Edit concept Question Editor Create issue ticket

Cardiac Metastasis

Cardiac Neoplasm Secondary


Presentation

  • The use of different imaging modalities was fundamental to a correct diagnosis considering the challenging presentation.[ncbi.nlm.nih.gov]
  • A woman presented with stage Ib2 cervical cancer metastatic to the tricuspid valve. She presented with small bowel obstruction from a small bowel metastasis 4 years after initial treatment with chemoradiation.[ncbi.nlm.nih.gov]
  • We present a 58-year-old woman patient with a history of tongue carcinoma who was admitted in emergency department for sudden chest pain.[ncbi.nlm.nih.gov]
  • To our knowledge, this is only the 2nd reported case of a phyllodes tumor that metastasized to the heart and presented as an intracavitary mass with cardiogenic shock.[ncbi.nlm.nih.gov]
  • The authors present clinical, laboratory and imaging data from a patient with a cardiac mass that was the first manifestation of a melanoma. No other tumor location was detected by imaging studies.[ncbi.nlm.nih.gov]
Congestive Heart Failure
  • Severe congestive heart failure was not detected. Moreover, while anamnesis collecting and further examination, it was found that in childhood the cryptorchidism was diagnosed, but no treatment was performed.[exp-oncology.com.ua]
  • Cardiac comorbidities [hypertension (HTN), cardiac arrhythmia (CAr), coronary artery disease (CAD), congestive heart failure (CHF), and myocardial infarction (MI)] were evaluated within 6 months prior to chemotherapy initiation.[cancerres.aacrjournals.org]
  • Despite emergency resection, the patient died of severe congestive heart failure 6 days after operation.[link.springer.com]
  • Sakai et al., [ 5 ] discussed a patient who experienced symptoms of congestive heart failure two weeks after Carboplatin therapy [ 5 ].[omicsonline.org]
Leg Edema
  • RESULTS: The most common symptoms of cardiac metastasis included asymptomatic in 19 cases (39.5%), bilateral lower leg edema in 18 cases (37.5%) and exertional dyspnea in 15 cases (31.3%).[ncbi.nlm.nih.gov]
Dyspnea
  • The patient presented with exertional dyspnea and tachycardia and was found to have a large mass in the right atrium. He underwent surgical removal of the tumor, but curative excision was not possible.[ncbi.nlm.nih.gov]
  • A 53-year-old man, who had been treated for penile origin diffuse large B cell type non-Hodgkin lymphoma (NHL), suffered from right femoral pain and dyspnea.[ncbi.nlm.nih.gov]
  • RESULTS: The most common symptoms of cardiac metastasis included asymptomatic in 19 cases (39.5%), bilateral lower leg edema in 18 cases (37.5%) and exertional dyspnea in 15 cases (31.3%).[ncbi.nlm.nih.gov]
  • Interrupt Herceptin infusion for dyspnea or clinically significant hypotension. Monitor patients until symptoms completely resolve.[herceptin.com]
  • Chapter 44 Metastatic Cardiac Lymphoma First published: 25 March 2018 Summary This chapter presents a case of a 49‐year‐old female who was admitted due to exertion dyspnea. The patient underwent biopsy.[onlinelibrary.wiley.com]
Heart Disease
  • Approximately 55% of patients with carcinoid syndrome develop a carcinoid heart disease, mostly affecting the right heart (in particular causing tricuspid valve stenosis or insufficiency) [2-4]. A small pericardial effusion can be present [5].[scmr.org]
  • Conference: 7th Annual ENETS Conference (2010) Category: Clinical Presenting Author: Christopher Wong #105 A pilot study using biochemical markers to predict acrcinoid heart disease in patients with carcinoid disease Introduction: Carcinoid heart disease[enets.org]
  • disease, heart failure, hypertension, ischaemic stroke, embolic or thrombotic events, arrhythmias, conductive disorders).[clinicaltrials.gov]
  • Related pages: - Heart disease causes and treatment - Diseases of the brain - Stop heart attack with a breathing exercise - Heart palpitations - Effects of breathing retraining on heart conditions . - Cancer and breathing , with links to the most effective[normalbreathing.com]
  • The number of patients with previous ischaemic heart disease (IHD) was significantly higher in the cohort of patients who developed cardiac toxicity. 3 out of 11 (27%) patients in the cohort who developed cardiac toxicity and 2 out of 50 (4%) patients[academic.oup.com]
Chest Pain
  • We describe a case of a patient presenting with chest pain and ECG abnormalities concerning for ST-elevation myocardial infarction that eventually was found to have an incidental right ventricular mass on chest CT angiogram.[ncbi.nlm.nih.gov]
  • We present a 58-year-old woman patient with a history of tongue carcinoma who was admitted in emergency department for sudden chest pain.[ncbi.nlm.nih.gov]
  • In June 2017, she returned to the hospital, this time with complaints of acute onset chest pain.[medpagetoday.com]
  • However, the differential diagnosis is critical and when a patient is encountered with chest pain and ST elevation, STEMI should not be the only diagnosis considered.[turkjemergmed.com]
  • Case presentation A 12-years-old girl was presented with an acute history of fever, cough and chest pain. She had associated difficulty in breathing, lower limb swelling and exercise intolerance.[clinmedjournals.org]
Tachycardia
  • In this case, a cardiac metastasis from a squamous cell carcinoma presented with both persistent ST elevation and paroxysmal supraventricular tachycardia.[ncbi.nlm.nih.gov]
  • The patient presented with exertional dyspnea and tachycardia and was found to have a large mass in the right atrium. He underwent surgical removal of the tumor, but curative excision was not possible.[ncbi.nlm.nih.gov]
  • […] manifested as tachycardia-bradycardia syndrome that mimicked sick sinus syndrome.[revespcardiol.org]
  • For this reason, paragangliomas can cause episodes of tachycardia, headaches, hypertension, and sweating.[verywellhealth.com]
  • Most often clinical signs are dyspnea, cough, tachycardia, arrhythmia, chest pain, heart failure, cardiac tamponade, and systemic thromboembolism [2].[exp-oncology.com.ua]
Cardiomegaly
  • The chest roentgenogram showed a massive right pleural effusion with apparent cardiomegaly. The cardiac silhouette over the right heart border was obliterated and the mediastinum was widened.[ncbi.nlm.nih.gov]
  • Chest x-ray showed mild cardiomegaly and minimal right pleural effusion. Hematology parameters were normal in the laboratory analysis. Creatinine was 2.3 mg/dL; Na , 140 mmol/L; K , 6,3 mmol/L, and digoxin was within therapeutic values.[revespcardiol.org]
  • Plain radiograph Findings are non-specific on chest x-ray, but may include: cardiomegaly (e.g. indicating pericardial effusion and/or cardiac congestion) gross mediastinal lymphadenopathy Comparison with previous films is important.[radiopaedia.org]
  • Chest radiography may demonstrate cardiomegaly with “water bottle” sign or an enlarged azygos vein if pericardial effusion is present [ 21 ]. Yet, echocardiography remains the most efficient method for initial diagnosis.[bmccancer.biomedcentral.com]
Hematuria
  • A 59-year-old man with a history of transitional cell bladder cancer status post cystectomy and chemotherapy, with neobladder placement, presented with hematuria, shortness of breath, murmur, and evidence of right-sided heart failure.[ncbi.nlm.nih.gov]
  • A 59-year-old Japanese man presented to his previous physician with hematuria. Computed tomography revealed masses in the heart and right kidney, and fluorodeoxyglucose-positron emission tomography showed abnormal uptake in the heart.[ncbi.nlm.nih.gov]
  • In fact, he suffered from macroscopic hematuria since one year. The Computered Tomography scanner showed a 62 mm mass syndrome without any pulmonary, hepatic or bone metastasis.[omicsonline.org]

