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Carcinoid Neoplasm of the Ovary
Ovarian Carcinoid Tumor

Presentation

In addition, we present a literature review of GTS of the ovary and some novel observations about this entity. [scienceopen.com]

Per operatively 15x10 cms left ovarian solid to cystic mass with single septation was present. Final histopathology report of ovarian mass shows tumor present in form of nests, trabeculae and ribbons. [article.sapub.org]

Metastatic carcinoids are nearly always bilateral with scattered tumor deposits present throughout both ovaries. Related Radiopaedia articles Promoted articles (advertising) [radiopaedia.org]

[…] as a post-menopausal virilizing neoplasm is extremely rare as described in the present case. [indianjcancer.com]

We present a rare case of ovarian mixed, trabecular and insular, carcinoid with lymph node metastases. [omicsonline.org]

Gastrointestinal

  • Diarrhea

    Even if modified Sambaek-tang showed partial effect on frequency of diarrhea, we concluded that it was not sufficient to be a therapeutic method of the diarrhea as carcinoid symptom. [dbpia.co.kr]

    This may be counterintuitive as the body loses bicarbonate during diarrhea, but if the diarrhea is chronic there are other mechanisms in the body. [lecturio.com]

    Diarrhea. The diarrhea of carcinoid syndrome does not necessarily correlate with flushing. Diarrhea appears to be related to increased gut motility, rather than to secretion of fluids. [aboutcancer.com]

    Potential causes of flushing in carcinoid syndrome include bradykinins, prostaglandins, tachykinins, substance P, and/or histamine, diarrhea, and heart problems. [en.wikipedia.org]

    The diarrhea may be so severe that vital nutrients of the body, such as potassium and water, are depleted creating life-threatening electrolyte imbalance. [rarediseases.org]

  • Chronic Diarrhea

    This may be counterintuitive as the body loses bicarbonate during diarrhea, but if the diarrhea is chronic there are other mechanisms in the body. [lecturio.com]

    For example, carcinoid tumors in the rectum and colon are incidentally found during colonoscopy performed for colon cancer screening, for iron deficiency anemia, or for chronic diarrhea. [medicinenet.com]

    The occurrence of episodic facial flushing and/or chronic diarrhea not diagnosed by standard tests as being a result of more common causes should lead to suspicion of carcinoid syndrome. [rarediseases.org]

Urogenital

  • Adnexal Mass

    A comparison of methods for preoperative discrimination between malignant and benign adnexal masses: the development of a new logistic regression model. [pelvicmass.tripod.com]

    Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977). [books.google.es]

    The vaginal examination revealed first degree cervical descent, a retroverted uterus and a left adnexal mass. A clinical diagnosis of mature cystic teratoma was kept and hysterectomy with bilateral salpingo-oophorectomy was performed. [ccij-online.org]

    About 6–7% of all adnexal masses found during physical examination are actually metastatic ovarian tumors, frequently unsuspected by gynecologists. 2 – 4 The metastasis often masquerades as a primary ovarian tumor and may even be the initial manifestation [clinicalgate.com]

Workup

Ultrasound

  • Ovarian Mass

    Per operatively 15x10 cms left ovarian solid to cystic mass with single septation was present. Final histopathology report of ovarian mass shows tumor present in form of nests, trabeculae and ribbons. [article.sapub.org]

    During her examination, a mobile cystic mass was detected in the right lower abdomen. Ultrasound indicated a right ovarian mass 10.5 × 6.3 cm, confirmed by CT scan. Further investigation revealed AFP levels (1539 ng/mL). [scienceopen.com]

    Histological analysis showed that the right ovarian mass contained stromal carcinoid tumor in a mature cystic teratoma. [jstage.jst.go.jp]

    Intra-operatively, there was a left ovarian mass 8 cm × 7 cm, solid, nodular, with bosselated surface, no papillary excrescences and an intact capsule. Rest all organs were normal and lymph nodes were not palpable. [indianjcancer.com]

    Similarly, the right ovary showed a cystic mass filled with sebum and hairs, measuring 6.5 × 5.0 × 4.0 cm. Frozen sections of the left ovarian mass were made. [wjso.biomedcentral.com]

Treatment

Clinical trials can test the effectiveness of promising new treatments or new ways of combining cancer treatments. Always discuss treatment options with your doctor. [cancervic.org.au]

Treatment Surgery is often used as the first treatment for carcinoid tumors. If the tumor hasn’t spread, surgery can cure the cancer. Surgery may also be combined with other treatments to reduce the tumor and the symptoms. [stopcancerfund.org]

