Edit concept Create issue ticket

Cecal Adenocarcinoma

Adenocarcinoma of Cecum


Presentation

  • We report a case of perforated adenocarcinoma of the cecum that presented as an abscess of the thigh. We also present a review of the literature on this subject.[ncbi.nlm.nih.gov]
  • Analysis of the rhabdoid cells with molecular techniques is also presented.[ncbi.nlm.nih.gov]
  • We report a 55-year-old man who presented with a gastric stromal tumor and cecal adenocarcinoma, necessitating right hemicolectomy and partial gastrectomy at the same sitting.[ncbi.nlm.nih.gov]
  • A 23-year-old male presented with occult gastrointestinal bleeding and iron deficiency anemia. A Tc-99m pertechnetate abdominal scan was positive and surgery revealed an adenocarcinoma of the cecum. No Meckel's diverticulum was identified.[ncbi.nlm.nih.gov]
  • This case is presented in order to emphasize the need for thorough investigation of any umbilical lesion especially in elderly patients.[ncbi.nlm.nih.gov]
Pleural Effusion
  • If lung metastases are present there may be pleural effusions causing breathlessness . Effusions may require drainage.[myvmc.com]
Weight Loss
  • Patients who have unexplained weight loss are less likely to respond compared to patients without unexplained weight loss, and patients with cancer localized to the cecal/ascending colon were likely to have worse response to bevacizumab treatment.[jcancer.org]
  • The patient noted a decrease in her stool caliber, anorexia, and a 18-kg weight loss over the prior 8 months. She denied fevers, melena, hematochezia, recent travel, or infections.[acgcasereports.gi.org]
  • Weight loss. Pathogenesis - see pathogenesis of colorectal carcinoma . Clinical - serum: CEA elevated. [1] CA19-9 elevated. Colon cancer-specific antigen-2 (CCSA-2) elevated. [2] Relatively new; preliminary in 2014.[librepathology.org]
  • loss with no known reason Fatigue Nausea or vomiting Because you may not have symptoms at first, it's important to have screening tests.[icdlist.com]
  • Weight loss: Unintentional weight loss is often seen with advanced tumors, and should always be investigated. Unintentional weight loss is defined as the loss of 5 percent of body weight or more over a 6 to 12 month period.[verywellhealth.com]
Anemia
  • A 23-year-old male presented with occult gastrointestinal bleeding and iron deficiency anemia. A Tc-99m pertechnetate abdominal scan was positive and surgery revealed an adenocarcinoma of the cecum. No Meckel's diverticulum was identified.[ncbi.nlm.nih.gov]
  • He then suffered anemia in November 2004. Colonoscopy showed findings compatible with mild ulcerative colitis, and detected a type-2 tumor in the cecum that proved in a biopsy to be well differentiated adenocarcinoma.[jstage.jst.go.jp]
  • Case report: An 18-year-old female Egyptian patient was admitted with hematochezia and remarkable anemia.[dovepress.com]
  • Left: Adenocarcinoma in an 85 year-old man with anemia and occult bleeding. Center: Sessile lesion in an 86 year-old man with anemia but no history of bleeding.[endoatlas.com]
  • Anemia, however, was related to a better survival, especially in patients with a Dukes' B carcinoma. Clinicopathological staging according to Dukes' is closely related to survival.[ncbi.nlm.nih.gov]
Pallor
  • Anemia can lead to fatigue, weakness and pallor. The cecum, a pouchlike structure, lies very close to the appendix.[livestrong.com]
  • Physical examination revealed moderate degree of skin pallor, bilateral pedal edema and an ovoid, firm, 6 5 cm, mobile, slightly tender, intra-abdominal lump in the epigastric region.[cancerjournal.net]
Abdominal Pain
  • Patients usually present with small bowel obstruction and abdominal pain in their sixth or seventh decade of life.[nature.com]
  • Her abdominal pain radiated to her cervical, thoracic, and lumbar back. The patient noted a decrease in her stool caliber, anorexia, and a 18-kg weight loss over the prior 8 months.[acgcasereports.gi.org]
  • Three days later, upon admission, the patient complained of episodes of abdominal pain with intervals of moderate well-being, associated with nausea, vomiting and an inability to pass stool (but not gas) for 36 hours.[annaliitalianidichirurgia.it]
  • A 68-year-old male with cecal cancer was admitted to our hospital because of colicky abdominal pain after taking a laxative.[wjgnet.com]
  • This torsion can lead to abdominal pain, swelling, cramps, nausea, and vomiting.[verywellhealth.com]
Diarrhea
