As per definition, CA is a movement disorder associated with coordination and balance problems. These are most easily recognized while observing the patient's gait as well as their limb and eye movements. In detail, the following may be observed [7]:

• Vertigo and dizziness
• Imbalance and unsteady, staggering gait as well as impaired tandem gait
• Hypotonia, tremor, dysdiadochokinesia, adysdiadochokinesia, grasping deficits and dysmetria, i.e., reduced muscle tones and involuntary contractions of muscles, the inability to rapidly perform alternating or targeted movements and to control motion ranges
• Instability of ocular alignment, saccadic intrusions and nystagmus, smooth pursuit impairment
• Abnormal vestibulo-ocular reflex

With regards to the patients life quality and if severe, these conditions may result in the inability to perform routine duties and may provoke frequent falls. In contrast, mild CA may only be noted while realizing determined tasks that require highly developed motor skills. Also, CA patients don't generally show all of the aforementioned symptoms.

The presence of additional symptoms may be helpful in identifying the cerebellum as the site of lesion: A patient presenting with ataxic dysarthria, for instance, is highly suspicious of cerebellar damage. Furthermore, cerebellar lesions often comprise cognitive and limbic regions and thus, corresponding non-motor neurological deficits may be observed, which in total have been referred to as Schmahmann's syndrome. They mainly consist in [8]:

• Impaired planning and execution of everyday tasks, attention deficits
• Disturbance of visual-spatial processing
• Personality changes and behavioral disorders
• Further issues regarding speech, writing and reading

• Movement Disorder

  “Clinicians must become familiar with these disorders because maximal therapeutic benefit is only possible when done early,” said Adolfo Ramirez-Zamora, MD, Philly Dake Chair in Movement Disorders at Albany Medical Center in New York. [mdedge.com]

  No cures are possible for most patients who suffer debilitating movement disorders called cerebellar ataxias. [sciencedaily.com]

  - No cures are possible for most patients who suffer debilitating movement disorders called cerebellar ataxias. [eurekalert.org]

  We implemented clinical exome sequencing, followed by filtering data for a 'movement disorders' gene panel, as a generic test to increase variant detection in 76 patients with these disorders. [ncbi.nlm.nih.gov]

• Epilepsy

  Antibodies targeting GAD-65 are of uncertain pathogenic significance and occur in stiff person syndrome, cerebellar ataxia, epilepsy, limbic encephalitis and combinations thereof and diabetes mellitus. [ncbi.nlm.nih.gov]

• Fatigue

  Increased fatigue - Patients with ataxia due to cerebellar atrophy often experience unexpected fatigue when performing normal activities. [hopkinsmedicine.org]

  The usual clinical features are constipation, fatigue, cold intolerance and weight gain. Rarely it can present with neurologic problems like reversible cerebellar ataxia, dementia, peripheral neuropathy, psychosis and coma. [ncbi.nlm.nih.gov]

  Drowsiness, fatigue, headache insomnia nausea and excess urination can also occur with baclofen use 17. [multiplesystematrophy.org]

• Difficulty Walking

  walking Speech disturbances with slurred speech and changes in tone, pitch, and volume Visual complaints Abnormal eye movements Headache Nausea and vomiting Lightheadedness Changes in mental state, such as personality or behavioral changes Chaotic eye [cookchildrens.org]

  They may have some of the following symptoms:</p><ul><li>falling while trying to walk or stand</li><li>difficulty walking in a straight line</li><li>bending forwards while walking</li><li>walking with feet spread wide apart</li><li>difficulty speaking [aboutkidshealth.ca]

  […] movements Difficulty swallowing Diagnosis You will be asked about your symptoms, and your medical and family history. [winchesterhospital.org]

  The first indication generally is difficulty walking (gait ataxia). The condition typically progresses to the arms and trunk. Muscles weaken and waste away over time, causing deformities, particularly in your feet, lower legs and hands. [medtransacademy.com]

• Anemia

  A 28 year old female from North India presented with a short febrile illness followed by an acute onset cerebellar ataxia, anemia, thrombocytopenia and transaminitis. [ncbi.nlm.nih.gov]

  In pernicious anemia there may be early localized or relatively diffuse cord swelling with increased T2 SI that is most evident in the posterior columns.35 Late atrophy and persistent gliosis may develop, or all findings may resolve with treatment.35 [ajnr.org]

  A personal or familial history of other autoimmune diseases, such as T1DM, hemolytic anemia or thyroiditis is frequent [ 6 ], while a paraneoplastic origin is exceptional [ 31 ]. [doi.org]

