We present two cases of cardiac sarcoidosis whose first presentation was in pregnancy. All findings confirmed the diagnosis of sarcoidosis with cardiac involvement in both patients. [ncbi.nlm.nih.gov]

In most cases, it presents with sudden death, arrhythmia, conduction disorders or cardiomyopathy. [ntvg.nl]

• Fever

  This local hyperactivity and dysregulation of immunological systems could lead to the development of granulomas. 5 Clinical presentation 5.1 acute sarcoidosis (10%) Fever Arthralgia Erythema nodosum Bilateral hilar adenopathy Dry cough Dyspnoe A combination [flexikon.doccheck.com]

  (including post-vaccination fever), mild to moderate pain (including pain relief after surgery ), painful menstruation, osteoarthritis, dental pain, headaches, and pain from kidney stones. [en.wikipedia.org]

• Military Personnel

  In Japanese persons, ophthalmologic and cardiac involvement are more common than in other races. [18] It is more common in certain occupations, namely firefighters, educators, military personnel, persons who work in industries where pesticides are used [en.wikipedia.org]

• Nausea

  […] breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma. [1] Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease. [1] It can be given by mouth or by injection. [1] Common side effects include nausea [en.wikipedia.org]

• Heart Failure

  He developed recurrent heart failure requiring several admissions to hospital and was finally referred to our institution with severe congestive heart failure. Despite medical treatment with inotropic agents, his symptoms gradually worsened. [ncbi.nlm.nih.gov]

  It usually manifests as either heart block, heart failure due to direct myocardial involvement, or cor pulmonale. We present the case of a patient with cardiac sarcoidosis who had ventricular tachycardia and congestive heart failure. [pediatrics.aappublications.org]

  Cardiac lesions due to sarcoidosis may lead to fatal arrhythmias or heart failure. [sarcoidosisnews.com]

  Cardiac sarcoidosis can cause complete heart block, ventricular and atrial arrhythmias (heart rhythm abnormalities affecting the bottom and top parts of the heart), and congestive heart failure. [ahajournals.org]

• Tachycardia

  We present the case of a patient with cardiac sarcoidosis who had ventricular tachycardia and congestive heart failure. Although there was other organ system involvement, the cardiac manifestation was the first to become clinically apparent. [pediatrics.aappublications.org]

  A 70-year old Caucasian man with recurrent ventricular tachycardia and progressive biventricular failure attributed to arrhythmogenic right ventricular cardiomyopathy/dysplasia was evaluated for heart transplantation. [ncbi.nlm.nih.gov]

  Supraventricular tachycardia Bryan C. Cannon, M.D., Mayo Clinic pediatric cardiologist and electrophysiology specialist, discusses the condition supraventricular tachycardia and potential treatment options in pediatric patients. [medprofvideos.mayoclinic.org]

• Heart Block

  Cardiac sarcoidosis is one of the uncommon causes of heart failure. Generally, it presents in the form of varying clinical manifestations ranging from asymptomatic to fatal arrhythmias such as ventricular tachycardia and complete heart block. [ncbi.nlm.nih.gov]

  Complete heart block may result in extremely slow heart rate, causing lightheadedness, loss of consciousness, or even death. [ahajournals.org]

  It usually manifests as either heart block, heart failure due to direct myocardial involvement, or cor pulmonale. We present the case of a patient with cardiac sarcoidosis who had ventricular tachycardia and congestive heart failure. [pediatrics.aappublications.org]

• Chest Pain

  The initial clinical manifestations were high-grade atrioventricular conduction block (n=4), heart failure (n=2), ventricular extrasystole (n=2) and acute myocarditis with chest pain and ST-segment elevations (n=1). [academic.oup.com]

  Symptoms: Irregular heartbeat (pounding or fluttering sensation, or a ‘skipping of beats’) Dizziness and/or fainting spells Shortness of breath Chest pain Swelling of the legs (in later stages) Pulmonary Hypertension Pulmonary sarcoidosis (sarcoidosis [sarcoidosisuk.org]

  pain, vasovagal syncope about 60 minute long and tinnitus in both ears. [revespcardiol.org]

