Edit concept Question Editor Create issue ticket

Carcinoma of the Penis

Penile Cancer


Presentation

  • This case is unique in its site of metastatic presentation as well as its pattern of presentation. Copyright 1999 S. Karger AG, Basel.[ncbi.nlm.nih.gov]
  • Optimal treatment includes coordination with a urologist if urethral disease is present.[ncbi.nlm.nih.gov]
  • Abstract Glandular and pseudoglandular tumors of the penile skin are extremely uncommon and can present diagnostic challenges.[ncbi.nlm.nih.gov]
  • Abstract The objective of this study is to describe the case of a patient presenting advanced epidermoid carcinoma of the penis associated to myiasis.[ncbi.nlm.nih.gov]
  • Grade 2 disease was present in 94.5% of cases. T1, T2, T3, T4, and Tx disease was present in 64.8%, 17.1%, 9.5%, 2.1%, and 6.5% of cases, respectively.[ncbi.nlm.nih.gov]
Fishing
  • The FISH status was not associated with protein expression. Altered FISH (polysomy and gene amplification) was an independent risk factor for dying of cancer.[ncbi.nlm.nih.gov]
Confusion
  • The glandular components of these lesions can present a confusing appearance, particularly when a large tumor is represented on a small biopsy.[ncbi.nlm.nih.gov]
Penile Lesion
  • Figure 1 Preoperative anterior view of the fungating penile lesion. Figure 2 Preoperative anterosuperior view of the fungating penile lesion. Figure 3 Anterosuperior view of the resected penile lesion.[casereports.bmj.com]
  • LIMITATIONS: This was a retrospective analysis CONCLUSION: This study suggests that, similarly to vulvar carcinoma, penile SCC occurs in association with two types of penile lesions: undifferentiated (or bowenoid) PIN and LS-linked differentiated PIN[ncbi.nlm.nih.gov]
  • Abstract Laser capture microdissection-polymerase chain reaction (LCM-PCR) supported by p16 was used for the first time to demonstrate human papillomavirus (HPV) DNA in histologically specific penile lesions, which were as follows: squamous hyperplasia[ncbi.nlm.nih.gov]
  • Invasive tumours require staging of the primary penile lesion and inguinal and pelvic lymph nodes. Local staging can be performed using magnetic resonance imaging (MRI).[patient.info]
  • This approach is best applied for very small distal penile lesions less than 1 cm. Following Moh’s surgery, the glans is often misshapen and meatal stenosis is common. Laser: Nd-YAG; This is acceptable for very rare and very superficial lesions.[umassmed.edu]

Workup

  • Imaging Metastatic workup should include CXR, bone scan, and CT scan of the abdomen and pelvis. Disseminated disease is present in less than 10% of patients at presentation.[health.am]
Suppression
  • These results suggest that the innate immune response might be suppressed in patients with these malignancies. Copyright 2017 Elsevier Inc. All rights reserved.[ncbi.nlm.nih.gov]
  • Chronic skin disease, especially lichen sclerosus and lichen planus Smoking Immune suppression by medications or disease Chronic irritation by urine, friction or injury to the penile area.[dermnetnz.org]
  • […] responsible include 16, 18, 31, 33, and 45, High-risk sexual behavior, such as multiple partners and unprotected sex Weakened immune system due to many reasons, such as organ transplant, old age, HIV/AIDS infection, or due to administration of immune suppressing[dovemed.com]

Treatment

  • BACKGROUND AND OBJECTIVES: We reviewed our long-term experience with surgical treatment of patients with penile carcinoma. METHODS: From 1960 to 2006, 688 patients with penile carcinoma underwent surgical treatment at our Institute.[ncbi.nlm.nih.gov]
  • Other non-demolitive therapies can be utilized, such as radiotherapy, brachytherapy and topical medical treatment.[ncbi.nlm.nih.gov]
  • One patient with T2 carcinoma apparently had a complete response to surgery; however, he was seen 56 months after the initial laser treatment with a new invasive penile tumor located at a different site that failed to respond to laser treatment and required[ncbi.nlm.nih.gov]
  • Carbon dioxide and neodymium:YAG lasers are two modalities that are successful in the treatment of in situ and probably early invasive penile carcinoma. Optimal treatment includes coordination with a urologist if urethral disease is present.[ncbi.nlm.nih.gov]
  • Without treatment, patients with penile SCC usually die within 2 years after diagnosis of the primary lesion, because of uncontrollable locoregional disease or from distant metastases.[ncbi.nlm.nih.gov]

