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Cardiac Dilatation


Presentation

  • The present study analyzed virtual CT morphometric and autopsy data of the heart to investigate terminal central congestion in forensic autopsy cases (n 113, within 3 days postmortem); the virtual total heart weight in situ was estimated using CT morphometry[ncbi.nlm.nih.gov]
  • Delayed enhancement may or may not be present in dilated cardiomyopathies, but when present it involves the subepicardium or mid-myocardium as opposed to the subendocardium.[med-ed.virginia.edu]
  • In the elderly patient, as opposed to that occurring in younger patients, the causal and facilitating mechanisms of the syndrome and its decompensations are generally varied and simultaneous, the clinical presentation is less specific, the diagnostic[revclinesp.es]
  • Sometimes pathologic Q waves are present in the precordial leads, simulating previous MI. Left bundle branch block and atrial fibrillation are common.[merckmanuals.com]
  • In this family, the variant was the only one found in the proband diagnosed with ARVC (5 genes related to this phenotype were analyzed), but showed no cosegregation with the disease as the proband’s mother, who also presented this phenotype, did not present[escardio.org]
Hyperthermia
  • The CDI was significantly lower in fatal hyperthermia (heatstroke) than in drowning, fatal methamphetamine abuse, alcohol/sedative-hypnotic intoxication and SCD.[ncbi.nlm.nih.gov]
  • Genetics Clinical syndromes & Mutations 60 mutations described Most cases with common mutations Heterozygous for 2nd mutation Ser113Leu: 60% of adult myopathy cases; Mild disease; Caucasians 413delAG: Ashkenazi Jews Pro50His: 10% Arg503Cys: Malignant hyperthermia[neuromuscular.wustl.edu]
Constipation
  • Any disturbance of the stomach should be corrected, constipation should be overcome, and hepatic derangements should be controlled. A few remedies will be indicated, and should be given to overcome special conditions.[henriettes-herb.com]
Jaundice
  • The liver becomes engorged, and then undergoes degeneration, jaundice being an accompanying factor. The mucous membrane of stomach and bowels becomes congested, giving rise to severe functional disturbance.[henriettes-herb.com]
Heart Disease
  • , myocardial, congenital, and thoracic/aortic heart disease.[books.google.com]
  • Eight patients showed infarct expansion, with disproportionate dilatation and transmural thinning in the infarcted zone, that was significantly different (P Funding and Disclosures Supported by a grant (50-HL-17655–04) from Ischemic Heart Disease, Specialized[nejm.org]
  • Some people are born with heart disease.[icdlist.com]
  • Understand Your Risk for Cardiomyopathy Symptoms and Diagnosis of Cardiomyopathy Prevention and Treatment of Cardiomyopathy Cardiomyopathy in Children Learn more: Family History and Heart Disease Alcohol and Heart Disease Cocaine, Marijuana and Other[heart.org]
  • I51.5 Myocardial degeneration I51.7 Cardiomegaly I51.8 Other ill-defined heart diseases I51.81 Takotsubo syndrome I51.89 Other ill-defined heart diseases I51.9 Heart disease, unspecified I52 Other heart disorders in diseases classified elsewhere I60[icd10data.com]
Anger
  • Heavy lifting by workmen who overtax their strength; strong emotional excitement, as intense anger or extraordinary fright, may also give rise to this form; in fact, any condition that gives rise to increased intra-cardiac pressure may produce dilatation[henriettes-herb.com]
Forgetful
  • —This will afford some relief to the distressing dyspnea, though we are not to forget the mechanical obstruction causing the difficult breathing and expect too much of the remedy. Apocynum is the remedy when dropsical effusion appears.[henriettes-herb.com]

Workup

Right Atrial Hypertrophy
  • There are peaked P waves in lead II suggestive of right atrial hypertrophy (not quite 2.5mm in height). This patient had four-chamber dilatation on echocardiography with severe congestive cardiac failure (awaiting cardiac transplantation).[lifeinthefastlane.com]

