A 54-year-old woman presented to a dental clinic with a 1-year history of oral swelling and a sore mouth. [nejm.org]

Numbers show each treatment plan (i.e. ‘1’ for a conventional parallel-opposed plan and ‘2’ for the present RTRT 4-beam plan). Figure 3. Dose–volume histogram (DVH). [academic.oup.com]

Presented with midline ulcerated mass. Diagnosis: Squamous cell carcinoma, arising actinic cheilitis 64 year old male with a long history of cigarette smoking presents with an a symetrical nodular mass in the retromolar region. [oralcancerfoundation.org]

Smoking and alcohol act synergistically in the development of oral cancer – the risk when both of these factors is present is more than double the risk of exposure to one factor alone. [myvmc.com]

These may present as a tumor over the neck. There are symptoms like sore throat, pain over the ear and feelings of something stuck in the throat. There may be bleeding. [news-medical.net]

• Crying

  About half way into radiation, I broke down crying because of all the pain, so my mom said she would drive me. That day literally was amazing. [sixstepscreening.org]

• Dysphagia

  It can affect the appearance of your mouth and make speaking and swallowing difficult (dysphagia). Dysphagia can be a potentially serious problem. [nhs.uk]

  This is called dysphagia and is usually seen if the pharynx or the throat is involved Pain or bleeding from within the mouth A loose tooth or teeth that occurs without any trauma, injury or reason Pain over the neck and jaws that refuses to relent Hoarseness [news-medical.net]

  Dysphagia can lead to malnutrition and food going down the wrong way, leading to choking, lung infections, or aspiration pneumonia. [medicalnewstoday.com]

  As the lesions increase in size, pain, dysarthria, and dysphagia may result. Biopsy Endoscopy to detect second primary cancer Chest x-ray and CT of head and neck Any suspicious areas should be biopsied. [merckmanuals.com]

   Infection, pain, and bleeding  Dehydration and malnutrition due to dysphagia  Xerostomia due to injury to the glands that produce saliva.  Trismus due to damage to the muscles and joints of the jaw and neck.  Hypovascularization (reduction in [slideshare.net]

• Jaw Pain

  Other mouth cancer symptoms may include: Persistent tongue and/or jaw pain A lump or thickening in the inside of the mouth A white or red patch on the gums, tongue, tonsil or lining of the mouth Difficulty swallowing or chewing Difficulty moving the jaw [cancercenter.com]

  Other symptoms of floor of mouth cancer may include: A sore in the mouth that continues to grow Mouth pain Dentures that no longer fit White, red or dark patches inside the mouth Difficulty moving the jaw Jaw pain or swelling Numb mouth Severe ear pain [cedars-sinai.edu]

  pain or irritation in the mouth that doesn't go away unexplained weight loss swelling in your jaw a lump or mass in your neck the constant feeling that something is caught in your throat Most often these symptoms are caused by other, less serious medical [drugs.com]

  pain or swelling Difficulty swallowing, chewing, speaking, or moving the tongue or jaw Numb tongue or area of the mouth Loose teeth or dentures Persistent bad breath Causes and Risk Factors While the exact cause of oral cancer is unclear, there are factors [verywell.com]

• Poor Oral Hygiene

  Other risk factors can include: Human Papillomavirus (HPV) Epstein-Barr virus (EBV) family history of mouth cancers poor oral hygiene and gum disease exposure to the sun chewing the seed of the areca palm tree (sometimes called areca or betel nut). [cancer.org.au]

  Risk factors may include: Tobacco use Regular and heavy alcohol consumption Advancing age Sun exposure Poor diet Poor oral hygiene Gum disease Habitual chewing of the lips or cheeks Irritants, such as breathing in smoky, or constantly polluted, atmospheres [betterhealth.vic.gov.au]

• Lesion of the Tongue

  Q: I have a premalignant lesion on the tongue will this spread to other parts of my mouth or body? A: Oral premalignant lesions do not typically spread as would a cancer or an infection. However, these lesions can transform into a cancer over time. [maaom.memberclicks.net]

  Anna Age 45 Stage IV Base of Tongue Cancer Non-smoker ANNA from Pennsylvania Symptoms: Painful lesion on lateral tongue. Radiation and chemo gave me nine years cancer free. [sixstepscreening.org]

• Neck Mass

  mass due to metastatic lymphadenopathy May have discomfort or pain under the mobile tongue, difficulty with protraction or swallowing, speech impairment Grading Grade 1: Well differentiated Grade 2: Moderately differentiated Grade 3: Poorly differentiated [pathologyoutlines.com]

  Other symptoms include: A sore on the lip that doesn't heal Persistent lip pain or lip numbness A lump or thickening on the lip A white or red patch on the lip A neck mass Treatments for lip cancer Our goal is to treat lip cancer in ways that cause as [cancercenter.com]

  Patients with tonsillar carcinomas may present with a neck mass, usually in the jugulodigastric region. Even if the neck mass is not evident on casual inspection, careful palpation may reveal cervical lymphadenopathy. [patient.info]

  If an adult has a neck mass that does not go away, a needle biopsy and/or CT scan may be necessary to diagnose the cause. [entnet.org]

