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Chemical Esophagitis


Presentation

  • His present research focusses on the gastrointestinal tract and its metabolic and microbiological functions. He has published more than 130 scientific articles in national and international indexed journals and presented more than 100 abstracts.[books.google.com]
  • The most accepted hypothesis is that it may be caused by allergic hypersensitivity to certain foods (like nuts and milk), air pollution or chemical components present in the modern industrialized foods and oral hygienic products.[news-medical.net]
  • Food allergies can present at any age, from infancy to adulthood. Patients present differently, some with itchy throat/mouth, hives, others with abdominal discomfort, or even vomiting.[kernallergy.com]
  • Presumably, the present case was caused by strong acidity due to incomplete dilution, and chemical burning from an exothermic reaction.[e-ce.org]
  • Gavin Young) While initially described in children, the characteristic clinical presentation is a middle-aged man with solid-food dysphagia.[incytepathology.wordpress.com]
Inflammation
  • Scientists don't know yet what can trigger this kind of esophageal inflammation.[news-medical.net]
  • The primary outcome was change in esophageal inflammation at 2 weeks determined by changes in lymphocyte, eosinophil and neutrophil infiltrates in esophageal biopsies, which were scored on a 0 to 3-point scale.[healio.com]
  • Non-specific features: a) Severe inflammation, b) Superficial necrosis c) Ulceration with the formation of granulation tissue and fibrosis 2.[medicotips.com]
  • The patients stopped taking PPIs, and the researchers assessed changes in esophageal inflammation for two weeks afterward.[consultant360.com]
  • Esophagitis Inflammation of the esophagus. e·soph·a·gi·tis ( ĕ-sof'ă-jī'tis ) Inflammation of the esophagus. esophagitis (isof əjītis), n an inflammation of the mucosal lining of the esophagus caused by infection or irritation of the mucosa by reflux[medical-dictionary.thefreedictionary.com]
Physician
  • “This study challenges some of the long-held beliefs about how gastroesophageal reflux damages the esophageal mucosa in patients with gastroesophageal reflux disease,” Kerry Dunbar, MD, PhD, associate professor of internal medicine and staff physician[healio.com]
  • It's important for physicians to have an accurate understanding of the mechanism of the disease that they are treating. And for the last 80 years our understanding of that has just been incorrect," he said.[consultant360.com]
  • These medications need to be prescribed by your physician. The doses for each of these medications depend on a person’s size and age among other factors.[eosinophilicesophagitishome.org]
  • Therefore, after communication with the prescribing physician, the patient was instructed to stop using the alendronate.[jcda.ca]
  • By looking at the esophagus and possibly taking a small sample, the physician can determine what caused the inflammation.[medicalnewstoday.com]
Asymptomatic
  • Chest pain or infectious esophagitis may be asymptomatic.[medicotips.com]
  • This new bile monitoring device required both clinical validation and an establishment of control values for asymptomatic, presumably healthy, population of volunteers [ 5 ].[hon.ch]
  • It connects the pharynx to the stomach ; swallowed food and liquids normally pass through it. [1] Esophagitis can be asymptomatic ; or can cause epigastric and/or substernal burning pain, especially when lying down or straining; and can make swallowing[en.wikipedia.org]
  • Materials and Methods Subjects The study was approved by the Human Subject Committee and conducted on 33 Caucasian asymptomatic volunteers (15 females and 18 males, mean age of 39, range 26-56) and 20 Caucasian patients with RE (7 females and 13 males[clinmedjournals.org]
  • All patients became asymptomatic within the first week of treatment with proton-pump inhibitors and prokinetics despite the maintenance of doxycycline therapy in patients with brucellosis.[saudijgastro.com]
Falling
  • Quick checklists cover all diagnostic possibilities to make sure nothing falls through the cracks. Full-text online access at expertconsult.com allows you to reference the book from any computer and download all of its images.[books.google.com]
