The report presents a rare case of primary lung sarcomatoid carcinoma with both gastric and colonic metastases, and reviews the literature about endoscopic presentation of colonic metastases. [ncbi.nlm.nih.gov]

• Mediastinal Lymphadenopathy

  Thoracic mediastinal lymphadenopathy. Pleural right effusion in moderate quantity Figure 2. First CT, second image. First CT, and bronchoscopy with biopsy were determinant for the diagnostic of squamous cell carcinoma of the right lung. [medichub.ro]

• Weight Loss

  Its typical characteristic in elderly patients is a short duration of symptoms with substantial weight loss. [ncbi.nlm.nih.gov]

  Symptoms can include cough, chest discomfort or pain, weight loss, and, less commonly, hemoptysis; however, many patients present with metastatic disease without any clinical symptoms. [merckmanuals.com]

  […] of appetite or weight loss Fatigue Doctors diagnose lung cancer using a physical exam, imaging, and lab tests. [medlineplus.gov]

  loss, shortness of breath, and chest pains.[1] The vast majority (85%) of cases of lung cancer are due to long-term tobacco smoking.[4] About 10–15% of cases occur in people who have never smoked.[13] These cases are often caused by a combination of [play.google.com]

• Lymphadenopathy

  Thoracic mediastinal lymphadenopathy. Pleural right effusion in moderate quantity Figure 2. First CT, second image. First CT, and bronchoscopy with biopsy were determinant for the diagnostic of squamous cell carcinoma of the right lung. [medichub.ro]

  Pneumonia, pleural effusion, wheeze, lymphadenopathy are not uncommon. Other symptoms may be secondary to metastases (bone, contralateral lung, brain, adrenal glands, and liver, in frequency order for NSCLC 12 ) or paraneoplastic syndromes. [radiopaedia.org]

  Symptoms of Lung Cancer Due to Distant Metastases Site Sign or symptom Frequency (%) Any site Any sign or symptom 33 Liver Weakness, weight loss, anorexia, hepatomegaly Up to 60 Bone Pain, fracture, elevated alkaline phosphatase Up to 25 Lymphatics Lymphadenopathy [aafp.org]

  Characterizing a mass as malignant, however, is often straightforward because it invades and crosses tissue planes, is associated with effusions and lymphadenopathy, or has visibly metastasized (Figure 11A). [onlinejacc.org]

  Peripheral lymphadenopathy as the initial manifestation of pericardial mesothelioma: a case report. Int. J. Surg. Pathol. 12, 403–405 10.1177/106689690401200415 [PubMed] [CrossRef] [Google Scholar] Yarborough C. M. (2006). [ncbi.nlm.nih.gov]

• Cough

  We report a patient with MEC who presented with cough, hemoptysis, and localized findings on chest examination. This case emphasizes the importance of obtaining adequate biopsy to establish the correct diagnosis. [ncbi.nlm.nih.gov]

  Symptoms vary, depending on the location of the cancer: Lung cancer—a new cough or cough that doesn’t go away, coughing up blood, shortness of breath, chest pain, hoarseness Cancer of the trachea—dry cough, hoarseness, breathlessness, difficulty swallowing [publichealth.va.gov]

  Cough A cough is a common symptom. There are different treatments that can help a cough. Some types of painkilling drugs given by mouth can help. You can have other drugs as a vapour that you inhale. [macmillan.org.uk]

• Pleural Effusion

  Subsequently, pleural effusion was detected, and an investigation of the pleural effusion revealed the existence of malignant cells with an epidermal growth factor (EGFR) mutation. Gefitinib was administered and the pleural effusion resolved. [ncbi.nlm.nih.gov]

  A pleural effusion may also be seen, and although it is associated with a poor prognosis, not all effusions are due to a malignant involvement of the pleural space. Some are due to venous obstruction or represent a parapneumonic effusion 4. [radiopaedia.org]

