We report a case of biopsy-proven acute interstitial nephritis in a 73-year-old diabetic woman, who had taken celecoxib for more than 1 year before presentation. [ncbi.nlm.nih.gov]

In this review, the authors present the status of preclinical development of anticancer analogs of celecoxib that are COX-2 inactive, with an emphasis on 2,5-dimethyl-celecoxib (DMC) and OSU-03012. [doi.org]

• Disability

  Simmons claimed to have discovered an enzyme that caused those side effects, and the new drug works to disable it. Continue reading the main story [nytimes.com]

  Alleviating these symptoms enables people to be more physically active, which has been shown to improve range of motion and reduce disability. See Rheumatoid Arthritis in the Spine Juvenile rheumatoid arthritis. [spine-health.com]

  Request copy Download PDF View all Life Science Posters Parkinson's Poster Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. [tocris.com]

• Epilepsy

  Download PDF View all Life Science Posters Epilepsy Poster Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. [tocris.com]

  […] pressure and migraines fluconazole, an antifungal agent lithium, a medicine used to treat some mood disorders warfarin, apixaban, dabigatran, and rivaroxaban, medicines used to stop blood clots rifampicin, an antibiotic carbamazepine, a medicine used for epilepsy [mydr.com.au]

  […] other heart problems fluconazole, an antifungal agent lithium, a medicine used to treat some mood disorders warfarin, apixaban, dabigatran, and rivaroxaban, medicines used to stop blood clots rifampicin, an antibiotic carbamazepine, a medicine used for epilepsy [news-medical.net]

• Cough

  The most commonly occurring (≥5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [rxlist.com]

  You should call your doctor immediately if you experience black, bloody or tarry stools or you cough up blood or vomit that looks like coffee grounds. [practicalpainmanagement.com]

  The most commonly occurring (≥ 5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [dailymed.nlm.nih.gov]

  Headache Dizziness Tell your doctor if troublesome Serious stomach problems such as really bad stomach pain, blood in the stool, black or dark colour in your stool, cough or vomit up blood, or dark coloured vomit Tell your doctor immediately or ring HealthLine [healthnavigator.org.nz]

• Pharyngitis

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  In the same study, a nonsignificant increased risk was observed for oral and pharyngeal cancer. [doi.org]

  […] unsteadiness watery or bloody diarrhea For Healthcare Professionals Applies to celecoxib: oral capsule General The most commonly reported adverse events included abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, accidental injury, dizziness, pharyngitis [drugs.com]

  Peripheral Edema 2.1% 1.1% 2.1% 1.0% 3.5% Injury-Accidental 2.9% 2.3% 3.0% 2.6% 3.2% Central, Peripheral Nervous system Dizziness 2.0% 1.7% 2.6% 1.3% 2.3% Headache 15.8% 20.2% 14.5% 15.5% 15.4% Psychiatric Insomnia 2.3% 2.3% 2.9% 1.3% 1.4% Respiratory Pharyngitis [rxlist.com]

• Abdominal Pain

  The most commonly occurring (≥5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [rxlist.com]

  The most commonly occurring (≥ 5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [dailymed.nlm.nih.gov]

  […] reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation, abdominal [medical-dictionary.thefreedictionary.com]

• Loss of Appetite

  Contact your doctor immediately if you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin. [medbroadcast.com]

• Intestinal Perforation

  • Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation, which can be fatal. These events can occur at any time during therapy and without warning. Elderly patients are at greater risk. [medical-dictionary.thefreedictionary.com]

  […] obstruction, intestinal perforation, gastrointestinal bleeding, colitis with bleeding, esophageal perforation, pancreatitis, ileus General: Sepsis, sudden death Liver and biliary: Cholelithiasis Hemic and lymphatic: Thrombocytopenia Nervous: Ataxia, [dailymed.nlm.nih.gov]

