Presentation
Per operatively 15x10 cms left ovarian solid to cystic mass with single septation was present. Final histopathology report of ovarian mass shows tumor present in form of nests, trabeculae and ribbons. [article.sapub.org]
In addition, we present a literature review of GTS of the ovary and some novel observations about this entity. [scienceopen.com]
It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. [books.google.com]
Metastatic carcinoids are nearly always bilateral with scattered tumor deposits present throughout both ovaries. Related Radiopaedia articles Promoted articles (advertising) [radiopaedia.org]
[…] as a post-menopausal virilizing neoplasm is extremely rare as described in the present case. [indianjcancer.com]
Entire Body System
- Weakness
Despite the weak evidence, fertility spare surgical approach for women wanting to preserve their genital tract might be a reasonable option. [scienceopen.com]
In extremely rare cases, the acute occurrence of flushing, blood pressure changes, weakness, palpitations, faintness and wheezing constitutes a carcinoid crisis that can be life-threatening. [rarediseases.org]
Hypokalemia may cause muscle cramps and weakness and cardiac complications. VIPomas also may cause facial flushing, profuse sweating, and achlorhydria. [lecturio.com]
These substances can damage heart valves, causing weakness, heart murmur, and shortness of breath. [encyclopedia.com]
You might also get problems like: Diarrhea Feel short of breath or wheeze Heartbeat starts to speed up Weight loss Feel weak Hair starts to grow on your body and face How Are Carcinoid Tumors Diagnosed? A lot of times they're found by chance. [webmd.com]
- Malnutrition
VIPomas in young children and infants may result in failure to thrive due to malnutrition and dehydration. Carcinoid tumors may metastasize anywhere throughout the body and are commonly found in the liver and lungs. [lecturio.com]
The symptoms of carcinoid syndrome include episodes of warmth and redness of the face, head and upper chest; diarrhea; marked changes in blood pressure (usually hypotension, a decrease in blood pressure); asthmatic-like wheezing; weight loss or gain; malnutrition [rarediseases.org]
- Familial Adenomatous Polyposis
Polyposis syndromes Intestinal polyposis syndromes can be divided into the broad categories of familial adenomatous polyposis (like Gardner syndrome), hamartomatous polyposis syndromes (like Peutz-Jeghers syndrome) and other rare polyposis syndromes. [radiologyassistant.nl]
Gastrointestinal
- Diarrhea
Even if modified Sambaek-tang showed partial effect on frequency of diarrhea, we concluded that it was not sufficient to be a therapeutic method of the diarrhea as carcinoid symptom. [dbpia.co.kr]
This may be counterintuitive as the body loses bicarbonate during diarrhea, but if the diarrhea is chronic there are other mechanisms in the body. [lecturio.com]
Diarrhea. The diarrhea of carcinoid syndrome does not necessarily correlate with flushing. Diarrhea appears to be related to increased gut motility, rather than to secretion of fluids. [aboutcancer.com]
Potential causes of flushing in carcinoid syndrome include bradykinins, prostaglandins, tachykinins, substance P, and/or histamine, diarrhea, and heart problems. [en.wikipedia.org]
The diarrhea may be so severe that vital nutrients of the body, such as potassium and water, are depleted creating life-threatening electrolyte imbalance. [rarediseases.org]
- Chronic Diarrhea
This may be counterintuitive as the body loses bicarbonate during diarrhea, but if the diarrhea is chronic there are other mechanisms in the body. [lecturio.com]
For example, carcinoid tumors in the rectum and colon are incidentally found during colonoscopy performed for colon cancer screening, for iron deficiency anemia, or for chronic diarrhea. [medicinenet.com]
The occurrence of episodic facial flushing and/or chronic diarrhea not diagnosed by standard tests as being a result of more common causes should lead to suspicion of carcinoid syndrome. [rarediseases.org]
Skin
- Flushing
A drug called octreotide can relieve flushing symptoms. Other treatments for flushing include phenothiazines (such as prochlorperazine ) and histamine-blocking drugs such as ranitidine. [msdmanuals.com]
