Case presentation. We present the case of a 15-month-old Asian male baby who presented with precocious puberty associated with hepatoblastoma.[mdanderson.elsevierpure.com]
Extensive imaging of the CNS for patients presenting with CPP is recommended.[thejns.org]
We present here a rare case of a 7-month-old infant girl with CPP and HH who was successfully treated with depot gonadotropin-releasing hormone (GnRH) analogue is presented.[ncbi.nlm.nih.gov]
Two types of precociouspuberty include the following: Gonadotropin-dependent precociouspuberty.[stanfordchildrens.org]
Central precociouspuberty in these children might follow extensive sex steroid exposure due to the peripheral precociouspuberty induced by the activating mutation of the Gs protein gene.[ncbi.nlm.nih.gov]
E-mail: jaydeepsskm@gmail.com The term Precociouspuberty refers to the appearance of pubertal signs at an earlier age than established standard. Precociouspuberty may be central or peripheral.[jcdr.net]
Treatment for precociouspuberty depends on the cause. However, in some cases, there is no identifiable cause for precociouspuberty.[mayoclinic.org]
Abstract The 22q13 deletion syndrome or Phelan-McDermid syndrome is a neurodevelopmental disorder associated with developmental delay, hypotonia, delayed or absent speech, autistic-like behavior, normal to acceleratedgrowth and dysmorphic faces.[ncbi.nlm.nih.gov]
[…] of 9: Penile enlargement Testicular development Increased muscle development Voice change Growth of body hair Acceleratedgrowth There are two types of precocious puberty: Central precocious puberty (CPP).[rileychildrens.org]
Precocious puberty Puberty is a complex biological process involving sexual maturation and acceleratedgrowth. These processes normally initiate when pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus begins.[imprinting-disorders.eu]
Early puberty acceleratesgrowth. These children may initially be considerably taller than their peers. Because bone maturation is also accelerated, growth may be completed at an unusually early age, resulting in short stature.[emedicine.medscape.com]
No cushingoid stigmata, mucocutaneous hyperpigmentation, café au lait macules, bony deformities or palpable abdominal lump were noted on clinical examination.[casereports.bmj.com]
Abstract Prader-Willi syndrome (PWS) is characterized by infantile lethargy and hypotonia causing poorfeeding and failure to thrive, childhood obesity, short stature, and hypogonadism.[ncbi.nlm.nih.gov]
There was history of frequent episodes of ill health withcough, fever, diarrhea and off and on vomiting.[sciedupress.com]
Other less frequent side effects include diarrhea, edema, fatigue, hypertension, constipation, pain, pneumonitis, as well as asymptomatic CPK elevation.[mdpi.com]
Case presentation A 15-month-old Asian male baby presented to our center with precocious puberty and a hepaticmass. He was a product of cesarean section at 37 weeks of gestation.[cyberleninka.org]
They denied any history of acneiformeruptions, malodorous secretions, deepening of voice, muscular prominence or rapid height and weight gain in the child.[casereports.bmj.com]
There was no clitoral enlargement, neckswelling, pigmented skin marks, bone pain/fractures. Parents could not comment on any recent height gain. She had no significant medical illness or radiation exposure in the past.[ijem.in]
Abstract Prader-Willi syndrome (PWS) is characterized by infantile lethargy and hypotonia causing poor feeding and failure to thrive, childhood obesity, short stature, and hypogonadism.[ncbi.nlm.nih.gov]
Histrelin implants have shown the greatest efficacy in delayingmenarche by at least one year and increasing adult height by up to 7cm from predicted height.[digitalcommons.butler.edu]
The clinical characteristics include rapidly somatic growth spurt, pubic and axillar hair, facial acne, painfulerections, penis enlargement and deep voice. 12 ‒14 In the blood samples an elevated level of androgens, primarily testosterone, and normal[medcraveonline.com]
When should you start a workup? What should you order and when do you refer to endocrinology? We discuss these things and more with our pediatric endocrine consultant.[hippoed.com]
Subsequent laboratory workup demonstrated highly elevated hormone levels: LH 1.38 mIU/ml (normal 0.7), and testosterone 164 ng/dl (normal 9.0). Additionally, bone age was advanced, at 11 years.[thejns.org]
Footnotes Contributors: PKS and KSGS contributed to the clinical diagnosis, initial laboratory workup and treatment.[ncbi.nlm.nih.gov]
Paraneoplastic features of hepatoblastoma are not uncommon at presentation and include thrombocytosis and increased alkaline phosphatase [ 2 ]. Occasionally, isosexual precocious puberty was reported in boys with hepatoblastoma [ 1, 3 – 15 ].[jmedicalcasereports.biomedcentral.com]
Paraneoplastic features of hepatoblastoma are not uncommon at presentation and include thrombocytosis and increased alkaline phosphatase [2]. Occasionally, isosexual precocious puberty was reported in boys with hepatoblastoma [1,3-15].[cyberleninka.org]
Ht and HtSDS after treatment were positively correlated with the predicted Ht (PAH) before treatment and negatively correlated with the bone age/statural age ratio before treatment (p 0.05).[ncbi.nlm.nih.gov]
All previously reported cases in the literature are old and prognosis was grim. Case presentation. We present the case of a 15-month-old Asian male baby who presented with precocious puberty associated with hepatoblastoma.[mdanderson.elsevierpure.com]
The patient did not receive medical care for his precocious pubertal development, because of adequate height prognosis, and reached normal height for both his target height and Klinefelter patients.[ncbi.nlm.nih.gov]
We conclude that precocious puberty in Klinefelter syndrome may result in normal body proportion by inducing a major growth spurt of the trunk rather than in the limbs, and that adult height prognosis is not altered by precocious puberty.[onlinelibrary.wiley.com]
What is the prognosis of central precocious puberty? Similar to the treatment of central precocious puberty, the prognosis is related to the precise cause of the child's disease.[rxlist.com]
Location Indianapolis, IN Subject Area Pharmacy, Health Sciences & Exercise Science Start Date 11-4-2014 8:30 AM End Date 11-4-2014 10:00 AM Description Background: Precocious puberty is a relatively rare disease with little documented information on etiology[digitalcommons.butler.edu]
In the present study, we aimed to evaluate the etiological factors in male CPP cases. METHODS: One hundred male CPP subjects, aged between 9 months and 10.5 years, were included.[ncbi.nlm.nih.gov]
OBJECTIVES: Precocious puberty seems to be increasing but epidemiological data are scarce. Our objective was to improve the epidemiologic knowledge on this disease.[ncbi.nlm.nih.gov]
Summary Epidemiology The prevalence of CPP has been evaluated at approximately 1/ 500 girls and 1/ 2,000 boys in Denmark. Girls are more affected than boys, with an overall male to female ratio of at least 1:10.[orpha.net]
, Jesús Argente Localización: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría ( AEP ) , ISSN 1695-4033, ISSN-e 1696-4608, Vol. 74, Nº. 5, 2011 , pág. 336 Idioma: español Títulos paralelos: Central precocious puberty: epidemiology[dialnet.unirioja.es]
The epidemiology of CPP is somewhat nebulous, with a commonly cited prevalence range of 1 in 5000 to 1 in 10,000 children 7 . CPP is known to occur more frequently in girls than in boys and has different predominant causes for each sex.[endo.com]