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Chemical Esophagitis


Presentation

  • Specific sections deal with Physiology and Pathophysiology, Clinical Presentation of Disease, Clinical Manifestations and Management (discussing the Mouth and Esophagus, The Stomach and Duodenum, The Intestine, and The Pancreas), Diagnosis of Gastrointestinal[books.google.com]
  • His present research focusses on the gastrointestinal tract and its metabolic and microbiological functions. He has published more than 130 scientific articles in national and international indexed journals and presented more than 100 abstracts.[books.google.com]
  • The most accepted hypothesis is that it may be caused by allergic hypersensitivity to certain foods (like nuts and milk), air pollution or chemical components present in the modern industrialized foods and oral hygienic products.[news-medical.net]
  • Food allergies can present at any age, from infancy to adulthood. Patients present differently, some with itchy throat/mouth, hives, others with abdominal discomfort, or even vomiting.[kernallergy.com]
  • Gavin Young) While initially described in children, the characteristic clinical presentation is a middle-aged man with solid-food dysphagia.[incytepathology.wordpress.com]
Falling
  • Quick checklists cover all diagnostic possibilities to make sure nothing falls through the cracks. Full-text online access at expertconsult.com allows you to reference the book from any computer and download all of its images.[books.google.com]
Abdominal Pain
  • This laxative may induce side effects including abdominal pain, persistent diarrhea, or electrolyte imbalance. However, picosulfate is still considered to be relatively safe, as these complications only occur in rare cases.[e-ce.org]
  • Bisphosphonates are commonly used for the prevention and treatment of osteoporosis as well as other conditions affecting bone (eg, Paget's disease).1 The use of these agents is associated with gastrointestinal adverse effects including: abdominal pain[ebmconsult.com]
  • Common signs and symptoms can vary with age: infants and toddlers may not be growing properly refusing foods, school-age children may be having abdominal pains or vomiting, and others may have difficulty of swallowing or foods stuck in the throat/ esophagus[kernallergy.com]
  • For chemical injuries caused by contact with corrosive materials, symptoms such as oropharyngeal pain, dysphagia, abdominal pain, hematemesis, and dyspnea occur during the acute phase.[omicsonline.org]
Hematemesis
  • Seven days after admission, the patient had no more hematemesis or melena. Ten days after admission, the patient underwent follow-up upper gastrointestinal endoscopy.[e-ce.org]
  • For chemical injuries caused by contact with corrosive materials, symptoms such as oropharyngeal pain, dysphagia, abdominal pain, hematemesis, and dyspnea occur during the acute phase.[omicsonline.org]
Odynophagia
  • The main presenting symptoms of our patients were odynophagia, retrosternal pain and dysphagia in 100, 92% and 69% of patients, respectively.[saudijgastro.com]
Constipation
  • Medical management of constipation. Clin Colon Rectal Surg 2012;25:12-19. 23449608. 5. Hoy SM, Scott LJ, Wagstaff AJ. Sodium picosulfate/magnesium citrate: a review of its use as a colorectal cleanser. Drugs 2009;69:123-136. 19192941. 6.[e-ce.org]
Heart Disease
  • The book provides you with all the at-a-glance information you need for a quick overview of common issues from nutrition, allergy, infectious disease, and adolescent medicine, to cancer and heart disease.[books.google.com]
Myopathy
  • […] resistance to phagocytosis, and host substrate utilization New information on changes in body weight Recent findings on fibrocoxib and diclofenac Expanded and reorganized coverage of critical care New material on inborn errors of metabolism and acquired myopathies[books.google.com]
Suggestibility
  • "Together, our results implicate MIF in the pathogenesis of EoE and suggest that targeting MIF might represent a novel therapy for EoE." There is no cure for EoE.[news-medical.net]
  • These findings suggest the pathogenesis of reflux esophagitis may be caused by inflammatory cytokines rather than chemical injury.[healio.com]
  • "If replicated, these findings suggest that the pathogenesis of reflux esophagitis may be cytokine mediated rather than the result of chemical injury," the researchers said online May 17 in JAMA.[consultant360.com]
  • However, new data suggests that it is time to reconsider this concept. André J. P. M. Smout & Albert J. Bredenoord News and Views 02 March 2016 Eosinophilic oesophagitis (EoE) is a clinicopathological condition.[nature.com]
  • 1990s, close to 500,000 prescriptions for alendronate were written world-wide with approximately 200 reported esophageal adverse drug reactions.2 Of the 200 reported events, greater than half were associated with improper medication administration which suggests[ebmconsult.com]

