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CANOMAD Syndrome

Chronic Inflammatory Demyelinating Polyradiculoneuropathy


Presentation

  • Motor weakness affecting the oculomotor and bulbar muscles is present as either a fixed or relapsing-remitting feature. Clinical electrophysiology and nerve biopsy show demyelinating and axonal features.[orpha.net]
  • In CANOMAD the IgM antibody is abnormally present. The term “paraprotein” actually refers to any abnormal plasma protein associated with a disease.[rarediseases.info.nih.gov]
  • His research focuses on understanding the variation in the clinical presentations of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) and finding biomarkers for them.[books.google.com]
  • The present study aimed to inv...[medworm.com]
  • P0 antibodies are present in a significant minority of CIDP patients and may play a role in its immunopathogenesis. —Michael Rubin Dr.[ahcmedia.com]
Goiter
  • […] teratoma postaxial sagittal Davy Mancer syndromeDanon diseaseDarier Donlan syndromeDavis Lafer syndromeDe Barsy Hauwere Leroy Adriaenssens Quervains diseaseDe conductive stapedial palsyDeafness craniofacial enamel defectsDeafness epiphyseal statureDeafness goiter[shecandothat.net]
Pachyonychia
  • BOsteogenesis Osteoglophonic dermopathy including neuroaxonal Osteopetrosis failureOta Kawamura Otopalato Otodental familialOuvrier Billson syndromeOvarian cancerOvarian tumorOvarian insufficiency FSH familialOvarian potential remnant FryerOxalosis Pachyonychia[shecandothat.net]
Strabismus
  • […] labyrinthine microtia microdontia DFNDeafness nonsyndromic isolated mitochondrial neurosensory DFNDeal Barratt Dillon apolipoprotein BDeficiency interleukin antagonistDegos cocarde hereditary stomatocytosis perinatal edemaDelayed membranous speech asymetry strabismus[shecandothat.net]
  • […] with or without Autistic Features Mental Retardation with Optic Atrophy, Facial Dysmorphism, Microcephaly, and Short Stature Mental Retardation with Spastic Paraplegia Mental Retardation Wolff Type MENTAL RETARDATION, ANTERIOR MAXILLARY PROTRUSION, AND STRABISMUS[rgd.mcw.edu]
Osteopenia
  • […] internal palmaris punctata superficial actinic Porokeratosis cutanea tardaPortal infrahepatic blockPositive Polio reactive column ataxiaPosterior urethral valvesPosterior illness aggravated myotoniaPotato syndromePotter Powell Buist Stenzel habitus osteopenia[shecandothat.net]
Withdrawn
  • He was withdrawn. No serious adverse events were seen in the IVIG group. Both groups experienced equal incidences of headache (approximately 30%), indigestion (20%), fever, rash, and hypotension.[ahcmedia.com]
Aura
  • […] syndromePectus Crohns ulcerative colitisPeeling syndromePEHO syndromePelvic limbsPelvic fogo familialPena Shokeir Pendred syndromePenile adultPenile childhoodPenis syndromePEPCK deficiencyPEPCK factors aphthous stomatitis pharyngitis biogenesis disordersPerry aura[shecandothat.net]

Workup

  • PMID 27198717 . a b c d e "Cold Agglutinin Disease Workup: Approach Considerations, Complete Blood Cell Count and Peripheral Smear, Reticulocytes and Spherocytes" . Medscape Reference . 2019-02-02. Archived from the original on 2017-10-06 .[en.wikipedia.org]

Treatment

  • Management and treatment Plasma exchange and intravenous immunoglobulin have been reported with temporary benefit in some cases. Other treatments (corticosteroids, beta-interferons and cytotoxic drugs) remain to be evaluated.[orpha.net]
  • Prednisolone and IVIG are equally efficacious for the treatment of CIDP. Although the former is inexpensive in the short term, long-term side effects of steroid treatment favor IVIG as the first-line therapy.[ahcmedia.com]
  • Study if the mycophenolate could improve the reduction of IVIG dose or could prolong the interval between two courses of IVIG compared to the baseline interval at month 12 and month 24 ( sparing treatment criteria).[clinicaltrials.gov]
  • His main scientific interests focus on cerebrovascular disorders including early treatment and rehabilitation.[books.google.com]
  • CLOSE Medical Disclaimer The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes.[diseaseinfosearch.org]

