The severity of PEP, asymptomatic hyperamylasemia, and post-ERCP pain were not significantly different between the 2 groups. There were no adverse events related to celecoxib treatment. [ncbi.nlm.nih.gov]

Clin Cancer Res 2005, 11: 1999-2007. 10.1158/1078-0432.CCR-04-1877 View Article PubMed Google Scholar Dawson NA, Slovin SF: Novel approaches to treat asymptomatic, hormone-naive patients with rising prostate-specific antigen after primary treatment for [ro-journal.biomedcentral.com]

The most commonly occurring ( 5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [rxlist.com]

You should call your doctor immediately if you experience black, bloody or tarry stools or you cough up blood or vomit that looks like coffee grounds. [practicalpainmanagement.com]

Check with your doctor immediately if any of the following side effects occur while taking celecoxib: More Common Cough fever skin rash sneezing sore throat swelling of the face, fingers, feet, or lower legs Less Common or Rare Abnormal growth in the [drugs.com]

Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

[…] unsteadiness watery or bloody diarrhea For Healthcare Professionals Applies to celecoxib: oral capsule General The most commonly reported adverse events included abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, accidental injury, dizziness, pharyngitis [drugs.com]

In the same study, a nonsignificant increased risk was observed for oral and pharyngeal cancer. [doi.org]

13%) 1-10% Fever (9%) Dyspepsia (8.8%) Upper respiratory tract infection (8.1%) Arthralgia (7%) Cough (7%) Vomiting (6%) Diarrhea (5.6%) Gastroesophageal reflux (5%) Sinusitis (5%) Abdominal pain (4.1%) Nausea (3.5%) Back pain (2.8%) Insomnia (2.3%) Pharyngitis [reference.medscape.com]

The most commonly occurring ( 5%) adverse experiences for naproxen-treated patients were headache, nausea, vomiting, fever, upper abdominal pain, diarrhea, cough, abdominal pain, and dizziness (Table 2). [rxlist.com]

However, withdrawals due to abdominal pain, diarrhoea, dyspepsia, nausea, or vomiting were not significantly increased with celecoxib compared with placebo. [dx.doi.org]

• Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation, which can be fatal. These events can occur at any time during therapy and without warning. Elderly patients are at greater risk. [medical-dictionary.thefreedictionary.com]

perforation, gastrointestinal bleeding, colitis with bleeding, esophageal perforation, pancreatitis, ileus General: Sepsis, sudden death Liver and biliary: Cholelithiasis Hemic and lymphatic: Thrombocytopenia Nervous: Ataxia, suicide [ see Drug Interactions [dailymed.nlm.nih.gov]

perforation, which can be fatal GI adverse events may occur at any time during use and without warning symptoms Elderly patients are at greater risk for serious GI events Contraindications Aspirin allergy, chronic hepatitis, perioperative pain resulting [reference.medscape.com]

abdominal pain, dyspepsia, and nausea) was superior to that of naproxen and that there was a lower incidence of upper GI ulcer complications (ie, bleeding, perforation, and gastric outlet obstruction) under celecoxib than with a conventional NSAIDs such [dx.doi.org]

An 87-year-old white man with chronic peptic esophageal stricture presented to us with dysphagia and odynophagia. The patient was taking Celecoxib for 5 months for trigeminal neuralgia. An upper endoscopy revealed severe desquamative esophagitis. [ncbi.nlm.nih.gov]

[…] pectors, myocardial infarction, tachycardia)). [dx.doi.org]

Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction, palpitation, tachycardia, and arrhythmia have been reported in 0.1% to 1.9% of patients taking celecoxib 100 to 200 mg twice a day or 200 mg once a day. [drugs.com]

[…] fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia, vertigo Hearing and vestibular: Deafness, tinnitus Heart rate and rhythm: Palpitation, tachycardia [dailymed.nlm.nih.gov]

dysfunction, concurrent diuretic, or ACE inhibitor therapy ( risk of renal impairment); Hypertension or fluid retention; Renal impairment (may precipitate acute renal failure); Serious dehydration (correct deficits before administering); Patients who [drugguide.com]

dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers Anemia may occur; monitor hemoglobin or hematorcrit in long term treatment patients Use caution in pediatrics with [reference.medscape.com]

