Presentation
In all there were 87 presentations by 108 scientists from 18 countries. Authors making multiple presentations at Park City combined their results into single, longer papers for this volume. [books.google.de]
A 4.3 kg, three-month-old patient, diagnosed with a perimembranous ventricular septal defect, presented for cardiac surgery. Upon initiation of cardiopulmonary bypass (CPB), the patient developed carboxyhemoglobinemia (11.1%). [ncbi.nlm.nih.gov]
The present disclosure provides methods of treating carboxyhemoglobinemia (or CO poisoning) in a subject by administering a therapeutically amount of an isolated or recombinant microperoxidase. [patentscope.wipo.int]
Entire Body System
- Anemia
There was no evidence of decreased tissue perfusion, hypotension, arterial hypoxemia, or anemia. [scholars.northwestern.edu]
Four new chapters cover anemias unique to the newborn period, pathology of LHC and other histiocytic disorders, tumors of the spleen, and pathology and classification of myeloproliferative disorders and mast cell disease. [books.google.com]
- Hypoxemia
Hypoxemia means low oxygen content of arterial blood. Hypoxaemia invariably leads to hypoxia but hypoxia can occur even without hypoxaemia. [drrajivdesaimd.com]
There was no evidence of decreased tissue perfusion, hypotension, arterial hypoxemia, or anemia. [scholars.northwestern.edu]
[…] for hypoxemia and contributes to the hypoxemia occurring in COPD and asthma. [merckmanuals.com]
Hypoxemia: abnormally low arterial oxygen tension (PaO 2 ) in the blood (hence the -emia ending) Hypoxia a condition of underoxygenation, which is an inadequate level of tissue oxygenation for cellular metabolism Hypoxemia frequently results in hypoxia [media.lanecc.edu]
- Asymptomatic
We report the case of an asymptomatic man with severe chronic obstructive lung disease and carboxyhemoglobin levels repeatedly in excess of 30% (maximum, 38.0%) due to smoking. [experts.umn.edu]
Continue oxygen therapy until the patient is asymptomatic (usually COHb < 10 per cent). In case of persistent severe symptoms or markers of severe toxicity, consideration should be given to treatment with HBO. [openanesthesia.org]
[…] or CO level < 10%) cardiac monitoring intubate the comatose patient Specific Treatment High flow O2 via non-rebreather mask until asymptomatic or for 24 hours while fetal well-being is assessed if pregnant Hyperbaric oxygen (HBO) role is uncertain 3 [lifeinthefastlane.com]
Potential associations between COHb levels and clinical findings include: COHb 10% - asymptomatic or headache COHb 20% - atypical dyspnea, throbbing headache, dizziness, nausea COHb 30% - severe headache, impaired thinking, disturbed vision COHb 40% - [ebmconsult.com]
Respiratoric
- Pneumonia
COMPLEMENTO C 3 COMPLEMENTO C 4 C1 INATTIVATORE CALCEMIA CALCIO IONIZZATO CALCIURIA CALPROTECTINA FECALE ( quantitativa ) CHLAMYDIA PNEUMONIAE Abs IgA CHLAMYDIA PNEUMONIAE Abs IgG CHLAMYDIA PNEUMONIAE Abs IgM CHLAMYDIA TRACHOMATIS Abs IgA CHLAMYDIA TRACHOMATIS [laboratoriobiocenter.it]
Imbruvica capsules can lead to pneumocystis jirovecii pneumonia. The agency updated the warnings and precautions section of the drug's label to include this disease. 6. [beckershospitalreview.com]
A 46-year-old man has been in the hospital two days with pneumonia. He was recovering but has just become diaphoretic, dyspneic, and hypotensive. [slideshare.net]
Slight increase in COHb – so slight to be of little clinical significance per se – is often a feature of severe inflammatory disease, e.g. sepsis, pneumonia [15]. It is thus a relatively common finding in critically ill patients [16]. [acutecaretesting.org]
[…] behaviors: silly smiles or frowning * Manneristic behavior * Irrational confabulatory talking * Insomnia * Depressed mood * Delusions * Echolalia * Elated mood Cardiorespiratory: * Myocardial necrosis * Cardiomyopathy * Pulmonary edema * Aspiration pneumonia [enotes.tripod.com]
- Sputum
[…] nasopharynx, oropharynx, larynx CO inhalation BELOW glottis CHEMICAL injury*** Ex: smoke containing aldehyde, sulfur oxide, phosgenes Sx: -ciliary dysFx -inflammation -hypersecretion -edema -ulceration -spasm Carboxyhemoglobinemia Symptoms -carbonaceous sputum [quizlet.com]
Cardiovascular: * Mild exposure: presyncope, palpitations * Moderate to severe exposure: chest pain, dyspnea on exertion, pink, frothy sputum Central nervous system: * Mild exposure: headache, nausea, vomiting, dizziness, weakness, impaired fine motor [enotes.tripod.com]
