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2.1
Cardiac Beriberi
Beriberi Heart Disease

Presentation

Mean age of presentation was 3.9 months and mean duration of illness was 7.5 days. All of them presented with tachypnea, chest indrawing and tachycardia. [academic.oup.com]

Due to the complex clinical presentation and to the lack of diagnostic tests, thiamine deficiency is still being missed, especially among non-alcoholics patients. We present two fatal cases of non - alcohol associated cardiac beriberi. [ncbi.nlm.nih.gov]

A rationalisation of the 1350 boxes used throughout the book gives a simpler and clearer presentation of the various categories. [books.google.de]

Entire Body System

  • Malnutrition

    Mots-clés Urgences, Hôpital, Béribéri, Avitaminose B, Insuffisance cardiaque, Malnutrition, Mayotte, Océan Indien [bspe.revuesonline.com]

    In industrial countries, not only alcoholics, but also deprived people with malnutrition, elderly patients and patients with AIDS are at risk of thiamine deficiency. [ncbi.nlm.nih.gov]

    2018, 161 CrossRef 2 Derrick Lonsdale, Chandler Marrs, Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition, 2017, 263 CrossRef 3 Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition, 2017, xi CrossRef 4 Tomoki [onlinelibrary.wiley.com]

    FEX: Thiamine content of F-75 for complicated severe acute malnutrition: time for a change? Summary of research1 Location: Global What we know: Complicated cases of severe acute malnutrition (SAM) are usually severely ill with comorbidities. [ennonline.net]

  • Congestive Heart Failure

    Sica, Domenic A, “Loop diuretic therapy, thiamine balance, and heart failure”, Congestive Heart Failure. 13(4):244-7, 2007 Jul-Aug. Suter, P M. Haller, J. Hany, A. [medicalnewsbulletin.com]

    Moreover, long-term furosemide use may be associated with thiamine deficiency through urinary loss, contributing to cardiac insufficiency in patients with congestive heart failure. [ncbi.nlm.nih.gov]

    […] confusion and sometimes heart failure. [medical-dictionary.thefreedictionary.com]

    Complications may include: Coma Congestive heart failure Death Psychosis Beriberi is extremely rare in the United States. [medlineplus.gov]

Cardiovascular

  • Heart Disease

    The heart becomes dilated and progresses to heart failure. Beriberi heart disease may cause sudden cardiac dysfunction within days of onset of symptoms. [wikidoc.org]

    The cases cover a spectrum of beriberi heart disease ranging from a hyperdynamic circulation to circulatory shock. [ncbi.nlm.nih.gov]

    And for a majority of heart disease patients, beriberi (B vitamin deficiency) of the heart is the underlying cause of the disease. [spineboy.com]

  • Tachycardia

    All of them presented with tachypnea, chest indrawing and tachycardia. [academic.oup.com]

    Majority presented with tachypnea, chest indrawing and tachycardia and cardiomegaly with dilatation of right heart and pulmonary hypertension on 2D-echocardiography. [ncbi.nlm.nih.gov]

Workup

(See Pathophysiology, Etiology, Presentation, and Workup.) [6, 7] Dietary thiamine Food that are rich in thiamine are as follows [1] (see Table 1, below): Whole-grain foods Meat/fish/poultry/eggs Milk and milk products Vegetables (ie, green, leafy vegetables [emedicine.medscape.com]

Treatment

Treatment Treatment including administration of 100 mg of IV thiamine, then 25 mg daily for about 2 weeks causes dramatic improvement. [wikidoc.org]

[…] of thiamine deficiency thiamine 100 mg orally daily Prevention and treatment of thiamine deficiency in severe alcoholics thiamine 100 to 200 mg IV daily for 3 days then thiamine 100 mg orally daily Treatment of Wernicke encephalopathy thiamine 500 mg [lifeinthefastlane.com]

Treatment consists of thiamine administration with rapid clinical improvement after supplementation. [ncbi.nlm.nih.gov]

Treatment Treatment with thiamine reverses the deficiency in the body and relieves most of the symptoms. [medical-dictionary.thefreedictionary.com]

Prognosis

Treatment and prognosis Optimal treatment of beriberi relies upon a two-pronged approach: thiamine supplementation supportive therapies e.g. cardiac support Recovery is often rapid once thiamine supplements are started. [radiopaedia.org]