  • A 52 year-old Hispanic man without significant past medical, surgical or family history presented with diffuse, intermittent, crampy abdominal pain and diarrhea of one week duration.[nature.com]
  • Symptoms of colorectal cancer include Diarrhea or constipation A feeling that your bowel does not empty completely Blood (either bright red or very dark) in your stool Stools that are narrower than usual Frequent gas pains or cramps, or feeling full or[icdlist.com]
  • Chemoradiation-related toxicity Acute gastrointestinal toxicity as diarrhea and abdominal pain was the most frequent complication in patients receiving adjuvant chemoradiation.[e-roj.org]
  • Apartment, 114/A, Barasat Road, Kolkata - 700 110 India Source of Support: None, Conflict of Interest: None DOI: 10.4103/0973-1482.126483 A 65-year-old male presented with painless hematochezia associated with episodic cramps in upper abdomen, watery diarrhea[cancerjournal.net]
  • […] important prognostic factor Clinical features Increased carcinoma risk in patients with polyposis syndromes, Lynch syndrome and inflammatory bowel disease Right sided tumors cause anemia, weakness and fatigue Left sided tumors cause change in bowel habits (diarrhea[pathologyoutlines.com]
Constipation
  • Constipation. Symptoms of bowel obstruction - nausea, vomiting. Weight loss. Pathogenesis - see pathogenesis of colorectal carcinoma . Clinical - serum: CEA elevated. [1] CA19-9 elevated.[librepathology.org]
  • Duplications may present a variety of clinical findings, including acute intestinal obstruction, palpable abdominal mass, vague abdominal pain over prolonged periods, or intermittent gastrointestinal bleeding, nausea, vomiting, abdominal distension, and constipation[kjim.org]
  • Symptoms of colorectal cancer include Diarrhea or constipation A feeling that your bowel does not empty completely Blood (either bright red or very dark) in your stool Stools that are narrower than usual Frequent gas pains or cramps, or feeling full or[icdlist.com]
  • Bowel symptoms that can occur in patients with cecal carcinoma include abdominal pain, constipation, weight loss, loss of appetite and vomiting, notes Santosh Kumar Mondal of the Department of Pathology, Medical College, Kolkata, India in a 2009 issue[livestrong.com]
  • The common presenting symptoms include constipation, diarrhea, colicky abdominal pain, change in bowel habit, bowel obstruction, lower gastrointestinal bleeding, intussusception or prolapse.[currentsurgery.org]
Abdominal Mass
  • A 41-year-old male patient was admitted because of a palpable abdominal mass. Abdominal computed tomography revealed a 6-cm, peripheral wall-enhanced, round, cystic mass in the cecal area.[kjim.org]
  • […] serrated adenoma esp. with dysplasia Syndromes familial adenomatous polyposis , Lynch syndrome , Peutz-Jeghers syndrome , Juvenile polyposis syndrome , serrated polyposis syndrome , MUTYH polyposis syndrome , Cowden syndrome Signs /-blood in stools, /-abdominal[librepathology.org]
  • Case Report A 65-year-old male presented with history of painless passage of bright red blood per anum for 5 months, episodic cramps over mid upper abdomen for 3 months, slowly growing mid upper abdominal mass and intermittent episodes of watery diarrhea[cancerjournal.net]
  • Of any age with a right lower abdominal mass consistent with involvement of the large bowel.[patient.info]
Melena
  • She denied fevers, melena, hematochezia, recent travel, or infections. She was afebrile but mildly hypertensive and tachycardic, with a heart rate 100 bpm and 94% oxygen saturation on ambient room air.[acgcasereports.gi.org]
  • Center: Large cecal carcinoma in a 91 year-old woman with weight loss, anemia and an episode of melena; she also had a large villous adenoma in the left colon.[endoatlas.com]
  • Dark, tarry stools (melena): When bleeding occurs in the cecum and ascending colon, it usually causes black stools that can appear tar-like, rather than the bright red blood seen with bleeding lower in the digestive tract.[verywellhealth.com]
  • The patient denied any history of hematemesis, dysphagia, odynophagia, melena, bright red blood per rectum, or jaundice. His past medical history was significant for rectal abscess, which resolved with incision and drainage 14 years ago.[currentsurgery.org]
Radiculopathy
  • Pelvic pain may be due to an upper lumbar or lower thoracic radiculopathy. This referral pattern must be recognized when evaluating cancer patients with occult pelvic pain.[ncbi.nlm.nih.gov]

