Edit concept Question Editor Create issue ticket

Carcinoid Neoplasm of the Ovary

Ovarian Carcinoid Tumor


Presentation

  • In addition, we present a literature review of GTS of the ovary and some novel observations about this entity.[scienceopen.com]
  • Per operatively 15x10 cms left ovarian solid to cystic mass with single septation was present. Final histopathology report of ovarian mass shows tumor present in form of nests, trabeculae and ribbons.[article.sapub.org]
  • Metastatic carcinoids are nearly always bilateral with scattered tumor deposits present throughout both ovaries. Related Radiopaedia articles Promoted articles (advertising)[radiopaedia.org]
  • […] as a post-menopausal virilizing neoplasm is extremely rare as described in the present case.[indianjcancer.com]
  • We present a rare case of ovarian mixed, trabecular and insular, carcinoid with lymph node metastases.[omicsonline.org]
Virilization
  • Primary ovarian carcinoid tumor simulating virilizing tumor of the ovary: A rare entity. Indian J Cancer [serial online] 2014 [cited 2019 May 14];51:529-30.[indianjcancer.com]
  • ., pelvic masses, ascites, or vaginal bleeding. 17, 19 Some patients with ovarian metastases have menstrual abnormalities, postmenopausal bleeding, and virilization, or they deliver a masculinized female fetus.[clinicalgate.com]
  • When the stroma is luteinized, this variant may be mistaken for a Sertoli–Leydig cell tumor, particularly in cases in which the patient is virilized ( Figure 14 ).[nature.com]
Lymphadenopathy
  • Ultrasound and contrast enhanced computed tomography imaging revealed a left ovarian solid mass with necrotic area 6 cm 8.7 cm 8.3 cm with no ascites, organomegaly, pelvic or para-aortic lymphadenopathy and normal uterus and contralateral ovary.[indianjcancer.com]
  • Lower MR-images show the same jejunal mass with shouldered borders and mesenteric lymphadenopathy (red arrows), consistent with adenocarcinoma. First study the images. Then continue reading.[radiologyassistant.nl]
Constitutional Symptom
  • The patient reported no associated constitutional symptoms. Physical examination findings were normal. Measurement of calcitonin levels in blood and metanephrines, normetanephrines and 5-hydroxyindoleacetic acid in urine was requested.[elsevier.es]
Aspiration
  • Inspection of the abdominal cavity is highlighted with evidence of: abundant ascites (1000 cc) which was aspirated and sent for examination; extensive omental adhesions with the parietal peritoneum; the uterus and the right annexe appeared regular in[omicsonline.org]
  • Needle aspiration cytology, immunocytochemistry, and electron microscopic study in a case of carcinoid of the male breast. Diagn Cytopathol. 1993;9:461–464.[breast-cancer.ca]
Diarrhea
  • Ovarian carcinoid either presented with abdominal mass or features of carcinoid syndrome, eg episodic cutaneous flushing, cyanosis, abdominal cramps, diarrhea, carcinoid heart disease. Surgery is the mainstay of treatment for ovarian carcinoid [4].[article.sapub.org]
  • They were not associated to high or low blood pressure, headache, diarrhea, or bronchospasm, but patient reported palpitations during them.[elsevier.es]
  • This may be counterintuitive as the body loses bicarbonate during diarrhea, but if the diarrhea is chronic there are other mechanisms in the body.[lecturio.com]
  • Diarrhea. The diarrhea of carcinoid syndrome does not necessarily correlate with flushing. Diarrhea appears to be related to increased gut motility, rather than to secretion of fluids.[aboutcancer.com]
  • Potential causes of flushing in carcinoid syndrome include bradykinins, prostaglandins, tachykinins, substance P, and/or histamine, diarrhea, and heart problems.[en.wikipedia.org]
Chronic Diarrhea
  • This causes chronic diarrhea and concomitant dehydration, metabolic alkalosis, and elevated bicarbonate.[lecturio.com]
  • For example, carcinoid tumors in the rectum and colon are incidentally found during colonoscopy performed for colon cancer screening, for iron deficiency anemia, or for chronic diarrhea.[medicinenet.com]
  • The occurrence of episodic facial flushing and/or chronic diarrhea not diagnosed by standard tests as being a result of more common causes should lead to suspicion of carcinoid syndrome.[rarediseases.org]
Early Satiety
  • A 62-year-old lady, P5L5, presented with an abdominal lump, complaints of early satiety, constipation and mild virilization. She was a known hypertensive controlled on beta blockers.[indianjcancer.com]
Lower Abdominal Pain
  • A woman of 47 years old presented with lower abdominal pain, ultrasound evaluation revealed a voluminous pelvic mass on the right side.[omicsonline.org]
Palpitations
  • They were not associated to high or low blood pressure, headache, diarrhea, or bronchospasm, but patient reported palpitations during them.[elsevier.es]
  • The syndrome may also be accompanied by stomach pain, blockage of the arteries in the liver, heart palpitations and excessive peptide excretion in the urine.[rarediseases.org]
  • In these rare cases (only about five percent of all carcinoid tumor cases), the tumor can cause unusually high amounts of hormones in the blood. 4 This situation, called carcinoid syndrome, could result in symptoms such as: flushing heart palpitations[stopcancerfund.org]
  • Other features include diarrhoea, abdominal pain, palpitations, hypotension and wheezing.[patient.info]
Adnexal Mass
  • Página 406 - Goldstein SR, Subramanyam B, Snyder JR et al: The postmenopausal cystic adnexal mass, the potential role of ultrasound in conservative management. Obstet Gynaecol 73:8, 1989. ‎ Página 46 - Kelly, SJ (1977).[books.google.es]
  • About 6–7% of all adnexal masses found during physical examination are actually metastatic ovarian tumors, frequently unsuspected by gynecologists. 2 – 4 The metastasis often masquerades as a primary ovarian tumor and may even be the initial manifestation[clinicalgate.com]
Clitoromegaly
  • She had male pattern of baldness, thickening of eyebrows, increased upper lip hair and mild clitoromegaly. There was a 6 cm 7 cm, firm-solid, non-tender, immobile mass in the left iliac fossa.[indianjcancer.com]