• Hoarseness

  Symptoms vary, depending on the location of the cancer: Lung cancer—a new cough or cough that doesn’t go away, coughing up blood, shortness of breath, chest pain, hoarseness Cancer of the trachea—dry cough, hoarseness, breathlessness, difficulty swallowing [publichealth.va.gov]

  Common symptoms of lung cancer include A cough that doesn't go away and gets worse over time Constant chest pain Coughing up blood Shortness of breath, wheezing, or hoarseness Repeated problems with pneumonia or bronchitis Swelling of the neck and face [medlineplus.gov]

  Clinical presentation can significantly vary and can present in the following ways: constitutional fever weight loss malaise primary tumor cough hemoptysis dyspnea local invasion dysphagia ( esophageal compression ) hoarseness ( recurrent laryngeal nerve [radiopaedia.org]

  Other symptoms include: constant chest pain shortness of breath wheezing recurring lung infections, such as pneumonia or bronchitis bloody or rust colored sputum hoarseness swelling of the neck and face caused by a tumor that presses on large blood vessels [beaumont.org]

  Common lung cancer symptoms: A chronic cough or one that continues to worsen Hoarseness Constant chest pain Frequent lung infections, such as bronchitis or pneumonia Shortness of breath and wheezing Coughing up blood Feeling weak or tired Loss of appetite [cancer.osu.edu]

• Hemoptysis

  We report a patient with MEC who presented with cough, hemoptysis, and localized findings on chest examination. This case emphasizes the importance of obtaining adequate biopsy to establish the correct diagnosis. [ncbi.nlm.nih.gov]

  Symptoms can include cough, chest discomfort or pain, weight loss, and, less commonly, hemoptysis; however, many patients present with metastatic disease without any clinical symptoms. [merckmanuals.com]

  Precursor lesion - uncommonly seen: Pulmonary neuroendocrine cell hyperplasia. [1] Clinical: +/-Hemoptysis. Gross Central location (close to large airways) - typical. Necrosis. Images Small cell carcinoma of the lung - centre of image. [librepathology.org]

  […] comorbidities, including low pulmonary reserve and presence of COPD. 3,4 Additionally, SqCC often involves the central airways, and the location of these tumors in proximity to large blood vessels can present treatment challenges, including bleeding and hemoptysis [targetedonc.com]

• Dry Cough

  CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss. [ncbi.nlm.nih.gov]

  Symptoms vary, depending on the location of the cancer: Lung cancer—a new cough or cough that doesn’t go away, coughing up blood, shortness of breath, chest pain, hoarseness Cancer of the trachea—dry cough, hoarseness, breathlessness, difficulty swallowing [publichealth.va.gov]

• Loss of Appetite

  […] of appetite or weight loss Fatigue Doctors diagnose lung cancer using a physical exam, imaging, and lab tests. [medlineplus.gov]

  […] of appetite loss of weight headache pain in other parts of the body not affected by the cancer bone fractures Other symptoms can be caused by substances made by lung cancer cells - referred to as a paraneoplastic syndrome. [beaumont.org]

  These include: diarrhea fatigue nausea vomiting major hair loss loss of appetite dry mouth mouth sores pain from nerve damage You should weigh these side effects against other options when deciding whether chemotherapy is right for you. [healthline.com]

  The main symptoms were: loss of appetite, fatigue, shortness of breath, cough. [medichub.ro]

  Common lung cancer symptoms: A chronic cough or one that continues to worsen Hoarseness Constant chest pain Frequent lung infections, such as bronchitis or pneumonia Shortness of breath and wheezing Coughing up blood Feeling weak or tired Loss of appetite [cancer.osu.edu]

• Skin Lesion

  Particularly, in a non-smoker, a young patient and the presence of skin lesions or chest wall involvement, these entities may rise to the top of the differential diagnosis. [nature.com]

  See the Critical Images slideshow Cutaneous Clues to Diagnosing Metastatic Cancer to help identify various skin lesions that are cause for concern. [emedicine.medscape.com]

• Macula

  Ophthalmic examination revealed a white elevated mass in the macula with hemorrhage, concerning for metastasis. [ncbi.nlm.nih.gov]

