and macrophages. [ncbi.nlm.nih.gov]
Reviewed by: Linda Vorvick, MD, Family Physician, Seattle Site Coordinator, Lecturer, Pathophysiology, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine. [web.archive.org]
The patient's history commonly reveals the following: Several days of fever that is unresponsive to broad-spectrum antimicrobials; frequently the only marker of infection Prolonged intravenous catheterization A history of several key risk factors (see Pathophysiology [emedicine.medscape.com]
Prevention
Utilize este identificador para referenciar este registo: Título: Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment Autor: Ferreira, Isabel C.F.R. [hdl.handle.net]
This might prevent unnecessary surgery or inappropriate treatment. Timely diagnosis of hepatosplenic candidiasis (HSC) is challenging, but can prevent further complications and dissemination, and may even prevent unnecessary invasive procedures. [ncbi.nlm.nih.gov]
For women who experience recurrent yeast infections (more than three per year), some evidence suggests that oral or intravaginal probiotics may help to prevent frequent infections. [web.archive.org]