Symptoma

Cerebrovascular Dementia

In the present study, serum concentrations of DHEA and DHEA-S were determined in 19 patients with AD, 21 patients with cerebrovascular dementia (CVD) and 45 age- and gender matched elderly control individuals from the Japanese community at large. [ncbi.nlm.nih.gov]

The study also found that atherosclerosis and arteriolosclerosis are associated with lower levels of thinking abilities, including in memory and other thinking skills, and these associations were present in persons with and without dementia. [sciencedaily.com]

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  • Amyloidosis

    The observation were reported as “consistent with a model of lateonset AD in which β-amyloidosis arises in later life on a background of preexisting structural and cognitive decline that is associated with aging and not with β-amyloid deposit”. [jneuro.com]

    Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Sturchler-Pierrat C, Burki K: Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. [immunityageing.biomedcentral.com]

    Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type. Arch Neurol. 1990; 47 :965–967. [ PubMed ] [ Google Scholar ] 72. [ncbi.nlm.nih.gov]

  • Euthyroid

    Patients with thyroid disease may be included in the study, provided they are euthyroid on treatment. 11. [clinicaltrials.gov]

  • Suggestibility

    These findings in a patient with vascular dementia may suggest increased oxygen extraction by activated neuronal structures. [ncbi.nlm.nih.gov]

  • Clumsiness

    For example, typical examples of so-called "lacunar syndrome" include pure motor hemiparesis, pure sensory stroke, sensorimotor stroke, clumsy hand-dysarthria, and hemiataxia-hemiparesis. The issue becomes a measure of impact on functional ability. [ncbi.nlm.nih.gov]

    Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease ), changes in speech, unsteady gait, clumsiness or frequent falls, changes in personality or mood or urinary symptoms. [my.clevelandclinic.org]

    These include: being unsteady on your feet clumsiness, and falling often urinary symptoms that aren’t related to a urinary infection or disease. [saga.co.uk]

    Focal signs included mild facial paresis, clumsiness of fine finger movements, reflex asymmetry, extensor plantar responses, and cortical sensory signs. None of the patients had visual field defects on clinical testing. [jnnp.bmj.com]

  • Long Tract Signs

    A person who develops cognitive impairment and long tract signs in their 50s or 60s is certainly going to be recognized as more impaired than an 80 year old individual who is retired and primarily is engaged in recreational activity. [ncbi.nlm.nih.gov]

  • Screaming

    The person may act impulsively and irritably, and sometimes scream. Vascular dementia is thought to be caused by small strokes that interfere with blood flow to the brain. [minddisorders.com]

  • Possibly Dementia

    dementia with Lewy bodies (DLB) Essential for a diagnosis of DLB is dementia, defined as a progressive cognitive decline of sufficient magnitude to interfere with normal social or occupational functions, or with usual daily activities. [indianjpsychiatry.org]

  • Organic Psychosis

    psychosis NOS Symptomatic psychosis NOS Code First the underlying physiological condition Type 1 Excludes psychosis NOS ( F29 ) due to or associated with disease cerebrovascular F01.50 ICD-10-CM Diagnosis Code F01.50 Vascular dementia without behavioral [icd10data.com]

Core elements of a workup for vascular dementia typically include: A thorough medical history, including family history of dementia. Evaluation of independent function and daily activities. Input from a family member or trusted friend. [alz.org]

“The right cognitive screening test is quick and easy to administer in the office as part of the initial workup,” says Gorelick. “We can do it in 10 minutes and get a pretty good idea of what's going on with that patient.” [heartinsight.heart.org]

  • Gliosis

    Demyelination, loss of axons, patchy gliosis and infiltration by macrophages were noted in the involved regions. The long penetrating vessels of the white matter showed advanced arteriosclerotic changes. There was a relative sparing of the cortex. [ncbi.nlm.nih.gov]

    Small vessel disease results in arterial wall changes, expansion of the Virchow-Robin spaces, and perivascular parenchymal rarefaction and gliosis. [emedicine.medscape.com]

    It causes diffuse and irregular loss of axons and myelin with widespread gliosis, tissue death due to an infarction, or loss of blood supply to the white matter of the brain. [merckmanuals.com]

    […] have been reports of different mechanisms of vascular damage such as small vessel atherosclerosis, large vessel arteriosclerosis, cortical and subcortical infarcts, lacunar infacts with gray/white matter lesions, WML (leukoaraoisis), demyelination, gliosis [scielo.br]

    Binswanger and Alzheimer, began a series of clinicopathological correlation studies attempting to isolate additional forms of dementia, describing four different form of vascular dementia (arteriosclerotic brain degeneration, perivascular gliosis of the [immunityageing.biomedcentral.com]

  • Ischemic Changes

    CT/MRI Both CT and MRI are able to provide evidence of ischemic damage, however, MRI is more sensitive, especially to white matter small vessel ischemic change as well as to microhemorrhages seen in cerebral amyloid angiopathy and chronic hypertensive [radiopaedia.org]

    Subcortical vascular dementia is a diffuse small vessel disease with minimal or absent infarction with homogenous pathological and clinical features. [3, 4] White matter ischemic changes affect executive dysfunction and cause slower processing speed, [emedicine.medscape.com]