Prognosis The prognosis for beriberi is usually good, unless patients have established Korsakoff syndrome. When patients have progressed to this stage, the degree of damage is only minimally reversible. [namrata.co]

If treated early the prognosis of beriberi is good prognosis but mortality still ranges between 10 and 20%. Despite early initiation of treatment, complete remission is rare as cognitive changes are not reversible in most cases [ 20 ]. [karger.com]

Prognosis Mortality is rare and is usually associated with the wet form due to cardiac failure. [ 26 ] Morbidity is also rare and usually presents in the dry form with neurological symptoms. [patient.info]

Etiology

In lactic acidosis and/or hyperdynamic circulation without any other apparent etiology in patients with possible vitamin B1 deficiency, the diagnosis of BB must be considered and thiamine should be administered. [ncbi.nlm.nih.gov]

In the study of the etiology of cardiovascular dysfunctions in general and of heart disease in particular, attention has been focused mainly on infectious and degenerative processes and on congenital malformations. [jamanetwork.com]

Etiology In general, those individuals with a poor diet are most likely to develop thiamine deficiency. [radiopaedia.org]

The nature of the disorder, certain symptoms of which started in infancy, was such that it strongly indicated a metabolic rather than a nutritional etiology, involving energy metabolism. [link.springer.com]

Importantly, we reviewed the literature on wet beriberi and summarized the etiology, reports of cardiac output (CO) and systemic vascular resistance (SVR), currently available diagnostic tests, and thiamine use in patients with wet beriberi. [journals.lww.com]

Epidemiology

It is caused by severe thiamine deficiency. [1] Epidemiology and Demographics This disease is most prevalent in the Far East, however, in the past decade its prevalence has markedly decreased. [wikidoc.org]

[…] concurrently, including Wernicke's encephalopathy (mainly affecting the central nervous system), Korsakoff's syndrome (amnesia with additional psychiatric manifestations), and Wernicke-Korsakoff syndrome (with both neurologic and psychiatric symptoms) Epidemiology [flipper.diff.org]

Methods: By means of systematic literature review, epidemiological data, clinical characteristics and diagnostic as well as therapeutic recommendations for bariatric beriberi were elicited. [karger.com]

Another translation is 'I cannot, I cannot'. [ 2 ] Epidemiology Beriberi was endemic in some areas of the world and may be related to the consumption of milled rice. [patient.info]

Pathophysiology

The disease is also common in fad diet appliers. [2] Pathophysiology Pathologically the heart in cardiac beriberi is most often hypertrophied and dilated, with involvement of both the right and left chambers. [wikidoc.org]

Pathophysiology Thiamine in the human body has a half-life of 18 days and is quickly exhausted, particularly when metabolic demands exceed intake. [flipper.diff.org]

(See Pathophysiology, Etiology, Presentation, and Workup.) [6, 7] Dietary thiamine Food that are rich in thiamine are as follows [1] (see Table 1, below): Whole-grain foods Meat/fish/poultry/eggs Milk and milk products Vegetables (ie, green, leafy vegetables [emedicine.medscape.com]

Attas M, Hanley HG, Stultz D (1978) Fulminant beri beri heart disease with lactic acidosis: presentation of a case with evaluation of left ventricular function and review of pathophysiologic mechanisms. Circulation 58:566–572 Google Scholar 4. [link.springer.com]

Prevention

Also known as aneurin, this vitamin helps prevent neuritic and beriberi. B1 vitamin benefits include prevention of severe eye fatigue and neurodegeneration. [newsmax.com]

In 2014, Save The Children commissioned Burnet to carry out a technical review of the evidence for the prevention of infantile beriberi to stimulate discussion and to advocate for prevention strategies in Lao PDR. [burnet.edu.au]

Article navigation 1From the Divisions for Heart Disease and Stroke Prevention (BAB) and Reproductive Health (WDB), National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA; and the Nutritional Biomarkers Branch, Division of Laboratory [ajcn.nutrition.org]

Thiamine before glucose to prevent Wernicke encephalopathy: examining the conventional wisdom. JAMA. 1998 Feb 25;279(8):583-4. [lifeinthefastlane.com]

When it comes to preventing beriberi modernus, it's every man for himself. Such is the current state of disease prevention in America today. The Best of Bill Sardi The Best of Bill Sardi [lewrockwell.com]

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