Workup

  • On imaging workup, including transthoracic echocardiography and cardiac computed tomography, we found a large right ventricular mass.[ncbi.nlm.nih.gov]
  • Further workup including bone scan showed no significant findings. The diagnosis of lung squamous cell carcinoma with cardiac invasion was made. INTERVENTIONS: She went on to received palliative chemotherapy.[ncbi.nlm.nih.gov]
  • A detailed cardiac workup revealed no significant findings on echocardiogram, nuclear medicine stress test, or holter monitoring. Further evaluation with octreoscan revealed a small focus of abnormal uptake adjacent to the left atrial appendage.[aocr.org]
  • He underwent multimodality imaging as part of a metastatic workup.[ahajournals.org]
Pericardial Effusion
  • Transthoracic echocardiography revealed massive localized pericardial effusion with the collapse of both ventricles and the mass-like echo in the left atrium.[ncbi.nlm.nih.gov]
  • Computed tomographic imaging revealed a small bowel mass as well as a pericardial effusion. Cardiac magnetic resonance imaging showed a tricuspid mass. Endomyocardial biopsy confirmed metastatic disease consistent with a cervical primary.[ncbi.nlm.nih.gov]
  • The patient died of cardiac arrest after evidence of massive malignant pericardial effusion. At autopsy, massive myocardial and pericardial neoplastic invasion was found.[ncbi.nlm.nih.gov]
  • This was diagnosed as a rare case of primary mediastinal malignant melanoma with a right atrial metastasis causing pericardial effusion.[mljsl.sljol.info]
  • Effects Nonspecific conduction defects and arrhythmias, cardiac dysfunction and heart failure due to pericardial effusion, intramural oedema due to lymphatic outflow, filling impairment due to endocardial involvement, and direct myocardial invasion.[medical-dictionary.thefreedictionary.com]
Multiple Pulmonary Nodules
  • The initial computed tomography (CT) scan showed the cardiac tumor, which was approximately 40 mm in size, and multiple pulmonary nodules. Serum levels of tumor markers CEA and CA19-9 were elevated aberrantly.[ncbi.nlm.nih.gov]
Small Bowel Mass
  • Computed tomographic imaging revealed a small bowel mass as well as a pericardial effusion. Cardiac magnetic resonance imaging showed a tricuspid mass. Endomyocardial biopsy confirmed metastatic disease consistent with a cervical primary.[ncbi.nlm.nih.gov]

