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Cerebellar Disease


  • The diagnosis is based on the present of high serum and CSF titers of GAD antibodies, with intrathecal production of such antibodies.[ncbi.nlm.nih.gov]
  • Cerebellar tumours will also cause hydrocephalus as they enlarge and will present usually with headaches, imbalance and papilledema. Again positional vertigo and nystagmus might be the presenting complaint 7.[otologytextbook.net]
  • Disturbances of syllable timing frequently were accompanied by abnormal contours of fundamental frequency, particularly monotone and syllable-falling patterns.[ncbi.nlm.nih.gov]
  • (In subtle cases, only heel-to-toe walking may be impaired: the patient duly falls to one side on cue.) Truncal ataxia is manifested by the patient having difficulty keeping his/her trunk upright, whether sitting or standing.[medicguide.blogspot.com]
  • I typically get them as I am falling asleep but I also noticed some very subtle action jerks while awake.[justanswer.com]
  • They may even fall over. A sign of flocculonodular lobe dysfunction. Lower limb Gait The classical cerebellar gait at rest is a wide-based stance. Tandem gait The cerebellar patient will not be able to walk heel-to-toe.[derangedphysiology.com]
Difficulty Walking
  • Contact your healthcare provider for a physical exam if you have an unsteady gait, difficulty walking or talking, or problems with coordination. The exact incidence of cerebellar ataxia syndrome in the United States is not known.[healthgrades.com]
  • The first indication generally is difficulty walking (gait ataxia). The condition typically progresses to the arms and trunk. Muscles weaken and waste away over time, causing deformities, particularly in your feet, lower legs and hands.[mayoclinic.org]
  • Abstract Background An 83-year-old man presented with hypertension, hyperlipidemia, and a previous basal cell carcinoma, having developed progressive worsening of his balance and difficulty walking at the age of 78 years.[nature.com]
  • Some common symptoms that are seen are clumsy body movements and eye movements, difficulty walking, nausea, vomiting, and headaches. [ citation needed ] Causes [ edit ] Post-viral cerebellar ataxia is caused by damage to or problems with the cerebellum[en.wikipedia.org]
  • In addition, the Extended Disability Status Scale was used; this scale may be insensitive to gait changes in patients with difficulty walking.[movementdisorders.org]
Psychiatric Symptoms
  • The case-history of a woman with psychiatric symptoms since childhood is reported, the best label for which was that of "chronic mania". Cerebellar atrophy was suspected on radiological grounds.[ncbi.nlm.nih.gov]
  • Isolated spinocerebellar affection may give gait ataxia. Vestibulocerebellar disease causes equilibrium disturbances with truncal ataxia and nystagmus.[ncbi.nlm.nih.gov]
  • (Adams et al., Principles of Neurology , 6th ed, p686) Gait Ataxia Ataxia of Gait Cerebellar Gait Cerebellar Gait Ataxia Gait Ataxia, Sensory Ataxia, Cerebellar Gait Ataxia, Gait Ataxia, Sensory Gait Ataxias, Cerebellar Gait Ataxias, Gait Ataxias, Sensory[icd9cm.chrisendres.com]
Cerebellar Disease
  • Results are discussed in terms of the effects of cerebellar disease on neuromuscular function.[ncbi.nlm.nih.gov]
Cerebellar Ataxia
  • PURPOSE: There is a lack of evidence-based recommendations for the physiotherapeutic intervention specifically for locomotor training in patients with cerebellar ataxia.[ncbi.nlm.nih.gov]
  • (From Adams et al., Principles of Neurology , 6th ed, p90) Spinocerebellar Degenerations Ataxias, Hereditary Cerebellar Ataxia, Early Onset Cerebellar Ataxia, Late Onset Cerebellar Degenerations, Primary Corticostriatal-Spinal Degeneration Marie Cerebellar[icd9cm.chrisendres.com]
  • ataxia associated with another disorder Secondary cerebellar ataxia ICD-10-CM G32.81 is grouped within Diagnostic Related Group(s) (MS-DRG v 36.0): 058 Multiple sclerosis and cerebellar ataxia with mcc 059 Multiple sclerosis and cerebellar ataxia with[icd10data.com]
  • The graphs in this article illustrate ocular flutter, dysmetria, abnormal (nonsmooth) pursuit, instability of fixation, faulty vestibular suppression, impaired optokinetic response, end-position nystagmus, and rebound nystagmus.[ncbi.nlm.nih.gov]
  • Abstract Tremor that occurs as a result of a cerebellar lesion, cerebellar tremor, is characteristically an intention tremor.[ncbi.nlm.nih.gov]
  • An intention tremor is one of the classic hallmarks of cerebellar disease. The person's tremor only occurs when he/she is wanting to touch a stationary object, and subsides once it has been reached.[medicguide.blogspot.com]


  • The image below illustrates the workup of paraneoplastic cerebellar degeneration. The workup of paraneoplastic cerebellar degeneration.[emedicine.medscape.com]


