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Ceftazidime

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Presentation

  • A 73-year-old diabetic presented with septic arthritis of the knee; Pseudomonas aeruginosa was isolated.[ncbi.nlm.nih.gov]
  • It is an insidious disease because of its variable clinical presentation, possible long-term asymptomatic carriage, broad-spectrum resistance to first-line antibiotics, and high mortality rate.[ncbi.nlm.nih.gov]
  • Results for three patients with pseudomonal scleritis who were treated with both topical anti-infectives and a combination of intravenous ceftazidime and aminoglycoside are presented in this case series.[ncbi.nlm.nih.gov]
  • We present the case of a 54-year-old man who was treated with ceftazidime for pneumonia and developed thrombocytosis during the treatment course.[ncbi.nlm.nih.gov]
  • A case report is presented on a 78-year-old man who entered the intensive care unit due to respiratory failure secondary to nosocomial pneumonia in the postoperative period of a laparoscopic hepatic bisegmentectomy for a hepatocarcinoma.[ncbi.nlm.nih.gov]
Asymptomatic
  • We report the case of a 59-year-old Chinese man who showed an asymptomatic coagulation factor V deficiency pattern after second intravenous treatment with ceftazidime.[ncbi.nlm.nih.gov]
  • It is an insidious disease because of its variable clinical presentation, possible long-term asymptomatic carriage, broad-spectrum resistance to first-line antibiotics, and high mortality rate.[ncbi.nlm.nih.gov]
  • The patient continues to remain asymptomatic. The case re-emphasizes the need to monitor the trend of B. pseudomallei in India, particularly the development of ceftazidime resistance, which incidentally is the drug of choice.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Tissue levels in patients after intravenous administration of ceftazidime. J Antimicrob Chemother. 1985; 16:757-61. 244. Kishiyam JL, Adelman DC. The cross-reactivity and immunology of β-lactam antibiotics. Drug Saf. 1994; 10:318-27. 245.[drugs.com]
  • Tissue levels in patients after intravenous administration of ceftazidime. J Antimicrob Chemother. 1985; 16:757-61. [PubMed 3912366] 244. Kishiyam JL, Adelman DC. The cross-reactivity and immunology of β-lactam antibiotics.[web.archive.org]
Fishing
  • KEYWORDS: Ceftazidime cross-linker; Cyamopsis tetragonoloba seeds; Ethylenediamine; Fish scale collagen; Guar gum[ncbi.nlm.nih.gov]
Pleural Effusion
  • We describe a case of a 39-year-old diabetic patient with left elbow septic arthritis, multiple liver, splenic abscesses, pneumonia, pleural effusion, followed by sepsis syndrome.[ncbi.nlm.nih.gov]
Fracture
  • Pseudomonas aeruginosa isolated from two patients with empyema and one with bronchopneumonia became less sensitive after treatment with ceftazidime, while Ps. aeruginosa persisted in a patient with an infected compound fracture of the tibia treated with[ncbi.nlm.nih.gov]

Workup

Epileptiform Activity
  • Repeated evaluation on day 6 showed normal EEG without epileptiform activity. She was later discharged with full recovery.[ncbi.nlm.nih.gov]
Mycobacterium Avium Complex
  • Objectives: To compare the efficacy of ceftazidime/avibactam plus tedizolid-based combination regimens with the standard therapy of azithromycin, ethambutol and rifabutin for the treatment of pulmonary Mycobacterium avium complex (MAC) disease.[ncbi.nlm.nih.gov]
  • Objectives: To determine if ceftaroline and ceftazidime combined with avibactam are efficacious against pulmonary Mycobacterium avium complex (MAC) disease.[ncbi.nlm.nih.gov]
Pleural Effusion
  • We describe a case of a 39-year-old diabetic patient with left elbow septic arthritis, multiple liver, splenic abscesses, pneumonia, pleural effusion, followed by sepsis syndrome.[ncbi.nlm.nih.gov]

Treatment

  • Treatment options are usually limited and effective treatment of infections caused by these pathogens is a considerable challenge for clinicians.[ncbi.nlm.nih.gov]
  • Ceftazidime treatment was associated with a 50% (95% CI 19-81%) lower overall mortality than conventional treatment (74% vs 37%; p 0.009) and should now become the treatment of choice for severe melioidosis.[ncbi.nlm.nih.gov]
  • Expert opinion: The role of ceftazidime-avibactam in combination with metronidazole in the treatment of cIAI is still to be defined.[ncbi.nlm.nih.gov]
  • RESULTS: The ratio of released ceftazidime and fluconazole was 453% and 648%, respectively, higher when used for treatment proportions than prophylaxis proportions.[ncbi.nlm.nih.gov]
  • This combination was recently recommended for the treatment of complicated urinary tract infections, including acute pyelonephritis, in adults with limited or no alternative treatment options.[ncbi.nlm.nih.gov]

Prognosis

  • Malignant external otitis: report on therapy with ceftazidime and review of therapy and prognosis. Clin Infect Dis. 1990; 12:173-80. 354. Tunkel AR, Harman BJ, Kaplan SL et al. Practice guidelines for the management of bacterial meningitis.[drugs.com]

Etiology

  • On admission at our hospital, anamnesis regarding etiology and management of prosthesis infection was not available. On clinical, laboratory findings and imaging studies infection was not suspected. A hip prosthesis was reimplanted.[ncbi.nlm.nih.gov]

Epidemiology

  • Author information 1 Department of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 2 Department of Infectious Diseases, Hospital Universitario Reina Sofía, Córdoba, Spain. 3 Instituto Maimónides de Investigación[ncbi.nlm.nih.gov]
  • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA).[drugs.com]
Sex distribution
Age distribution

Pathophysiology

  • These findings support the pathophysiological theory of Kounis syndrome, with cellular infiltration proposed as the cause of myocardial injury rather than an effect related to the healing process.[ncbi.nlm.nih.gov]

Prevention

  • This antagonism could be prevented by inhibition of derepression of beta-lactamase with clindamycin.[ncbi.nlm.nih.gov]
  • To prevent possible relapses, an oral maintenance regimen of amoxicillin and clavulanic acid was prescribed for a period of three months. Melioidosis is caused by Pseudomonas pseudomallei.[ncbi.nlm.nih.gov]
  • Additionally, the use of serum drug level monitoring may be necessary to better prevent or predict toxicity.[ncbi.nlm.nih.gov]
  • Author information 1 Department of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 2 Department of Infectious Diseases, Hospital Universitario Reina Sofía, Córdoba, Spain. 3 Instituto Maimónides de Investigación[ncbi.nlm.nih.gov]
  • CONCLUSION: Our in vitro findings suggest that ceftazidime and fluconazole can be added into polymethyl methacrylate for the prevention/treatment of infections associated to joint surgery.[ncbi.nlm.nih.gov]

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