- Hyperpnea
Isocapnic hyperpnea accelerates carbon monoxide elimination. American journal of respiratory and critical care medicine. 159(4 Pt 1):1289-92. 1999. [ pubmed ] Henry CR, Satran D, Lindgren B, Adkinson C, Nicholson CI, Henry TD. [lifeinthefastlane.com]
Ears
- Tinnitus
Cardiovascular: * Mild exposure: presyncope, palpitations * Moderate to severe exposure: chest pain, dyspnea on exertion, pink, frothy sputum Central nervous system: * Mild exposure: headache, nausea, vomiting, dizziness, weakness, impaired fine motor skills, tinnitus [enotes.tripod.com]
Eyes
- Retinal Hemorrhage
Hepatic: * Lobar necrosis with chronic repeated exposure Renal: * Acute renal failure; parenchymatous degeneration leading to necrosis Hematologic: * Bone marrow hypertrophy in chronic CO hypoxia Skin: * Erythema, blisters, and gangrene Ophthalmologic: * Retinal [enotes.tripod.com]
Musculoskeletal
- Myalgia
In severe cases, oxygen delivery is reduced to such a degree that symptoms of tissue hypoxia, such as confusion, angina, and myalgias, result. Stopping the causative drug or chemical exposure is often sufficient. [merckmanuals.com]
Features: * Headache * Dizziness * Fever * Chills * Cough * Runny nose * Nausea * Vomiting * Myalgias Gastroenteritis Viruses are a common cause of gastroenteritis. Foodborne illness often has a bacterial etiology. [enotes.tripod.com]
Psychiatrical
- Delusion
Dysphagia Psychiatric: * Apathy * Disorientation * Amnesia * Hypokinesia * Mutism * Irritability, distractibility * Apraxia * Bizarre behaviors: silly smiles or frowning * Manneristic behavior * Irrational confabulatory talking * Insomnia * Depressed mood * Delusions [enotes.tripod.com]
- Fear
[…] chest pain, dyspnea, syncope, severe headache, ataxia, mental confusion, seizures, coma and death * Development of delayed neuropsychiatric sequelae, including dementia, psychosis, parkinsonism, chorea, peripheral neuropathy, and incontinence, are the feared [enotes.tripod.com]
Neurologic
- Irritability
Symptoms of severe CO poisoning include malaise, shortness of breath, headache, nausea, chest pain, irritability, ataxia, altered mental status, other neurologic symptoms, loss of consciousness, coma, and death; signs include tachycardia, tachypnea, hypotension [cdc.gov]
[…] respiratory surfaces and binds to hemoglobin Hydrogen sulfide causes toxicity and is a respiratory irritant Ethanol, marijuana, etc., may lull, slow, and immobilize user Cocaine may worsen toxicity by increasing the metabolic rate Special patient groups [enotes.tripod.com]
0.007 10 Common in cigarette smokers; dyspnea during vigorousexertion; occasional tightness in forehead; dilation of cutaneous blood vessels 0.012 20 Dyspnea during moderate exertion; occasional throbbing headache in temples 0.022 30 Severe headache; irritability [lakesidepress.com]
Fallot) results from a failure to load oxygen onto hemoglobin adequately in the lungs.4,5 The hematocrit may range from 60% to 75% and cause profound symptoms of hyperviscosity, including headache, dizziness, visual disturbances, fatigue, paresthesias, irritability [what-when-how.com]
- Apathy
[…] presentation - smoke inhalation presents initially with: * Tachypnea * Cough * Dyspnea * Wheezing * Hoarseness * Stridor Chronic CO poisoning - symptoms include: * Nausea * Vomiting * Headache * Dizziness * Fatigue * Paresthesias * Visual disturbances * Apathy [enotes.tripod.com]
- Personality Change
70 – 80% (circulatory and ventilatory failure, cardiac arrest, death) However, the COHb% changes rapidly and variably, but generally to a greater extent in the severely poisoned. [lifeinthefastlane.com]
- Echolalia
Psychiatric: * Apathy * Disorientation * Amnesia * Hypokinesia * Mutism * Irritability, distractibility * Apraxia * Bizarre behaviors: silly smiles or frowning * Manneristic behavior * Irrational confabulatory talking * Insomnia * Depressed mood * Delusions * Echolalia [enotes.tripod.com]
- Impaired Judgement
/ impaired judgement/ clumsiness/ vis-ual field defects, blindness/ altered MS/ seizures/ resp-iratory depression/ cerebral edema (with papilledema or optic atrophy) –Up to 30% of cases with LOC have persistent neuro changes (ranging from altered personality [mdnxs.com]
Workup