Workup

  • […] structures (T4) N0 M0 Stage IIA T3 N0 M0 Stage IIB T4a N0 M0 Stage IIC T4b N0 M0 Stage IIIA T1-2 T1 N1/N1c N2a M0 Stage IIIB T3-4a T2-3 T1-2 N1/N1c N2a N2b M0 Stage IIIC T4a T3-4a T4b N2a N2b N1-2 M0 Stage IVA T1-4 N1-3 M1a Stage IVB T1-4 N1-3 M1b See Workup[emedicine.medscape.com]
Staphylococcus Aureus
  • The bronchoalveolar lavage and endobronchial biopsy revealed atypical lymphocytosis and scant growth of Staphylococcus Aureus prompting antibiotic therapy resulting in resolution of cough and atelectasis (B).[kundoc.com]
Pleural Effusion
  • If lung metastases are present there may be pleural effusions causing breathlessness . Effusions may require drainage.[myvmc.com]

Treatment

  • This highlights the importance of accurate immunohistochemistry and imaging in planning further management and treatment.[eprints.whiterose.ac.uk]
  • Adult intussusception with cecal adenocarcinoma: Successful treatment by laparoscopy-assisted surgery following preoperative reduction.[wjgnet.com]
  • CONCLUSIONS: The radical resection of primary duodenal adenocarcinoma is considered the treatment of choice, which should be accompanied by adjuvant chemotherapy preventing a recurrence at distant sites.[link.springer.com]
  • This unique pictorial resource is a superb complement to treatment handbooks and major oncological texts.[books.google.it]
  • These simple treatment plans could not spare the small bowel, which is main cause of treatment-related toxicity in abdominal radiation.[e-roj.org]

Prognosis

  • Occasionally it will cause perforation, which carries a worse prognosis. We report a case of perforated adenocarcinoma of the cecum that presented as an abscess of the thigh. We also present a review of the literature on this subject.[ncbi.nlm.nih.gov]
  • Analysis was performed to determine the influence of stage and grade of the primary tumor on prognosis. Implications for adjuvant therapy are discussed.[ncbi.nlm.nih.gov]
  • Because of the small number of patients, the prognosis of adenocarcinoma arising in an intestinal duplication is not well understood.[kjim.org]
  • However, it lacks specific symptoms and its diagnosis may be delayed with poor prognosis. Villous adenomas are considered as premalignant lesions with high risk malignant transformation.[link.springer.com]
  • References 1 Beckwith JB and Palmer NF: Histopathology and prognosis of Wilms tumors: results from the First National Wilms Tumor Study. Cancer. 41:1937–1948. 1978.[spandidos-publications.com]

Etiology

  • A consistent chapter organization covers each disease’s incidence, epidemiology, etiology, and histopathology — as well as molecular biology, clinical features, diagnostic studies, and current clinical and pathologic staging — providing all the assistance[books.google.it]
  • It is most commonly emergency explorative laparotomy which clarifies the etiology of the occlusion.[annaliitalianidichirurgia.it]
  • Intussusception in the adult is a rare entity that differs greatly in etiology compared with that seen in the pediatric population.[wjgnet.com]
  • Etiology The true etiology of gastrointestinal lipomas is still not clearly understood [ 28 , 29 ] . Colonic lipomas originate from the sub mucosa and protrude into the gastrointestinal lumen.[currentsurgery.org]
  • With regard to the etiology of axillary lymph node metastasis of colorectal carcinoma, the last case cited suggests that the axillary lymph node metastasis may have developed from the site of the breast metastasis, which is considered as hematogenous[surgicalcasereports.springeropen.com]

Epidemiology

  • A consistent chapter organization covers each disease’s incidence, epidemiology, etiology, and histopathology — as well as molecular biology, clinical features, diagnostic studies, and current clinical and pathologic staging — providing all the assistance[books.google.it]
  • Nevertheless, in the past few years epidemiological and clinical studies have shed new light on the management of patients with mucinous cancer.[esmo.org]
  • Using nationally representative Surveillance, Epidemiology, and End Results (SEER) data, we compared survival rates associated with colon cancer stages defined according to both AJCC systems.[academic.oup.com]
  • Cancer of the large intestine: epidemiologic findings. Dis Colon Rectum 1973;16:371–7. 3. Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer 200;101:403–8. 4. Tong D, Russell AH, Dawson LE, et al.[e-roj.org]
  • However, most of these studies were retrospective epidemiologic studies and have yet to be validated in prospective, placebo-controlled, interventional trials.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management . 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 126. National Cancer Institute website.[medlineplus.gov]
  • Pathophysiology Genetically, colorectal cancer represents a complex disease, and genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma.[emedicine.medscape.com]

Prevention

  • Genetic prenatal screening for early detection is the best option for primary prevention. Keywords: isolated, Peutz–Jeghers syndrome, hematochezia This work is published and licensed by Dove Medical Press Limited.[dovepress.com]
  • CONCLUSIONS: The radical resection of primary duodenal adenocarcinoma is considered the treatment of choice, which should be accompanied by adjuvant chemotherapy preventing a recurrence at distant sites.[link.springer.com]
  • Prevention Early detection is the key to prevention. Having intestinal polyps removed before they become cancerous may help prevent colon cancer. Physicians recommend having a sigmoidoscopy every three to five years beginning at age 50.[healthyliving.azcentral.com]
  • Prevention Get screened for colon cancer People with an average risk of colon cancer can consider screening beginning at age 50.[mayoclinic.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!