Prognosis

  • Abstract Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis.[ncbi.nlm.nih.gov]
  • PURPOSE: We evaluated the role of primary tumor histopathological features for predicting regional metastasis and the prognosis in patients with penile squamous cell carcinoma.[ncbi.nlm.nih.gov]
  • This article focuses on the most important issues that surround the prognosis of squamous cell carcinoma of the penis, with special attention to the prognostic nomograms for penile cancer patients published in 2006.[ncbi.nlm.nih.gov]
  • PURPOSE OF REVIEW: Prognosis of penile squamous cell cancer (PeSCC) depends on the involvement of the groin(s) as first step. We introduce the current available evidences that should rule the use of surgery in the management of PeSCC.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The factors worsening the prognosis in patients with penile cancer after lymphadenectomy include delayed lymphadenectomy, involvement of lymph nodes other than the superficial inguinal, involvement of more than one lymph node, crossing the[ncbi.nlm.nih.gov]

Etiology

  • Abstract Few etiologic studies of squamous cell carcinoma (SCC) of the penis have been carried out in populations where childhood circumcision is rare.[ncbi.nlm.nih.gov]
  • BACKGROUND: In contrast to vulvar squamous cell carcinoma (SCC), the etiologic factors and precancerous lesions associated with penile carcinoma remain uncertain.[ncbi.nlm.nih.gov]
  • Although human papillomavirus (HPV) infection is an established etiologic agent in at least 40% of penile SCCs, relatively little is known about the epidemiology of this malignancy.[ncbi.nlm.nih.gov]
  • Etiology Chronic inflammation of the penis Risk factors Phimosis, particularly if left untreated Tobacco use Infections Human papillomavirus ( HPV ) infection, especially type H PV -16 and HPV -18 HIV Precancerous skin lesions (see “Differential diagnoses[amboss.com]
  • Human papillomavirus, particularly types 16 and 18, plays a role in etiology. Premalignant lesions include erythroplasia of Queyrat, Bowen disease, and bowenoid papulosis.[merckmanuals.com]

Epidemiology

  • Further research is needed to better understand the epidemiology of penile cancer including the role of HPV.[ncbi.nlm.nih.gov]
  • METHODS: Relying on the Surveillance, Epidemiology and End Results database, we identified 655 patients diagnosed with primary SCCP between 1988 and 2006. Cumulative incidence plots were used to graphically depict the effect of CSM relative to OCM.[ncbi.nlm.nih.gov]
  • METHODS AND MATERIALS: Subjects with SCC of the penis were identified using the National Cancer Institute Surveillance, Epidemiology and End Results (SEER) Program database between 1988 and 2006.[ncbi.nlm.nih.gov]
  • More studies are necessary to delineate the epidemiological, clinical, and molecular features of this unusual penile neoplasm.[ncbi.nlm.nih.gov]
  • Epidemiology Rare type of malignancy in industrialized countries More common in developing countries in Africa, South America, and Asia Peak incidence : 60 years of age References: [1] Epidemiological data refers to the US, unless otherwise specified.[amboss.com]
Sex distribution
Age distribution

Prevention

  • Previous regional lymphadenectomy did not prevent subsequent development of regional recurrence. This clinical presentation and the literature are discussed.[ncbi.nlm.nih.gov]
  • Preventive surgery could be driven by DSNB, which needs an accurate multistep pathway.[ncbi.nlm.nih.gov]
  • HPV-Associated Penile Cancer Rates by Race and Ethnicity] Center for Disease Control and Prevention Brandel France de Bravo; Maushami DeSoto; Krystle Seu (April 2009). "HPV: Q&A". Cancer Prevention and Treatment Fund.[en.wikipedia.org]
  • METHODS: Population-based data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program, the Centers for Disease Control and Prevention's National Program for Cancer Registries, and the National Center for Health[ncbi.nlm.nih.gov]
  • However, some experts believe that many cases of penile cancer are preventable, and the best way to prevent it is by avoiding risk factors. Aside from age, all risk factors for penile cancer can be avoided.[beaumont.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!