Treatment

  • Treatment .—The patient must clearly understand that severe muscular or mental exertion, or anything that causes unusual excitement, must be positively forbidden.[henriettes-herb.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia Bridging the Gap Challenge Yourself[nejm.org]
  • Treatments for dilated cardiomyopathy At present there is no cure for DCM, but treatments are available to help control your symptoms and prevent complications. Your treatment will depend on how your heart is affected and what symptoms you have.[bhf.org.uk]
  • Patients whose dilated cardiomyopathy is well-compensated with treatment may be stable for many years.[merckmanuals.com]

Prognosis

  • A detailed analysis demonstrated an association between prognosis and amount of LGE in combination with impaired left ventricular ejection fraction.[wikiecho.org]
  • These limitations predispose to more episodes of decompensation and hospital admission, a higher risk of physical disability and poor symptom control, and worse short- or middle- term survival prognosis.[revclinesp.es]
  • Prognosis of dilated cardiomyopathy generally has been poor, although prognosis has improved with current management regimens (eg, use of beta-blockers, angiotensin-converting enzyme [ACE] inhibitors, mineralocorticoid receptor antagonists, implantable[merckmanuals.com]
  • Conclusions An entirely normal stress MPS study does not always imply an excellent prognosis.[onlinejacc.org]

Etiology

  • About half of cases are idiopathic, but the rest are usually due to metabolic, infectious, inflammatory, or toxic etiology.[med-ed.virginia.edu]
  • Treatment/Prognosis The first step for the treatment of DCM is in the case of a secondary etiology the treatment of the underlying disease or leave out the cardiotoxic substances.[wikiecho.org]
  • Increased LA pressure - Pulm HTN - RV Pressure Overload - RV failure & Tricuspid Regurgitation Etiology: Rheumatic Heart Disease Symptoms: Dyspnea, Orthopnea, PND Cough & Hemoptysis Atrial Fibrillation, LA thrombus and systemic Embolization RV failure[brown.edu]
  • […] thickness Epidemiology DCM is the most common cause of congestive cardiac failure (CCF), with an estimated prevalence of at least 36.5 per 100,000 persons in the USA It occurs more frequently in men than women and is most common between ages 20 and 60 years Etiology[pathologyoutlines.com]

Epidemiology

  • Cerevisiae, homolog of (FLAD1; FADS) ; Chromosome 1q21.3; Recessive Epidemiology: 9 patients Genetics Mutations: Biallelic, Frameshift, Missense or 1 amino acid deletion Mutation locations Molybdopterin binding (MPTb) domain, upstream of FADS domain:[neuromuscular.wustl.edu]
  • Definition / general Dilated cardiomyopathy (DCM) is characterized by a poorly contracting dilated left ventricle with a normal or reduced left ventricular wall thickness Epidemiology DCM is the most common cause of congestive cardiac failure (CCF), with[pathologyoutlines.com]
Sex distribution
Age distribution

Pathophysiology

  • Previous studies demonstrated possible application of postmortem quantitative CT data analysis of the heart and lung in situ to investigate terminal cardiopulmonary pathophysiology.[ncbi.nlm.nih.gov]
  • Figure 3 -- Pathophysiology of acute and chronic mitral regurgitation Fig 3: Pathophysiology of mitral regurgitation.[brown.edu]
  • Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation. 2008 Apr 1;117(13):1717-31.[escardio.org]

Prevention

  • In osteoglycin null mice, adenoviral overexpression of osteoglycin was unable to prevent rupture-related mortality because of insufficiently restoring osteoglycin protein levels in the heart.[ncbi.nlm.nih.gov]
  • The primary goal is to improve cardiac function and prevent symptoms. Individuals with DCM need to be followed by a cardiologist on a regular basis.[cincinnatichildrens.org]
  • His research aims to find better ways to diagnose, treat and prevent people dying from this disease, and beat the heartbreak. Donate[bhf.org.uk]
  • In some cases, this prevents the heart from filling with blood as it should. Over time, it can affect the other chambers. Symptoms Many people with dilated cardiomyopathy have no symptoms. Some that do have only minor ones, and live a normal life.[webmd.com]
  • In the normal heart, left ventricular (LV) contraction during systole forces blood exclusively through the aortic valve into the aorta; the closed mitral valve prevents regurgitation into the left atrium (LA).[brown.edu]

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