  • All tests were performed before and after treatment. RESULTS: Before treatment, both groups showed comparable values in all sway and gait variables and in BBS. FIM score was higher in degenerative than vascular patients.[ncbi.nlm.nih.gov]
  • […] of the underlying cause. [8] For example, paraneoplastic cerebellar degeneration may improve after successful treatment of the underlying cancer .[rarediseases.info.nih.gov]


  • Over the 6-month follow-up period, 57.9% of patients showed a poor prognosis (mRS: 3), while 42.1% showed a good prognosis (mRS: Conclusion: Determination and evaluation of the factors that could influence the prognosis and mortality of patients with[ncbi.nlm.nih.gov]
  • For alcoholic/nutritional cerebellar degeneration, symptoms are often relieved with discontinuation of alcohol abuse, a normal diet and dietary supplementation with thiamine and other B vitamins. [9] Last updated: 12/15/2014 The long-term outlook ( prognosis[rarediseases.info.nih.gov]
  • Affected individuals or parents of affected children should talk to their physician and medical team about their specific case, associated symptoms and overall prognosis.[rarediseases.org]
  • Correct clinical and genetic diagnosis is important for appropriate genetic counseling and prognosis and, in some instances, pharmacological treatment.[orpha.net]
  • […] spectroscopy elevated lactate 1,2 slightly reduced NAA (by about 10%) 1,2 reduced myo-inositol (by 30-80%) reduced choline (by 20-50%) reduced Cho/Cr ratio 2 PET/SPECT FDG-PET: shows increased uptake Tl- 201 SPECT: shows increased uptake Treatment and prognosis[radiopaedia.org]


  • Code First Code First Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • Cerebellar agenesis is a descriptive term implying complete absence of the cerebellum, irrespective of its underlying cause (etiology).[rarediseases.org]
  • Etiology The exact etiology of MSC-c is unknown while the presence of cytoplasmic aggregates of α-synuclein, primarily in the oligodendroglia, in combination with predominant neurodegeneration of the olivopontocerebellar structures are pathological hallmark[orpha.net]
  • The group of inherited ataxia, although genetically well identified, was heterogeneous in its composition: 2 SCA1, 1 SCA2, 2 SCA6, 1 SCA8 and 6 with a genetic etiology unknown, 2 SCA3. In the sporadic group of cerebellar disease were cases of MSA.[scielo.br]
  • CCA was defined as an SCA of unknown etiology with imaging evidence of isolated cerebellar atrophy.[movementdisorders.org]


  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Summary Epidemiology This group encompasses a large number of rare diseases, the most frequent in the Caucasian population being Friedreich ataxia (estimated prevalence 2-4/100,000), ataxia-telangiectasia (1-2.5/100,000) and early onset cerebellar ataxia[orpha.net]
  • The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis[wiley.com]
  • Epidemiology Frequency United States In one study, paraneoplastic cerebellar degeneration was observed in 25% of paraneoplastic neurologic syndromes, occurring in 2 of every 1000 patients with cancer. [12] Mortality/Morbidity In the study cited above,[emedicine.medscape.com]
Sex distribution
Age distribution


  • This in turn will permit a greater understanding of cerebellar pathophysiology to inform mechanistically rationalised therapies, which are desperately needed in this field.[ncbi.nlm.nih.gov]
  • Minagar has significant interest in pathophysiology and neuroimaging features of the inflammatory disease of human central nervous system, in general, and multiple sclerosis, in particular.[elsevier.com]
  • The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis[wiley.com]
  • "Pathophysiology of cerebellar ataxia". Movement Disorders. 7 (2): 95–109. doi : 10.1002/mds.870070202. PMID 1584245. Multiple System Atrophy differential at eMedicine Manto, Mario; Marien, Peter (2015).[en.wikipedia.org]
  • Reciprocal neuroanatomical connections linking the cerebral association areas and paralimbic regions with the cerebellum constitute the basis to explain the pathophysiological mechanisms of the cerebellar induced cognitive and affective deficits.[cerebellumandataxias.biomedcentral.com]


  • Excision of ataxin-7 from BG partially rescued the behavioral phenotype, but did not prevent BG process loss or molecular layer thinning, while excision of ataxin-7 from PCs and inferior olive provided significantly greater rescue and prevented both pathological[ncbi.nlm.nih.gov]
  • For decades, the most it could do for people with HIV was to prevent them from dying of AIDS. Now, new therapies are raising hopes for something more: a world in which the virus will no longer cause suffering or fear.[rockefeller.edu]
  • Distinct from the shuffling gait of Parkinsonism, the wide stance of cerebellar ataxia helps patients feel more stable and prevents falls and injuries.[multiplesystematrophy.org]
  • Reducing your risk of stroke by exercising, maintaining a healthy weight, and keeping blood pressure and cholesterol in check can also be helpful in preventing ACA.[healthline.com]

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