Workup

Suppression
  • “Although this radical change in the concept of how acid reflux damages the esophagus of GERD patients will not change our approach to its treatment with acid-suppressing medications in the near future, it could have substantial long-term implications[healio.com]
  • Alongside your gastroenterologist, we will recommend treatments including proton pump inhibitor medication and swallowed topical corticosteroids to control the inflammation and to suppress the eosinophils.[kernallergy.com]

Treatment

  • Treatment of infectious esophagitis: Treatment varies with the causative agent. it is treated with antibacterial, antiviral or antifungal drugs depending on the causative agent that is whether it is a bacteria, virus or fungus.[medicotips.com]
  • Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.[books.google.com]
  • Spechler concluded, "will really paint the way for research on new treatments for this disease, treatments that may target directly those cytokines and inflammatory cells." The U.S.[consultant360.com]
  • "We are now one step closer to an effective treatment for this condition." Source: D'Or Institute for Research and Education[news-medical.net]
  • “Although this radical change in the concept of how acid reflux damages the esophagus of GERD patients will not change our approach to its treatment with acid-suppressing medications in the near future, it could have substantial long-term implications[healio.com]

Prognosis

  • Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.[books.google.com]
  • Prognosis; Complications If the cause of the esophagitis is an infection, and the infection is treated, the inflammation is likely to improve. If a chemical such as lye, bleach, or gasoline is ingested, the esophagus can perforate, or rupture.[diagnose-me.com]
  • […] reported than those caused by alkaline agents in the United States. 1 Early endoscopic intervention is very useful in suspected cases of corrosive esophagitis, not only for determining the degree of mucosal injury and severity, but also for predicting prognosis[e-ce.org]

Etiology

  • Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • The current data confirmed the role of oral doxycycline intake, the timing and the amount of concurrent fluid in the etiology of esophageal ulcerations. How to cite this article: Al Mofarreh MA, Al Mofleh IA.[saudijgastro.com]
  • The etiology for this histological finding is not clear. It could be assumed that bromazepam is able to interact with the epithelial surface in an acid milieu.[bmcgastroenterol.biomedcentral.com]

Epidemiology

  • References Christesen HB (1994) Caustic ingestion in adults--epidemiology and prevention. J Toxicol Clin Toxicol 32: 557-568. Kamijo Y (2009) Corrosive substances. In: Soma K (ed.), Clinical Toxicology. (1stedn), Igaku-shoin Ltd, Tokyo.[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow.[books.google.com]
  • Specific sections deal with Physiology and Pathophysiology, Clinical Presentation of Disease, Clinical Manifestations and Management (discussing the Mouth and Esophagus, The Stomach and Duodenum, The Intestine, and The Pancreas), Diagnosis of Gastrointestinal[books.google.com]
  • Pathophysiology of esophageal adenocarcinoma How? develops from Barrett's esophagus, usually in the distal 1/3 of esophagus, where cells become more dysplastic and cancerous.[quizlet.com]
  • Pathophysiology of gastroesophageal reflux disease: esophageal epithelial resistance. In: Castell DO, ed. The esophagus. Boston: Little Brown & Co., 1992:463-478. 11. Sarosiek J, McCallum RW.[hon.ch]
  • […] includes toluene, 6 and diluted pendimethalin, a herbicide, have also been reported. 7 As previously stated, both alkaline and acidic substances can induce corrosive esophagitis, but the effects of these two types of agents are explained by different pathophysiologic[e-ce.org]

Prevention

  • Furthermore, the early administration of a drug that blocks the effect of MIF prevented the eosinophils accumulation in the esophagus and the development of esophagitis in treated mice.[news-medical.net]
  • In other words, the hydrophobic properties of the phospholipids prevent gastric acid from reaching the epithelium.[ebmconsult.com]
  • Although prevention of esophagitis is not always possible, there are some wise measures that one can take. Maintaining a healthy weight, avoiding smoking, and limiting alcohol intake may decrease the risk of esophagitis.[diagnose-me.com]
  • If chemicals have been swallowed, treatment may include drugs and surgery to prevent infection and reduce scarring.[cedars-sinai.edu]
  • Milk (50 mL) was administered 6 h after the patient had first ingested the acid, but it failed to prevent sequential pyloric stenosis.[omicsonline.org]

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