  Patient history: A 50 year old mixed race man was admitted in Coronary Care Unit after an episode of syncope and sudden onset chest pain associated with palpitations. [scmr.org]

  It is less likely to be diagnosed ante-mortem because less than 10% of patients have cardiovascular symptoms. 1,2 It is, therefore, important to recognise overt and non-specific symptoms such as chest pain, breathlessness, palpitations and dizziness, [bjcardio.co.uk]

• Heart Disease

  Sarcoid heart disease should be considered in every patient with diagnostic sarcoidosis and heart disease but also in every case of difficult heart disease without an obvious aetiology. [ntvg.nl]

  A 58-year-old male with no history of heart disease was admitted to hospital for congestive heart failure due to severe left ventricular dysfunction, and clinically diagnosed with dilated cardiomyopathy. [ncbi.nlm.nih.gov]

• Myopathy

  "Mycophenolate mofetil may be effective in CNS sarcoidosis but not in sarcoid myopathy". Neurology. 76 (13): 1168–72. doi : 10.1212/WNL.0b013e318212aafb. PMID 21444902. ^ Judson MA (October 2012). "The treatment of pulmonary sarcoidosis". [en.wikipedia.org]

• Dizziness

  A 60-year-old woman with biopsy-proven cardiac sarcoidosis status post implantable cardioverter defibrillator placement presented with periodic dizziness and dyspnea on exertion. [ncbi.nlm.nih.gov]

  Common Symptoms of Cardiac Sarcoidosis Common Symptoms of Cardiac Sarcoidosis • Dizziness/lightheadedness • Syncope (fainting) • Leg swelling • Cough • Shortness of breath • Heart beating too quickly, too slowly, or irregularly What Causes Sarcoidosis [ahajournals.org]

  Symptoms: Irregular heartbeat (pounding or fluttering sensation, or a ‘skipping of beats’) Dizziness and/or fainting spells Shortness of breath Chest pain Swelling of the legs (in later stages) Pulmonary Hypertension Pulmonary sarcoidosis (sarcoidosis [sarcoidosisuk.org]

"Sarcoidosis Workup". Medscape Reference. WebMD. Archived from the original on 1 March 2014. Retrieved 19 February 2014. ^ Allmendinger A, Perone R (2009). "Case of the Month". Diagnostic Imaging. 31 (9): 10. ^ Joanne Mambretti (2004). [en.wikipedia.org]

• Right Bundle Branch Block

  The first patient displayed no cardiac symptoms; the electrocardiogram showed an incidental right bundle branch block. [ncbi.nlm.nih.gov]

  Electrocardiogram: Showed sinus rhythm with different degrees of AV block, included periods of complete AV block and right bundle branch block (RBBB)-like escape rhythm. [scmr.org]

  […] and 61% had left or right bundle branch blocks. [bjcardio.co.uk]

  Intraventricular right bundle branch are most frequent [ 2, 8, 14, 16, 99, 100, 101 ], sinus blocks are exceptional [ 102 ]. [em-consulte.com]

• Myocardial Fibrosis

  Non tropical, non hypereosinophilic endo myocardial fibrosis has been reported in literature and is a rare entity. [ncbi.nlm.nih.gov]

  fibrosis, and regional myocardial dysfunction. 6-8 Our case, which meets the diagnostic criteria for cardiac sarcoidosis, enables illustrating the morphology of cardiac lesions using MRI. [revespcardiol.org]

  Myocardial granulomata – granulomata with associated fibrosis are bright on LGE imaging relative to the surrounding myocardium. [dovepress.com]

Five months later, she presented with acute progressive heart failure that was refractory to conventional treatment. Her sIL2R and ACE levels decreased spontaneously over time, without steroid treatment. [ncbi.nlm.nih.gov]

The treatment protocol was infliximab 5mg/kg iv infusions every 8 weeks. The mean treatment time on infliximab was 14.8 (4–37) months. Eight of nine patients had received other immunosuppressant(s) prior infliximab. [academic.oup.com]

