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2.1
Cerebral Neoplasm
Tumor of the Cerebrum

Presentation

In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. [fpnotebook.com]

Any middle-aged or elderly patients presenting with a first seizure should have CNS tumor high in the differential diagnosis. Patients with a brain tumor may present with acute neurologic changes mimicking those associated with stroke. [emedicine.medscape.com]

As such, at the present time, we can only assume that these peaks are representative of glutamine and glutamate. [ajnr.org]

This toxicity presents risks for bleeding, anemia, and infection. [childhoodbraintumor.org]

We present four patients with BTRE treated with OXC in monotherapy who shoed, during concomitant brain radiotherapy, a major skin reaction, that disappeared after OXC withdrawal. [moh-it.pure.elsevier.com]

Workup

[…] include incompatibility with certain medical equipment, longer imaging times (increased risk of motion artifact), and poor visualization of the subarachnoid space Neither CT nor MRI can be used to differentiate tumor recurrence from radionecrosis See Workup [emedicine.medscape.com]

Specific testing may also be warranted based on symptoms and exam findings: these include audiology for acoustic neuroma, lumbar puncture for abnormal tumor cells, endocrine workup for hormonal abnormalities, and electroencephalogram for suspected seizure [now.aapmr.org]

The patient had an unremarkable collagen vascular workup. There was also no evidence of an infectious or drug-induced cause of vasculitis. [ajnr.org]

AMYLOIDOSIS Case Examples 14i and 14ii: Amyloidoma After the initial clinical and radiologic workup, the lesion in case 14i was thought to be a schwannoma of the fifth nerve, which would fit the imaging features and presentation. [archivesofpathology.org]

Treatment

Download full chapter on “Treatment Options” from Frankly Speaking Treatment Center Options Choosing a treatment center can be difficult. [braintumor.org]

[…] for diagnosis and treatment. [hopkinsmedicine.org]

Regular follow-up treatment is extremely important after treatment for a brain tumor. [radiologyinfo.org]

See Answer What about a second opinion for brain tumor treatment? Before starting treatment, you might want a second opinion about your diagnosis and treatment plan. [medicinenet.com]

Prognosis

Key message: Ependymomas are a group of CNS tumours with moderately good prognosis, though higher grade tumours have slightly poorer survival. The prognosis for spinal ependymomas is better than that for cerebral tumours. [ncin.org.uk]

Prognosis 5-year survival: 40-50% 10-year survival: 47-68% Better prognosis: Young age Infratentorial Gross total excision Low-grade histology 52. II. [slideshare.net]

Your neurosurgeon will be able to give you a more clear idea of prognosis when the final diagnosis has been made. [uhs.nhs.uk]

Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) and treatment options for primary brain and spinal cord tumors depend on the following: The type and grade of the tumor. [my.clevelandclinic.org]

PMID: 476715 See all (1) Prognosis High-grade cerebral neuroblastoma: a case study. Wyche M, Stokes BA, Shepherd JM, Kakulas BA, Ojeda VJ Med J Aust 1989 May 1;150(9):505-7. PMID: 2542739 See all (1) [ncbi.nlm.nih.gov]

Etiology

Epidemiology and etiology of meningioma. J Neurooncol., 99, hal.307. [e-journal.unair.ac.id]

[from NCI] Etiology Cent Eur J Public Health 2017 Dec;25 Suppl 2:S59-S63. doi: 10.21101/cejph.a5055. PMID: 29524371 Eichler AF, Lamont EB J Neurooncol 2009 Dec;95(3):427-431. Epub 2009 Jun 27 doi: 10.1007/s11060-009-9943-z. [ncbi.nlm.nih.gov]

Clinical Clues to Nonmalignant Brain Lesions Clinical clues Suggested etiology Abnormalities found on more extensive imaging that are suggestive of an etiology Cysticercosis, fungal infections, sarcoidosis, tuberculosis Chronic fever; recent dental procedure [aafp.org]

Although the cause of this disorder is unclear, a viral etiology, as well as an association with lymphoma, has been reported (2, 3). [ajnr.org]

Lesion patterns and etiology of ischemia in superior cerebellar artery territory infarcts.Cerebrovasc Dis. 2005; 19:283–290.CrossrefMedlineGoogle Scholar 12. Jauch EC, Saver JL, Adams HP, Bruno A, Connors JJ, Demaerschalk BM, et al.. [ahajournals.org]

Epidemiology

References:[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Pilocytic astrocytoma Medulloblastoma Description:: a highly malignant tumor derived from primitive, neuroectodermal tissue Epidemiology [amboss.com]

The descriptive epidemiology of craniopharyngiomas. J Neurosurg. 1998;89:547-551. http://www.ncbi.nlm.nih.gov/pubmed/9761047?tool=bestpractice.com [16] Haupt R, Magnani C, Pavanello M, et al. Epidemiological aspects of craniopharyngioma. [bestpractice.bmj.com]

Epidemiology As a general rule, brain tumors increase in frequency with age, with individual exceptions (e.g. pilocytic astrocytoma, the vast majority of which are found in young patients), and a number of uncommon tumors found in infancy (see brain tumors [radiopaedia.org]

Angiology (103) Gastroenterology and Hepatology (98) Microbiology (82) Endocrinology, Metabolism (79) Haematology (76) Oncology, Radiation Therapy (75) Neurosurgery (70) Psychiatry, Psychology, Sexology (69) Obstetrics, Gynaecology (64) Nephrology (63) Epidemiology [portal.mefanet.cz]

Epidemiology and etiology of meningioma. J Neurooncol., 99, hal.307. [e-journal.unair.ac.id]

Pathophysiology

Moreover, a better understanding of the pathophysiological mechanisms underlying the presence of post-stroke mood disorders could improve their management. [clinicaltrials.gov]

Paediatrics, Neonatology (387) Internal Medicine (386) Pathology and Forensic Medicine (274) Neurology (261) Physiology and Pathophysiology (242) Genetics (224) Surgery, Traumatology and Orthopaedics (183) Medical Chemistry and Biochemistry (174) Infectology [portal.mefanet.cz]

Brain Neoplasms: Practice Essentials, Background, Pathophysiology. Medscape website. emedicine.medscape.com/article/779664-overview#showall. Published November 9, 2015. Accessed February 10, 2017. 8. [pharmacytimes.com]

In one study of almost 2000 consecutive stroke patients, cerebellar strokes had nearly twice the mortality rate (23%) of more common cerebral strokes (12.5%), with brainstem strokes falling in between (17%).[3] Pathophysiology Presenting neurologic deficits [ncbi.nlm.nih.gov]

Prevention

Management or prevention of these conditions can significantly decrease your risk of stroke. [winchesterhospital.org]

In general, chemotherapy can make it possible to delay, decrease or eliminate the radiation normally given to the entire brain and spine in an attempt to prevent relapse distant from the site of the primary tumor. [childhoodbraintumor.org]

Fisher to discover a new pharmacological agent that could – with additional chemistry – lead to a new drug to prevent radiation-induced invasion of GBM cells. [nfcr.org]

Collaborative initiatives with the UChicago Medicine Comprehensive Cancer Center aim to substantially advance the treatment and prevention of brain and spinal cord metastases. [uchospitals.edu]

[…] shrink the tumor or prevent the tumor from growing back Comfort measures, safety measures, physical therapy, occupational therapy, and other such steps may be required to improve quality of life. [medlineplus.gov]

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