The observation were reported as “consistent with a model of lateonset AD in which β-amyloidosis arises in later life on a background of preexisting structural and cognitive decline that is associated with aging and not with β-amyloid deposit”. [jneuro.com]

Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K: Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. [immunityageing.biomedcentral.com]

Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type. Arch Neurol. 1990; 47 :965–967. [ PubMed ] [ Google Scholar ] 72. [ncbi.nlm.nih.gov]

Patients with thyroid disease may be included in the study, provided they are euthyroid on treatment. 11. [clinicaltrials.gov]

These findings in a patient with vascular dementia may suggest increased oxygen extraction by activated neuronal structures. [ncbi.nlm.nih.gov]

Supporting clinical features for diagnosis of VaD include early presence of gait disturbance, history of unsteadiness and frequent unprovoked falls, early urinary symptoms, personality and mood changes, depression, psychomotor retardation and abnormal [link.springer.com]

For example, typical examples of so-called "lacunar syndrome" include pure motor hemiparesis, pure sensory stroke, sensorimotor stroke, clumsy hand-dysarthria, and hemiataxia-hemiparesis. The issue becomes a measure of impact on functional ability. [ncbi.nlm.nih.gov]

Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease ), changes in speech, unsteady gait, clumsiness or frequent falls, changes in personality or mood or urinary symptoms. [my.clevelandclinic.org]

These include: being unsteady on your feet clumsiness, and falling often urinary symptoms that aren’t related to a urinary infection or disease. [saga.co.uk]

Focal signs included mild facial paresis, clumsiness of fine finger movements, reflex asymmetry, extensor plantar responses, and cortical sensory signs. None of the patients had visual field defects on clinical testing. [jnnp.bmj.com]

A person who develops cognitive impairment and long tract signs in their 50s or 60s is certainly going to be recognized as more impaired than an 80 year old individual who is retired and primarily is engaged in recreational activity. [ncbi.nlm.nih.gov]

The person may act impulsively and irritably, and sometimes scream. Vascular dementia is thought to be caused by small strokes that interfere with blood flow to the brain. [minddisorders.com]

psychosis NOS Symptomatic psychosis NOS Code First the underlying physiological condition Type 1 Excludes psychosis NOS ( F29 ) due to or associated with disease cerebrovascular F01.50 ICD-10-CM Diagnosis Code F01.50 Vascular dementia without behavioral [icd10data.com]

dementia with Lewy bodies (DLB) Essential for a diagnosis of DLB is dementia, defined as a progressive cognitive decline of sufficient magnitude to interfere with normal social or occupational functions, or with usual daily activities. [indianjpsychiatry.org]

bundle branch block, or arrhythmias) is stable on appropriate medication for 3 months prior to Screening. [clinicaltrials.gov]

Demyelination, loss of axons, patchy gliosis and infiltration by macrophages were noted in the involved regions. The long penetrating vessels of the white matter showed advanced arteriosclerotic changes. There was a relative sparing of the cortex. [ncbi.nlm.nih.gov]

Small vessel disease results in arterial wall changes, expansion of the Virchow-Robin spaces, and perivascular parenchymal rarefaction and gliosis. [emedicine.medscape.com]

It causes diffuse and irregular loss of axons and myelin with widespread gliosis, tissue death due to an infarction, or loss of blood supply to the white matter of the brain. [merckmanuals.com]

[…] have been reports of different mechanisms of vascular damage such as small vessel atherosclerosis, large vessel arteriosclerosis, cortical and subcortical infarcts, lacunar infacts with gray/white matter lesions, WML (leukoaraoisis), demyelination, gliosis [scielo.br]

Binswanger and Alzheimer, began a series of clinicopathological correlation studies attempting to isolate additional forms of dementia, describing four different form of vascular dementia (arteriosclerotic brain degeneration, perivascular gliosis of the [immunityageing.biomedcentral.com]

CT/MRI Both CT and MRI are able to provide evidence of ischemic damage, however, MRI is more sensitive, especially to white matter small vessel ischemic change as well as to microhemorrhages seen in cerebral amyloid angiopathy and chronic hypertensive [radiopaedia.org]

Subcortical vascular dementia is a diffuse small vessel disease with minimal or absent infarction with homogenous pathological and clinical features. [3, 4] White matter ischemic changes affect executive dysfunction and cause slower processing speed, [emedicine.medscape.com]

Ischemic changes in the brain are irreversible, but the patient with vascular dementia can demonstrate periods of stability or even mild improvement. [21] Since stroke is an essential part of vascular dementia, [7] the goal is to prevent new strokes. [en.wikipedia.org]