• Abdominal Distension

  (4.4) 1 (1.3) Diarrhea 6 (2.7) 2 (2.9) 0 Dyspepsia 5 (2.2) 2 (2.9) 1 (1.3) Gastroesophageal reflux disease 6 (2.7) 0 0 Constipation 4 (1.8) 0 1 (1.3) Abdominal pain lower 3 (1.3) 0 0 Abdominal pain upper 1 (0.4) 2 (2.9) 0 Vomiting 0 1 (1.5) 1 (1.3) Abdominal [ped-rheum.biomedcentral.com]

• Tachycardia

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  […] pectors, myocardial infarction, tachycardia)). [dx.doi.org]

  Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction, palpitation, tachycardia, and arrhythmia have been reported in 0.1% to 1.9% of patients taking celecoxib 100 to 200 mg twice a day or 200 mg once a day. [drugs.com]

  […] fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia, vertigo Hearing and vestibular: Deafness, tinnitus Heart rate and rhythm: Palpitation, tachycardia [dailymed.nlm.nih.gov]

• Liver Dysfunction

  […] cardiovascular disease (may ↑ risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, especially with prolonged use or use of higher doses); avoid use in patients with recent MI or HF; Pre-existing renal disease, heart failure, liver [drugguide.com]

  A 50 percent dose reduction is recommended in patients with moderate liver dysfunction. Use of celecoxib is not recommended in patients with severe liver impairment or advanced kidney disease. [ems1.com]

  dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers Anemia may occur; monitor hemoglobin or hematorcrit in long term treatment patients Use caution in pediatrics with [reference.medscape.com]

  […] necrosis, and hepatic failure (sometimes fatal) reported rarely with NSAIAs. 1 Monitor for symptoms and/or signs suggesting liver dysfunction; monitor abnormal liver function test results. 1 Discontinue if signs or symptoms of liver disease or systemic [drugs.com]

• Flushing

  Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, or unusual flushing or warmth of the skin. [mayoclinic.org]

  cyst, pain Postmarketing reports : Conjunctivitis [ Ref ] Asthenia fatigue, fever, hot flushes, influenza -like illness, cyst, and pain were reported in 0.1% to 1.9% of patients taking celecoxib 100 to 200 mg twice a day or 200 mg once a day. [ Ref [drugs.com]

  However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. [nlm.nih.gov]

  […] stomatitis, tenesmus, vomiting Cardiovascular: Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction General: Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes [dailymed.nlm.nih.gov]

  Researchers are investigating whether cognitive behavioural therapy can help control hot flushes and night sweats. [cancerresearchuk.org]

• Angioedema

  Adverse reactions such as urticaria, angioedema, asthma, and anaphylaxis are known to be associated with nonsteroidal anti-inflammatory agents (NSAIDs). [ncbi.nlm.nih.gov]

  In October 2002, the CPMP asked additional questions relating to serious hypersensitivity reactions (anaphylaxis and angioedema) and serious skin reactions including Stevens- Johnson syndrome, toxic epidermal necrolysis, erythema multiforme and exfoliative [ema.europa.eu]

  […] reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure Cardiovascular: Vasculitis, deep venous thrombosis General: Anaphylactoid reaction, angioedema [dailymed.nlm.nih.gov]

  […] treatment of patients with: 3 Acute pain Osteoarthritis Rheumatoid arthritis Ankylosing spondylitis Primary dysmenorrhoea As with other NSAIDs, celecoxib is contraindicated in patients with NSAID hypersensitivity, e.g. those with asthma, urticaria, angioedema [bpac.org.nz]

• Tinnitus

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  Rare side effects of celecoxib include: allergic reactions such as skin rashes or wheezing headaches, dizziness or ringing in the ears (tinnitus) unusual bruising or bleeding kidney problems gastrointestinal problems — celecoxib can cause irritation to [arthritis.ca]

  One patient had tinnitus through the trial on both drugs. Two other patients had this with celecoxib only. Other severe events on celecoxib were trembles, upper body rash, loss of energy and indigestion/heartburn. [doi.org]