After surgery, flushing episodes disappeared, and 5-hydroxyindoleacetic acid and normetanephrine levels normalized. Octreoscan ® and CT performed six months after surgery were normal. [elsevier.es]
Synonym: argentaffinoma. (19 Jan 1998) carcinoid flush Periodic hyperaemia (flushing) of the skin of the face and other parts of the body seen in patients with a carcinoid tumour; the mediator has not been identified but it is not serotonin; flush can [kmle.co.kr]
Flushing is most frequent, followed by diarrhea, heart disease, and bronchoconstriction. Flushing. Two types of flushing accompany the usual metastatic ileal carcinoid. [aboutcancer.com]
They primarily consist of diarrhea, wheezing, and flushing of the head and neck. [lecturio.com]
- Erythema
These symptoms included a generalized hot sensation not associated to sweating or facial erythema which spontaneously resolved at 55 years (two years before the start of current symptoms). The patient reported no associated constitutional symptoms. [elsevier.es]
Urogenital
- Adnexal Mass
A comparison of methods for preoperative discrimination between malignant and benign adnexal masses: the development of a new logistic regression model. [pelvicmass.tripod.com]
Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. Página 46 - Kelly, SJ (1977). [books.google.es]
The vaginal examination revealed first degree cervical descent, a retroverted uterus and a left adnexal mass. A clinical diagnosis of mature cystic teratoma was kept and hysterectomy with bilateral salpingo-oophorectomy was performed. [ccij-online.org]
About 6–7% of all adnexal masses found during physical examination are actually metastatic ovarian tumors, frequently unsuspected by gynecologists. 2 – 4 The metastasis often masquerades as a primary ovarian tumor and may even be the initial manifestation [clinicalgate.com]
- Hot Flushes
Persistent hot flushes in older postmenopausal women. Arch Intern Med, 168 (2008), pp. 840-846 [8] E. Seregni, L. Ferrari, E. Bajetta, A. Martinetti, E. Bombardieri. Clinical significance of blood chromogranin A measurement in neuroendocrine tumors. [elsevier.es]
Workup
Ultrasound
- Ovarian Mass
Per operatively 15x10 cms left ovarian solid to cystic mass with single septation was present. Final histopathology report of ovarian mass shows tumor present in form of nests, trabeculae and ribbons. [article.sapub.org]
During her examination, a mobile cystic mass was detected in the right lower abdomen. Ultrasound indicated a right ovarian mass 10.5 × 6.3 cm, confirmed by CT scan. Further investigation revealed AFP levels (1539 ng/mL). [scienceopen.com]
Histological analysis showed that the right ovarian mass contained stromal carcinoid tumor in a mature cystic teratoma. [jstage.jst.go.jp]
Intra-operatively, there was a left ovarian mass 8 cm × 7 cm, solid, nodular, with bosselated surface, no papillary excrescences and an intact capsule. Rest all organs were normal and lymph nodes were not palpable. [indianjcancer.com]
Similarly, the right ovary showed a cystic mass filled with sebum and hairs, measuring 6.5 × 5.0 × 4.0 cm. Frozen sections of the left ovarian mass were made. [wjso.biomedcentral.com]
Treatment
The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. [books.google.com]
Clinical trials can test the effectiveness of promising new treatments or new ways of combining cancer treatments. Always discuss treatment options with your doctor. [cancervic.org.au]
Treatment Surgery is often used as the first treatment for carcinoid tumors. If the tumor hasn’t spread, surgery can cure the cancer. Surgery may also be combined with other treatments to reduce the tumor and the symptoms. [stopcancerfund.org]
Omeprazole treatment was therefore discontinued three weeks before control laboratory tests, and chromogranin A levels normalized (63.3 and 37 ng/mL; No.: 19.4–98.1). [elsevier.es]
The NCCN Templates are not exhaustive and do not represent the full spectrum of care or treatment options described in the NCCN Guidelines or the NCCN Compendium or include all appropriate approaches or combinations of drugs or biologics for the treatment [nccn.org]
Prognosis
