Case presentation. We present the case of a 15-month-old Asian male baby who presented with precocious puberty associated with hepatoblastoma. [mdanderson.elsevierpure.com]

Extensive imaging of the CNS for patients presenting with CPP is recommended. [thejns.org]

We present here a rare case of a 7-month-old infant girl with CPP and HH who was successfully treated with depot gonadotropin-releasing hormone (GnRH) analogue is presented. [ncbi.nlm.nih.gov]

• Precocious Puberty

  Two types of precocious puberty include the following: Gonadotropin-dependent precocious puberty. [stanfordchildrens.org]

  Central precocious puberty in these children might follow extensive sex steroid exposure due to the peripheral precocious puberty induced by the activating mutation of the Gs protein gene. [ncbi.nlm.nih.gov]

  E-mail: [email protected] The term ‘Precocious puberty’ refers to the appearance of pubertal signs at an earlier age than established standard. Precocious puberty may be central or peripheral. [jcdr.net]

  Precocious puberty in an infant with hepatoblastoma: A case report. Journal of Medical Case Reports, 5, [422]. [mdanderson.elsevierpure.com]

• Accelerated Growth

  Abstract The 22q13 deletion syndrome or Phelan-McDermid syndrome is a neurodevelopmental disorder associated with developmental delay, hypotonia, delayed or absent speech, autistic-like behavior, normal to accelerated growth and dysmorphic faces. [ncbi.nlm.nih.gov]

  […] of 9: Penile enlargement Testicular development Increased muscle development Voice change Growth of body hair Accelerated growth There are two types of precocious puberty: Central precocious puberty (CPP). [rileychildrens.org]

  Precocious puberty Puberty is a complex biological process involving sexual maturation and accelerated growth. These processes normally initiate when pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus begins. [imprinting-disorders.eu]

  Primary hypothyroid may manifest with thelarche in girls without accelerated growth. Some may have elevated Prolactin, Galactorrhora or ovarian cysts. Congenital adrenal hyperplasia manifests with hetero sexual pubertal development in girls. [ijem.in]

• Poor Growth

  Poor growth potential is further affected by central precocious puberty (CPP) which is frequent in these patients. [ncbi.nlm.nih.gov]

• Neck Swelling

  There was no clitoral enlargement, neck swelling, pigmented skin marks, bone pain/fractures. Parents could not comment on any recent height gain. She had no significant medical illness or radiation exposure in the past. [ijem.in]

• Learning Difficulties

  Each patient's height and weight were normal at the most recent follow-up (9-11 years after surgery), and none had experienced learning difficulties. Central precocious puberty due to HH can be successfully treated with resection. [ncbi.nlm.nih.gov]

  Their most clinical features were: overweight or obesity ( n 15), born small for gestational age ( n 10), learning difficulties/intellectual disability/autistic spectrum ( n 7), short stature ( n 7), motor and/or speech delay ( n 6), high palate ( n 6 [frontiersin.org]

• Imperforate Hymen

  Imaging also revealed imperforate hymen, vaginal atresia, and mucocolpos. [ncbi.nlm.nih.gov]

Laboratory workup revealed Serum Sodium 138 mmol/L (Ref Values: 135-145), Serum Potassium 4.1 mmol/L (Ref Values: 3.5-5.0), Serum Chloride 101 mmol/L (Ref Values: 97-106). [sciedupress.com]

When should you start a workup? What should you order and when do you refer to endocrinology? We discuss these things and more with our pediatric endocrine consultant. [hippoed.com]

Subsequent laboratory workup demonstrated highly elevated hormone levels: LH 1.38 mIU/ml (normal 0.7), and testosterone 164 ng/dl (normal 9.0). Additionally, bone age was advanced, at 11 years. [thejns.org]

Footnotes Contributors: PKS and KSGS contributed to the clinical diagnosis, initial laboratory workup and treatment. [ncbi.nlm.nih.gov]

Ht and HtSDS after treatment were positively correlated with the predicted Ht (PAH) before treatment and negatively correlated with the bone age/statural age ratio before treatment (p 0.05). [ncbi.nlm.nih.gov]

All previously reported cases in the literature are old and prognosis was grim. Case presentation. We present the case of a 15-month-old Asian male baby who presented with precocious puberty associated with hepatoblastoma. [mdanderson.elsevierpure.com]

The patient did not receive medical care for his precocious pubertal development, because of adequate height prognosis, and reached normal height for both his target height and Klinefelter patients. [ncbi.nlm.nih.gov]

What is the prognosis of central precocious puberty? Similar to the treatment of central precocious puberty, the prognosis is related to the precise cause of the child's disease. [rxlist.com]

Location Indianapolis, IN Subject Area Pharmacy, Health Sciences & Exercise Science Start Date 11-4-2014 8:30 AM End Date 11-4-2014 10:00 AM Description Background: Precocious puberty is a relatively rare disease with little documented information on etiology [digitalcommons.butler.edu]

In the present study, we aimed to evaluate the etiological factors in male CPP cases. METHODS: One hundred male CPP subjects, aged between 9 months and 10.5 years, were included. [ncbi.nlm.nih.gov]

OBJECTIVES: Precocious puberty seems to be increasing but epidemiological data are scarce. Our objective was to improve the epidemiologic knowledge on this disease. [ncbi.nlm.nih.gov]

Summary Epidemiology The prevalence of CPP has been evaluated at approximately 1/ 500 girls and 1/ 2,000 boys in Denmark. Girls are more affected than boys, with an overall male to female ratio of at least 1:10. [orpha.net]

Guillén, Jesús Argente Localización: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP ), ISSN 1695-4033, ISSN-e 1696-4608, Vol. 74, Nº. 5, 2011, pág. 336 Idioma: español Títulos paralelos: Central precocious puberty: epidemiology [dialnet.unirioja.es]

The epidemiology of CPP is somewhat nebulous, with a commonly cited prevalence range of 1 in 5000 to 1 in 10,000 children 7. CPP is known to occur more frequently in girls than in boys and has different predominant causes for each sex. [endo.com]

In addition, we discussed the recent findings on the pathophysiology of OPG development in NF1. [mdpi.com]

Reproductive endocrinology:Physiology, pathophysiology and clinical management. 4th ed. Philadelphia:WB Saunders;1999. p.153-190. P.214 掲載の参考文献 3) 伊藤裕ら:ナトリウム利尿ペプチド系の分子生物学と分子薬理. 日本臨牀 1993;51:140-148. 4) 伊藤裕ら:Na利尿ペプチドファミリーとジギタリス様因子の役割は. 矢崎義雄ら編. [molcom.jp]

[…] premature closure of the epiphyseal growth plates, thereby preventing short stature. [ncbi.nlm.nih.gov]