Presentation
He has been the Editor in Chief, JAMA Neurology (1997- present) and a member of the Editorial Board of JAMA (1997-present). [books.google.com]
Long QT syndrome (LQTS) should be suspected in individuals on the basis of ECG characteristics, clinical presentation, and family history. [centogene.com]
Cataracts may also be present among other disorders of iron metabolism. [disorders.eyes.arizona.edu]
Patients typically present clinical symptoms between the ages of… Continue Reading BridgeBio Pharma Raises 299 Million January 23, 2019 By Daniel S. [globalgenes.org]
Initially, a cataract presents discretely and may even go unnoticed, but the visual impairment worsens as the cataract grows larger. [amboss.com]
Entire Body System
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Falling
Negative outcomes during the waiting period could include vision loss, an increased rate of falls, and reduced quality of life. 16 When Surgery Should Be Performed Nonsurgical options prior to surgery have a limited role, but include changing the patient [uspharmacist.com]
Cryotherapy: A fall from grace, but not a crash. Ophthalmology Times. October, 15, 2005. [en.wikibooks.org]
The laser can be aimed very accurately, and the small part of the capsule which is cut falls harmlessly to the bottom of the inside of the eye. [en.wikipedia.org]
There have been numerous studies about the benefits of cataract surgery including decreasing the frequency of falls, lessening depression and improving the general quality of life. [lakeshorevision.com]
Schweitzer is a cornea, glaucoma, cataract and refractive surgery specialist at Vance Thompson Vision in Sioux Falls, SD. [reviewofoptometry.com]
Gastrointestinal
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Diarrhea
[…] health implications The present study supports the hypothesis of Shinohara et al. [ 63 ] which states that a cataract can be considered a window that can indicate the presence of systemic disorders such as metabolic syndrome, diabetes mellitus, severe diarrhea [omicsonline.org]
Eyes
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Visual Impairment
The clouding causes distortion of light, as it passes through the lens, resulting in visual impairment and glare. Initially, a cataract presents discretely and may even go unnoticed, but the visual impairment worsens as the cataract grows larger. [amboss.com]
UniProtKB/Swiss-Prot : 76 Cataract 39, multiple types: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. [malacards.org]
Variables Presence of visual impairment n 29 Mean SD or n(%) Absence of visual impairment n 66 Mean SD or n(%) P Age (years) 60.3 11.8 50 12.1 0.001* DM duration (years) 9.7 7.2 8.7 7.7 0.545 Sex Men 8(27.6) 25(37.9) 0.332 Women 21(72.4) 41(62.1) Family [omicsonline.org]
Cataract is an opacification of the eye lens and causes visual impairment or blindness. CTRCT9 may be associated with microcornea but without other systemic anomalies. [cags.org.ae]
Globally, in 2002, there were more than 161 million people with visual impairment, of whom about 37 million were blind. 1 Vision 2020 estimates that 18 million people are bilaterally blind from cataract. 2 In North America, the amount of blindness due [uspharmacist.com]
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Strabismus
In addition to cataract of multiple types, affected patients may have microcornea, coloboma of the iris, microphthalmia, decreased visual acuity, nystagmus, strabismus and glaucoma. [cags.org.ae]
J Pediatr Ophthalmol Strabismus 1980;17:159–161. Duke-Elder S: Diseases of the lens; in Duke Elder S (ed): System of Ophthalmology. London, Henry Kimpton, 1969, vol XI, pp 175–182. [karger.com]
J Pediatr Ophthalmol Strabismus 1987;24:45–48 PubMed Google Scholar 21. Nishi O. Fibrinous membrane formation on the posterior chamber lens during the early postoperative period. J Cataract Refract Surg 1998;14:73–77 Google Scholar 22. [link.springer.com]
Hypertelorism, strabismus and telecanthus have also been noted. However, optic nerve atrophyor aplasia, RPE atrophy, microphthalmia, ptosis, and cataracts are sometimes present while strabismus is more common. [disorders.eyes.arizona.edu]
Eye muscle surgeries typically correct strabismus and include the following [30] [48] : Loosening / weakening procedures Recession involves moving the insertion of a muscle posteriorly towards its origin. [en.wikibooks.org]
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Corneal Opacity
The anterior segment may also be involved as evidenced by the presence of peripheral anterior synechiae, corneal opacities, cataracts, and glaucoma. [disorders.eyes.arizona.edu]
severe edema, partial or total tarsorrhaphy), keratoprosthesis, corneal opacities (e.g., scars, severe edema), hyphema, hypopyon, miosis, pupillary membranes, dense cataracts, or vitreous opacities (e.g., hemorrhage, inflammatory debris). [aetna.com]
[email protected] PURPOSE: To report a case of corneal opacity and iatrogenic cataract after laser-assisted in situ keratomileusis. METHOD: Case report. [lasikcomplications.com]
Musculoskeletal
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Fracture
According to research from the Hoskins Center and the University of California, Los Angeles, patients enjoyed a 16 percent reduction of in the one-year incidence rate of hip fractures. The reduction was greatest among patients in their eighties. [docshop.com]
Neurologic
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Excitement
Pascual is interested in the molecular mechanisms that cause inherited metabolic and excitability disorders using electrophysiology and nuclear magnetic resonance both in human subjects and in models of human diseases. [books.google.com]