Prognosis

  • Prognosis - CANOMAD syndrome Infants and children are rarely affected with chronic CAD, although M pneumoniae and infectious mononucleosis are diseases of young persons.[checkorphan.org]
  • Prognosis The functional outcome is generally guarded-to-poor with the majority of patients suffering some degree of permanent disability from the sensory ataxia that defines the illness.[orpha.net]
  • Mild to moderate primary (unknown cause) cold agglutinin disease can also be associated with a good prognosis if excessive exposure to the cold is avoided.[en.wikipedia.org]

Etiology

  • Etiology The etiology remains incompletely characterized. Evidence suggests direct damage to dorsal root ganglia (DRG) and to the nodal axolemma. It is generally accepted that antibodies against gangliosides are pathogenic.[orpha.net]
  • "Cold Agglutinin Disease: Practice Essentials, Pathophysiology, Etiology" . Medscape Reference . Retrieved 2019-02-11 . a b c d e f g h i j k l m Berentsen, Sigbjørn; Beiske, Klaus; Tjønnfjord, Geir E. (2007-07-21).[en.wikipedia.org]
  • Early ( 45 years) and late-onset RLS differ etiologically.[neuroweb.us]

Epidemiology

  • Summary Epidemiology The exact prevalence is unknown but less than 30 cases have been reported in the literature.[orpha.net]
  • (Last, A Dictionary of Epidemiology, 2d ed) Troponin I One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.[bioportfolio.com]
  • Summary Epidemiology The disease is rare with less than 100 cases reported in the literature. The disease predominantly affects males with a ratio of 3:1 (males:females).[orpha.net]
  • Use at onset of corticosteroid Rx to prevent vascular occlusion Systemic connective tissue disorders & Vasculitis: Specific syndromes 4 Rheumatoid Arthritis Neuropathy: Vasculitic Epidemiology 10% of all RA 50% of RA with systemic vasculitis Longstanding[neuromuscular.wustl.edu]
Sex distribution
Age distribution

Pathophysiology

  • The ongoing identification of anti-nerve auto-antibodies continues to allow us to develop a better understanding of the pathophysiology of inflammatory neuropathies.[content.iospress.com]
  • ., London, United-Kingdom Pathophysiology of autoimmune polyneuropathies Marinos C.[em-consulte.com]
  • "Cold Agglutinin Disease: Practice Essentials, Pathophysiology, Etiology" . Medscape Reference . Retrieved 2019-02-11 . a b c d e f g h i j k l m Berentsen, Sigbjørn; Beiske, Klaus; Tjønnfjord, Geir E. (2007-07-21).[en.wikipedia.org]
  • This Drug Therapy article discusses the new generation of antipsychotic medications, as well as recent developments in brain imaging and in knowledge of the pathophysiology and molecular.[gozifycilijol.tk]
  • Willison and colleagues in 1996 demonstrated in a rodent model that the antidisialosyl antibody itself exerted pathophysiological action on the peripheral nervous system and proposed the acronym CANOMAD to encompass the clinical features seen in this[omicsonline.org]

Prevention

  • Symptoms - CANOMAD syndrome Causes - CANOMAD syndrome Prevention - CANOMAD syndrome Not supplied. Diagnosis - CANOMAD syndrome Not supplied.[checkorphan.org]
  • Since 2005, he also acts as director of the Department of Clinical Medicine and Preventive Medicine at the Danube University. His main scientific interests focus on cerebrovascular disorders including early treatment and rehabilitation.[books.google.com]
  • IVIg may prevent relapses in responsive patients while rituximab may be most effective in halting disease progression.[orpha.net]

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