We report a case of biopsy-proven acute interstitial nephritis in a 73-year-old diabetic woman, who had taken celecoxib for more than 1 year before presentation. [ncbi.nlm.nih.gov]

In this review, the authors present the status of preclinical development of anticancer analogs of celecoxib that are COX-2 inactive, with an emphasis on 2,5-dimethyl-celecoxib (DMC) and OSU-03012. [doi.org]

• Prolonged Bleeding

  Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. [reference.medscape.com]

• Cough

  The most commonly occurring (≥5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [rxlist.com]

  The most commonly occurring (≥ 5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [dailymed.nlm.nih.gov]

  You should call your doctor immediately if you experience black, bloody or tarry stools or you cough up blood or vomit that looks like coffee grounds. [practicalpainmanagement.com]

  Check with your doctor immediately if any of the following side effects occur while taking celecoxib: More Common Cough fever skin rash sneezing sore throat swelling of the face, fingers, feet, or lower legs Less Common or Rare Abnormal growth in the [drugs.com]

• Pharyngitis

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  In the same study, a nonsignificant increased risk was observed for oral and pharyngeal cancer. [doi.org]

  […] unsteadiness watery or bloody diarrhea For Healthcare Professionals Applies to celecoxib: oral capsule General The most commonly reported adverse events included abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, accidental injury, dizziness, pharyngitis [drugs.com]

  13%) 1-10% Fever (9%) Dyspepsia (8.8%) Upper respiratory tract infection (8.1%) Arthralgia (7%) Cough (7%) Vomiting (6%) Diarrhea (5.6%) Gastroesophageal reflux (5%) Sinusitis (5%) Abdominal pain (4.1%) Nausea (3.5%) Back pain (2.8%) Insomnia (2.3%) Pharyngitis [reference.medscape.com]

• Abdominal Pain

  The most commonly occurring (≥5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [rxlist.com]

  The most commonly occurring (≥ 5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [dailymed.nlm.nih.gov]

  Stop taking celecoxib and get medical help right away if you notice any of these rare but serious side effects: stomach/abdominal pain that doesn't go away, black/tarry stools, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of [webmd.com]

  pain, arthralgia (joint pain), cough, diarrhea, fever, headache, upper respiratory infection, nausea, upper abdominal pain, and vomiting. [spine-health.com]

• Intestinal Perforation

  • Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation, which can be fatal. These events can occur at any time during therapy and without warning. Elderly patients are at greater risk. [medical-dictionary.thefreedictionary.com]

  […] obstruction, intestinal perforation, gastrointestinal bleeding, colitis with bleeding, esophageal perforation, pancreatitis, ileus General: Sepsis, sudden death Liver and biliary: Cholelithiasis Hemic and lymphatic: Thrombocytopenia Nervous: Ataxia, [dailymed.nlm.nih.gov]

  […] risk NSAIDs are contraindicated for perioperative pain in setting of coronary artery bypass graft (CABG) surgery Gastrointestinal risk NSAIDs increase risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and gastric or intestinal [reference.medscape.com]

• Tachycardia

  […] pectors, myocardial infarction, tachycardia)). [dx.doi.org]

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction, palpitation, tachycardia, and arrhythmia have been reported in 0.1% to 1.9% of patients taking celecoxib 100 to 200 mg twice a day or 200 mg once a day. [drugs.com]

  […] fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia, vertigo Hearing and vestibular: Deafness, tinnitus Heart rate and rhythm: Palpitation, tachycardia [dailymed.nlm.nih.gov]

• Liver Dysfunction

  […] cardiovascular disease (may ↑ risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, especially with prolonged use or use of higher doses); avoid use in patients with recent MI or HF; Pre-existing renal disease, heart failure, liver [drugguide.com]

  dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers Anemia may occur; monitor hemoglobin or hematorcrit in long term treatment patients Use caution in pediatrics with [reference.medscape.com]

  A 50 percent dose reduction is recommended in patients with moderate liver dysfunction. Use of celecoxib is not recommended in patients with severe liver impairment or advanced kidney disease. [ems1.com]

• Angioedema

  Adverse reactions such as urticaria, angioedema, asthma, and anaphylaxis are known to be associated with nonsteroidal anti-inflammatory agents (NSAIDs). [ncbi.nlm.nih.gov]

  In October 2002, the CPMP asked additional questions relating to serious hypersensitivity reactions (anaphylaxis and angioedema) and serious skin reactions including Stevens- Johnson syndrome, toxic epidermal necrolysis, erythema multiforme and exfoliative [ema.europa.eu]

  […] reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure Cardiovascular: Vasculitis, deep venous thrombosis General: Anaphylactoid reaction, angioedema [dailymed.nlm.nih.gov]

• Tinnitus

  Rare side effects of celecoxib include: allergic reactions such as skin rashes or wheezing headaches, dizziness or ringing in the ears (tinnitus) unusual bruising or bleeding kidney problems gastrointestinal problems — celecoxib can cause irritation to [arthritis.ca]

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  One patient had tinnitus through the trial on both drugs. Two other patients had this with celecoxib only. Other severe events on celecoxib were trembles, upper body rash, loss of energy and indigestion/heartburn. [dx.doi.org]

• Insomnia

  Common side effects of celecoxib include ankle swelling/edema, dizziness, headache, insomnia, skin rash, stomach or abdominal upset or pain, cough or respiratory infections. Celecoxib may cause or worsen high blood pressure. [practicalpainmanagement.com]

  Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

  Adverse Reactions/Side Effects CNS: dizziness, headache, insomnia CV: HF, MYOCARDIAL INFARCTION, STROKE, THROMBOSIS, edema, hypertension GI: GI BLEEDING, abdominal pain, diarrhea, dyspepsia, flatulence, nausea Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON [drugguide.com]

  Hypertension (13%) 1-10% Fever (9%) Dyspepsia (8.8%) Upper respiratory tract infection (8.1%) Arthralgia (7%) Cough (7%) Vomiting (6%) Diarrhea (5.6%) Gastroesophageal reflux (5%) Sinusitis (5%) Abdominal pain (4.1%) Nausea (3.5%) Back pain (2.8%) Insomnia [reference.medscape.com]

• Paresthesia

  […] atherosclerosis, sinus bradycardia, ventricular hypertrophy, or deep vein thrombosis were reported in at least 0.1% of patients to less than 1% of patients. [ Ref ] Nervous system Leg cramps, hypertonia, hypoesthesia, migraine, neuralgia, neuropathy, paresthesia [drugs.com]

  Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia [dailymed.nlm.nih.gov]

  Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral: Leg cramps, hypertonia, hypoesthesia, Nervous system: migraine, paresthesia [rxlist.com]

Cardiac workup was initiated because of the recurrence and severity of bradycardia and hypotension; results of the workup were unremarkable. The patient was discharged in stable condition. [ncbi.nlm.nih.gov]

• Transaminases Increased

  Diclofenac had worse hepatic tolerability than celecoxib in terms of AEs of transaminase increase. The occurrence of headache as a TEAE was unexpectedly high in all of the treatment groups. [dx.doi.org]

For the primary analysis baseline, VAS and age were used as covariates; and sex, treatment and pooled centre as factors. Treatment contrasts were mainly computed with two-sided 95% CIs for the treatment difference between celecoxib and diclofenac. [dx.doi.org]

COX-2 expression in cervical biopsies declined from pre-treatment to the end of treatment with celecoxib; it did not change with placebo. [ncbi.nlm.nih.gov]

Adjudicated Outcomes in the On-Treatment Population. [doi.org]

Withdrawal rates with active treatment were lower. [bmj.com]

KEYWORDS: PIK3CA; breast cancer; celecoxib; predictive biomarker; prognosis [ncbi.nlm.nih.gov]

Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension. 1994; 24 : 793–801. [ahajournals.org]

Juuti A, Louhimo J, Nordling S, Ristimäki A, Haglund C (2006) Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. J Clin Pathol 59:382–386 PubMed Google Scholar 139. [doi.org]

Machtay M, Mesic JB, Hanks GE, Coughlin CT, Pilepich MV: Updated results of the phase III Radiation Therapy Oncology Group (RTOG) trial 85-31 evaluating the potential benefit of androgen suppression following standard radiation therapy for unfavorable prognosis [ro-journal.biomedcentral.com]

OBJECTIVE: Recent studies have focused on the role of inflammatory cascades as one of the possible etiologic factors of bipolar disorder. [ncbi.nlm.nih.gov]

[…] study K Off NSAID 69–N/A Primary sclerosing cholangitis Still present Permanently discontinued Other illness: primary sclerosing cholangitis G Off NSAID 452–N/A Septic arthritis Still present No action taken Other illness: septic arthritis of unknown etiology [ped-rheum.biomedcentral.com]

Finally, a series of epidemiologic analyses have also raised questions about the cardiovascular safety of the coxibs. [oadoi.org]

3 Department of Entomology, University of California Davis, Sacramento, California, United States of America. 4 UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, California, United States of America. 5 Department of Epidemiology [ncbi.nlm.nih.gov]

Zeidler Epidemiology and economics of NSAIDs-induced gastropathy Scand J Rheumatol, 21 (1992), pp. 3-8 [3.] A. Lanas, M.T. [gacetasanitaria.org]

Following an FDA Advisory Committee meeting held in 2005, in which data from large clinical outcome trials in a wide range of indications and epidemiology studies of several individual NSAIDs were considered, FDA concluded that the risk for cardiovascular [fda.gov]

The virus may play a role in the pathophysiology of migraine headaches, and this is the first case report of successful migraine headache treatment with these medications. [ncbi.nlm.nih.gov]

[…] than that commonly used in adults and children with; 2) favourable side effect profile of this drug (particularly at the dosing required); 3) the fact that celecoxib crosses the blood brain barrier and 4) demonstration of efficacy in a genetically and pathophysiologically [clinicaltrials.gov]

Sleisenger and Fordtran's gastrointestinal and liver disease: pathophysiology/diagnosis/management. 6th ed. Vol. 1. Philadelphia: W.B. Saunders, 1998:343-57. 6. Meade EA, Smith WL, DeWitt DL. [oadoi.org]

[…] long term prevention studies. [web.archive.org]

Using patient samples from the randomized, placebo-controlled phase III selenium/celecoxib (Sel/Cel) trial for the prevention of colorectal adenomatous polyps, we analyzed plasma concentrations of 74 oxylipins in a subset of participants who received [ncbi.nlm.nih.gov]

This trial documented prevention of premalignant adenomas with celecoxib but was not designed to assess effectiveness of the drug for the prevention of colorectal cancer, and no claims about its use in this regard can be made from our data. [dx.doi.org]