Charcot-Marie-Tooth disease type 4 characterized by childhood- to adulthood-onset of variably severe, rapidly progressive, axonal and demyelinating sensorimotor neuropathy typically manifesting with delayed motor development, proximal and distal asymmetric muscle weakness [orpha.net]

Symptoms CMT4 causes muscle weakness, mostly in the distal muscles (those far from the center of the body), but sometimes also in proximal muscles (those close to the center of the body). [charcot-marie-toothnews.com]

weakness and atrophy of the lower and upper extremities, severe motor dysfunction with mildly reduced sensory impairment, and areflexia. [orpha.net]

Symptoms CMT4 causes muscle weakness, mostly in the distal muscles (those far from the center of the body), but sometimes also in proximal muscles (those close to the center of the body). [charcot-marie-toothnews.com]

When CMT4 begins in infancy, it is characterized by low muscle tone (loose, floppy muscles). CMT4 patients also may develop other symptoms such as cataracts or deafness. The symptoms vary from mild to severe. [charcot-marie-toothnews.com]

[…] demyelinating sensorimotor neuropathy typically manifesting with delayed motor development, proximal and distal asymmetric muscle weakness and atrophy of the lower and upper extremities, severe motor dysfunction with mildly reduced sensory impairment, and areflexia [orpha.net]

Hearing loss, vocal cord involvement, and facial paresis (partial paralysis) have been reported. The nerve conduction velocity (the speed at which nerve signals travel across nerve cells) is slow and usually ranges between 16 and 36 m/s in the arms. [charcot-marie-toothnews.com]