• Suggestibility

  These results suggest that antimitotic drug-resistant cancer cells can be strongly sensitized by co-treatment with COX-2 inhibitors, without P-gp inhibitory activity. [ncbi.nlm.nih.gov]

• Insomnia

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  Common side effects of celecoxib include ankle swelling/edema, dizziness, headache, insomnia, skin rash, stomach or abdominal upset or pain, cough or respiratory infections. Celecoxib may cause or worsen high blood pressure. [practicalpainmanagement.com]

  Adverse Reactions/Side Effects CNS: dizziness, headache, insomnia CV: HF, MYOCARDIAL INFARCTION, STROKE, THROMBOSIS, edema, hypertension GI: GI BLEEDING, abdominal pain, diarrhea, dyspepsia, flatulence, nausea Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON [drugguide.com]

  Back pain (2.8 percent), peripheral edema (2.1 percent), dizziness (2 percent), insomnia (2.3 percent), and skin rash are also common. [ems1.com]

• Paresthesia

  […] atherosclerosis, sinus bradycardia, ventricular hypertrophy, or deep vein thrombosis were reported in at least 0.1% of patients to less than 1% of patients. [ Ref ] Nervous system Leg cramps, hypertonia, hypoesthesia, migraine, neuralgia, neuropathy, paresthesia [drugs.com]

  Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia [dailymed.nlm.nih.gov]

  Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral: Leg cramps, hypertonia, hypoesthesia, Nervous system: migraine, paresthesia [rxlist.com]

• Encephalopathy

  There was no other identifiable cause of ACS such as any recognized cause of metabolic encephalopathy, meningoencephalitis, cerebrovascular accident, or drug intoxication. [ncbi.nlm.nih.gov]

  Laurence Lalanne, Marie-Emmanuelle Meriot, Elisabeth Ruppert, Marie-Agathe Zimmermann, Jean-Marie Danion and Pierre Vidailhet, Attempted infanticide and suicide inaugurating catatonia associated with Hashimoto’s encephalopathy: a case report, BMC Psychiatry [doi.org]

  Rather, they are a feature of many insults to and disease of the central nervous system including (but not limited to) acute head injury, stroke, spinal cord injury, multiple sclerosis, HIV infection of the brain and other viral encephalopathies, and [google.com]

Cardiac workup was initiated because of the recurrence and severity of bradycardia and hypotension; results of the workup were unremarkable. The patient was discharged in stable condition. [ncbi.nlm.nih.gov]

[…] mL), 3-bromo-2-phenylpyridine (Intermediate 1; 85mg), 4-( tert -butyldimethylsilyloxy)phenylboronic acid (184 mg), tetrakis(triphenylphosphine)palladium(0) (40 mg) and THF (oxygen free; 1 mL) was reacted for 18 hrs under reflux, subjected to aqueous workup [doi.org]

• Hypercholesterolemia

  […] to 1.9% of patients taking celecoxib 100 to 200 mg twice a day or 200 mg once a day. [ Ref ] Metabolic Uncommon (0.1% to 1%): Hyperkalemia Frequency not reported : Increased blood urea nitrogen, increased creatinine phosphokinase, diabetes mellitus, hypercholesterolemia [drugs.com]

  […] paresthesia, vertigo Hearing and vestibular: Deafness, tinnitus Heart rate and rhythm: Palpitation, tachycardia Liver and biliary: Hepatic enzyme increased (including SGOT increased, SGPT increased) Metabolic and nutritional: BUN increased, CPK increased, hypercholesterolemia [dailymed.nlm.nih.gov]

  […] paresthesia, vertigo Hearing and vestibular: Deafness, tinnitus Heart rate and rhythm: Palpitation, tachycardia Liver and biliary: Hepatic enzyme increased (including SGOT increased, SGPT increased) Metabolic and BUN increased, CPK increased, nutritional: hypercholesterolemia [rxlist.com]

