The present study analyzed virtual CT morphometric and autopsy data of the heart to investigate terminal central congestion in forensic autopsy cases (n 113, within 3 days postmortem); the virtual total heart weight in situ was estimated using CT morphometry [ncbi.nlm.nih.gov]

Perspectives The present results indicate a high prevalence of ascending aorta dilatation in essential (uncomplicated) hypertensive patients. [journals.lww.com]

Delayed enhancement may or may not be present in dilated cardiomyopathies, but when present it involves the subepicardium or mid-myocardium as opposed to the subendocardium. [med-ed.virginia.edu]

Hypertrophic cardiomyopathy is present in some relatives of patients with idiopathic DCM. Familial DCM is present in patients with a previous diagnosis of alcoholic DCM. [revespcardiol.org]

Sometimes pathologic Q waves are present in the precordial leads, simulating previous MI. Left bundle branch block and atrial fibrillation are common. [merckmanuals.com]

• Hyperthermia

  The CDI was significantly lower in fatal hyperthermia (heatstroke) than in drowning, fatal methamphetamine abuse, alcohol/sedative-hypnotic intoxication and SCD. [ncbi.nlm.nih.gov]

  Genetics Clinical syndromes & Mutations 60 mutations described Most cases with common mutations Heterozygous for 2nd mutation Ser113Leu: 60% of adult myopathy cases; Mild disease; Caucasians 413delAG: Ashkenazi Jews Pro50His: 10% Arg503Cys: Malignant hyperthermia [neuromuscular.wustl.edu]

• Hematochezia

  Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia Bridging the Gap Challenge Yourself [nejm.org]

• Heart Disease

  myocardial, congenital, and thoracic/aortic heart disease. [books.google.com]

  Eight patients showed infarct expansion, with disproportionate dilatation and transmural thinning in the infarcted zone, that was significantly different (P Funding and Disclosures Supported by a grant (50-HL-17655–04) from Ischemic Heart Disease, Specialized [nejm.org]

  Some people are born with heart disease. [icdlist.com]

  I51.5 Myocardial degeneration I51.7 Cardiomegaly I51.8 Other ill-defined heart diseases I51.81 Takotsubo syndrome I51.89 Other ill-defined heart diseases I51.9 Heart disease, unspecified I52 Other heart disorders in diseases classified elsewhere I60 [icd10data.com]

  Understand Your Risk for Cardiomyopathy Symptoms and Diagnosis of Cardiomyopathy Prevention and Treatment of Cardiomyopathy Cardiomyopathy in Children Learn more: Family History and Heart Disease Alcohol and Heart Disease Cocaine, Marijuana and Other [heart.org]

• Anger

  Heavy lifting by workmen who overtax their strength; strong emotional excitement, as intense anger or extraordinary fright, may also give rise to this form; in fact, any condition that gives rise to increased intra-cardiac pressure may produce dilatation [henriettes-herb.com]

Treatment .—The patient must clearly understand that severe muscular or mental exertion, or anything that causes unusual excitement, must be positively forbidden. [henriettes-herb.com]

Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia Bridging the Gap Challenge Yourself [nejm.org]

Treatments for dilated cardiomyopathy At present there is no cure for DCM, but treatments are available to help control your symptoms and prevent complications. Your treatment will depend on how your heart is affected and what symptoms you have. [bhf.org.uk]

Patients whose dilated cardiomyopathy is well-compensated with treatment may be stable for many years. [merckmanuals.com]

A detailed analysis demonstrated an association between prognosis and amount of LGE in combination with impaired left ventricular ejection fraction. [wikiecho.org]

These limitations predispose to more episodes of decompensation and hospital admission, a higher risk of physical disability and poor symptom control, and worse short- or middle- term survival prognosis. [revclinesp.es]

As such, lack of timely reperfusion due to ineffective treatment or delayed presentation portends an unfavorable prognosis. [acc.org]

Conclusions An entirely normal stress MPS study does not always imply an excellent prognosis. [onlinejacc.org]

