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Chemical Meningitis


Presentation

  • We describe an unusual presentation of RCC in which the patient presented with a clinical picture of chemical meningitis consisting of meningeal irritation, inflammatory cerebrospinal fluid profile, and enhancing pituitary and hypothalamic lesions, in[ncbi.nlm.nih.gov]
Hyperthermia
  • A BRAF-V600E-mutated melanoma leptomeningeal metastases patient, treated by dabrafenib and liposomal cytarabine, presented after the first injection of liposomal cytarabine with hyperthermia and headaches.[ncbi.nlm.nih.gov]
Fever of Unknown Origin
  • Recurrent fever of unknown origin, coma, and meningismus due to a leaking craniopharyngioma. Am J Med. 1988. 84: 543-5 3. Kumar A, Kasliwal MK, Suri A, Sharma BS.[surgicalneurologyint.com]
Soft Tissue Mass
  • tissue mass in the left basifrontal region Click here to view Figure 3: T1 weighted fat saturated axial image showing suppressed hyperintense foci confirming the fat content Click here to view Discussion Dermoid cysts are thick-walled cysts lined by[wajradiology.org]
Rhinorrhea
  • They rarely had temperatures 39.4 degrees C or cerebrospinal fluid rhinorrhea or otorrhea.[ncbi.nlm.nih.gov]
  • Findings unusual for chemical meningitis: (1) temperature 39.4 C (2) purulent wound drainage (3) significant wound erythema and/or tenderness (4) coma or loss of consciousness (5) onset of a new seizure disorder (6) focal neurological signs (7) CSF rhinorrhea[meducator3.net]
  • Wound abnormalities and CSF rhinorrhea.[cid.oxfordjournals.org]
Aspiration
  • To prevent postoperative chemical meningitis, several authors recommend puncture of the cysts using a syringe and aspiration of the contents before incision (Wang et al. 2011 ).[springerplus.springeropen.com]
  • The fat like substance was aspirated from the subarachnoid spaces of the frontal and temporal lobes. The cyst wall was punctured and the fatty substances were aspirated initially.[wajradiology.org]
Headache
  • : Emergency physicians should consider intrathecal entry and pneumocephalus in patients who present with a headache after an epidural intervention.[ncbi.nlm.nih.gov]
  • Sometimes the headache may begin as a lingering headache, and typical orthostatic features may appear days or weeks later. At times the headache may be preceded by neck pain or interscapular pain for days or weeks.[braintalkcommunities.org]
Neck Stiffness
  • A 41-yr-old man was admitted with acute headache, neck stiffness, and febrile sensation. Cerebrospinal fluid examination showed pleocytosis, an increased protein level and, a decreased glucose concentration.[ncbi.nlm.nih.gov]
  • Another important symptom to take note is neck stiffness. This is also called as nuchal rigidity. This symptom is characterized by muscle spasms in the neck area. The patient will also have a difficulty moving the neck forward.[tandurust.com]
  • Headache and neck stiffness gradually improved over the next six days with conservative treatment with methylprednisolone and antibiotics.[synapse.koreamed.org]
  • While she was waiting for the transphenoidal excision of the lesion, she developed fever, altered sensorium with neck stiffness. Vision status remained same as before.[surgicalneurologyint.com]
Dysarthria
  • On the 7th day of the attack, confusion, dysarthria, and right-sided facial paralysis and hemiparesis were noted. Cerebral infarction on the left basal ganglia was confirmed.[ncbi.nlm.nih.gov]
  • On the 7th day of apoplexy, the patient complained of aggravated headache and exhibited intermittent confusion, dysarthria, and right-side facial paralysis and hemiparesis.[synapse.koreamed.org]
Generalized Seizure
  • The patient presented with generalized seizures. Included: ventilatory support, externalization of the shunt, correction of the metabolic abnormalities and administration of anticonvulsants and steroids.[ncbi.nlm.nih.gov]
Communicating Hydrocephalus
  • This case illustrates an unusual occurrence of reflux of bile into the CNS through a lumbar-gallbladder shunt in a patient with long-term complex communicating hydrocephalus. It also demonstrates its mode of presentation and successful management.[ncbi.nlm.nih.gov]

Workup

  • Complete septic workup failed to identify an organism in either patient. Both patients responded to treatment with corticosteroid medication used to modulate the inflammatory response induced by the coil implants.[uthscsa.influuent.utsystem.edu]

Treatment

  • CLINICAL PRESENTATION: Two previously healthy patients underwent endovascular treatment for large ( 2 cm) cerebral aneurysms.[uthscsa.influuent.utsystem.edu]
  • Dose reduction and appropriate symptomatic treatment permitted the administration of 15 injections of liposomal cytarabine combined with dabrafenib.[ncbi.nlm.nih.gov]
  • Treatment for Meningitis Tips 1. Acute bacterial meningitis requires prompt treatment with intravenous antibiotics to ensure recovery and reduce the risk of complications. 2.[lfpro.bztronics.com]
  • A single antibiotic agent was used for the most of the treatment period in 8 patients with bacterial meningitis and in 3 patients with IC meningitis; the remainder received combination treatment.[cid.oxfordjournals.org]