• Vomiting

  Nausea and vomiting Cerebellar lesions can produce nausea and/or vomiting. Sudden vomiting (without warning) after a positional change, without preceding nausea, is suggestive of a posterior fossa lesion. [patient.info]

  Presentation History of fever one week ago, then developed headache, vomiting and sudden convulsion. Patient Data Age: 10 years Gender: Female Loading images... [radiopaedia.org]

  A 65-year-old woman presented in October 2000 with a week history of vertigo and vomiting. She denied symptoms of previous infectious disease. Neurologic examination revealed dysarthria, horizontal nystagmus, and severe limb and gait ataxia. [n.neurology.org]

  […] may include: Uncoordinated movements of the limbs or trunk Clumsiness with daily activities Difficulty walking Speech disturbances with slurred speech and changes in tone, pitch, and volume Visual complaints Abnormal eye movements Headache Nausea and vomiting [cookchildrens.org]

  […] may cause: Uncoordinated movements of the limbs or trunk Clumsiness with daily activities Difficulty walking Speech disturbances with slurred speech and changes in tone, pitch, and volume Visual complaints Abnormal eye movements Headache Nausea and vomiting [winchesterhospital.org]

• Nausea

  Nausea and vomiting Cerebellar lesions can produce nausea and/or vomiting. Sudden vomiting (without warning) after a positional change, without preceding nausea, is suggestive of a posterior fossa lesion. [patient.info]

  The discovery was made when the woman was admitted to the Chinese PLA General Hospital of Jinan Military Area Command in Shandong Province complaining of dizziness and nausea. [newscientist.com]

  […] cerebellar ataxia may include: Uncoordinated movements of the limbs or trunk Clumsiness with daily activities Difficulty walking Speech disturbances with slurred speech and changes in tone, pitch, and volume Visual complaints Abnormal eye movements Headache Nausea [cookchildrens.org]

  […] cerebellar ataxia may cause: Uncoordinated movements of the limbs or trunk Clumsiness with daily activities Difficulty walking Speech disturbances with slurred speech and changes in tone, pitch, and volume Visual complaints Abnormal eye movements Headache Nausea [winchesterhospital.org]

• Dysphagia

  Life-threatening status epilepticus and intractable seizure or severe dysphagia are rare. [orpha.net]

  He also had progressive dysphagia requiring gastrostomy tube for nutrition. [ncbi.nlm.nih.gov]

  Cough and dysphagia are not related. They progress inversely, coughing being the inaugural manifestation and tending to subside, but dysphagia being a late manifestation of the disease when ataxia is already disabling. [jamanetwork.com]

• Heart Disease

  Other signs and symptoms that may develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal curvature (scoliosis); and heart disease, including heart enlargement (cardiomyopathy [medtransacademy.com]

  Other signs and symptoms that might develop as the disease progresses include slow, slurred speech (dysarthria); fatigue; rapid, involuntary eye movements (nystagmus); spinal curvature (scoliosis); hearing loss; and heart disease, including heart enlargement [mayoclinic.org]

• Incontinence

  People with the condition can become incontinent. Other symptoms can include difficulties with swallowing and slurred speech. Sight and hearing can be affected. In rare cases, they can be lost altogether. [news.bbc.co.uk]

  It is occasionally so severe that patients become cyanosed and collapse or have urine incontinence without loss of conscience. The duration is short (ie, minutes), and drinking cold water can abort episodes. [jamanetwork.com]

  MSA is suggested by the following characteristics: Disability progresses rapidly Patients are poorly responsive to levodopa Autonomic features such as urinary retention or incontinence or orthostatic hypotension are pronounced Rigidity and bradykinesia [emedicine.medscape.com]

  The following symptoms are persistent too: Memory loss with spoken language Muscle stiffness Muscle cramps Loss of sensation in hands and feet (peripheral neuropathy) Decreased bladder control (incontinence) Lifespan is decreased as the symptoms progress [blog.cognifit.com]

• Urinary Incontinence

  We speculated his parkinsonism, as well as dementia, might be due to comorbid multiple cerebral infarction. b Both patients had mild urinary frequency, but not urinary incontinence or orthostatic hypotension. [jns-journal.com]

  At the age of 24 years (in 2015), the patient returned to the Neurology Clinic because of several episodes of urinary incontinence, limited ambulation, and a decrease in tactile sensitivity from the pubic to the foot region. [bmcwomenshealth.biomedcentral.com]

  incontinence and sleep disturbance36. [scielo.br]

• Ataxia

  KEYWORDS: Cerebellar ataxia; Gait; Local dynamic stability; Trunk stability [ncbi.nlm.nih.gov]