In dealing with industrial exposures or organic aerosol abuse, a carboxyhemoglobin level should be part of the initial diagnostic workup, and treatment with oxygen is mandatory until toxicity resolves. [ohsu.pure.elsevier.com]
A patient’s travel history should be taken to determine the likelihood of high-altitude effect and thus possibly avoid having to conduct an extensive workup. [what-when-how.com]
Treatment
( en ) 2014-05-22 2015-05-19 Use of microperoxidases for the treatment of carboxyhemoglobinemia AU2015264362A AU2015264362A1 ( en ) 2014-05-22 2015-05-19 Use of microperoxidases for the treatment of carboxyhemoglobinemia Publications (1) ID=54554610 [google.co.kr]
In dealing with industrial exposures or organic aerosol abuse, a carboxyhemoglobin level should be part of the initial diagnostic workup, and treatment with oxygen is mandatory until toxicity resolves. [ohsu.pure.elsevier.com]
This new volume discusses the implications of these new findings on the pathophysiology, development, and treatment of hypoxic metabolic acidosis. [books.google.ro]
الصفحة 336 - EORTC classification for primary cutaneous lymphomas: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 90: 354-371. [books.google.com]
Prognosis
Hydrogen cyanide poisoning can accompany CO poisoning, worsening the toxicity and the prognosis. [enotes.tripod.com]
Ventricular arrhythmias are the most common cause of acute mortality Prognosis is not correlated with CoHb level References xxx [mdnxs.com]
Etiology
Epidemiology Leading cause of death by poisoning in the USA Etiology Portable heaters/ wood stoves/ gasoline engines: CO generated by incomplete combustion of fuel Smoke Inhalation (see [[Smoke Inhalation]]): accounts for most cases of lethal CO intoxication [mdnxs.com]
Known Etiologies of Acquired Methemoglobinemia Table 3. Known Etiologies of Acquired Methemoglobinemia × [anesthesiology.pubs.asahq.org]
An immediate exploration for the cause failed to identify an obvious etiology. An arterial blood gas was drawn; results were a pH 7.43, PaCO 2 31 and PaO 2 498. [ispub.com]
Foodborne illness often has a bacterial etiology. [enotes.tripod.com]
The hemolytic anemias are a group of conditions of variable etiology whose common pathological feature is increased rate of red-cell destruction (hemolysis). [acutecaretesting.org]
Epidemiology
Epidemiology Leading cause of death by poisoning in the USA Etiology Portable heaters/ wood stoves/ gasoline engines: CO generated by incomplete combustion of fuel Smoke Inhalation (see [[Smoke Inhalation]]): accounts for most cases of lethal CO intoxication [mdnxs.com]
Epidemiology of carbon-monoxide poisoning Deliberate or accidental poisoning by carbon monoxide remains a significant problem. [acutecaretesting.org]
[…] children, owing to their high minute ventilation and increased metabolic rates; the elderly and those with comorbid conditions that predispose to poor cardiovascular reserves; and pregnant patients (fetal toxicity) SX | DX | Diff-Dx | RX | Prognosis Epidemiology [enotes.tripod.com]
Pathophysiology
This new volume discusses the implications of these new findings on the pathophysiology, development, and treatment of hypoxic metabolic acidosis. [books.google.ro]
[…] of Cardiac Tamponade Clinical Signs Associated with Pericardial Effusion Diagnosis of Pericardial Effusion Pericardiocentesis Postpericardiocentesis Monitoring Complications of Pericardiocentesis Summary Pathophysiology of Microcirculatory Dysfunction [books.google.com]
Prevention
[…] tissue hypoxia/ may be required in some severe cases or cases unresponsive to 100% oxygen In comatose cases, proven to shorten duration of coma (may also prevent delayed sequelae) Consider in cases with coma/neuro deficits/pregnancy/acidosis/chest pain [mdnxs.com]
Therefore, flushing the breathing circuit with fresh gas before use (such as during a pre-use check) will not prevent or relieve the problem. [mdsr.ecri.org]
A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 1995; 86:3598-3603. [books.google.com]
A comparison of filtered leukocyte-reduced and cytomegalovirus (CMV) seronegative blood products for the prevention of transfusion-associated CMV infection after marrow transplant. Blood 1995; 86:3598-3603. [books.google.ro]
Stay up-to-date with the latest information on advances in burn prevention, education, and research – on your computer or on the go. [journals.lww.com]