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Cerebral Cortical Atrophy


Presentation

  • Addison's disease or other causes of dehydration and abnormal fluid balance occasionally present with cerebral cortical atrophy on CT and may be reversible with treatment.[neuroradiologycases.com]
  • In this article, a 12-month-old female infant with psychomotor developmental retardation who was referred to our hospital with the initial diagnosis of leukemia due to the finding of pancytopenia is presented.[scopemed.org]
  • Cerebral atrophy is frequent in patients with PTSD, whereas in patients with depression, besides cerebral atrophy, silent brain infarct is also frequently present.[ncbi.nlm.nih.gov]
  • Most cases present with neonatal-onset hypotonia, lactic acidosis, hyperammonemia, hypertrophic cardiomyopathy, and 3-methylglutaconic aciduria. Many patients die within a few months or years (summary by Mayr et al., 2010 ).[mendelian.co]
  • We report a typical case of a patient with PCA who presented initially with visuospatial deficit and apraxia.[omicsonline.org]
Respiratory Insufficiency
  • Affected individuals may have respiratory insufficiency, foot deformities, or seizures, and all reported patients have died in infancy.[mendelian.co]
Hyperreflexia
  • […] stagnation Ovoid thoracolumbar vertebrae Pallor Dense calvaria Nystagmus Abnormal facial shape Blindness Inguinal hernia Midface retrusion Hernia Absent speech Mandibular prognathia Visual loss Feeding difficulties in infancy Retinal degeneration Lower limb hyperreflexia[mendelian.co]
  • In some cases, pyramidal signs (generalized hyperreflexia and positive Babinski sign) are observed.[orpha.net]
Mental Deterioration
  • Four Clinical Cases Who Mentally Deteriorated 1. A 25-year-old female was referred with severe chronic pain due to fibromyalgia. She claimed undertreatment for at least three years which interfered with her promising career.[practicalpainmanagement.com]
Urinary Incontinence
  • Clinical manifestations include autonomic failure (orthostatic hypotension, syncope, respiratory disturbances (sleep apnea, stridor and inspiratory sighs), constipation, bladder dysfunction (early urinary incontinence), erectile dysfunction in males and[orpha.net]

Treatment

  • RESULTS: Average age of the group of patients studied was 48 /-9.7 years, and average duration of psychiatric treatment was 6 /-7.3 years.[ncbi.nlm.nih.gov]
  • Addison's disease or other causes of dehydration and abnormal fluid balance occasionally present with cerebral cortical atrophy on CT and may be reversible with treatment.[neuroradiologycases.com]
  • Replacement therapy with vitamin B12 resulted in marked improvement of psychomotor status, and cranial MRI performed 7 months following the diagnosis and treatment initiation revealed resolution of cortical atrophy.[scopemed.org]
  • Pulmonary arteriovenous malformations: evaluation with CT of the chest before and after treatment. ‏ الصفحة 233 - Magnetic resonance imaging in planning limb-salvage surgery for primary malignant tumors of bone.[books.google.com]
  • Cerebral Atrophy treatment in Ayurveda According to Ayurveda, cerebral atrophy is caused due to disruption in the vata dosha, which controls the motor and sensory activities in the body.[nirogam.com]

Prognosis

  • Disorders such as stroke can affect a person's quality of life and lifespan. x Prognosis Cerebral atrophy can affect a person's lifespan.[ninds.nih.gov]
  • Prognosis is poor with a median survival of 6-9 years. The documents contained in this web site are presented for information purposes only.[orpha.net]
  • Therapy and prognosis. Am J Med 1975;58:644-654 2. Abel T, Gladman D, Urowitz M. Neuropsychiatric lupus. J Rheumatol 1980;7:325-333 3. Hughes G. Central nervous system lupus-diagnosis and treatcment. J Rheumatol 1980;7:405-41 1 4.[rheum-care.com]

Etiology

  • Although high doses of steroids may have been responsible for some of the lesions, alternate etiologies are required to explain the abnormality in others cases.[ncbi.nlm.nih.gov]
  • Etiology Etiology of MSA is unknown but presence of cytoplasmic aggregates of α-synuclein, primarily in oligodendroglia, in combination with neurodegeneration in striatonigral and olivopontocerebellar structures are the pathological hallmark features.[orpha.net]
  • The clinical cerebral manifestations of SLE were termed ”cerebritis” and included any abnormality of central neurologic function with a change from the prior state in the absence of other possible etiologies.[rheum-care.com]

Epidemiology

  • Annals of Epidemiology , 7 , 219 – 224 . Biessels , G. J. , De Leeuw , F. E. , Lindeboom , J. , Barkhof , F. and Scheltens , P. ( 2006 ). Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus .[cambridge.org]
  • Summary Epidemiology Prevalence ranges from 1/50,000-1/20,000. MSA-parkinsonian type (MSA-p) predominates in the Western Hemisphere and MSA-cerebellar type (MSA-c) predominates in the Eastern Hemisphere. Genders are equally distributed.[orpha.net]
Sex distribution
Age distribution

Pathophysiology

  • Although the study was not powered to assess the role of T2DM, the results suggested that glucose dysregulation may contribute to the pathophysiology of Alzheimer disease ( 32 ).[care.diabetesjournals.org]

Prevention

  • Experts are still trying to figure out the answers to this question, and research into the prevention of cerebral SVD is ongoing.[betterhealthwhileaging.net]
  • This type of atrophy is preventable and often reversible if steps to improve B12 levels are implemented.[livestrong.com]
  • Regular practice of pranayama can prevent further degenerative process. It is better to consult an Ayurvedic doctor personally and undergo proper therapies. You may find some positive changes within 6 months to 1 year. Subscribe to our newsletter![nirogam.com]
  • All parties must be educated about this fact and aggressively attempt to prevent brain atrophy in chronic pain patients.[practicalpainmanagement.com]
  • "Currently there are no treatments that will prevent or cure Alzheimer's disease, but information about risk of rapid decline may help patients with MCI and their families plan for the future," Dr. McEvoy said.[sciencedaily.com]

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