Omeprazole treatment was therefore discontinued three weeks before control laboratory tests, and chromogranin A levels normalized (63.3 and 37 ng/mL; No.: 19.4–98.1). [elsevier.es]

The NCCN Templates are not exhaustive and do not represent the full spectrum of care or treatment options described in the NCCN Guidelines or the NCCN Compendium or include all appropriate approaches or combinations of drugs or biologics for the treatment [nccn.org]

These diagnostic tests also help us to identify the course of treatment, which may include surgery and, in some cases, chemotherapy or radiation therapy. [upmc.com]

Prognosis

Prognosis The prognosis varies, depending on the location of the tumor and whether or not the tumor has metastasized. If the tumor is caught early, it can be surgically removed and cured. [lahey.org]

Prognosis depends on site. [patient.info]

Prognosis With hearing aids, prognosis is good for most affected individuals with WS2. The documents contained in this web site are presented for information purposes only. [orpha.net]

My onocolgist says it is a much better prognosis than if it was a typical ovarian cancer, but at the same time he says I don't want to hear my name in the same sentence with the word cancer. [csn.cancer.org]

In general, ovarian carcinoid tumors are slow growing, and have a good prognosis, but some cases of metastasis or recurrence have been reported. Therefore, these borderline tumors require careful evaluation [jstage.jst.go.jp]

Etiology

Rosenberg SA (eds): AIDS: Etiology, Diagnosis. Treatment, and Prevention. ‏ الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R. [books.google.com]

Etiology WS2 is genetically very heterogeneous and still much of the etiology of WS2 remains elusive. Mutations have been found in MITF (3p14-p13; subtype designated as WS2A), SNAI2 (8q11.21; WS2D), and SOX10 (22q13.1; WS2E) genes. [orpha.net]

Etiology of Carcinoid Syndrome Causes of the carcinoid syndrome Both carcinoid tumors and VIPomas arise from abnormal cell development resulting in unregulated cell replication. [lecturio.com]

Wilms' tumor a rapidly developing malignant mixed tumor of the kidneys, made up of embryonal elements, occurring chiefly in children before the seventh year; a genetic component is suspected in its etiology. [medical-dictionary.thefreedictionary.com]

(Etiology) The exact cause and mechanism of formation of Primary Carcinoid Tumor of Uterus is unknown. Some researchers believe that the tumor occurs due to genetic mutations within the cells in the endometrium (the lining of the uterus). [dovemed.com]

Epidemiology

Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R. An epidemiologic study of cancer of the cervix, vagina, and vulva based on the Third National Cancer Survey in the United States. [books.google.com]

Summary Epidemiology The prevalence of WS2 is unknown; the worldwide prevalence of WS is estimated at around 1/40,000. WS2 is one of the most common types of Waardenburg syndrome. [orpha.net]

Epidemiology and survival inpatients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. 2001;12:1295-300. Oberg K. Chemotherapy and biotherapy in the treatment of neuroendocrine tumours. [rarediseases.org]

Epidemiology and survival in patients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. 2001 Sep. 12(9):1295-300. [Medline]. [Full Text]. Berge T, Linell F. Carcinoid tumours. [emedicine.medscape.com]

Pathophysiology

Pathology and Pathophysiology of Carcinoid Syndrome VIPomas release large amounts of vasoactive intestinal peptide (VIP). Under normal circumstances, VIP relaxes the GI tract, increases secretion of pancreatic bicarbonate and digestive enzymes. [lecturio.com]

Pathophysiology Pathophysiology is closely related to the sites of the primary tumors. When these tumors spread to the liver, patients usually begin to develop malignant carcinoid syndrome. [emedicine.medscape.com]

Prevention

[…] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. [nccn.org]

Prevention There is no sure way to prevent carcinoid tumors from forming. Some studies indicate that quitting smoking may help reduce your risk of developing a carcinoid tumor. [knowcancer.com]

Treatment, and Prevention. ‏ الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R. [books.google.com]

Preventive Services Task Force Reaffirmation Recommendation Statement. USPSTF [On-line information]. Available online at http://www.uspreventiveservicestaskforce.org/uspstf12/ovarian/ovarartaddend.htm. [labtestsonline.it]

[…] growth of gastrointestinal carcinoids by blocking or shrinking the blood vessels that nourish them how nuclear medicine can contribute to early detection of gastrointestinal carcinoids Prevention There is no known way to prevent gastrointestinal carcinoids [encyclopedia.com]

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