Despite postoperative combination chemotherapy, he developed pulmonary and retroperitoneal metastases and died 20 months after presentation. [ncbi.nlm.nih.gov]

• Fatigue

  They include fever, fatigue, and a burning sensation in the bladder. Interferon is another biological therapy option. [medicalnewstoday.com]

  The side effects of radiation treatment may include vomiting, diarrhea, fatigue, or skin irritations resembling a sunburn. Chemotherapy may also be indicated for treatment of bladder cancers. [britannica.com]

  Side effects from radiation therapy may include fatigue, mild skin reactions, and loose bowel movements. [cancer.net]

  This may include: CT scans to check for the spread or return of cancer Monitoring symptoms that might suggest the disease is getting worse, such as fatigue, weight loss, increased pain, decreased bowel and bladder function, and weakness Complete blood [medlineplus.gov]

  Viral platforms under evaluation in bladder cancer clinical trials include Adenovirus : a family of common viruses that can cause a wide range of typically mild effects including sore throat, fatigue, and cold-like symptoms Coxsackievirus : a virus that [cancerresearch.org]

• Abdominal Pain

  Urinary obstruction, abdominal pain, urinary tract infection and weigh loss are occasionally present. [orpha.net]

  For example, cancer that has spread to the lungs may cause a cough or shortness of breath, spread to the liver may cause abdominal pain or jaundice (yellowing of the skin and whites of the eyes), and spread to the bone may cause bone pain or a fracture [cancer.net]

  Case presentation A 68-year-old Japanese man was admitted to our hospital because of sudden hematuria and abdominal pain. Endoscopic and imaging techniques including CT, MRI, and PET revealed a bladder tumor. [casesjournal.biomedcentral.com]

  pain (2.3%); Urinary tract infection (2.3%); Ectopic ACTH secretion (2.3%) 0.5% 38.6% Abrahams 2005[ 9 ] 51 4:1 67 (39-87) - 74% Haematuria (63%); Dysuria (12%); Abdominal pain (2%); Urinary obstruction (2%); Weight loss (2%); Urinary tract infection [ojrd.biomedcentral.com]

• Suprapubic Pain

  Other symptoms may include suprapubic pain after voiding, bladder irritability, dribbling, and nocturia. Physical examination The physical examination is usually normal. [medical-dictionary.thefreedictionary.com]

• Heart Failure

  failure requiring treatment (NYHA grade 2) LVEF 50 as determined by MUGA scan or ECHO Uncontrolled hypertension (refer to WHO-ISH guidelines History or presence of clinically significant ventricular arrhythmias, atrial fibrillation, resting bradycardia [clinicaltrials.gov]

• Dysuria

  The literature on squamous metaplasia and leukoplakia progressing to epidermoid carcinoma of the chronic dysuria, bladder infections, and long histories of squamous metaplasia of the bladder should be followed up very closely. [ncbi.nlm.nih.gov]

  The main symptom is gross hematuria (63 to 88% of cases) with dysuria as the second most common symptom. Urinary obstruction, abdominal pain, urinary tract infection and weigh loss are occasionally present. [orpha.net]

  They can also present with symptoms simulating urinary tract infections such as frequency, dysuria, urgency. Blood in the urine does not always indicate bladder cancer, and cystitis (inflammation of the bladder) is a much commoner cause. [myvmc.com]

  […] urothelial carcinoma, occasionally adenocarcinoma Also endometriosis, pelvic lipomatosis, Schistosoma haematobium Chronic irritation of bladder, including nonfunctioning bladder Clinical features Usually present with hematuria, rarely with mucusuria, dysuria [pathologyoutlines.com]

• Nocturia

  […] stones, bladder diverticula, chronic indwelling catheters, prolonged cyclophosphamide treatment, Schistosoma haematobium infection in Egypt / Sudan Also associated with smoking Difficult to detect since arises insidiously; often gross hematuria, dysuria, nocturia [pathologyoutlines.com]

  Managing symptoms of locally advanced or metastatic cancer [ 10 ] Bladder symptoms: Palliative radiotherapy may benefit those with symptoms of haematuria, dysuria, urinary frequency or nocturia caused by advanced bladder cancer. [patient.info]

  Other signs of bladder cancer could include increased frequency of urination, a feeling of urgency to urinate, nocturia (waking up at night due to having to urinate), pain (burning) with urination, and the feeling of incomplete bladder emptying. [oncolink.org]