Our expert speakers will focus on the clinical diagnosis, management and prognosis of cardiac sarcoidosis – both from a cardiac and a respiratory perspective. 5 CPD points available Registration fee: £150 for consultants £100 for trainees, nurses & students [bnms.org.uk]

Cardiac involvement in sarcoidosis has been reported to be as high as 50% of cases and it is well documented that it is associated with a poorer prognosis. [ncbi.nlm.nih.gov]

Early treatment prevents irreversible damage of the heart and seems to be associated with better prognosis. [orbi.uliege.be]

Sarcoidosis is a systemic disease of unknown etiology, in which granulomas develop in various organs, including the skin, lungs, eyes, or heart. [ncbi.nlm.nih.gov]

This case is presented to illustrate a somewhat unusual, but nevertheless important, etiology of ventricular tachyarrhythmias. [pediatrics.aappublications.org]

You can manage this and all other alerts in My Account The alert will be sent to: × Supplements Abstract Purpose: : Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. [iovs.arvojournals.org]

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology. [ijpmonline.org]

Due to hypercalzaemia related to sarcoidosis in 15% of the cases, chronic kidney failure can be a result of chronic nephrolithiasis. 4 Etiology No casuistic explanation for the pathophysiology of sarcoidosis has yet been found. [flexikon.doccheck.com]

Background This study was designed to assess the epidemiology, characteristics, and outcome of cardiac sarcoidosis (CS) in Finland. [escardio.org]

Keywords: autoimmune disease • clinical (human) or epidemiologic studies: outcomes/complications • retinitis © 2012, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. [iovs.arvojournals.org]

It can affect any organ, most prominently it clinically presents with pulmonary symptoms. 2 Epidemiology The peak age group for first manifestation is 20-40 years. [flexikon.doccheck.com]

James DG, Wiliams WJ (1985) Epidemiology. In: James DG, Wiliams WJ (eds) Sarcoidosis and other granuloatous disorders. WB Saunders Co., Philadelphia, pp 233–246 7. [springermedizin.de]

Surveillance Epidemiology and End Results (SEER). Bethesda, MD: National Cancer Institute. Archived from the original on 26 September 2009. Retrieved 3 November 2009. Table 1.4: Age-Adjusted SEER Incidence and U.S. [en.wikipedia.org]

Due to hypercalzaemia related to sarcoidosis in 15% of the cases, chronic kidney failure can be a result of chronic nephrolithiasis. 4 Etiology No casuistic explanation for the pathophysiology of sarcoidosis has yet been found. [flexikon.doccheck.com]

Pathophysiology and clinical management of cardiac sarcoidosis. Nat Rev Cardiol. 2015;12(5):278-88. [escardio.org]

The development and accumulation of granulomas are fundamental to the pathophysiology of sarcoidosis. [dovepress.com]

This article will update the reader on the clinical manifestations and pathophysiology of cardiac sarcoidosis, with a special focus on recent diagnostic and therapeutic modalities. [ncbi.nlm.nih.gov]

“We collected data on 235 patients with cardiac sarcoidosis and showed that implantable cardiac defibrillators helped to prevent the risk of sudden death,” she said. [vcuphc-thebeat.org]

Treatment aims to control the systemic inflammatory condition while preventing further cardiac damage. However, even with adequate diagnosis and treatment strategies, prognosis remains poor. [ncbi.nlm.nih.gov]

In some cases, catheter ablation aims at the pathway between the atria and the ventricles (the A-V node) in order to prevent the ventricles from beating too fast. [heart.templehealth.org]

Early treatment prevents irreversible damage of the heart and seems to be associated with better prognosis. [orbi.uliege.be]

Infliximab prevents the formation of sarcoid granulomas and has been successfully used in pulmonary sarcoidosis. However, prior studies indicate that infliximab worsens outcome in chronic ischemic and non-ischemic heart failure. [academic.oup.com]