• Back Pain

  CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss. [ncbi.nlm.nih.gov]

• Confusion

  Following the treatment he experienced complete remission of mental confusion, and improvement, however his blood pressure did not normalize (150/100 mmHg). [casesjournal.biomedcentral.com]

  Certain lung cancer cells produce a substance that causes a sharp drop in the level of sodium in the blood, which can cause many symptoms, including confusion and sometimes even coma. None of these symptoms is a sure sign of lung cancer. [beaumont.org]

  Four subtypes are recognized 4 : papillary clear cell small cell (not to be confused with small cell lung cancer ) basaloid Immunohistochemistry SCC consistently express P63 and is negative for TTF1 6. [radiopaedia.org]

  This can cause dehydration, constipation, kidney problems and confusion. Symptoms Early on, squamous cell lung cancer may have no symptoms. [drugs.com]

A complete staging workup for NSCLC should be carried out to evaluate the extent of disease. (See Workup .) Treatment primarily involves surgery, chemotherapy, or radiation therapy. [emedicine.medscape.com]

• Atelectasis

  Staging of LUNG CANCER• T1 - Tumor < 3 cm without pleural / main stem bronchus involvement• T2 - Tumor 3 cm / involvement of main stem bronchus 2 cm from carina, visceral, pleural, lobar atelectasis• T3 - Tumor with involvement of chest wall, diaphragm [slideshare.net]

  Central tumours generally produce symptoms of cough, dyspnea, atelectasis, postobstructive pneumonia, wheezing, and hemoptysis; whereas, peripheral tumours, in addition to causing cough and dyspnea, can lead to pleural effusion and severe pain as a result [pathophys.org]

  T2: Tumour with any of the following features: >3cm in greatest dimension Involves main bronchus, 2cm or more distal to the carina Invades visceral pleura Associated with atelectasis or obstructive pneumonitis, extending to the hilar region but not involving [myvmc.com]

  First CT in 13.01.2015: expansive process at central lung, which causes atelectasis of medium lobe, and partial right lower lobe. Thoracic mediastinal lymphadenopathy. Pleural right effusion in moderate quantity Figure 2. First CT, second image. [medichub.ro]

  Squamous cell carcinoma and small cell carcinoma often are centrally located and may appear to be pneumonia (inflammation of the lungs), atelectasis (collapsed lung), or pit-like masses. [healthcommunities.com]

• Pleural Effusion

  Subsequently, pleural effusion was detected, and an investigation of the pleural effusion revealed the existence of malignant cells with an epidermal growth factor (EGFR) mutation. Gefitinib was administered and the pleural effusion resolved. [ncbi.nlm.nih.gov]

  A pleural effusion may also be seen, and although it is associated with a poor prognosis, not all effusions are due to a malignant involvement of the pleural space. Some are due to venous obstruction or represent a parapneumonic effusion 4. [radiopaedia.org]

Thus, it does not benefit from treatment with somatostatin analogs and peptide receptor radionuclide therapy (PRRT). [ncbi.nlm.nih.gov]

About this NSCLC Treatment Information The following is a general overview of treatment for stage IIIB NSCLC. Cancer treatment may consist of chemotherapy, targeted therapy, or a combination of these treatment techniques. [texasoncology.com]

This determines treatment options. [en.wikipedia.org]

KEYWORDS: CXCR4; Non-small cell lung cancer; Prognosis; SDF-1 [ncbi.nlm.nih.gov]

Etiology of Bronchogenic carcinoma• 40 - 70 yrs [peak 50 - 60 yrs]• Tobacco smoking• Industrial hazards• Air pollution• Dietary factors• Genetic factors• Scarring of lung tissue 8. Tobacco smoking1. Statistical evidence2. Clinical evidence3. [slideshare.net]

[…] bronchus or lung Sites Lung: central / bronchial / hilar; rarely a peripheral nodule Submucosal growth Metastasis to liver, adrenals, bone, bone marrow, brain; often widespread Pathophysiology Arises from neuroendocrine cells of basal bronchial epithelium Etiology [pathologyoutlines.com]