All patients included for analysis had undergone a standard metastatic workup and all were staged M0 at the time of diagnosis. All patients were treated with curative intent. [journalotohns.biomedcentral.com]

Treatment in Alberta with curative intent Exclusion criteria were defined as 1. Previous oral cavity cancer with or without treatment. 2. Refusal of prescribed treatment 3. Treatment with palliative intent 4. [journalotohns.biomedcentral.com]

This was probably due to the short treatment period of our regimen. There is accumulating evidence that suggests overall treatment time is a definite prognostic factor. [academic.oup.com]

Two years after treatment, she remained free of recurrence. A 54-year-old woman presented to a dental clinic with a 1-year history of oral swelling and a sore mouth. [nejm.org]

Coughing and breathlessness from lung involvement may require specific treatment. [myvmc.com]

The medicines will usually be tested against another treatment called a control. This will either be a dummy treatment (a placebo) or a standard treatment already in use. [nhs.uk]

But patients normally presents when pain and discomfort is predominant and then the prognosis becomes poor. [oralcancerawareness.org]

Prognosis of mouth cancer While it is not possible to predict the exact course of a disease, your doctor may give you a prognosis, the likely outcome of your disease based on the type of cancer, your test results and the rate of tumour growth. [cancer.org.au]

Imaging findings, treatment and prognosis are sometimes subsite -specific and are therefore in some cases discussed separately: squamous cell carcinoma of the tongue squamous cell carcinoma of the floor of mouth squamous cell carcinoma of the retromolar [radiopaedia.org]

The proliferative lesion, although it looks dangerous, is easily treatable and long-term prognosis is good, as the metastasis to the local lymph nodes is relatively late. [patient.info]

Of note, the role of human papillomavirus (HPV) as an etiological factor for squamous cell carcinoma is strongest oral cavity (compared to other regions in the head and neck), with HPV DNA isolated from up to 50% of cases, and thought responsible for [radiopaedia.org]

The etiology is unknown. But a number of etiological factors have been implicated. [slideshare.net]

Certain HPV strains are etiologic risk factors for Oropharyngeal Squamous Cell Carcinoma (OSCC) It is important to note that over 25% of all oral cancers occur in people who do not smoke and who only drink alcohol occasionally. [webmd.com]

Oral human papillomavirus (HPV), typically acquired via oral-genital contact, may have a role in the etiology of some oral cancers; however, HPV is identified in oral cancer much less often than it is in oropharyngeal cancer. [merckmanuals.com]

Some studies in Australia, Brazil and Germany pointed to alcohol-containing mouthwashes as also being etiologic agents in the oral cancer risk family. Chewing betel, paan and Areca is known to be a strong risk factor for developing oral cancer. [disabled-world.com]

As they share epidemiology, pathology and general principles with other squamous cell carcinomas of the upper aerodigestive tract, those topics are covered there. Below are a few general comments specific to the oral cavity. [radiopaedia.org]

Oral Oncol 34:284–291. 7- Ho T, Wei Q, Sturgis EM (2007) Epidemiology of carcinogen metabolism genes and risk of squamous cell carcinoma of the head and neck. [otorrinocontiplanes.com]

*SEER Surveillance, Epidemiology, and End Results [cancer.org]

[…] the lower alveolar ridge to the undersurface of the tongue Posterior boundary is base of anterior pillar of tonsil Divided into two sides by the submaxillary and sublingual salivary glands SCC of floor of mouth is categorized under SCC of oral cavity Epidemiology [pathologyoutlines.com]

International Journal of Epidemiology. 2010;39:182-96. 12. Moore C. Smoking and Cancer of the Mouth, Pharynx, and Larynx. The Journal of the American Medical Association. 1965 Jan 26;191(4):107-10. [canada.ca]

[…] mouth is categorized under SCC of oral cavity Epidemiology Age: fifth - sixth decade; 85 - 95% are males 5% of all cancers in United States and 50% in India Sites In decreasing order of frequency: anterior, lateral or posterior part of floor of mouth Pathophysiology [pathologyoutlines.com]

Pathophysiology In oral squamous cell carcinoma (OSCC), modern DNA technology, especially allelic imbalance (loss of heterozygosity) studies, have identified chromosomal changes suggestive of the involvement of tumor suppressor genes (TSGs), particularly [emedicine.medscape.com]

[…] say whether the HPV vaccine will prevent these cancers. [mouthhealthy.org]

These cancers are very treatable if caught early, and are easily preventable. The most common causes of head and neck cancer are tobacco and alcohol use. [my.clevelandclinic.org]

BC Cancer's Oral Cancer Prevention Program works with dentists and dental hygienists to prevent the development of oral cancer, and to detect it at the earliest possible stage. [bccancer.bc.ca]

Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004. P.63-67 2. International Agency for Research on Cancer. [canada.ca]

Preventing mouth cancer The three most effective ways of preventing mouth cancer developing, or preventing it coming back after successful treatment, are: not smoking ensuring you don't drink more than the recommended weekly limits for alcohol eating [nhs.uk]