Workup

Ovarian Mass
  • On staging laparotomy, a 15x10 cms ovarian mass was present on left side, solid in consistency with few septations. This ovarian mass was sent for frozen section, which reported as malignant epithelial neoplasm of ovary.[article.sapub.org]
  • Ultrasound indicated a right ovarian mass 10.5 6.3 cm, confirmed by CT scan. Further investigation revealed AFP levels (1539 ng/mL). The ovarian mass was excised by laparoscopy, leaving intact the remaining right ovary.[scienceopen.com]
  • Intra-operatively, there was a left ovarian mass 8 cm 7 cm, solid, nodular, with bosselated surface, no papillary excrescences and an intact capsule. Rest all organs were normal and lymph nodes were not palpable.[indianjcancer.com]
  • Histological analysis showed that the right ovarian mass contained stromal carcinoid tumor in a mature cystic teratoma.[jstage.jst.go.jp]
  • Through the frozen sections, the left ovarian mass was diagnosed as MCT, and therefore, no further intervention was performed at the time of the operation.[wjso.biomedcentral.com]
Ovarian Mass
  • On staging laparotomy, a 15x10 cms ovarian mass was present on left side, solid in consistency with few septations. This ovarian mass was sent for frozen section, which reported as malignant epithelial neoplasm of ovary.[article.sapub.org]
  • Ultrasound indicated a right ovarian mass 10.5 6.3 cm, confirmed by CT scan. Further investigation revealed AFP levels (1539 ng/mL). The ovarian mass was excised by laparoscopy, leaving intact the remaining right ovary.[scienceopen.com]
  • Intra-operatively, there was a left ovarian mass 8 cm 7 cm, solid, nodular, with bosselated surface, no papillary excrescences and an intact capsule. Rest all organs were normal and lymph nodes were not palpable.[indianjcancer.com]
  • Histological analysis showed that the right ovarian mass contained stromal carcinoid tumor in a mature cystic teratoma.[jstage.jst.go.jp]
  • Through the frozen sections, the left ovarian mass was diagnosed as MCT, and therefore, no further intervention was performed at the time of the operation.[wjso.biomedcentral.com]

Treatment

  • Omeprazole treatment was therefore discontinued three weeks before control laboratory tests, and chromogranin A levels normalized (63.3 and 37 ng/mL; No.: 19.4–98.1).[elsevier.es]
  • From cover to cover, it gives practical, timely advice on screening, diagnosis, and treatment. Ovarian cancer is the leading cause of death from gynecologic malignancies in the Western world.[books.google.com]
  • Treatment, and Prevention. ‏ الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R.[books.google.com]
  • Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer 1991;68:227-32. [Figure 1], [Figure 2][indianjcancer.com]
  • Surgery is the mainstay of treatment for ovarian carcinoid [4]. Role of chemotherapy is not very well defined for it. And our patient was also staged as stage 1A and not given adjuvant chemotherapy and patient had not shown any signs of recurrence.[article.sapub.org]