A 50 percent dose reduction is recommended in patients with moderate liver dysfunction. Use of celecoxib is not recommended in patients with severe liver impairment or advanced kidney disease. [ems1.com]

dysfunction; monitor abnormal liver function test results. 1 Discontinue if signs or symptoms of liver disease or systemic manifestations (e.g., eosinophilia, rash) occur. 1 Anemia reported rarely. 1 Determine hemoglobin concentration or hematocrit in [drugs.com]

One patient had tinnitus through the trial on both drugs. Two other patients had this with celecoxib only. Other severe events on celecoxib were trembles, upper body rash, loss of energy and indigestion/heartburn. [dx.doi.org]

Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

Rare side effects of celecoxib include: allergic reactions such as skin rashes or wheezing headaches, dizziness or ringing in the ears (tinnitus) unusual bruising or bleeding kidney problems gastrointestinal problems — celecoxib can cause irritation to [arthritis.ca]

The serious AEs were angina pectoris, dyspnoea, sudden hearing loss in the celecoxib 200 mg once a day, deterioration of AS, familial Mediterranean fever in the celecoxib 200 mg twice a day, and myocardial infarction and tinnitus in the diclofenac treatment [dx.doi.org]

Adverse reactions such as urticaria, angioedema, asthma, and anaphylaxis are known to be associated with nonsteroidal anti-inflammatory agents (NSAIDs). [ncbi.nlm.nih.gov]

In October 2002, the CPMP asked additional questions relating to serious hypersensitivity reactions (anaphylaxis and angioedema) and serious skin reactions including Stevens- Johnson syndrome, toxic epidermal necrolysis, erythema multiforme and exfoliative [ema.europa.eu]

[…] reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure Cardiovascular: Vasculitis, deep venous thrombosis General: Anaphylactoid reaction, angioedema [dailymed.nlm.nih.gov]

Skin patch testing showed positive reaction to 1% celecoxib without cross-reactivity to 1% sulfamethoxazole-trimethoprim. [ncbi.nlm.nih.gov]

Drug-provoked cutaneous eruptions includes acute generalized exanthematous pustulosis (AGEP) and acneiform eruption. [ncbi.nlm.nih.gov]

Common side effects of celecoxib include ankle swelling/edema, dizziness, headache, insomnia, skin rash, stomach or abdominal upset or pain, cough or respiratory infections. Celecoxib may cause or worsen high blood pressure. [practicalpainmanagement.com]

Adverse reactions CNS: dizziness, drowsiness, headache, insomnia, fatigue, stroke CV: angina, tachycardia, peripheral edema, myocardial infarction EENT: ophthalmic effects, tinnitus, epistaxis, pharyngitis, rhinitis, sinusitis GI: nausea, diarrhea, constipation [medical-dictionary.thefreedictionary.com]

Adverse Reactions/Side Effects CNS: dizziness, headache, insomnia CV: HF, MYOCARDIAL INFARCTION, STROKE, THROMBOSIS, edema, hypertension GI: GI BLEEDING, abdominal pain, diarrhea, dyspepsia, flatulence, nausea Derm: EXFOLIATIVE DERMATITIS, STEVENS-JOHNSON [drugguide.com]

Hypertension (13%) 1-10% Fever (9%) Dyspepsia (8.8%) Upper respiratory tract infection (8.1%) Arthralgia (7%) Cough (7%) Vomiting (6%) Diarrhea (5.6%) Gastroesophageal reflux (5%) Sinusitis (5%) Abdominal pain (4.1%) Nausea (3.5%) Back pain (2.8%) Insomnia [reference.medscape.com]

[…] atherosclerosis, sinus bradycardia, ventricular hypertrophy, or deep vein thrombosis were reported in at least 0.1% of patients to less than 1% of patients. [ Ref ] Nervous system Leg cramps, hypertonia, hypoesthesia, migraine, neuralgia, neuropathy, paresthesia [drugs.com]

Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia [dailymed.nlm.nih.gov]

Hypersensitivity, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain Central, peripheral: Leg cramps, hypertonia, hypoesthesia, Nervous system: migraine, paresthesia [rxlist.com]

tremor 0 1 (2) Restless legs 0 1 (2) Poor circulation 0 1 (2) T able 5. [dx.doi.org]

Diclofenac had worse hepatic tolerability than celecoxib in terms of AEs of transaminase increase. The occurrence of headache as a TEAE was unexpectedly high in all of the treatment groups. [dx.doi.org]

Liver biopsy specimens showed a cholestatic pattern of liver injury with only minimal mononuclear infiltrate in the portal tracts. This case report supports the notion that celecoxib may cause bland, long term cholestasis. [ncbi.nlm.nih.gov]