  • For example, if a patient who has difficulty swallowing tablets is bedridden or confined to a wheelchair, the risk of a fall resulting in hip or vertebral fracture may be relatively low under supervised care.[jcda.ca]
  • Fungal esophagitis Medical therapy for fungal conditions falls into the following three categories: Topically active agents include nystatin, clotrimazole, and oral amphotericin B Orally administered absorbable agents include fluconazole and itraconazole[emedicine.medscape.com]
Surgical Procedure
  • Fundoplication - a surgical procedure that allows you to restore the functional capacity of the valve, located between the esophagus and the stomach, to prevent the return of stomach contents.[hmcisrael.com]
Cough
  • However, it is increasingly apparent that the pathogenesis of esophagitis is distinct from that of the spectrum of potential GERD symptoms ranging from heartburn to regurgitation, chest pain, dysphagia, laryngitis, and cough,” he wrote, adding that a[healio.com]
  • Common Symptoms: Heartburn Bitter/sour taste in the back of the throat Sense of a lump in the throat Abdominal bloating/Abdominal discomfort Gas Chronic Cough Feeling the food is trapped behind the breastbone or in the throat Nausea after eating Burning[physio-pedia.com]
  • Examples include coughing and asthma. These secondary symptoms seem to affect those with esophageal damage because there are shared nerves that control the cough reflex and esophagus. These shared nerves can become inflamed and damaged over time.[draxe.com]
  • […] oesophagitis The main symptoms of GERD which causes the patient to seek medical attention are: Discomfort in the chest, alternated by pain as the disease progresses Pain in the upper abdomen Recurrent sore throat, recurrent inflammation of the oropharynx Cough[hmcisrael.com]
  • These are the signs and symptoms most commonly linked to esophagitis: abdominal pain pain and difficulty when swallowing food becoming stuck in the esophagus lack of appetite nausea and possibly vomiting cough pain in the chest when eating, heartburn[medicalnewstoday.com]
Dysphagia
  • […] sticking in the oesophagus (in case of chemical or drug esophagitis) d) In the case of radiation esophagitis, there will be Mucosal atrophy, submucosal fibrosis and Vascular intimal thickening Clinical Features and signs (infectious esophagitis) 1. dysphagia[medicotips.com]
  • However, it is increasingly apparent that the pathogenesis of esophagitis is distinct from that of the spectrum of potential GERD symptoms ranging from heartburn to regurgitation, chest pain, dysphagia, laryngitis, and cough,” he wrote, adding that a[healio.com]
  • Dysphagia. [serial on the Internet. (2009 December), [cited March 31, 2011]; 24(4): 403–411. Available from: PubMed.][physio-pedia.com]
  • The patient had progressive odynophagia and dysphagia, which markedly impaired her oral intake, and hematemesis.[nejm.org]
Abdominal Pain
  • This laxative may induce side effects including abdominal pain, persistent diarrhea, or electrolyte imbalance. However, picosulfate is still considered to be relatively safe, as these complications only occur in rare cases.[e-ce.org]
  • Bisphosphonates are commonly used for the prevention and treatment of osteoporosis as well as other conditions affecting bone (eg, Paget's disease).1 The use of these agents is associated with gastrointestinal adverse effects including: abdominal pain[ebmconsult.com]
  • These are the signs and symptoms most commonly linked to esophagitis: abdominal pain pain and difficulty when swallowing food becoming stuck in the esophagus lack of appetite nausea and possibly vomiting cough pain in the chest when eating, heartburn[medicalnewstoday.com]
Regurgitation
  • However, it is increasingly apparent that the pathogenesis of esophagitis is distinct from that of the spectrum of potential GERD symptoms ranging from heartburn to regurgitation, chest pain, dysphagia, laryngitis, and cough,” he wrote, adding that a[healio.com]
  • Primary esophagitis, caused by physical irritants, causes spasm and obstruction, with pain on swallowing or palpation, profuse salivation, regurgitation of slimy, blood-stained saliva and feed, and may lead to stricture formation.[medical-dictionary.thefreedictionary.com]
  • Symptoms The main symptom of reflux esophagitis is heartburn, with or without regurgitation of gastric contents into the mouth, which worsens on bending over. Complications of GERD include esophagitis and possibly massive but limited hemorrhage.[healthcentral.com]
