Edit concept Question Editor Create issue ticket

Cecal Adenocarcinoma

Adenocarcinoma of Cecum


Presentation

  • We report a case of perforated adenocarcinoma of the cecum that presented as an abscess of the thigh. We also present a review of the literature on this subject.[ncbi.nlm.nih.gov]
  • In a large autopsy series, metastases to the gallbladder were present in 5.8% of patients [8, 9]. Chen et al. reported a case of transverse colon cancer presenting with manifestations of cholecystitis.[hindawi.com]
  • Isolated extramural tumour deposits Present Apical node involvement Present Venous and small vessel invasion Intramural vein invasion Present Extramural vein invasion Present Small vessel invasion Present Perineural invasion Present Mismatch repair immunohistochemistry[radiopaedia.org]
Anemia
  • A 23-year-old male presented with occult gastrointestinal bleeding and iron deficiency anemia. A Tc-99m pertechnetate abdominal scan was positive and surgery revealed an adenocarcinoma of the cecum. No Meckel's diverticulum was identified.[ncbi.nlm.nih.gov]
  • Original Articles: PDF Only Abstract Author Information Authors A 23-year-old male presented with occult gastrointestinal bleeding and iron deficiency anemia.[journals.lww.com]
  • He then suffered anemia in November 2004. Colonoscopy showed findings compatible with mild ulcerative colitis, and detected a type-2 tumor in the cecum that proved in a biopsy to be well differentiated adenocarcinoma.[jstage.jst.go.jp]
  • Case report: An 18-year-old female Egyptian patient was admitted with hematochezia and remarkable anemia.[dovepress.com]
  • Left: Adenocarcinoma in an 85 year-old man with anemia and occult bleeding. Center: Sessile lesion in an 86 year-old man with anemia but no history of bleeding.[endoatlas.com]
Weight Loss
  • Common presentations of CRC include alterations in bowel habit, weight loss, and lower gastrointestinal bleeding.[hindawi.com]
  • He had a four-month history of abdominal discomfort, namely intermittent abdominal cramping pain of mild to moderate severity in the middle and lower quadrants, and diarrhea with occasional traces of blood, unquantified weight loss and nausea, and without[scielo.mec.pt]
  • Patients who have unexplained weight loss are less likely to respond compared to patients without unexplained weight loss, and patients with cancer localized to the cecal/ascending colon were likely to have worse response to bevacizumab treatment.[jcancer.org]
  • The patient noted a decrease in her stool caliber, anorexia, and a 18-kg weight loss over the prior 8 months. She denied fevers, melena, hematochezia, recent travel, or infections.[acgcasereports.gi.org]
  • Weight loss. Pathogenesis - see pathogenesis of colorectal carcinoma. Clinical - serum: CEA elevated. [1] CA19-9 elevated. Colon cancer-specific antigen-2 (CCSA-2) elevated. [2] Relatively new; preliminary in 2014.[librepathology.org]
Pallor
  • Anemia can lead to fatigue, weakness and pallor. The cecum, a pouchlike structure, lies very close to the appendix.[livestrong.com]
  • Physical examination revealed moderate degree of skin pallor, bilateral pedal edema and an ovoid, firm, 6 5 cm, mobile, slightly tender, intra-abdominal lump in the epigastric region.[cancerjournal.net]
  • 食道損傷 esophageal perforation食道穿孔 esophageal varices食道静脈瘤 esophagitis食道炎 esophagography食道造影 excretory duct導管 exocrine gland外分泌腺 external biliary fistula外胆汁瘻 extracorporeal shock wave lithotripsy (ESWL)体外衝撃波結石破砕術(ESWL) extrahepatic bile duct肝外胆管 f facial pallor[tokyo-med.ac.jp]
Pleural Effusion
  • If lung metastases are present there may be pleural effusions causing breathlessness. Effusions may require drainage.[myvmc.com]
  • […] pancreatectomy膵切除術 pancreatic calcification膵石灰化 pancreatic cyst (cyst of pancreas)膵嚢胞 pancreatic duct cell carcinoma膵管癌 pancreatic functioning diagnostant (PFD) test (BT-PABA test, bentiromide test)PFD試験 BT-PABA試験、ベンチロミド試験 pancreatic juice膵液 pancreatic pleural[tokyo-med.ac.jp]
Hemoptysis
  • DISCUSSION: Primary Pulmonary lymphomas are a rare disease and may present with cough, dyspnea, and hemoptysis with majority of the patients being asymptomatic (1).[kundoc.com]
Abdominal Pain
  • A 77-year-old woman was transferred to our institution for abdominal pain, fever, and leukocytosis. The patient complained of approximately 2 weeks of vague progressive abdominal pain accompanied by fever, chills, nausea, and anorexia.[ajronline.org]
  • Patients usually present with small bowel obstruction and abdominal pain in their sixth or seventh decade of life.[nature.com]
  • A 77-year-old woman presented with a 1-month history of intermittent abdominal pain associated with nausea and distended abdomen. Imaging showed a complex elongated sausage-shaped mass in the transverse colon with no obstructive pattern or free air.[tandfonline.com]
  • Her abdominal pain radiated to her cervical, thoracic, and lumbar back. The patient noted a decrease in her stool caliber, anorexia, and a 18-kg weight loss over the prior 8 months.[acgcasereports.gi.org]