• Macroscopic Hematuria

  When symptoms of bladder cancer do occur, they include: Red or rust colored urine caused by the presence of many red blood cells (called macroscopic hematuria) Painful urination or burning when urinating More frequent urination than normal Diagnosis Your [drugs.com]

  Visible blood in the urine is referred to as gross, or macroscopic, hematuria. Bladder cancer often causes no symptoms until it reaches an advanced stage that is difficult to cure. [emedicinehealth.com]

  Rhéaume-Lanoie J, Lepanto L, Fradet V et al: Diagnostic performance of ultrasound for macroscopic hematuria in the era of multidetector computed tomography urography. Can Assoc Radiol J 2014; 65: 253. [auanet.org]

C 18 Complete blood count, blood chemistry tests, liver function tests, chest radiography, and CT or magnetic resonance imaging of the abdomen and pelvis should be included in the metastatic workup for invasive bladder cancer. [aafp.org]

Cystoscopy, cytology, and biopsy when necessary are the principal diagnostic tests (see Workup ). [emedicine.medscape.com]

Five percent of the population can have thyroid nodules, and the majority will be benign. [6] Appropriate workup includes an ultrasound of the neck, followed by lab studies. [en.wikipedia.org]

Advanced UC has a poor prognosis and new treatments are needed. Molecular profiling of UC might identify biomarkers associated with targeted therapies or chemotherapeutics, providing physicians with new treatment options. [ncbi.nlm.nih.gov]

A variety of treatment modalities have been described, but optimal treatment requires rather a multimodality approach. [dx.doi.org]

KEYWORDS: miR-133b; prognosis; progression; urothelial carcinoma of the bladder Publication type, MeSH terms, Substances Publication type Research Support, Non-U.S. [ncbi.nlm.nih.gov]

Our results suggest that both consensus and different alterations exist between Chinese and Caucasian UC, indicating that genetic alterations of cancer can vary between different ethnic populations due to genetic and/or etiological discrepancies. [ncbi.nlm.nih.gov]

Etiology The etiology of the disease is unknown but a multipotent stem cell anomaly is thought to be a likely mechanism. A history of smoking is found in 65% to 79% of cases. [orpha.net]

Bochner B, Epidemiology and etiology of bladder cancer, UpToDate, 2005. Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Harrison’s Principles of Internal Medicine. 15th Edition. McGraw-Hill. 2001. Cotran RS, Kumar V, Collins T. [myvmc.com]

[…] urothelial carcinoma component Epicenter is mucosa, not muscularis propria (which is found in urachal adenocarcinoma) Epidemiology Less than 2% of all bladder malignancies 2/3 in men; mean age 68 years Sites Usually lateral wall or trigone of bladder Etiology [pathologyoutlines.com]

Abstract Squamous cell carcinoma (SCC) can occur in both nonbilharzial and bilharzial bladders; the two subtypes differ in epidemiology, pathogenesis and clinicopathological features. [ncbi.nlm.nih.gov]

Summary Epidemiology SCCB is extremely rare with an annual incidence of less than 1-9/1,000,000. Since 1980, fewer than 1,500 cases have been identified. [orpha.net]

[…] transitional cell carcinoma of the urinary tract TCCs in other locations: transitional cell carcinoma of the renal pelvis transitional cell carcinoma of the ureter other histologies: squamous cell carcinoma of the bladder adenocarcinoma of the bladder Epidemiology [radiopaedia.org]

Bochner B, Epidemiology and etiology of bladder cancer, UpToDate, 2005. Braunwald, Fauci, Kasper, Hauser, Longo, Jameson. Harrison’s Principles of Internal Medicine. 15th Edition. McGraw-Hill. 2001. Cotran RS, Kumar V, Collins T. [myvmc.com]

Nonurothelial primary bladder tumors are extremely rare and may include small cell carcinoma, carcinosarcoma, primary lymphoma, and sarcoma (see Pathophysiology ). [emedicine.medscape.com]

Both miR-30a and small interfering RNA Notch1 negatively regulated cell proliferation (P 0.002 and P 0.035 in T24; P 0.029 and P 0.037 in 5637 cell lines), activated cell cycle arrest (both P 0.001 in T24; both P 0.001 in 5637 cell lines), and prevented [ncbi.nlm.nih.gov]

It helps to prevent the tumor from coming back and helps prevent development of muscle invasive disease. About 6 weeks after completing the BCG, the doctor will do a cystoscopy again to make sure all of the cancer is gone. [urology.wustl.edu]

TUR alone is effective in preventing recurrences in approximately 50% of patients with superficial bladder cancer. [texasoncology.com]