[…] is the most frequently present. [scielo.br]

Clinical description Most patients initially present with two of the three tumors (incomplete Carney's triad). The main symptoms at presentation are gastrointestinal bleeding, epigastric pain, anemia and palpable abdominal mass. [orpha.net]

• Fishing

  CGH, fluorescent in situ hybridization (FISH) and loss-of-heterozygosity (LOH) studies Tumours that showed losses of 1q region by CGH (samples CTRS9, CTRS5T, CTRS6, CTRS7, CTRS10, CTRS13, CTRS19, CTRS21 and CTRS36) were subjected to interphase FISH, using [ncbi.nlm.nih.gov]

• Marfanoid Habitus

  MEN2B ( 4 ), one of the syndromes, also included nonendocrine tumors, mucosal neuromas, and congenital anomalies, including marfanoid habitus and other connective tissue abnormalities. [academic.oup.com]

• Recurrent Infection

  All except one of the patients studied were asymptomatic. (3) In our patient, the pulmonary component appeared as an endobronchial obstructive lesion, leading to signs and symptoms of pulmonary suppurative disease with recurrent infections. [scielo.br]

• Developmental Disorder

  The syndrome is likely a developmental disorder. The component tumors tend to be multifocal in affected organs (Carney et al., 1977; Carney, 1983; Carney, 1999). [atlasgeneticsoncology.org]

• Keratosis

  She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. [endocrine-abstracts.org]

Metaiodobenzylguanidine scanning may be helpful in the diagnostic workup. [journals.aace.com]

• Chest X-Ray Normal

  Table 1 Patients with the triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma (Carney triad) Patient Id Sex Age Tumours Other Reference CTRS2 1 F 15 GIST, PGL Chest X-ray normal; metastatic GIST; multiple PGLs [ncbi.nlm.nih.gov]

• Gastric Filling Defect

  Imaging studies showed one or more gastric filling defects, sometimes with evidence of ulceration. [academic.oup.com]

• Atelectasis

  A computed tomography scan of the chest confirmed atelectasis and revealed a small calcified lesion in the right lower lobe bronchus ( Figure 2 ), in addition to bronchiectasis with probable impacted mucus in the collapsed pulmonary lobe. [scielo.br]

• Mediastinal Mass

  She was found to have a mediastinal mass in the aortopulmonary window. [journals.aace.com]

• Microcytic Anemia

  A calcified lung tumor and microcytic anemia in a young woman: partial expression of the Carney triad. Surgeon. 2008;6:249–251. [PubMed] [Google Scholar] 6. Allievi A, Araya V, Calvar C, et al. [ncbi.nlm.nih.gov]

Management and treatment The treatment of choice for GIST and its metastases (overall rate: 50%) is surgical resection. GIST associated with Carney's triad are mostly indolent. [orpha.net]

GISTs of the Carney triad involve predominantly the body and the antrum of the stomach, are generally multifocal, and have a better prognosis than sporadic GISTs. [ncbi.nlm.nih.gov]

The prognosis is better than in adult GIST, with a slow course of progression even after metastasis has occurred. However, many patients require repeated surgeries for recurring tumors. [gistsupport.org]

[…] chondroma), familial GIST syndrome, Carney-Stratakis syndrome ( Am J Med Genet 2002;108:132 ) Sites: stomach (60%), jejunum and ileum (30%), duodenum (5%), colorectum (5%), rarely esophagus, appendix, retroperitoneum, abdomen (extra GI stromal tumors) Prognosis [pathologyoutlines.com]

Prognosis Further pulmonary nodule soften develop but metastases do not occur. Patients are likely to develop the other features of Carney's triad. [e-immunohistochemistry.info]

[…] doi: 10.1097/PCR.0000000000000175 Case Reviews Abstract Author Information Authors Article Metrics Metrics Carney triad is a rare, multitumoral, nonfamilial syndrome of unknown etiology. [journals.lww.com]

Etiology The etiology is not completely understood. [orpha.net]

Carney triad is a rare syndrome of unknown etiology characterized by having at least two out of three following neoplasms: gastrointestinal stromal tumor, pulmonary chondroma and extra-adrenal paraganglioma. [ncbi.nlm.nih.gov]

Summary Epidemiology Less than 100 cases have been reported worldwide. Carney's triad primarily affects young women (mean age of onset 20 years). [orpha.net]

This respected cardiology reference covers everything you need to know - from epidemiology and pathophysiology through diagnosis, risk stratification, treatment, outcome studies, concomitant diseases, special populations and special situations, and future [books.google.com]

Epidemiology Less than 100 cases have been reported worldwide. Carney's triad primarily affects young women (mean age of onset 20 years). Clinical description Most patients initially present with two of the three tumors (incomplete Carney's triad). [rarediseases.info.nih.gov]

This respected cardiology reference covers everything you need to know - from epidemiology and pathophysiology through diagnosis, risk stratification, treatment, outcome studies, concomitant diseases, special populations and special situations, and future [books.google.com]

(See Pathophysiology and Etiology.) [emedicine.medscape.com]

The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. N Engl J Med 335: 1870, 2005. CrossRef Google Scholar 9. Andersson HC, Frentz J, Martinez JE, Tuck-Muller CM, Bellizaire J. [link.springer.com]

Medical Triads (The Study of Threes) http://threesology.org --- Diagnostic Triads in Medical science --- http://forum.facmedicine.com/pathology-pathophysiology/8518-diagnostic-triads-medical-science.html wernicke triad: - 1)Confusion 2)Opthalmoplegia [threesology.org]

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