• Transaminases Increased

  Diclofenac had worse hepatic tolerability than celecoxib in terms of AEs of transaminase increase. The occurrence of headache as a TEAE was unexpectedly high in all of the treatment groups. [dx.doi.org]

For the primary analysis baseline, VAS and age were used as covariates; and sex, treatment and pooled centre as factors. Treatment contrasts were mainly computed with two-sided 95% CIs for the treatment difference between celecoxib and diclofenac. [dx.doi.org]

2); 100 mg celecoxib (Treatment 3); and 100 mg IR tramadol and 100 mg celecoxib (Treatment 4). [ncbi.nlm.nih.gov]

[…] celecoxib [ sel″ĕ-kok´sib ] a nonsteroidal antiinflammatory drug of the cox-2 inhibitors group, administered orally for symptomatic treatment of arthritis. celecoxib Celebrex Pharmacologic class : Nonsteroidal cyclooxygenase-2 (COX-2) inhibitor, nonsteroidal [medical-dictionary.thefreedictionary.com]

KEYWORDS: PIK3CA; breast cancer; celecoxib; predictive biomarker; prognosis [ncbi.nlm.nih.gov]

Pleomorphic ILCs are more invasive in nature with poor prognosis compared to other ILCs [ 18 ]. [doi.org]

Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension. 1994; 24 : 793–801. [ahajournals.org]

OBJECTIVE: Recent studies have focused on the role of inflammatory cascades as one of the possible etiologic factors of bipolar disorder. [ncbi.nlm.nih.gov]

[…] study K Off NSAID 69–N/A Primary sclerosing cholangitis Still present Permanently discontinued Other illness: primary sclerosing cholangitis G Off NSAID 452–N/A Septic arthritis Still present No action taken Other illness: septic arthritis of unknown etiology [ped-rheum.biomedcentral.com]

Because they are unique features of the disease, many investigators have focused on the etiology and effects of amyloid plaques and neurofibrillary tangles. [google.com]

Finally, a series of epidemiologic analyses have also raised questions about the cardiovascular safety of the coxibs. [dx.doi.org]

3 Department of Entomology, University of California Davis, Sacramento, California, United States of America. 4 UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, California, United States of America. 5 Department of Epidemiology [ncbi.nlm.nih.gov]

Zeidler Epidemiology and economics of NSAIDs-induced gastropathy Scand J Rheumatol, 21 (1992), pp. 3-8 [3.] A. Lanas, M.T. [gacetasanitaria.org]

Epidemiology of colorectal adenomas. Epidemiol Rev 1994 ;16: 273 - 297 8. Neugut AI, Jacobson JS, DeVivo I. Epidemiology of colorectal adenomatous polyps. Cancer Epidemiol Biomarkers Prev 1993 ;2: 159 - 176 9. [doi.org]

The virus may play a role in the pathophysiology of migraine headaches, and this is the first case report of successful migraine headache treatment with these medications. [ncbi.nlm.nih.gov]

[…] than that commonly used in adults and children with; 2) favourable side effect profile of this drug (particularly at the dosing required); 3) the fact that celecoxib crosses the blood brain barrier and 4) demonstration of efficacy in a genetically and pathophysiologically [clinicaltrials.gov]

Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology/diagnosis/management. 6th ed. Vol. 1. Philadelphia: W.B. Saunders, 1998:343-57. 6. Meade EA, Smith WL, DeWitt DL. [dx.doi.org]

[…] long term prevention studies. [web.archive.org]

CONCLUSIONS: Oral administration of celecoxib had no beneficial preventive effect on PEP. [ncbi.nlm.nih.gov]

This trial documented prevention of premalignant adenomas with celecoxib but was not designed to assess effectiveness of the drug for the prevention of colorectal cancer, and no claims about its use in this regard can be made from our data. [doi.org]