This makes cataract surgery an exciting time, because patients who had been nearsighted or farsighted can now be made to have excellent vision without glasses. 20 years ago all patients receive the same type of lens with their cataract surgery. [beyereye.com]
MDA bound to TBA (MDA-TBA) was specifically analyzed by high-performance liquid chromatography (HPLC) (excitation, 525 nm; emission, 551 nm) using phosphate-buffered methanol as eluent. [lasikcomplications.com]
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Ataxia
He described Machado-Joseph disease (MJD), an autosomal dominant ataxia, with William Nyhan, M.D. Ph.D, in 1976, for the first time. MJD is now the most common autosomal domiant spinocerebellar ataxia world-wide. Dr. [books.google.com]
Peroxisome Biogenesis Disorder 7b PBD7B 614873 Genetic Test Registry Peroxisome Biogenesis Disorder 8a (Zellweger) PBD8A 614876 Genetic Test Registry Peroxisome Biogenesis Disorder 8b PBD8B 614877 Genetic Test Registry Polyneuropathy, Hearing Loss, Ataxia [ukgtn.nhs.uk]
Treatment
Ocular exams were performed at baseline, frequently during treatment, and 6 months following discontinuation of treatment. [bloodjournal.org]
Food and Drug Administration has chosen Wave Life Sciences’ planned phase 2/3 study of suvodirsen, its lead experimental therapy for the treatment of Duchenne muscular dystrophy, to break new ground. [globalgenes.org]
Treatment Treatment Options: No treatment is available. [disorders.eyes.arizona.edu]
However, if these measures do not help, surgery is often the only effective treatment. Surgery involves removing the cloudy lens and replacing it with an artificial lens. [rarediseases.info.nih.gov]
Prognosis
If glaucomatous-like visual field is present prior to surgical intervention, the prognosis for the patient is not as good as if the visual field were completely intact. Thus, a visual field test may be done prior to surgery. [surgeryencyclopedia.com]
Prognosis [ edit ] Postoperative care [ edit ] Slit lamp photo of anterior capsular opacification visible a few months after implantation of intraocular lens in eye, magnified view A South African woman experiences newfound eyesight after a patch was [en.wikipedia.org]
Etiology
Etiology Clouding of the lens may be congenital or acquired. [amboss.com]
The etiological role of these risk factors in the outcome of cataract is confirmed by the estimates of attributable risk proportion. [ijo.in]
Laser iridotomy may be also be indicated for patients with malignant glaucoma to help identify the etiology of elevated IOP. [surgeryencyclopedia.com]
It is likely that multiple entities are represented but until the molecular etiologies are identified, no more specific classification is possible. Studies in mice document that the Atoh7 gene is important to retinal ganglion cell neurogenesis. [disorders.eyes.arizona.edu]
CONCLUSION: This case shows the importance of considering the diagnosis and determining the specific etiology of interface fluid syndrome, even years after the laser in situ keratomileusis surgery, when endothelial cell function has been compromised with [lasikcomplications.com]
Epidemiology
Epidemiology Leading cause of visual impairment and blindness in the world Prevalence of acquired cataracts Increases with age Sex: References: [1] [2] [3] [4] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]
This epidemiologic study also did not identify significant association of BMI and cataract. [ijo.in]
Population based epidemiological studies in Melbourne 57 and Framingham 58 have reported a twofold to threefold elevation in cataract prevalence among subjects with affected siblings for cortical and nuclear/subcapsular cataract respectively. [bjo.bmj.com]
The relationship between obesity and cataracts has been investigated in many epidemiological studies, but the findings are not universally consistent. [omicsonline.org]
Epidemiology. 14 (6): 707–712. doi : 10.1097/01.ede.0000086881.84657.98. PMID 14569187. Javitt JC, Wang F, West SK (1996). "Blindness Due to Cataract: Epidemiology and Prevention" (PDF). [en.wikipedia.org]
Pathophysiology
A third possibility is that identifying the genes controlling age related cataract will lead to a better understanding of lens pathophysiology, which in turn will result in the discovery of specific anticataract agents which are broadly effective and [bjo.bmj.com]
Several pathophysiological mechanisms have been proposed to explain the association of obesity and cataracts. [omicsonline.org]
Prevention
This DNA vaccine has the potential to be a safe and effective therapy to prevent Alzheimer disease. He described Machado-Joseph disease (MJD), an autosomal dominant ataxia, with William Nyhan, M.D. Ph.D, in 1976, for the first time. [books.google.com]
Prevention strategies for age related cataract: present limitations and future possibilities Nathan G Congdon Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University Schools of Medicine and Public Health Wilmer 120, 600 [bjo.bmj.com]
Natural Cataract Symptoms Prevention and Treatment It’s said that cataracts aren’t completely preventable, but everyone seems to agree that their occurrence can definitely be delayed. [draxe.com]
Cataract prevention Though there is significant controversy about whether cataracts can be prevented, a number of studies suggest certain nutrients and nutritional supplements may reduce your risk of cataracts. [allaboutvision.com]
Again blood sugar control is preventive. Return to Home Page or visit the U.S. N.I.D.D.K. Site on Diabetic Eye Disease or the National Eye Institute for more information. [diabetesnet.com]