  • Rarely, the solid food becomes impacted, that is, it can neither pass into the stomach nor be regurgitated.[idahogastro.com]
  • Symptoms Common signs and symptoms of esophagitis include: Difficult swallowing Painful swallowing Chest pain, particularly behind the breastbone, that occurs with eating Swallowed food becoming stuck in the esophagus (food impaction) Heartburn Acid regurgitation[mayoclinic.org]
Odynophagia
  • The patient had progressive odynophagia and dysphagia, which markedly impaired her oral intake, and hematemesis.[nejm.org]
  • Nausea Vomiting, possibly even bloody vomit ( hematemesis ) Gastrointestinal chest pain – burning (heartburn), aching, sharp pain similar to cardiac chest pain Difficulty swallowing ( dysphagia ) Painful swallowing (odynophagia) Lack of appetite Unintentional[healthhype.com]
  • The main presenting symptoms of our patients were odynophagia, retrosternal pain and dysphagia in 100, 92% and 69% of patients, respectively.[saudijgastro.com]
  • Severe symptoms include dysphagia, odynophagia, bleeding, weight loss, anemia, and those at risk for Barrett's esophagus.[physio-pedia.com]
  • […] patients with severe pain who fail to respond to medical management (eg, some patients with esophagitis and chronic gastroesophageal reflux disease [GERD]). [53] In general, no particular dietary restrictions are necessary; however, if the patient has odynophagia[emedicine.medscape.com]
Hematemesis
  • Seven days after admission, the patient had no more hematemesis or melena. Ten days after admission, the patient underwent follow-up upper gastrointestinal endoscopy.[e-ce.org]
  • Nausea Vomiting, possibly even bloody vomit ( hematemesis ) Gastrointestinal chest pain – burning (heartburn), aching, sharp pain similar to cardiac chest pain Difficulty swallowing ( dysphagia ) Painful swallowing (odynophagia) Lack of appetite Unintentional[healthhype.com]
  • The patient had progressive odynophagia and dysphagia, which markedly impaired her oral intake, and hematemesis.[nejm.org]
  • For chemical injuries caused by contact with corrosive materials, symptoms such as oropharyngeal pain, dysphagia, abdominal pain, hematemesis, and dyspnea occur during the acute phase.[omicsonline.org]
Chest Pain
  • Chest pain or infectious esophagitis may be asymptomatic.[medicotips.com]
  • However, it is increasingly apparent that the pathogenesis of esophagitis is distinct from that of the spectrum of potential GERD symptoms ranging from heartburn to regurgitation, chest pain, dysphagia, laryngitis, and cough,” he wrote, adding that a[healio.com]
  • pain Experience pain in your mouth or throat when you eat Have shortness of breath or chest pain that occurs shortly after eating Vomit large amounts, often have forceful vomiting, have trouble breathing after vomiting or have vomit that is yellow or[mayoclinic.org]
  • Occasionally an injured esophagus can develop a hole, causing sudden worsening of chest pain, shortness of breath or fever. Report these symptoms to your doctor immediately.[drugs.com]
  • Its most frequent symptoms are: diarrhea vomiting heartburn chest pain food sticking difficulty swallowing Many who suffer from eosinophili esophagitis also have seasonal allergies, rhinitis, asthma or eczema.[healthblurbs.com]
Suggestibility
  • "Together, our results implicate MIF in the pathogenesis of EoE and suggest that targeting MIF might represent a novel therapy for EoE." There is no cure for EoE.[news-medical.net]
  • These findings suggest the pathogenesis of reflux esophagitis may be caused by inflammatory cytokines rather than chemical injury.[healio.com]
  • "If replicated, these findings suggest that the pathogenesis of reflux esophagitis may be cytokine mediated rather than the result of chemical injury," the researchers said online May 17 in JAMA.[consultant360.com]
  • However, new data suggests that it is time to reconsider this concept. André J. P. M. Smout & Albert J. Bredenoord News and Views 02 March 2016 Eosinophilic oesophagitis (EoE) is a clinicopathological condition.[nature.com]
  • John Yates, M.D., for their referrals of patients, helpful suggestions, and critical review of the manuscript.[nejm.org]
Uremia
  • Uremia 5. Radiotherapy Morphology: 1. Non-specific features: a) Severe inflammation, b) Superficial necrosis c) Ulceration with the formation of granulation tissue and fibrosis 2.[medicotips.com]