  Cerebellar ataxia Specialty Neurology Cerebellar ataxia is a form of ataxia originating in the cerebellum.[1] Non-progressive congenital ataxia (NPCA) is a classical presentation of cerebral ataxias. [en.wikipedia.org]

  ataxia Cerebellar ataxia (loss of muscle coordination) Cerebellar ataxia due to toxin Cerebellar ataxia, early-onset Cerebellar ataxia, late-onset Drug-induced cerebellar ataxia Early onset cerebellar ataxia Early onset cerebellar ataxia with essential [icd9data.com]

• Cerebellar Ataxia

  Cerebellar ataxia Specialty Neurology Cerebellar ataxia is a form of ataxia originating in the cerebellum.[1] Non-progressive congenital ataxia (NPCA) is a classical presentation of cerebral ataxias. [en.wikipedia.org]

  ataxia Cerebellar ataxia (loss of muscle coordination) Cerebellar ataxia due to toxin Cerebellar ataxia, early-onset Cerebellar ataxia, late-onset Drug-induced cerebellar ataxia Early onset cerebellar ataxia Early onset cerebellar ataxia with essential [icd9data.com]

  KEYWORDS: Cerebellar ataxia; Gait; Local dynamic stability; Trunk stability [ncbi.nlm.nih.gov]

  Call your provider if any symptoms of ataxia appear. Cerebellar ataxia; Ataxia - acute cerebellar; Cerebellitis; Post-varicella acute cerebellar ataxia; PVACA Mink JW. Movement disorders. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. [nlm.nih.gov]

• Dysarthria

  Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal dominant cerebellar ataxias clinically characterized by progressive ataxia, dysarthria and a range of other concomitant neurological symptoms. [ncbi.nlm.nih.gov]

  Group data indicated no change in the Dysarthria Impact Profile in respect of three sections ( The effect of dysarthria on me as a person ; How I feel others react to my speech ; and How dysarthria affects my communication with others ). [doi.org]

  Inherited periodic ataxia, dysarthria, nystagmus and vertigo. [patient.info]

• Dysmetria

  Cerebellar Hemiataxias Cerebellar Incoordinations Dysmetria, Cerebellar Dysmetrias Dysmetrias, Cerebellar Hemiataxia, Cerebellar Hemiataxias, Cerebellar Hypermetrias Incoordination, Cerebellar Incoordinations, Cerebellar Ataxia, Cerebellar Adiadochokinesis [decs.bvs.br]

  Ataxias, Cerebellar rare ataxia Ataxia, Cerebellar ataxia Cerebellar Ataxias ataxia syndrome Cerebellar Dysmetria spinocerebellar ataxia Cerebellar Dysmetrias edit English cerebellar ataxia cerebellar disease characterized by ataxia originating in the [wikidata.org]

  Motor[edit] Motor dysmetria is the customary term used when a person refers to dysmetria. [en.wikipedia.org]

  Function Posterior (Flocculo-nodular lobe; Archicerebellum) Eye movement disorders: Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction Midline (Vermis; paleocerebellum)Truncal & gait ataxia Hemisphere (Neocerebellum)Limb ataxia: Dysmetria [neuromuscular.wustl.edu]

  A 45-year-old man with a cerebellar gait ataxia, dysmetria, nystagmus and mild cerebellar dysarthria was diagnosed with insulin-dependent diabetes mellitus a year after the onset of neurological symptoms. [ncbi.nlm.nih.gov]

• Seizure

  To date, six de novo SNAP25 mutations have been reported in patients with neurological features including seizures, intellectual disability, severe speech delay, and cerebellar ataxia. [ncbi.nlm.nih.gov]

  Life-threatening status epilepticus and intractable seizure or severe dysphagia are rare. [orpha.net]

  Gabapentin Widely known by the trade name Neurontin, this anti-seizure drug is modeled after the neurotransmitter gamma-amino butyric acid, or GABA. [multiplesystematrophy.org]

Diagnosis of CA and its underlying disease is based on thorough anamnesis, general and neurologic examination as well as neuroimaging. The former are particularly important since they may allow for a differentiation between spinal and cerebellar causes of ataxia, and because cerebellar lesions seen in images are often unspecific. For instance, it may not be possible to associate those findings to a determined entity without knowing if symptoms worsen progressively, or if the disease is characterized by episodes of remission and recurrence. Age is another key factor.

Virtually all patients with suspected CA should undergo magnetic resonance imaging (MRI) of the brain. Exceptions may be made for patients with a family history of a corresponding genetic disorder. With regards to MRI, the most common finding is cerebellar atrophy. Neuroimaging may also reveal the presence of a neoplasm or an abscess.