Prognosis

  • […] of approximately 8 cases per 100,000 population. 1 Only 1–2% of these tumors originate in ovarian tissue, 2 where they often seat, as in the reported case, on a cystic teratoma or dermoid tumor. 3 According to some studies, this confers them a better prognosis[elsevier.es]
  • Prognosis The prognosis varies, depending on the location of the tumor and whether or not the tumor has metastasized. If the tumor is caught early, it can be surgically removed and cured.[lahey.org]
  • Prognosis depends on site.[patient.info]
  • My onocolgist says it is a much better prognosis than if it was a typical ovarian cancer, but at the same time he says I don't want to hear my name in the same sentence with the word cancer.[csn.cancer.org]
  • In general, ovarian carcinoid tumors are slow growing, and have a good prognosis, but some cases of metastasis or recurrence have been reported. Therefore, these borderline tumors require careful evaluation[jstage.jst.go.jp]

Etiology

  • Rosenberg SA (eds): AIDS: Etiology, Diagnosis. Treatment, and Prevention. ‏ الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R.[books.google.com]
  • Wilms' tumor a rapidly developing malignant mixed tumor of the kidneys, made up of embryonal elements, occurring chiefly in children before the seventh year; a genetic component is suspected in its etiology.[medical-dictionary.thefreedictionary.com]
  • Etiology of Carcinoid Syndrome Causes of the carcinoid syndrome Both carcinoid tumors and VIPomas arise from abnormal cell development resulting in unregulated cell replication.[lecturio.com]
  • (Etiology) The exact cause and mechanism of formation of Primary Carcinoid Tumor of Uterus is unknown. Some researchers believe that the tumor occurs due to genetic mutations within the cells in the endometrium (the lining of the uterus).[dovemed.com]

Epidemiology

  • Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R. An epidemiologic study of cancer of the cervix, vagina, and vulva based on the Third National Cancer Survey in the United States.[books.google.com]
  • Ovarian Cancer, a volume in the American Cancer Society Atlas of Clinical Oncology series, thoroughly discusses pathology, biology, epidemiology, genetics and screening.[books.google.com]
  • Epidemiology and survival inpatients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. 2001;12:1295-300. Oberg K. Chemotherapy and biotherapy in the treatment of neuroendocrine tumours.[rarediseases.org]
  • Epidemiology and survival in patients with carcinoid disease in The Netherlands. An epidemiological study with 2391 patients. Ann Oncol. 2001 Sep. 12(9):1295-300. [Medline]. [Full Text]. Berge T, Linell F. Carcinoid tumours.[emedicine.medscape.com]
  • Original Papers Clinical Oncology or Epidemiology Summary Carcinoid tumors of the ovary are uncommon, but 150 cases of primary ovarian carcinoids and 40 cases of carcinoid tumors metastatic to the ovary have been reported.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • Pathology and Pathophysiology of Carcinoid Syndrome VIPomas release large amounts of vasoactive intestinal peptide (VIP). Under normal circumstances, VIP relaxes the GI tract, increases secretion of pancreatic bicarbonate and digestive enzymes.[lecturio.com]
  • Pathophysiology Pathophysiology is closely related to the sites of the primary tumors. When these tumors spread to the liver, patients usually begin to develop malignant carcinoid syndrome.[emedicine.medscape.com]

Prevention

  • Treatment, and Prevention. ‏ الصفحة 190 - Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med. ‏ الصفحة 193 - Henson D, Tarone R.[books.google.com]
  • […] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.[nccn.org]
  • Prevention There is no sure way to prevent carcinoid tumors from forming. Some studies indicate that quitting smoking may help reduce your risk of developing a carcinoid tumor.[knowcancer.com]
  • […] growth of gastrointestinal carcinoids by blocking or shrinking the blood vessels that nourish them how nuclear medicine can contribute to early detection of gastrointestinal carcinoids Prevention There is no known way to prevent gastrointestinal carcinoids[encyclopedia.com]
  • Pellagra may be prevented by ensuring adequate protein in the diet and by taking niacin. Drugs that block the production of serotonin, such as methyldopa, also help prevent pellagra.[msdmanuals.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!