We report a rare case of SRCC of the ampulla of Vater in a 38-year-old woman who presented with a small tumor at the Vater, discovered by the contrast-enhanced ultrasound (CEUS). Histopathological examination showed prominent signet-ring features. [ncbi.nlm.nih.gov]

Case presentation The patient was a 61-year-old male who presented to our hospital with increased blood levels of hepatobiliary system enzymes detected during a health check-up. He had a past medical history of hypertension and appendectomy. [surgicalcasereports.springeropen.com]

Of all 162 patients with ampullary lesions, eight cases (4.9%) were diagnosed as SRC, with a mean age at presentation of 60 years. The presenting symptoms information was available for all eight cases. [spandidos-publications.com]

We present an elderly patient with SRCC of Vater’s Ampulla without nodal metastasis. 2. Case Presentation We report the case of a 57-year-old man, admitted with jaundice, abdominal pain four months ago and 10 kg weight loss. [file.scirp.org]

The present case suggests that curative surgery may be effective in improving the prognosis in patients with MANEC. [jstage.jst.go.jp]

We highlight such a case, and its diagnostic workup. Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. MRI scan showed a stricture in the distal common bile duct suggestive of a neoplasm. [journals.sjp.ac.lk]

Choledocholithiasis Duodenal Ulcers Gallbladder Cancer Gallbladder Tumors Lymphoma, Non-Hodgkin Pancreatic Cancer Pancreatitis, Chronic Papillary Necrosis Papillary Tumors Other Problems to be Considered: Duodenal carcinoma Adenoma at the ampulla of Vater WORKUP [oncology-articles.blogspot.com]

(ie, for staging purposes) Positron emission tomography (PET) or PET-CT scanning: PET or PET-CT scans can detect metastases that are too small to be reliably detected on a CT scan See Workup for more detail. [emedicine.medscape.com]

Fig. 6A – pre-treatment blood tests Treatment We offered a comprehensive approach to properly manage the pain, improve nutritional status and treat the cancer. [medicorcancer.com]

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer. National Cancer Institute of the United States. National Cancer Institute of Canada. ‏ [books.google.com]

Greater awareness on the impact of metastatic LNR may help clinicians provide appropriate adjuvant treatment for high-risk CAV patients. [ncbi.nlm.nih.gov]

Adjuvant chemotherapy may be appropriate in the treatment of ampullary SRCC associated with locoregional metastasis. [file.scirp.org]

As for prognosis, Hara et al ( 12 ) showed that SRC localized in the ampulla of Vater has a poor prognosis and lymph node involvement is also regarded as a key prognostic factor. [spandidos-publications.com]

In multivariate analysis, patients with a metastatic LNR 0.056 had a significantly poor prognosis in both OS and DFS.A metastatic LNR 0.056 predicted a poor DFS and OS in CAV patients after radical surgery. [ncbi.nlm.nih.gov]

Accumulation of p53 protein and the Ki-67 labeling index revealed no significant difference in prognosis. [nature.com]

On the other hand, undifferentiated carcinoma of the common bile duct grew in a polypoid pattern and could be discovered in an early stage, leading to favorable prognosis [ 3 ]. [surgicalcasereports.springeropen.com]

Perineural, vascular, and lymphatic invasion are associated with a poor prognosis. Liver is the most common site (66%) of distant metastasis, followed by lymph nodes (22%). In advanced cases, lung metastasis also may occur. [thehealthscience.com]

The fully revised and updated Sixth Edition of the AJCC Cancer Staging Manual brings together all currently available information on staging of cancer at various anatomic sites and incorporates newly acquired knowledge on the etiology and pathology of [books.google.com]

In this theory, signet-ring cell carcinoma originates from periampullary duodenal heterotopias of an ulcerative etiology and expands to the ampulla of Vater. [file.scirp.org]

Causes: The etiology of the disease is poorly understood. Patients with familial adenomatous polyposis (FAP) have an increased risk of both benign and malignant ampullary tumors (Burke, 1999). [oncology-articles.blogspot.com]

Between 1973 and 2005, 5,625 cases were recorded in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. [thehealthscience.com]

A population-based study with database of Survellaince Epidemiology and End Results (SEER) reported data that support this theory for periampullary neoplasms. [clinical-epigenetics.imedpub.com]

  Epidemiology,  Clinical manifestations,  Diagnosis and staging,  Treatment and prognosis. [slideshare.net]

Pathophysiology Periampullary carcinoma includes tumors arising in the head, neck, or uncinate process of the pancreas, tumors arising in the distal common bile duct, tumors arising in the duodenum, as well as tumors arising from the ampulla of Vater. [thehealthscience.com]

Pathophysiology: Ninety percent of ampullary tumors are adenocarcinomas. Neuroendocrine tumors, cystadenomas, and adenomas represent additional, but uncommon, histologic types. [oncology-articles.blogspot.com]

We gave the patient routine supplementation with R alpha lipoic acid 150mg t.i.d. and benfotiamine 80mg b.i.d. to help prevent DCA side effects. Within 1 week, the patient’s fevers disappeared. [medicorcancer.com]

Deterrence/Prevention: Those with FAP and their family members should be counseled about the possibility of acquiring ampullary carcinoma. [oncology-articles.blogspot.com]

This concept suggests that improved LC, through addition of radiation therapy, may potentially prevent both local and subsequent distant recurrences. [jgo.amegroups.com]

Prevention Ampullary cancer is such a rare condition that experts aren’t sure what steps, if any, can be taken to prevent it. It does appear to be more common among men than women. [essentiahealth.org]

[…] through the ampulla: the sphincter of the pancreatic duct, the sphincter of the bile duct, and the sphincter of Oddi. [ citation needed ] The sphincter of Oddi controls the introduction of bile and pancreatic secretions into the duodenum, as well as preventing [en.wikipedia.org]