Depending on the results obtained so far, additional diagnostic measures may be necessary to determine the underlying disorder. If gene defects are suspected, samples for genetic screens have to be obtained.

Regeneration capacities of the central nervous systems are very limited. Accordingly, neurological deficits provoked by cerebellar lesions are often irreversible, and it is of great importance to initiate treatment as early as possible in order to avoid an aggravation of symptoms. Specific treatment options largely depend on the underlying disease and may range from dietary adjustments to drug therapy to surgical intervention. In any case, patients suffering from CA should participate in rehabilitation programs. Patients are to perform balance and coordination exercises to regain their ability to walk independently, to dominate their posture and to use their limbs in a controlled manner [9]. Frenkel exercises are often recommended to this end. Nevertheless, some patients may not be able to return to their everyday lives without using orthopedic aids [10].

With regards to symptomatic therapy of CA, modulators of serotonergic signaling may be applied. In particular, buspirone, an agonist of serotonin receptor 1A, is used to treat mild to moderate CA [11]. However, some patients may not respond to such treatment and this also applies to the use of serotonin reuptake inhibitors and antagonists of serotonin receptor 3 [12] [13]. Additionally, few studies suggest that administration of amantadine, memantine and riluzole may have beneficial effects [14].

More recent approaches to CA therapy involve transcranial direct current stimulation and magnetic stimulation of the cerebellum [15] [16]. Both aim at modulating the excitability of cerebellar neurons.

The life expectancy of CA patients is unaltered, unless cerebellar lesions are caused by diseases associated with a poor prognosis for life. Such may be the case in patients suffering from brain tumors. However, for many forms of CA, treatment options are very limited. Neuronal damage is frequently irreversible, but it may be possible to halt disease progression. Few diseases are associated with a very good prognosis. Acute cerebellar ataxia, for instance, is usually self-limiting and patients can expect to recover fully within few weeks [6].

Congenital forms of CA are to be distinguished from acquired forms of the disease. With respect to the former, several genetic disorders have been related to cerebellar malfunction and consequent ataxia. Such diseases may be inherited with an autosomal recessive (ARCA), autsomal dominant (ADCA), X-linked or mitochondrial trait. Both ARCA and ADCA are heterogenous groups of neurodegenerative diseases, but the latter designations also comprise several entities. Some of those diseases pertaining to these four groups are listed below; the interested reader is referred to more extensive reviews available elsewhere [1] [2] [3].

• ARCA
  
  • Ataxia-telangiectasia
  • Ataxia with oculomotor apraxia
  • Ataxia with vitamin E deficiency
  • Friedreich ataxia
  • Spastic ataxia of Charlevoix-Saguenay
• ADCA
  
  • Episodic ataxia
  • Spinocerebellar ataxia
  • Vestibulocerebellar syndrome
• X-linked
  
  • Cerebellar hypoplasia due to mutations of the OPHN1 or CASK gene
  • Fragile X-associated tremor/ataxia syndrome
• Mitochondrial inheritance [2]
  
  • Kearns-Sayre syndrome
  • MELAS syndrome
  • Myoclonic epilepsy with ragged red fibers (MERRF)

To some extent, these diseases differ regarding their manifestation. For instance, loss of proprioception and pallesthesia as well as blunted reflexes are most commonly observed in ARCA.

Besides hereditary forms of CA, there are numerous other factors that may inflict cerebellar damage and thus provoke CA.

• Autoimmune disease
• Cerebellar stroke syndrome
• Demyelinating disease like multiple sclerosis
• Infection (e.g., acute cerebellar ataxia manifests few weeks after viral infection and infectious mononucleosis, influenza, measles or mumps)
• Intoxication with alcohol, illicit drugs or statins
• Neoplasm
• Nutritional deficiency (e.g., vitamins B12 and E, folate and copper)
• Trauma

Of note, other classification systems than the one presented here exist. Forms of CA may also be assigned to distinct groups on the basis of the underlying pathophysiological mechanisms (e.g., metabolic and degenerative disorders), further involved anatomical structures (e.g., pure cerebellar and spinocerebellar diseases), the course of the disease (e.g., intermittent, persistent, chronic and progressive) as well as the mean age at symptom onset (early-onset vs. late-onset).