  • We present a case of a 60-year-old female with abdominal pain for about 2 weeks, with right lower quadrant tenderness, without nauseas, vomiting, fever or chills.[sages.org]
Diarrhea
  • A 52 year-old Hispanic man without significant past medical, surgical or family history presented with diffuse, intermittent, crampy abdominal pain and diarrhea of one week duration.[nature.com]
  • He had a four-month history of abdominal discomfort, namely intermittent abdominal cramping pain of mild to moderate severity in the middle and lower quadrants, and diarrhea with occasional traces of blood, unquantified weight loss and nausea, and without[scielo.mec.pt]
  • Symptoms of colorectal cancer include Diarrhea or constipation A feeling that your bowel does not empty completely Blood (either bright red or very dark) in your stool Stools that are narrower than usual Frequent gas pains or cramps, or feeling full or[icdlist.com]
  • Apartment, 114/A, Barasat Road, Kolkata - 700 110 India Source of Support: None, Conflict of Interest: None DOI: 10.4103/0973-1482.126483 A 65-year-old male presented with painless hematochezia associated with episodic cramps in upper abdomen, watery diarrhea[cancerjournal.net]
  • […] important prognostic factor Clinical features Increased carcinoma risk in patients with polyposis syndromes, Lynch syndrome and inflammatory bowel disease Right sided tumors cause anemia, weakness and fatigue Left sided tumors cause change in bowel habits (diarrhea[pathologyoutlines.com]
Constipation
  • Constipation. Symptoms of bowel obstruction - nausea, vomiting. Weight loss. Pathogenesis - see pathogenesis of colorectal carcinoma. Clinical - serum: CEA elevated. [1] CA19-9 elevated.[librepathology.org]
  • Duplications may present a variety of clinical findings, including acute intestinal obstruction, palpable abdominal mass, vague abdominal pain over prolonged periods, or intermittent gastrointestinal bleeding, nausea, vomiting, abdominal distension, and constipation[kjim.org]
  • Bowel symptoms that can occur in patients with cecal carcinoma include abdominal pain, constipation, weight loss, loss of appetite and vomiting, notes Santosh Kumar Mondal of the Department of Pathology, Medical College, Kolkata, India in a 2009 issue[livestrong.com]
  • Symptoms of colorectal cancer include Diarrhea or constipation A feeling that your bowel does not empty completely Blood (either bright red or very dark) in your stool Stools that are narrower than usual Frequent gas pains or cramps, or feeling full or[icdlist.com]
Hematochezia
  • Case report: An 18-year-old female Egyptian patient was admitted with hematochezia and remarkable anemia.[dovepress.com]
  • Patients with right-side colon adenocarcinoma usually present with cachexia, weight loss, anemia, and positive fecal occult blood unlike those with left-sided colon cancers, which usually manifest with changes in bowel habit, hematochezia, and symptoms[hindawi.com]
  • […] old woman with abdominal pain and hematochezia.[endoatlas.com]
  • She denied fevers, melena, hematochezia, recent travel, or infections. She was afebrile but mildly hypertensive and tachycardic, with a heart rate 100 bpm and 94% oxygen saturation on ambient room air.[acgcasereports.gi.org]
  • Proximal tumors will cause occult fecal blood and anemia, whereas distal tumors will cause more changes in bowel habits and hematochezia.[med-ed.virginia.edu]
Melena
  • She denied fevers, melena, hematochezia, recent travel, or infections. She was afebrile but mildly hypertensive and tachycardic, with a heart rate 100 bpm and 94% oxygen saturation on ambient room air.[acgcasereports.gi.org]
  • Center: Large cecal carcinoma in a 91 year-old woman with weight loss, anemia and an episode of melena; she also had a large villous adenoma in the left colon.[endoatlas.com]
  • Clinical Features Often asymptomatic Hematochezia / melena, abdominal pain, change in bowel habits Weakness, anemia, weight loss, palpable mass, obstructionSpread Direct extension, lymphatic, hematogenous (liver most common, lung, rarely bone and[slideshare.net]
  • Dark, tarry stools (melena): When bleeding occurs in the cecum and ascending colon, it usually causes black stools that can appear tar-like, rather than the bright red blood seen with bleeding lower in the digestive tract.[verywellhealth.com]
  • Dark, tarry stools (melena): When bleeding occurs in the cecum and ascending colon, it usually causes black stools that can appear tar-like, rather than the bright red blood seen with bleeding lower in the digestive tract.[verywell.com]
Peripheral Neuropathy
  • Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy. Cetuximab Cetuximab is a partially humanized monoclonal antibody against the EGFR.[cancer.gov]
Radiculopathy
  • Pelvic pain may be due to an upper lumbar or lower thoracic radiculopathy. This referral pattern must be recognized when evaluating cancer patients with occult pelvic pain.[ncbi.nlm.nih.gov]