Treatment

  • Treatment of infectious esophagitis: Treatment varies with the causative agent. it is treated with antibacterial, antiviral or antifungal drugs depending on the causative agent that is whether it is a bacteria, virus or fungus.[medicotips.com]
  • Spechler concluded, "will really paint the way for research on new treatments for this disease, treatments that may target directly those cytokines and inflammatory cells." The U.S.[consultant360.com]
  • "We are now one step closer to an effective treatment for this condition." Source: D'Or Institute for Research and Education[news-medical.net]
  • “Although this radical change in the concept of how acid reflux damages the esophagus of GERD patients will not change our approach to its treatment with acid-suppressing medications in the near future, it could have substantial long-term implications[healio.com]
  • He has pioneered the use of minimally invasive endoscopic treatments for reflux in childhood over the past 10 years.[books.google.com]

Prognosis

  • Normally, the prognosis would be good with no serious illnesses. If there are more causes than one, the prognosis could move to fair.[en.wikipedia.org]
  • Prognosis; Complications If the cause of the esophagitis is an infection, and the infection is treated, the inflammation is likely to improve. If a chemical such as lye, bleach, or gasoline is ingested, the esophagus can perforate, or rupture.[diagnose-me.com]
  • Prognosis for esophagitis is normally good. Esophagitis can be caused by certain allergies. Being overweight increases the risk of esophagitis. Depending on the cause of esophagitis, there are various possible treatments.[medicalnewstoday.com]
  • Prognosis Almost all cases of esophagitis can be cured. Some causes, such as acid reflux, may require long-term treatment. External resources American College of Gastroenterology P.O.[drugs.com]
  • […] reported than those caused by alkaline agents in the United States. 1 Early endoscopic intervention is very useful in suspected cases of corrosive esophagitis, not only for determining the degree of mucosal injury and severity, but also for predicting prognosis[e-ce.org]

Etiology

  • Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • The current data confirmed the role of oral doxycycline intake, the timing and the amount of concurrent fluid in the etiology of esophageal ulcerations. How to cite this article: Al Mofarreh MA, Al Mofleh IA.[saudijgastro.com]
  • The etiology for this histological finding is not clear. It could be assumed that bromazepam is able to interact with the epithelial surface in an acid milieu.[bmcgastroenterol.biomedcentral.com]
  • […] which a thin tube is placed in the esophagus, through the mouth, to measure acid levels and the pH [5] Esophageal manometry a procedure where a thin tube is placed in the esophagus, through the mouth or nose, to measure the pressure of the esophagus [5] Etiology[physio-pedia.com]

Epidemiology

  • Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol. 2009 Oct. 7(10):1055-61. [Medline]. Nurko S, Rosen R, Furuta GT.[emedicine.medscape.com]
  • References Christesen HB (1994) Caustic ingestion in adults--epidemiology and prevention. J Toxicol Clin Toxicol 32: 557-568. Kamijo Y (2009) Corrosive substances. In: Soma K (ed.), Clinical Toxicology. (1stedn), Igaku-shoin Ltd, Tokyo.[omicsonline.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology of gastroesophageal reflux disease: esophageal epithelial resistance. In: Castell DO, ed. The esophagus. Boston: Little Brown & Co., 1992:463-478. 11. Sarosiek J, McCallum RW.[hon.ch]
  • […] includes toluene, 6 and diluted pendimethalin, a herbicide, have also been reported. 7 As previously stated, both alkaline and acidic substances can induce corrosive esophagitis, but the effects of these two types of agents are explained by different pathophysiologic[e-ce.org]
  • Chapter First Online: 25 March 2017 Abstract Inflammatory processes in the pediatric esophagus have received a disproportionately small amount of attention until recently, when appreciation of their pathophysiology and concordant clinical importance has[link.springer.com]
  • Several reports showed these symptoms, but pathophysiology was uncertain in some symptoms. It is difficult to deduce the intake of acid toilet bowl detergents from the viewpoint of toxidrome.[omicsonline.org]
  • The postulated pathophysiologic mechanisms were direct esophageal irritation, and possibly reflux of drug-containing gastric contents. 5 Failure of the alendronate tablet to pass through the esophagus may result in prolonged local mucosal exposure to[nejm.org]

Prevention

  • Furthermore, the early administration of a drug that blocks the effect of MIF prevented the eosinophils accumulation in the esophagus and the development of esophagitis in treated mice.[news-medical.net]
  • In other words, the hydrophobic properties of the phospholipids prevent gastric acid from reaching the epithelium.[ebmconsult.com]
  • Although prevention of esophagitis is not always possible, there are some wise measures that one can take. Maintaining a healthy weight, avoiding smoking, and limiting alcohol intake may decrease the risk of esophagitis.[diagnose-me.com]
  • To prevent reflux esophagitis, avoid acidic foods, caffeine, eating before going to bed, alcohol, fatty meals, and smoking.[en.wikipedia.org]
  • Prevention The most common cause of esophagitis, acid reflux, sometimes can be prevented by some very simple measures: Avoid heavy meals, especially within several hours of bedtime Cut out cigarettes and alcohol Avoid large amounts of caffeine, chocolate[drugs.com]

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