Prognosis The prognosis varies, depending on the location of the tumor and whether or not the tumor has metastasized. If the tumor is caught early, it can be surgically removed and cured. [lahey.org]
Prognosis depends on site. [patient.info]
Prognosis With hearing aids, prognosis is good for most affected individuals with WS2. The documents contained in this web site are presented for information purposes only. [orpha.net]
My onocolgist says it is a much better prognosis than if it was a typical ovarian cancer, but at the same time he says I don't want to hear my name in the same sentence with the word cancer. [csn.cancer.org]
In general, ovarian carcinoid tumors are slow growing, and have a good prognosis, but some cases of metastasis or recurrence have been reported. Therefore, these borderline tumors require careful evaluation [jstage.jst.go.jp]
Etiology
Etiology WS2 is genetically very heterogeneous and still much of the etiology of WS2 remains elusive. Mutations have been found in MITF (3p14-p13; subtype designated as WS2A), SNAI2 (8q11.21; WS2D), and SOX10 (22q13.1; WS2E) genes. [orpha.net]
Rosenberg SA (eds): AIDS: Etiology, Diagnosis. Treatment, and Prevention. الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. الصفحة 193 - Henson D, Tarone R. [books.google.com]
Wilms' tumor a rapidly developing malignant mixed tumor of the kidneys, made up of embryonal elements, occurring chiefly in children before the seventh year; a genetic component is suspected in its etiology. [medical-dictionary.thefreedictionary.com]
Etiology of Carcinoid Syndrome Causes of the carcinoid syndrome Both carcinoid tumors and VIPomas arise from abnormal cell development resulting in unregulated cell replication. [lecturio.com]
(Etiology) The exact cause and mechanism of formation of Primary Carcinoid Tumor of Uterus is unknown. Some researchers believe that the tumor occurs due to genetic mutations within the cells in the endometrium (the lining of the uterus). [dovemed.com]
Epidemiology
Diagnostic criteria and microbial and epidemiologic associations. Am J Med. الصفحة 193 - Henson D, Tarone R. An epidemiologic study of cancer of the cervix, vagina, and vulva based on the Third National Cancer Survey in the United States. [books.google.com]
Summary Epidemiology The prevalence of WS2 is unknown; the worldwide prevalence of WS is estimated at around 1/40,000. WS2 is one of the most common types of Waardenburg syndrome. [orpha.net]
Epidemiology and survival inpatients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. 2001;12:1295-300. Oberg K. Chemotherapy and biotherapy in the treatment of neuroendocrine tumours. [rarediseases.org]
Epidemiology and survival in patients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. 2001 Sep. 12(9):1295-300. [Medline]. [Full Text]. Berge T, Linell F. Carcinoid tumours. [emedicine.medscape.com]
Pathophysiology
Pathology and Pathophysiology of Carcinoid Syndrome VIPomas release large amounts of vasoactive intestinal peptide (VIP). Under normal circumstances, VIP relaxes the GI tract, increases secretion of pancreatic bicarbonate and digestive enzymes. [lecturio.com]
Pathophysiology Pathophysiology is closely related to the sites of the primary tumors. When these tumors spread to the liver, patients usually begin to develop malignant carcinoid syndrome. [emedicine.medscape.com]
Prevention
[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]
Prevention There is no sure way to prevent carcinoid tumors from forming. Some studies indicate that quitting smoking may help reduce your risk of developing a carcinoid tumor. [knowcancer.com]
Treatment, and Prevention. الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. الصفحة 193 - Henson D, Tarone R. [books.google.com]
[…] growth of gastrointestinal carcinoids by blocking or shrinking the blood vessels that nourish them how nuclear medicine can contribute to early detection of gastrointestinal carcinoids Prevention There is no known way to prevent gastrointestinal carcinoids [encyclopedia.com]
Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information]. Available online at http://www.uspreventiveservicestaskforce.org/uspstf12/ovarian/ovarartaddend.htm. [labtestsonline.it]