Etiology The smoking of tobacco is the primary cause of lung cancer and patterns of occurrence are largely determined by historical exposure. [atlasgeneticsoncology.org]

Etiology Surg Oncol Clin N Am. 2011 Oct;20(4):605-18. Clin Chest Med. 2011 Dec;32(4):605-44. Biochem Pharmacol. 2011 Oct 15;82(8):1015-21. [pathophys.org]

(Etiology) The exact cause of Adenosquamous Carcinoma of Lung is unknown. [dovemed.com]

Specifically, research, as well as epidemiology, diagnosis, and treatment options, are discussed in detail by an international list of experts. [springer.com]

Epidemiology Smoking increases the risk of all histological subtypes but is most strongly associated with squamous cell and small cell disease. [atlasgeneticsoncology.org]

Epidemiological data show recently that overall survival (OS) gains more pronounced for patients with adenocarcinoma histology, less for patients with squamous-cell tumors(2). [medichub.ro]

Testicular cancer, in Cancer Epidemiology and Prevention, 3rd Edn, eds Schottenfeld D., Fraumeni J. F., editors. [ncbi.nlm.nih.gov]

A review of the epidemiology of lung adenocarcinoma". International Journal of Epidemiology. 26 (1): 14–23. doi : 10.1093/ije/26.1.14. PMID 9126499. Archived from the original on 5 December 2008. ^ Kadara H, Kabbout M, Wistuba II (January 2012). [en.wikipedia.org]

The current approach to the anesthetic procedure and postoperative intensive therapy after esophageal resection for esophageal carcinoma, as well as characteristic perioperative pathophysiological events are presented. [lijecnicki-vjesnik.hlz.hr]

Symptoms Mechanism and pathophysiology Primary lung lesion symptoms Cough (50-70%) Presence of a mass irritates the cough receptors in the airway More common in squamous cell carcinoma andSCLC (more commonly found in the central airways) Obstruction from [pathophys.org]

[…] coding ICD-10: C34.90 - malignant neoplasm of unspecified part of unspecified bronchus or lung Sites Lung: central / bronchial / hilar; rarely a peripheral nodule Submucosal growth Metastasis to liver, adrenals, bone, bone marrow, brain; often widespread Pathophysiology [pathologyoutlines.com]

Supplementary Material E-Mail Print Share: METRICS 1 Crossref 5,112 View 80 Download Clinical Characteristics of Early-Stage Gallbladder Cancer 2015 February;88(2) Clinical Characteristics of Hematologic Diseases in the Elderly 2013 July;85(1) Clinical and Pathophysiological [ekjm.org]

Pathophysiology Both exposure (environmental or occupational) to particular agents and an individual’s susceptibility to these agents are thought to contribute to one’s risk of developing lung cancer. [emedicine.medscape.com]

Gov't MeSH terms Animals Apoptosis Blotting, Western Carcinoma, Mucoepidermoid/metabolism Carcinoma, Mucoepidermoid/pathology Carcinoma, Mucoepidermoid/prevention & control* Carcinoma, Non-Small-Cell Lung/metabolism Carcinoma, Non-Small-Cell Lung/pathology [ncbi.nlm.nih.gov]

Women treated with tamoxifen to prevent or treat breast cancer are also at increased risk. [stoptheclot.org]

Find events and organizations MAY Skin Cancer Detection and Prevention Month Grab your sunscreen and show your support for skin cancer prevention! May is Skin Cancer Detection and Prevention Month. [navigatelungcancer.bmsinformation.com]

[…] immunosuppression and increase the survival of cancer-fighting T cells ICOS : activating this co-stimulatory pathway on T cells can help enhance immune responses against cancer IDO : blocking this enzyme’s activity can help prevent cancer-fighting T [cancerresearch.org]

Prevention Never smoking is the best way to prevent lung cancer, and smoking cessation is helpful. [aafp.org]