Incidence and prevalence rates as well as gender, racial and age distribution patterns vary with different forms of CA. With regards to inherited CA, the most frequent disorder is Friedreich ataxia, which affects 1 in 30,000 to 50,000 people. CA due to multiple sclerosis, stroke, trauma or tumor are rather common forms of acquired CA. In sum, CA prevalence may amount to approximately 8 per 100,000 inhabitants, with 5 and 3 people suffering from hereditary and non-hereditary diseases, respectively [4].

While onset of symptoms related to genetic diseases typically occurs in infancy or childhood, the aforementioned forms of acquired CA is usually diagnosed in adults and the elderly. Children presenting with acquired ataxia most commonly suffer from acute cerebellar ataxia. It has been reported that the median age of CA symptom onset is in the fourth decade of life, but due to the aforementioned heterogeneity of disorders associated with CA, this statistical specification is of little relevance to clinical practice.

Cerebellum and pons are the main parts of the metencephalon and this part of the brain is located in the posterior cranial fossa. The cerebellum plays a pivotal role in motor control and maintenance of balance and posture. From an anatomical point of view, it consists of three main portions, the anterior lobe, the posterior lobe and the flocculonodular lobe. These correspond only partially to the cerebellum's functional sections, which have been designated vestibulocerebellum, spinocerebellum and pontocerebellum: The vestibular system is connected to the vestibulocerebellum by sensory afferent nerves, and based on the input received, balance, posture and eye movements are coordinated. This function is complemented by the spinocerebellum, whose task is to process afferent stimuli originating from the spinal cord and muscle spindles, i.e., to control the position of limbs, trunk and head, and to adjust the muscle tone if necessary. Many complex movements require participation of the cerebral cortex and a connection between both structures is established by the pontocerebellum. Consequently, the single most characteristic symptom of cerebellar lesions is CA.

The molecular basis of CA varies widely. Since ion channels are of major importance for neuronal function, it is little surprising that several forms of CA are indeed channelopathies. Corresponding gene defects are often inherited with an autosomal dominant trait and affect calcium and potassium channels [5]. Such has been proven for ADCA episodic ataxia and spinocerebellar ataxia, but the pathomechanisms causing vestibulocerebellar syndrome are only poorly understood.

For most forms of CA, no specific measures can be recommended. Since acute cerebellar ataxia is associated with viral infectious diseases, compliance with vaccination plans may reduce the individual risk of this disorder, though.

In general, the term ataxia describes a movement disorder characterized by a limited ability to maintain balance and posture, and/or to move limbs and eyes in a coordinated way. This description already implies that the clinical presentation of ataxic patients varies largely, and this may partially be explained by the fact that distinct parts of the central nervous system as well as subordinated structures are involved in planning and execution of a targeted movement. In detail, lesions of sensory pathways, spinal cord, basal ganglia, cerebellum and cerebral cortex may cause ataxia [1]. If cerebellar function is impaired and provokes such movement disorders, the patient is diagnosed with cerebellar ataxia (CA).

As is the case with lesions of any of the aforementioned structures, neurological deficits are rarely limited to ataxia in patients who sustained cerebellar damage. Besides CA, motor and coordination deficits of speech are observed frequently. Also, cognitive and affective functions may be impaired. Only the entirety of anamnestic data, neurological findings and data obtained by means of neuroimaging allow for associating an individual case with one of several differential diagnoses. As it is, CA may be related to genetic disorders, to inflammatory or immune-mediated pathophysiological processes, to neoplasms, trauma, vascular accidents or nutrient deficiencies.

In general, the term ataxia describes the patient's reduced ability to coordinate their movements, to maintain posture and balance. Complex neural circuits are involved in those processes and accordingly, ataxia may be triggered by a wide variety of lesions. In detail, functional impairment of sensory pathways, spinal cord, basal ganglia, cerebellum and cerebral cortex may cause ataxia. If ataxia occurs to pathophysiological events interfering with cerebellar function, the respective patient is diagnosed with cerebellar ataxia (CA).

CA may be provoked by genetic disorders, by autoimmune diseases, strokes, traumas and tumors, among others. CA typically manifests in form of vertigo and dizziness, an unsteady gait and problems upon controlling the movements of limbs and eyes. Moreover, cerebellar lesions are often associated with difficulties while speaking, writing and reading. All these symptoms are rather unspecific and in order to obtain more detailed information regarding the underlying disease, patients usually have to undergo magnetic resonance imaging and possibly additional procedures.

Only if a reliable diagnosis can be made, the appropriate therapeutic approach can be chosen. Causal treatment is available for few diseases associated with CA only, and symptomatic support may be provided in form of medication or surgery. Some patients, e.g., children suffering from post-infectious CA, have a very good prognosis, while others, namely those diagnosed with brain tumors, have a poor one.

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