A 52-year-old woman presented with central nervous system depression and a Glasgow Coma Score of 9 secondary to ingestion of carisoprodol, a centrally acting muscle relaxant analgesic. [ncbi.nlm.nih.gov]

• Acute Intermittent Porphyria

  Hypersensitivity to carisoprodol and related compounds (e.g., meprobamate, tybamate); acute intermittent porphyria; children Impaired liver or kidney function, addiction-prone individuals. Muscle Spasm Adult: PO 350 mg t.i.d. [robholland.com]

  intermittent porphyria Precautions: Use caution in renal or hepatic dysfunction. [rheumaknowledgy.com]

  Acute intermittent porphyria (a hereditary condition that occurs due to absence of an enzyme ), hypersensitivity, lactation. • • It should be used only for acute treatment. • Caution should be exercised in patients with history of liver or kidney disease [medindia.net]

  Contraindications Hypersensitivity to carisoprodol, meprobamate, mebutamate, tybamate History of acute intermittent porphyria Effects of drug abuse None Short-Term Effects See “What Are Side Effects Associated with Using Carisoprodol?” [rxlist.com]

  Carisoprodol and Other Contraindications Acute intermittent porphyria, hypersensitivity. Lactation Storage Oral: Store at 15-30°C Lab interference Oral: Store at 15-30°C [drugsupdate.com]

• Nocturnal Leg Cramp

  International Carisoprodol In the US, Carisoprodol (carisoprodol systemic) is a member of the drug class skeletal muscle relaxants and is used to treat Muscle Spasm and Nocturnal Leg Cramps. [drugs.com]

• Osteoporosis

  Patients with chronic back pain; at increased risk for vertebral fracture (e.g., history of osteoporosis); with a history of spinal pathology (e.g., herniated nucleus pulposus, spondylolisthesis or spinal stenosis); with inflammatory back pain, or with [dailymed.nlm.nih.gov]

  Exclusion criteria included sciatic pain, history of spinal pathology, neurologic signs, concurrent chronic back pain, osteoporosis, or rheumatic disease. Medications were given for one week. [medpagetoday.com]

• Leg Cramp

  International Carisoprodol In the US, Carisoprodol (carisoprodol systemic) is a member of the drug class skeletal muscle relaxants and is used to treat Muscle Spasm and Nocturnal Leg Cramps. [drugs.com]

  STERN, VALUE OF CARISOPRODOL (SOMA) IN RELIEVING LEG CRAMPS, Journal of the American Geriatrics Society, 11, 10, (1008-1113), (2015). Grace E. [doi.org]

• Petechiae

  […] e.g., hyperpyrexia, chills, angioedema, bronchospasm, anaphylaxis, stomatitis, proctitis, oliguria, anuria, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, bullous dermatitis). 109 Leukopenia, acute nonthrombocytopenic purpura, petechiae [drugs.com]

• Purpura

  […] severe (e.g., hyperpyrexia, chills, angioedema, bronchospasm, anaphylaxis, stomatitis, proctitis, oliguria, anuria, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, bullous dermatitis). 109 Leukopenia, acute nonthrombocytopenic purpura [drugs.com]

• Oliguria

  […] patients receiving mebrobamate, a metabolite of carisoprodol. 109 Reactions may be mild (e.g., pruritus, urticaria, erythematous maculopapular rash) or more severe (e.g., hyperpyrexia, chills, angioedema, bronchospasm, anaphylaxis, stomatitis, proctitis, oliguria [drugs.com]

• Myoclonus

  He developed agitation, tachycardia, myoclonus, and coma. The blood carisoprodol was 71 micrograms/mL; the meprobamate was 26 micrograms/mL. Carisoprodol overdose is thought to induce simple central nervous system depression. [ncbi.nlm.nih.gov]

  He had generalized rigidity with distal upper limb myoclonus. [joacp.org]

  Overdose can cause progressive obtundation, coma, neuromuscular rigidity, myoclonus and seizures. [livertox.nih.gov]

• Encephalopathy

  This case demonstrates a severe overdose with symptoms more consistent with myoclonic encephalopathy. [ncbi.nlm.nih.gov]