Workup

  • Our case showed clinical features primarily because of adenocarcinoma of caecum and coexistence with other primary neoplasm, i.e., RCC that was diagnosed on CT scan of abdomen during workup staging.[omicsonline.org]
  • Investigations Colonoscopy (best), look for synchronous lesions - Alternative: air contrast barium enema (“apple core” lesion) sigmoidoscopy If a patient is FOBT ve, microcytic anemia or has a change in bowel habits, do colonoscopy Metastatic workup[slideshare.net]
  • In addition, every medical doctor should always try to perform thorough medical workup of his patients in order to avoid overlooking tiny, but sometimes crucial, aspects leading to diagnosis.[hindawi.com]
  • […] structures (T4) N0 M0 Stage IIA T3 N0 M0 Stage IIB T4a N0 M0 Stage IIC T4b N0 M0 Stage IIIA T1-2 T1 N1/N1c N2a M0 Stage IIIB T3-4a T2-3 T1-2 N1/N1c N2a N2b M0 Stage IIIC T4a T3-4a T4b N2a N2b N1-2 M0 Stage IVA T1-4 N1-3 M1a Stage IVB T1-4 N1-3 M1b See Workup[emedicine.medscape.com]
Atelectasis
  • The bronchoalveolar lavage and endobronchial biopsy revealed atypical lymphocytosis and scant growth of Staphylococcus Aureus prompting antibiotic therapy resulting in resolution of cough and atelectasis (B).[kundoc.com]
Microcytic Anemia
  • Investigations Colonoscopy (best), look for synchronous lesions - Alternative: air contrast barium enema (“apple core” lesion) sigmoidoscopy If a patient is FOBT ve, microcytic anemia or has a change in bowel habits, do colonoscopy Metastatic workup[slideshare.net]
Pleural Effusion
  • If lung metastases are present there may be pleural effusions causing breathlessness. Effusions may require drainage.[myvmc.com]
  • […] pancreatectomy膵切除術 pancreatic calcification膵石灰化 pancreatic cyst (cyst of pancreas)膵嚢胞 pancreatic duct cell carcinoma膵管癌 pancreatic functioning diagnostant (PFD) test (BT-PABA test, bentiromide test)PFD試験 BT-PABA試験、ベンチロミド試験 pancreatic juice膵液 pancreatic pleural[tokyo-med.ac.jp]

