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Cantharidin


Presentation

  • A overview of the clinical effects of cantharidin toxicity and its treatment is presented.[ncbi.nlm.nih.gov]
Localized Pain
  • Nonetheless, many patients and their parents seek active treatment of MC because of local pain, pruritus, embarrassment due to the lesions, or desire to reduce transmission to siblings.[ncbi.nlm.nih.gov]
Vomiting
  • This medicine may be harmful if swallowed, leading to symptoms such as: burning of the mouth, nausea, painful swallowing, painful/bloody urine, change in the amount of urine, bloody vomit, or vomit that looks like coffee grounds.[myhealth.alberta.ca]
  • Initially, patient complaints include burning and blistering of the mouth, tongue, and oropharynx, dysphagia, abdominal cramping, vomiting and haematemesis.[ckj.oxfordjournals.org]
  • DO NOT induce vomiting or attempt to neutralize! 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4.[cameochemicals.noaa.gov]
  • If possible, the patient should swallow generous quantities of water but should avoid fatty foods (such as milk) because they increase cantharidin absorption. 35 Vomiting should not be induced, as oropharyngeal and esophageal damage is increased with[archderm.ama-assn.org]
Abdominal Cramps
  • Initially, patient complaints include burning and blistering of the mouth, tongue, and oropharynx, dysphagia, abdominal cramping, vomiting and haematemesis.[ckj.oxfordjournals.org]
  • cramping, hematemesis, and vomiting.[archderm.ama-assn.org]
Abdominal Pain
  • She presented with many of the classic signs and symptoms of cantharidin poisoning including haematuria and abdominal pains. This was recognised only after consultation with the drug information centre.[ncbi.nlm.nih.gov]
  • It can also damage the Kidneys , cause blood in the urine and abdominal pain . More rarely, and heightening it's undeserved reputation, it can cause a lengthy (but painful) erection .[house.wikia.com]
  • The signs seen most frequently include varying degrees of abdominal pain, depression, anorexia, and frequent attempts to drink small amounts of water or submerge the muzzle in water.[merckvetmanual.com]
  • Six hours later he was admitted to the emergency room with abdominal pain, dysuria, gross haematuria with clots, hypotension, fever and renal insufficiency. With intravenous fluid therapy, he recovered clinically.[ckj.oxfordjournals.org]
Diarrhea
  • Less frequent signs include oral erosions; salivation; synchronous diaphragmatic flutter; a stiff, short-strided gait; and diarrhea that may contain blood.[merckvetmanual.com]
  • Also, it may be restless, irritable, sweating, have diarrhea and/or submerge its muzzle in water, (a common sign of cantharidin toxicosis).[addl.purdue.edu]
  • Exposure: Acute exposure to cantharidin may produce the following signs and symptoms: salivation, difficulty in swallowing, thirst, severe vesication (blistering) of the upper gastrointestinal tract following ingestion, abdominal pain, vomiting and bloody diarrhea[cameochemicals.noaa.gov]
Nausea
  • Symptoms of cantharidin poisoning include burning of the mouth, dysphagia, nausea, hematemesis, gross hematuria, and dysuria. Mucosal erosion and hemorrhage is seen in the upper gastrointestinal (GI) tract.[ncbi.nlm.nih.gov]
  • This medicine may be harmful if swallowed, leading to symptoms such as: burning of the mouth, nausea, painful swallowing, painful/bloody urine, change in the amount of urine, bloody vomit, or vomit that looks like coffee grounds.[myhealth.alberta.ca]
Hypotension
  • Six hours later he was admitted to the emergency room with abdominal pain, dysuria, gross haematuria with clots, hypotension, fever and renal insufficiency. With intravenous fluid therapy, he recovered clinically.[ckj.oxfordjournals.org]
  • Tachycardia (rapid heart beat) with normal blood pressure, hypotension (low blood pressure), and abnormal heart conduction are not uncommon.[cameochemicals.noaa.gov]
Foot Disease
Dysuria
  • Symptoms of cantharidin poisoning include burning of the mouth, dysphagia, nausea, hematemesis, gross hematuria, and dysuria. Mucosal erosion and hemorrhage is seen in the upper gastrointestinal (GI) tract.[ncbi.nlm.nih.gov]
  • He was doing well, but complained of dysuria and haematuria.[ckj.oxfordjournals.org]
  • One unusual report from South Africa describes a case in which topical cantharidin was applied to an area of abdominal skin approximately 18 8 cm as a treatment for pleurisy (cantharidin was thought to act medicinally as a counterirritant). 45 Dysuria[archderm.ama-assn.org]
Hematuria
  • Cantharidin poisoning should be suspected in any patient presenting with unexplained hematuria or with GI hemorrhage associated with diffuse injury of the upper GI tract.[ncbi.nlm.nih.gov]
  • In acutely affected horses, urinalysis reveals markedly decreased specific gravity, often less than 1.101, and hematuria with or without myoglobinuria.[addl.purdue.edu]
  • […] unusual report from South Africa describes a case in which topical cantharidin was applied to an area of abdominal skin approximately 18 8 cm as a treatment for pleurisy (cantharidin was thought to act medicinally as a counterirritant). 45 Dysuria and hematuria[archderm.ama-assn.org]
Oliguria
  • These symptoms are accompanied by renal function impairment with oliguria [ 5 ]. Serum electrolytes may be affected, manifesting as hyponatraemia, hyperkalaemia and hypocalcaemia [ 6 ].[ckj.oxfordjournals.org]

Treatment

  • This formulation is a promising alternative treatment modality for plantar warts.[ncbi.nlm.nih.gov]

Prognosis

  • Description of clinical features, laboratory data, treatment and prognosis.[ncbi.nlm.nih.gov]
  • The prognosis for affected horses improves daily if no complications occur. Prevention is by feeding beetle-free hay.[merckvetmanual.com]
  • The ultimate prognosis is good with regard to renal function if the patient survives the acute phase [ 2 ]. In our case, the diagnosis was suggested by the abrupt onset of symptoms just after the beetle ingestion in an otherwise healthy young man.[ckj.oxfordjournals.org]

Etiology

  • Etiologic agents, incidence, and improved diagnostic methods of cantharidin toxicosis in horses. Am J Vet Res 50: 187-191. Ray AC, Tamulinas SH, Reagor JC: 1979.[addl.purdue.edu]

Epidemiology

  • Leptospirosis was also a possible aetiology of AKI in our minds (fever, acute phase inflammatory markers, LDH increase, thrombocytopaenia, AKI and epidemiologic data).[ckj.oxfordjournals.org]
Sex distribution
Age distribution

Prevention

  • Scouting the fields for beetles and treating with a short residual insecticide before cutting helps to prevent blister beetle infestation. Sevin XLR has been has been used for prevention of infestation by blister beetles and other toxic insects.[addl.purdue.edu]
  • […] cantharidin, LB1, with significant PP2A inhibition activity but without apparent toxicity, greatly enhanced the effectiveness of the standard anti-sarcoma chemotherapeutic agent, doxorubicin (DOX), in the xenograft growth inhibition and lung metastases prevention[ncbi.nlm.nih.gov]

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