    Ischemic changes in the brain are irreversible, but the patient with vascular dementia can demonstrate periods of stability or even mild improvement. [21] Since stroke is an essential part of vascular dementia, [7] the goal is to prevent new strokes. [en.wikipedia.org]

After treatment, these findings disappeared. The regional cerebral blood flow values by Xe-CT in both patients did not show significant changes from before treatment to the values after treatment. [ncbi.nlm.nih.gov]

Status of treatment of vascular dementia. Neuroepidemiology 1998; 17(1): 10–3 PubMed CrossRef Google Scholar 73. Rother M, Erkinjuntti T, Roessner M, et al. Propentofylline in the treatment of Alzheimer’s disease and vascular dementia. [link.springer.com]

His main research interests are the early detection and treatment of Alzheimer's disease and the care of the depressed elderly. [books.google.com]

Research into environmental factors is currently focused on cerebrovascular risk factors. 1 Treatment of vascular risk factors has been associated with slower cognitive decline and reduced risk of AD in older populations. 2 Genetics are important in rare [jnnp.bmj.com]

Patients with thyroid disease may be included in the study, provided they are euthyroid on treatment. 11. [clinicaltrials.gov]

Similarly, no single prognosis can be given, being largely dependent on the underlying cause and the degree to which successful treatment can be initiated. Promoted articles (advertising) [radiopaedia.org]

Prognosis for People With Vascular Dementia If the conditions that cause vascular dementia go untreated, the prognosis is not good. [webmd.com]

Prognosis [ edit ] Many studies have been conducted to determine average survival of patients with dementia. [en.wikipedia.org]

The severity of vascular dementia affects a person’s prognosis. The greater the damage to the brain, the more likely a person is to need assistance with everyday tasks. [healthline.com]

Code First Code First Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10data.com]

multiple infarctions involving cortex and underlyig white matter) that are judged to be etiologically related to the disturbance. D. The deficits do not ocurr exclusively during the course of a delirium. [strokecenter.org]

Etiology and pathophsyiology VaD as a clinical syndrome relates to different vascular mechanisms and changes in the brain, and has different causes and clinical manifestations. [encyclopedia.com]

Neuro-imaging indicates a probable vascular etiology with white matter changes and infarction. 21. Vascular Dementia Alzheimer’s Dementia Mixed Disorder Genetic Disorder 22. [slideshare.net]

Wharton SB, Brayne C, Savva GM (2011) Epidemiological neuropathology: the MRC Cognitive Function and Aging experience. J Alzheimers Dis 25:359-372. [jneuro.com]

Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease. Arch Med Res. 2015 Jul;46(5):328-38. Pubmed search conducted September 2015 using search terms “risk AND factors AND cerebrovascular” Arboix A. [cambridgecognition.com]

The epidemiology of the dementias of the elderly. In: Brody JA, Maddox GL, eds. Epidemiology and Aging. An International Perspective. New York, NY: Springer Publishing Company; 1988 : 36–53. [stroke.ahajournals.org]

Epidemiology Epidemiologic studies of VaD have been hampered by the "lack of clear and universal diagnostic criteria, by the use of different strategies in detecting dementia cases of vascular origin, by the difficulties of developing an effective case-finding [immunityageing.biomedcentral.com]

Epidemiology of dementia. In: Boller F, Cappa S, eds. Handbook of Neuropsychology: Vol. 6: Aging and Dementia. 2nd ed. Amsterdam, Netherlands: Elsevier Science; 2001. 7. Centers for Disease Control and Prevention. [uspharmacist.com]

This study investigated the involvement of Chitotriosidase (ChT), a chinolitic enzyme mainly produced by activated macrophages, in the pathophysiology of Alzheimer's disease (AD) and ischemic CvD. [ncbi.nlm.nih.gov]

Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. [books.google.ro]

Pathophysiology, Diagnosis and Treatment Review Article First Online: 14 September 2012 25 Downloads 35 Citations Abstract Vascular dementia (VaD) is the second most common cause of dementia and can coexist with other causes of dementia. [link.springer.com]

Understanding the pathophysiologic interactions between renal impairment and brain function in CKD patients is important in order to minimize the risk for future cognitive impairment. [jasn.asnjournals.org]

[…] mechanism (eg, subcortical ischemic vascular disease, amyloid angiopathy, cortical infarction, etc.); and the potential for intervention and prevention based on the pathophysiological mechanism of the “brain-at-risk” stage. 3 Because both AD and stroke [stroke.ahajournals.org]

Measures that prevent CVD are similar to those that prevent coronary heart disease and include active treatment of hypertension, hyperlipidaemia and diabetes. [jneuro.com]

Therefore, finding ways to treat or prevent the disease "is a major goal," Arvanitakis said. [sciencedaily.com]

VaD may be preventable and improvement with therapy is possible; thus, early diagnosis is essential. The conventional concept of VaD is that of multi-infarct dementia. [link.springer.com]

However, "large prospective clinical trials are needed to identify vascular biomarkers, prevention strategies, and both pharmacologic and nonpharmacologic treatments, Grysiewicz wrote. [medpagetoday.com]

Because lipid-lowering agents are key in preventing cardiovascular disease, they are of interest for prevention of VaD. [uspharmacist.com]