  Vinson and Susan Kim, Carisoprodol-Induced Myoclonic Encephalopathy, Journal of Toxicology: Clinical Toxicology, 36, 6, (609), (1998). [doi.org]

  Carisoprodol-induced myoclonic encephalopathy. J Toxicol Clin Toxicol 1998; 36: 609-12. PubMed Citation (Case report of patient with carisoprodol overdose who developed coma, but had no liver abnormalities). Chou R, Peterson K, Helfand M. [livertox.nih.gov]

• Hand Tremor

  The clinical effects of carisoprodol as measured by the clinical test for impairment (CTI) resembled those of benzodiazepines with some important differences such as tachycardia, involuntary movements, hand tremor and horizontal gaze nystagmus, which [ncbi.nlm.nih.gov]

• Tremulousness

  Symptoms of carisoprodol withdrawal include anxiety, tremulousness, insomnia, jitteriness, muscle twitching, and hallucinations. [ncbi.nlm.nih.gov]

• Screaming

  A Pseudo-MDMA high peth Tramadol, Ativan, Valium, Kratom, Soma, Cannabis & Alcohol A Question of Trust Samsa Methamphetamine, LSD, Tramadol, Cyclobenziprize, Carisoprodol & Alcohol Perfect Synergy Psych0naut Carisoprodol & Heroin Very Relaxed Primal Scream [erowid.org]

BACKGROUND: Carisoprodol, a centrally active skeletal muscle relaxant, is widely used for the treatment of acute, painful musculoskeletal disorders. [ncbi.nlm.nih.gov]

Finding a Treatment for Carisoprodol (Soma) Abuse Treatment for carisoprodol addiction is available on both an inpatient and outpatient basis. Inpatient treatment is more intensive and takes place in a residential facility. [detox.net]

All it takes is a commitment to go through treatment. [projectknow.com]

OBJECTIVE: The aim of this review was to discuss the etiology of low back pain and the relative risks and benefits of muscle relaxants commonly prescribed for the management of back pain. [ncbi.nlm.nih.gov]

It describes in great detail the characteristics of these syndromes and various etiological models. [books.google.es]

Martin, Factors Influencing Long-Term Opioid Use Among Opioid Naive Patients: An Examination of Initial Prescription Characteristics and Pain Etiologies, The Journal of Pain, 10.1016/j.jpain.2017.06.010, 18, 11, (1374-1383), (2017). [doi.org]

Yourself organic viagra buy online cheap severe that with blood ours both move hypertensive men give etiologies experienced for of psychogenic former of causes ED including reductions and varying mill moderate and they pressure 3 mild. young trauma number [grunauerkc.com]

Norsk Epidemiologi, 18 (2). https://doi.org/10.5324/nje.v18i2.29 Copyright (c) 2015 Norsk epidemiologi This work is licensed under a Creative Commons Attribution 4.0 International License. [ntnu.no]

Jouko Miettunen, Jaana Suvisaari, Jari Haukka and Matti Isohanni, Use of Register Data for Psychiatric Epidemiology in the Nordic Countries, Textbook of Psychiatric Epidemiology, (117-131), (2011). [doi.org]

METHODS: This study used data from six Texas poison centers to describe the epidemiology of carisoprodol abuse and drug identification (ID) calls from 1998 to 2003. RESULTS: Drug ID and abuse calls were 217% higher in 2003 than in 1998. [ncbi.nlm.nih.gov]

The book's three main sections examine the nature of addiction, including epidemiology, symptoms, and course; alcohol and drug use among adolescents and college students; and detailed descriptions of a wide variety of addictive behaviors and disorders [books.google.es]

CONCLUSION: Thus being an underrecognized drug of abuse, carisoprodol is in need of wider awareness and regulatory measures to prevent its emergence as a greater menace in the future. Copyright © 2013 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

Baclofen is tapered over 1-2 weeks to prevent development of psychoses and hallucinations. [nurseslabs.com]

The Indiana Prevention Resource Center notes that ER visits related to the drug more than doubled between the years 2004 and 2009. [projectknow.com]