Prognosis

  • Treatment and prognosis Although each attack is self limited, given the strong association with HSV-2 therapy and prophylaxis with acyclovir or valacyclovir has been proposed 2.[radiopaedia.org]
  • Although complete surgical excision improved the prognosis, based on previous studies suggesting recurrence between 4 months and 14 years (Preece et al. 2006 ), this case warranted long-term clinical and radiological follow-up.[springerplus.springeropen.com]
  • Prognosis Meningitis kills more UK children under the age of 5 than any other infectious disease. [ 2 ] Prognosis depends on the pathogen, the patient's age and condition and the severity of acute illness.[patient.info]
  • Other treatments will include: Fluids through a vein (IV) Medicines to treat symptoms, such as brain swelling, shock, and seizures Outlook (Prognosis) Early diagnosis and treatment of bacterial meningitis is essential to prevent permanent neurological[mountsinai.org]
  • In general, prognosis is grave with an aneurysm, better with an arteriovenous malformation, and best when 4-vessel angiography does not detect a lesion, presumably because the bleeding source is small and has sealed itself.[msdmanuals.com]

Etiology

  • Etiology The condition by definition is idiopathic. See the discussion on terminology above.[radiopaedia.org]
  • The etiology of postdural puncture meningitis is very debatable.[mjdrdypu.org]
  • Journal of Meningitis focuses on causative agents, pathophysiology, etiology, preventive measures, treatment, management of meningitis, etc.[omicsonline.org]
  • Staphylococcus aureus. in pure or mixed culture, was the most common etiologic organism found (8 of 20 patients). Table 2 Microbiology of bacterial meningitis in 20 patients. Table 2 Microbiology of bacterial meningitis in 20 patients.[cid.oxfordjournals.org]

Epidemiology

  • Infection Control & Hospital Epidemiology ISSN: 0899-823X EISSN: 1559-6834 URL: /core/journals/infection-control-and-hospital-epidemiology Unfortunately you do not have access to this content, please use the Get access link below for information on how[journals.cambridge.org]
  • School-based clusters of meningococcal disease in the United States: descriptive epidemiology and a case-control analysis. JAMA 1997;277:389-95. Brooks R, Woods CW, Benjamin, DK Jr, Rosenstein NE.[imic.or.jp]
  • (日本神経学会) f) 参 照 1) 細菌性髄膜炎診療ガイドライン2014 (日本神経学会) 2) 髄膜炎菌性髄膜炎とは (NIID 国立感染症研究所) 3) Meningococcal Disease (CDC) meningitis belt (CDC) 4) Meningococcal meningitis (WHO) 5) MENINGOCOCCAL DISEASE: HISTORY, EPIDEMIOLOGY, PATHOGENESIS,CLINICAL MANIFESTATIONS,[bdj.co.jp]
  • Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950-1981, I: epidemiology. Ann Neurol. 1984 Sep;16(3):283-94. Bilukha OO, Rosenstein N.[lifeextension.com]
  • Epidemiology Meningitis occurs in people of all age groups but infants, young children and the elderly are more predisposed to meningitis. [ 3 ] Viral meningitis is the most common cause.[patient.info]
Sex distribution
Age distribution

Pathophysiology

  • One complication of the lumbar-gallbladder shunt is discussed as well as its pathophysiologic theory and management.[ncbi.nlm.nih.gov]
  • 14 What exactly is the pathophysiology of bacterial meningitis? Invasionand Response: Bacterial meningitis usually begins with nasopharyngeal colonization by an organism, followed by invasion and bacteremia.[healthtap.com]
  • ., Intern doctor at Dhulikhel hospital Published on Dec 13, 2016 pathophysiology and csf analysis in simpler form 1. Meningitis Group- 5 Tutor:Dr.Rajiv Shrestha 2.[slideshare.net]
  • It is a diagnosis of exclusion and its pathophysiological mechanism remains unclear.[nature.com]
  • Pathophysiology of meningococcal meningitis and septicaemia. Arch Dis Child. 2003 Jul;88(7):601-7. Pathan N, Sandiford C, et al. Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med. 2002 Oct;30(10):2191-8.[lifeextension.com]

Prevention

  • The single best prevention method is proper hand hygiene. Wash your hands often. Use alcohol-based gels only when your hands are not visibly soiled. Another prevention method is proper cleaning of surfaces.[lfpro.bztronics.com]
  • To prevent the chemical meningitis risk, dexametasone sodium phosphate 8 mg/day was administered by intravenous injection. Our patients suffered most probably from chemical meningitis.[encyclopedia2.thefreedictionary.com]
  • To prevent postoperative chemical meningitis, several authors recommend puncture of the cysts using a syringe and aspiration of the contents before incision (Wang et al. 2011 ).[springerplus.springeropen.com]
  • […] to Know (Centers for Disease Control and Prevention) [ Read More ][icdlist.com]
  • Prevention Certain vaccines can help prevent some types of bacterial meningitis: Haemophilus vaccine ( HiB vaccine ) given to children helps Pneumococcal vaccine is given to children and adults Meningococcal vaccine is given to children and adults ; some[mountsinai.org]

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