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Carcinoma of Ampulla of Vater

Ampulla Vater Cancer Carcinoma


Presentation

  • We report a rare case of SRCC of the ampulla of Vater in a 38-year-old woman who presented with a small tumor at the Vater, discovered by the contrast-enhanced ultrasound (CEUS). Histopathological examination showed prominent signet-ring features.[ncbi.nlm.nih.gov]
  • Case presentation The patient was a 61-year-old male who presented to our hospital with increased blood levels of hepatobiliary system enzymes detected during a health check-up. He had a past medical history of hypertension and appendectomy.[surgicalcasereports.springeropen.com]
  • We present an elderly patient with SRCC of Vater’s Ampulla without nodal metastasis. 2. Case Presentation We report the case of a 57-year-old man, admitted with jaundice, abdominal pain four months ago and 10 kg weight loss.[file.scirp.org]
  • The present case suggests that curative surgery may be effective in improving the prognosis in patients with MANEC.[jstage.jst.go.jp]
  • Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. MRI scan showed a stricture in the distal common bile duct suggestive of a neoplasm.[journals.sjp.ac.lk]
Intermittent Fever
  • Abstract The hepatic intermittent fever of Charcot is due to recurrent biliary obstruction with secondary infection, and is characterized by recurrent attacks of chills, fever and sweats. Jaundice is variable and may deepen after each paroxysm.[annals.org]
Dyspnea
  • Combination therapy with gemcitabine plus cisplatin was administered, but the patient developed dyspnea, which was attributed to heart failure secondary to mitral valve prolapse as diagnosed using echocardiography.[surgicalcasereports.springeropen.com]
Mitral Valve Prolapse
  • Moreover, the symptoms of mitral valve prolapse-associated heart failure worsened at this time and continuation of chemotherapy became difficult. The patient died of the primary disease 15 months postoperatively.[surgicalcasereports.springeropen.com]
Jaundice
  • Jaundice is variable and may deepen after each paroxysm. Abdominal pain, which is sometimes severe and colicky, is frequently absent.[annals.org]
  • The patient was hospitalized for right upper quadrant abdominal pain and jaundice which had developed 10 days prior. Computed tomography (CT) and ultrasonography (US) revealed dilatation of the common bile duct and the intrahepatic bile duct.[e-ce.org]
  • Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. MRI scan showed a stricture in the distal common bile duct suggestive of a neoplasm.[journals.sjp.ac.lk]
  • Our patient had the typical characteristics of other cases in terms of age, jaundice, macroscopic appearance.[file.scirp.org]
  • CASE REPORT A 72-year-old man was admitted to our hospital with jaundice. He had a 15-year history of diabetes mellitus. There were no palpable masses or lymph nodes at physical examination.[joplink.net]

Workup

  • We highlight such a case, and its diagnostic workup. Case Report: A 61 year old woman presented with painless obstructive jaundice of 2 months duration. MRI scan showed a stricture in the distal common bile duct suggestive of a neoplasm.[journals.sjp.ac.lk]

Treatment

  • Fig. 6A – pre-treatment blood tests Treatment We offered a comprehensive approach to properly manage the pain, improve nutritional status and treat the cancer.[medicorcancer.com]
  • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer. National Cancer Institute of the United States. National Cancer Institute of Canada. ‏[books.google.com]
  • Greater awareness on the impact of metastatic LNR may help clinicians provide appropriate adjuvant treatment for high-risk CAV patients.[ncbi.nlm.nih.gov]
  • الصفحة 263 - Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC). ‏[books.google.com]
  • Adjuvant chemotherapy may be appropriate in the treatment of ampullary SRCC associated with locoregional metastasis.[file.scirp.org]

Prognosis

  • In multivariate analysis, patients with a metastatic LNR 0.056 had a significantly poor prognosis in both OS and DFS.A metastatic LNR 0.056 predicted a poor DFS and OS in CAV patients after radical surgery.[ncbi.nlm.nih.gov]
  • On the other hand, undifferentiated carcinoma of the common bile duct grew in a polypoid pattern and could be discovered in an early stage, leading to favorable prognosis [ 3 ].[surgicalcasereports.springeropen.com]
  • Accumulation of p53 protein and the Ki-67 labeling index revealed no significant difference in prognosis.[nature.com]
  • The present case suggests that curative surgery may be effective in improving the prognosis in patients with MANEC.[jstage.jst.go.jp]
  • Perineural, vascular, and lymphatic invasion are associated with a poor prognosis. Liver is the most common site (66%) of distant metastasis, followed by lymph nodes (22%). In advanced cases, lung metastasis also may occur.[thehealthscience.com]

Etiology

  • The fully revised and updated Sixth Edition of the AJCC Cancer Staging Manual brings together all currently available information on staging of cancer at various anatomic sites and incorporates newly acquired knowledge on the etiology and pathology of[books.google.com]
  • In this theory, signet-ring cell carcinoma originates from periampullary duodenal heterotopias of an ulcerative etiology and expands to the ampulla of Vater.[file.scirp.org]

Epidemiology

  • Between 1973 and 2005, 5,625 cases were recorded in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute.[thehealthscience.com]
  • A population-based study with database of Survellaince Epidemiology and End Results (SEER) reported data that support this theory for periampullary neoplasms.[clinical-epigenetics.imedpub.com]
  • .   Epidemiology,  Clinical manifestations,  Diagnosis and staging,  Treatment and prognosis.[slideshare.net]
  • 胆嚢癌 (GBC) の予測:主要18市場 Epiomic Epidemiology Series: Gallbladder Cancer Forecast in 18 Major Markets 2015-2025 出版日: 2015年09月16日 ページ情報: 英文 62 Pages 概要 胆嚢癌 (GBC) は、主に胆嚢自体に発生するだけでなく、肝外胆管や、ファーター膨大部、指定されていない胆管腫瘍なども含まれます。[gii.co.jp]
  • Epidemiology of cholangiocarcinoma: an update focusing on risk factors. Cancer Sci 2010; 101: 579-585 Bosetti C, Bertuccio P, Negri E, et al. Pancreatic cancer: overview of descriptive epidemiology.[sapd.es]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology Periampullary carcinoma includes tumors arising in the head, neck, or uncinate process of the pancreas, tumors arising in the distal common bile duct, tumors arising in the duodenum, as well as tumors arising from the ampulla of Vater.[thehealthscience.com]

Prevention

  • We gave the patient routine supplementation with R alpha lipoic acid 150mg t.i.d. and benfotiamine 80mg b.i.d. to help prevent DCA side effects. Within 1 week, the patient’s fevers disappeared.[medicorcancer.com]
  • Prevention Ampullary cancer is such a rare condition that experts aren’t sure what steps, if any, can be taken to prevent it. It does appear to be more common among men than women.[essentiahealth.org]
  • […] through the ampulla: the sphincter of the pancreatic duct, the sphincter of the bile duct, and the sphincter of Oddi. [ citation needed ] The sphincter of Oddi controls the introduction of bile and pancreatic secretions into the duodenum, as well as preventing[en.wikipedia.org]
  • Read Full Post 3/13/2019 12:00 AM Lifestyle changes that may reduce your risk of cancer Studies reported by the National Institutes of Health have found that at least 75 to 80 percent of cancers in the United States may be prevented by lifestyle changes[cancercenter.com]
  • Table of Contents List of Tables and Figures Introduction Cause of the Disease Risk Factors & Prevention Diagnosis of the Disease Variation by Geography/Ethnicity Disease Prognosis & Clinical Course Key Co-morbid Conditions/ Features Associated with the[gii.co.jp]

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