Treatment

  • Selected patients may benefit from multimodality treatment.[ncbi.nlm.nih.gov]
  • After 12 courses of chemotherapy during 10 months of treatment, the patient continued to show a partial response, and she remained asymptomatic with continuation of the treatment through 15 courses.[ncbi.nlm.nih.gov]
  • The lesion was debulked surgically and multimodal treatment followed. The patient survived 1 year after diagnosis with good performance status during which time no other lesion was discovered.[ncbi.nlm.nih.gov]
  • As a result of the treatment, the patient remains in a good general condition. This is the second described case of cardiac metastasis of PNEN.[ncbi.nlm.nih.gov]
  • The location of the metastasis and the characteristics of the primary tumor determine the treatment modality. In some previously published reports, various treatment choices have been described.[ncbi.nlm.nih.gov]

Prognosis

  • Patients who are diagnosed with localized disease usually have a favorable prognosis, while those who present with widespread metastases usually have a poor prognosis and ultimately, succumb to their disease.[ncbi.nlm.nih.gov]
  • Cervical cancer metastatic to the heart is rare and associated with a poor prognosis. Selected patients may benefit from multimodality treatment.[ncbi.nlm.nih.gov]
  • The first is hematogenous, via the IVC, even in the absence of renal vein involvement; it is generally circumscribed and has a good prognosis after surgery.[ncbi.nlm.nih.gov]
  • The prognosis of cardiac metastases from thyroid cancer is unclear as survival data are often missing or absent in reported cases. However, as many patients died suddenly from cardiac complications, the prognosis seems poor.[ncbi.nlm.nih.gov]
  • The prognosis of patients with metastatic renal cell carcinoma has been radically influenced by the introduction of tyrosine kinase inhibitors, but very few reports in the literature have described their activity in heart metastasis.[ncbi.nlm.nih.gov]

Etiology

  • Etiology of large pericardial effusions. Am J Med 1993;95:209-13. Levy PY, Corey R, Berger P, et al. Etiologic diagnosis of 204 pericardial effusions. Medicine (Baltimore) 2003;82:385-91.[acc.org]
  • On the etiology of anal squamous carcinoma. Dan Med Bull. 2002 Aug; 49(3):194-209. [6] Meyer JEet al. HIV positivity but not HPV/p16 status is associated with higher recurrence rate in anal cancer.[article.sapub.org]
  • Evaluation of clinical context from past medial history, cardiovascular risk factors, image work-up including chest X-ray and echocardiography may provide insight into the etiology of the acute myocardial infarction.[jtd.amegroups.com]
  • On TTE evaluation, the patient was found to have a pericardial effusion requiring pericardial window and drainage; 800 cc of bloody fluid was removed, and fluid analysis confirmed the presence of squamous cell carcinoma from cervical etiology.[medpagetoday.com]

Epidemiology

  • Epidemiological information relating to cardiac metastases is predominantly based on autopsy studies. The reported incidence ranges from 2.3-18.3%. It is usually found in the presence of widely disseminated disease.[ncbi.nlm.nih.gov]
  • We briefly discuss epidemiology and pathogeny of cardiac metastases.[kns.cnki.net]
  • Lifecourse Health Policy and Insurance Research Therapeutics Research and Infectious Disease Center for Cancer Policy and Program Evaluation (CarPE) Precision Medicine Translational Research (PROMoTeR) Office of Sponsored Programs TEACHING Clinical Epidemiology[populationmedicine.org]
Sex distribution
Age distribution

Pathophysiology

  • AIM: To investigate the clinical and pathologic findings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis.[ncbi.nlm.nih.gov]
  • ., et al. (2013) Symptomatic cardiac metastases of breast cancer 27 years after mastectomy: A case report with literature review—Pathophysiology of molecular mechanisms and metastasic pathways, clinical aspects, diagnostic procedures and treatment modalities[scirp.org]
  • Pathophysiology and clinical signifi- cance of atherosclerotic plaque. 5 g 7. There was less bleeding in the bivalirudin arm.[masa42.ru]
  • CT provides superior spatial resolution and renders the assessment of extracardiac structures. 1 Pathophysiological changes that often occur in patients with cardiac metastasis include right-sided heart failure, increased coagulopathy, thrombocytopenia[medpagetoday.com]

Prevention

  • […] and early detection of cervical cancer: American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.[nccn.org]
  • A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy. Detailed Study Description PRIMARY OBJECTIVES: I.[centerwatch.com]
  • As HPV vaccination cannot be given in immunocompromised HIV patients for primary prevention, we need to start early screening in HPV and HIV coinfected patients for anal cancer by doing regular anal pap smears.[article.sapub.org]
  • Her domains of interest are heart failure, echocardiography, prevention medicine and cardio-oncology. Email: [email protected] PDF HTML[omicsonline.org]
  • We must, however, as suggested by Nabozny et al, 1 be very careful with this type of resuscitation and not hesitate to reassess daily the number of organ failures to prevent the use of unreasonable and futile ICU care after initial successful CPR. 1 Thus[jamanetwork.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!