About half of cases are idiopathic, but the rest are usually due to metabolic, infectious, inflammatory, or toxic etiology. [med-ed.virginia.edu]

Treatment/Prognosis The first step for the treatment of DCM is in the case of a secondary etiology the treatment of the underlying disease or leave out the cardiotoxic substances. [wikiecho.org]

Increased LA pressure - Pulm HTN - RV Pressure Overload - RV failure & Tricuspid Regurgitation Etiology: Rheumatic Heart Disease Symptoms: Dyspnea, Orthopnea, PND Cough & Hemoptysis Atrial Fibrillation, LA thrombus and systemic Embolization RV failure [brown.edu]

Etiology The causes of cardiomyopathies are varied ( Table 2 ). 1 Dilated cardiomyopathy in adults is most commonly caused by CAD (ischemic cardiomyopathy) and hypertension, although viral myocarditis, valvular disease, and genetic predisposition may [aafp.org]

Cerevisiae, homolog of (FLAD1; FADS) ; Chromosome 1q21.3; Recessive Epidemiology: 9 patients Genetics Mutations: Biallelic, Frameshift, Missense or 1 amino acid deletion Mutation locations Molybdopterin binding (MPTb) domain, upstream of FADS domain: [neuromuscular.wustl.edu]

Definition / general Dilated cardiomyopathy (DCM) is characterized by a poorly contracting dilated left ventricle with a normal or reduced left ventricular wall thickness Epidemiology DCM is the most common cause of congestive cardiac failure (CCF), with [pathologyoutlines.com]

[…] of CV disease: Epidemiology of Cardiovascular Disease in the 21 st Century: Updated Numbers and Updated Facts. [bmcresnotes.biomedcentral.com]

Aortic root dilatation at sinuses of valsalva and aortic regurgitation in hypertensive and normotensive subjects: the Hypertension Genetic Epidemiology Network Study. Hypertension 2001; 37:1229–1235. 3. [journals.lww.com]

B 9 Epidemiology In 2006, the AHA classified cardiomyopathies as primary (i.e., genetic, mixed, or acquired) or secondary (e.g., infiltrative, toxic, inflammatory). 1 The four major types are dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive [aafp.org]

Previous studies demonstrated possible application of postmortem quantitative CT data analysis of the heart and lung in situ to investigate terminal cardiopulmonary pathophysiology. [ncbi.nlm.nih.gov]

Figure 3 -- Pathophysiology of acute and chronic mitral regurgitation Fig 3: Pathophysiology of mitral regurgitation. [brown.edu]

The idiopathic category should continue to diminish as more information explaining pathophysiologic mechanisms, specifically genetic-environmental interactions, becomes available. Toxins are a significant cause. [emedicine.medscape.com]

Pathophysiology Dilated cardiomyopathy represents the final common morphologic outcome of various biologic insults. The combination of myocyte injury and necrosis associated with myocardial fibrosis results in impaired mechanical function. [clevelandclinicmeded.com]

PubMed PubMed Central View Article Google Scholar Santulli G, Trimarco B, Iaccarino G: G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms. [bmcresnotes.biomedcentral.com]

In osteoglycin null mice, adenoviral overexpression of osteoglycin was unable to prevent rupture-related mortality because of insufficiently restoring osteoglycin protein levels in the heart. [ncbi.nlm.nih.gov]

Neurohormonal blockade in patients with acute MI is shown to prevent adverse remodeling, prevent HF, and prolong survival. A reduction in wall stress during MI has been proposed to reduce infarct expansion and acute dilation. [acc.org]

The primary goal is to improve cardiac function and prevent symptoms. Individuals with DCM need to be followed by a cardiologist on a regular basis. [cincinnatichildrens.org]

In some cases, this prevents the heart from filling with blood as it should. Over time, it can affect the other chambers. Symptoms Many people with dilated cardiomyopathy have no symptoms. Some that do have only minor ones, and live a normal life. [webmd.com]

His research aims to find better ways to diagnose, treat and prevent people dying from this disease, and beat the heartbreak. Donate [bhf.org.uk]