Treatment

  • This highlights the importance of accurate immunohistochemistry and imaging in planning further management and treatment.[eprints.whiterose.ac.uk]
  • The Physiology of the Cochlea Sammelreferat 113 Cesarean Section in the Treatment of Eclampsia 119 No 2 104 A MONTHLY JOURNAL 112 CONTENTS 127 nd Avenue and Twentieth Street 234 FostGraduate 212 The Symptomatology and Therapeutics of Fear A CRAMER 247[books.google.it]
  • Adult intussusception with cecal adenocarcinoma: Successful treatment by laparoscopy-assisted surgery following preoperative reduction.[wjgnet.com]
  • This enables accurate diagnosis and appropriate treatment. Conclusions This case demonstrates a rare isolated hematogenous spread to the prostate from a primary cecal adenocarcinoma, several years after definitive treatment and excision.[jmedicalcasereports.biomedcentral.com]
  • CONCLUSIONS: The radical resection of primary duodenal adenocarcinoma is considered the treatment of choice, which should be accompanied by adjuvant chemotherapy preventing a recurrence at distant sites.[link.springer.com]

Prognosis

  • Occasionally it will cause perforation, which carries a worse prognosis. We report a case of perforated adenocarcinoma of the cecum that presented as an abscess of the thigh. We also present a review of the literature on this subject.[ncbi.nlm.nih.gov]
  • Because of the small number of patients, the prognosis of adenocarcinoma arising in an intestinal duplication is not well understood.[kjim.org]
  • However, it lacks specific symptoms and its diagnosis may be delayed with poor prognosis. Villous adenomas are considered as premalignant lesions with high risk malignant transformation.[link.springer.com]
  • References 1 Beckwith JB and Palmer NF: Histopathology and prognosis of Wilms tumors: results from the First National Wilms Tumor Study. Cancer. 41:1937–1948. 1978.[spandidos-publications.com]

Etiology

  • A consistent chapter organization covers each disease’s incidence, epidemiology, etiology, and histopathology — as well as molecular biology, clinical features, diagnostic studies, and current clinical and pathologic staging — providing all the assistance[books.google.it]
  • It is most commonly emergency explorative laparotomy which clarifies the etiology of the occlusion.[annaliitalianidichirurgia.it]
  • Intussusception in the adult is a rare entity that differs greatly in etiology compared with that seen in the pediatric population.[wjgnet.com]
  • CK7 and CK20 expression patterns play a major role in the diagnosis of many carcinomas of epithelial etiology [11, 12]. CK7 is found in many ductal and glandular epithelial tissues, including breast, lung, ovary, and endometrium.[hindawi.com]
  • […] blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology EH ethnology ET etiology[decs.bvs.br]

Epidemiology

  • A consistent chapter organization covers each disease’s incidence, epidemiology, etiology, and histopathology — as well as molecular biology, clinical features, diagnostic studies, and current clinical and pathologic staging — providing all the assistance[books.google.it]
  • English: BS blood supply BL blood CF cerebrospinal fluid CI chemically induced CH chemistry CL classification CO complications CN congenital DI diagnosis DG diagnostic imaging DH diet therapy DT drug therapy EC economics EM embryology EN enzymology EP epidemiology[decs.bvs.br]
  • Summary Epidemiology Bloom syndrome (BSyn) overall prevalence is unknown, but in the Ashkenazi Jewish population it is estimated at approximately 1/ 48,000 births.[orpha.net]
  • Nevertheless, in the past few years epidemiological and clinical studies have shed new light on the management of patients with mucinous cancer.[esmo.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology 11. Prevention Increase fibre in diet Decrease animal fat and red meat, Decrease smoking and EtOH Increase exercise and decrease BMI Secondary prevention with screening 12.[slideshare.net]
  • Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 126. National Cancer Institute website.[medlineplus.gov]
  • Pathophysiology Genetically, colorectal cancer represents a complex disease, and genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma.[emedicine.medscape.com]

Prevention

  • Genetic prenatal screening for early detection is the best option for primary prevention. Keywords: isolated, Peutz–Jeghers syndrome, hematochezia This work is published and licensed by Dove Medical Press Limited.[dovepress.com]
  • CONCLUSIONS: The radical resection of primary duodenal adenocarcinoma is considered the treatment of choice, which should be accompanied by adjuvant chemotherapy preventing a recurrence at distant sites.[link.springer.com]
  • Canadian Task Force on Preventive Health Caregrading of health promotion actions A: Good evidence to  D: Fair evidence to recommend the recommend against the preventive health preventive health measure measure B: Fair evidence to  E: Good evidence[slideshare.net]
  • Prevention Early detection is the key to prevention. Having intestinal polyps removed before they become cancerous may help prevent colon cancer. Physicians recommend having a sigmoidoscopy every three to five years beginning at age 50.[healthyliving.azcentral.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!