The present study was undertaken to evaluate the effect of low-power laser on the prevention of mucositis, xerostomia and pain as a result of chemotherapy. [ncbi.nlm.nih.gov]

Unfortunately, we can conclude that the interventions presented in this thesis did not lead to a decrease in the severity of mucositis in rats. [rug.nl]

In patients undergoing chemotherapy at standard doses, oral mucositis generally presents as grades 1 and 2 rather than grades 3 and 4. [touchoncology.com]

• Weight Loss

  Seite 228 - The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. ‎ Seite 216 - EORTC International antimicrobial Therapy Cooperative group. [books.google.de]

  Mucositis can be severe enough to require narcotics for pain and can significantly interfere with oral nutrition resulting in weight loss. [news.cancerconnect.com]

  Alternative nutritional support should be considered if malnutrition results in >5% weight loss. [practicalpainmanagement.com]

  Reduction of caloric intake can lead to weight loss, loss in muscle mass strength and other complications, including a decrease in immunity and a longer healing time from treatments. [oralcancerfoundation.org]

  They tend to have a greater impact on quality of life; however, these adverse effects may also affect the patients ability to maintain adequate nutritional intake, leading to weight loss. [emedicine.medscape.com]

• Collapse

  Collapse all Expand all Antecedentes La mucositis oral es un efecto secundario de la quimioterapia, la radioterapia de cabeza y cuello y el tratamiento dirigido, que afecta a más del 75% de los pacientes de alto riesgo. [cochranelibrary.com]

• Xerostomia

  The present study was undertaken to evaluate the effect of low-power laser on the prevention of mucositis, xerostomia and pain as a result of chemotherapy. [ncbi.nlm.nih.gov]

  Acupuncture for Xerostomia An educational session held at ASTRO 2003 on complementary medicine in radiation oncology practice evaluated the evidence for acupuncture in the treatment of xerostomia. [news.cancerconnect.com]

  (Editor's Note: Links to Part 1, Part 2, and Part 3 ) Mucositis Mucositis and xerostomia (stomatitis) are common side effects following CT and/or RT. [practicalpainmanagement.com]

  Management of xerostomia Prevention of salivary gland hypofunction and xerostomia To prevent or reduce the extent of salivary gland hypofunction and xerostomia, parotid-sparing intensity-modulated radiation therapy (IMRT) is recommended as a standard [cancer.gov]

• Oral Ulcers

  Previous studies exploring the use of propolis, a waxy substance produced by bees that is considered to be a complementary therapy to anticancer agents, for the treatment of esophagitis, stomatitis, oral ulcers, and other conditions achieved mixed results [oncologynurseadvisor.com]

  ABSTRACT Mucositis is an inflammatory response of the mucosal epithelium to the cytotoxic effects of chemotherapy and radiation therapy, causing pain and severe oral ulceration. [pesquisa.bvsalud.org]

  Oral ulcerative mucositis is a common, painful, dose-limiting toxicity of drug and radiation therapy for cancer. It is characterized by breakdown of the oral mucosa resulting in the formation of ulcerative lesions. [biomodels.com]

  Keywords: Oral mucosits, oral pain, mouth sores, oral ulcers, chemotherapy-induced side effects, reBalanceCa, xerostomia, oral mucosa, chemotherapy [touchoncology.com]

  Within the oral cavity, the loss of rapidly dividing mucosal cells results in atrophy, necrosis, and ulceration. [ahcmedia.com]

• Periodontitis

  A recent study showed that hangeshashinto (TJ-14) might be useful for periodontal disease via downregulating pro-inflammatory prostaglandins in the cyclooxygenase pathway in human. [wjon.org]

  Poor oral care with concomitant dental and periodontal pathology such as dental caries, ill-fitting prostheses, defective restorations, orthodontic appliances, piercings, periodontitis, and third molar pathology leads to a greater risk for oral complications [ahcmedia.com]

  Myeloablated cancer patients with chronic periodontal disease may develop acute periodontal infections, with associated systemic sequelae.[ 3, 9 - 12 ] Extensive ulceration of sulcular epithelium associated with periodontal disease is not directly observable [cancer.gov]

  Patients with pulpal disease from dental caries or trauma, periodontal disease, and low-grade soft-tissue infections (especially those associated with partially erupted third molars) are at increased risk for bacteremia due to oral viridans streptococci [emedicine.medscape.com]

  Methotrexate and etoposide (Etopophos) are secreted into the saliva, with direct toxic effects on the mucosa (Table 2). 4 Prevention of Mucositis Risk factors for the development of mucositis include poor oral hygiene, dental caries, periodontal disease [practicalpainmanagement.com]

• Sore Mouth

  Mucositis is when your mouth or gut is sore and inflamed. It's a common side effect of chemotherapy and radiotherapy for cancer. It can be very unpleasant, but usually stops in a few weeks. [nhs.uk]

  Clinical trials have demonstrated that Ethyol® can reduce dry mouth and may prevent mouth sores; however, more research is needed to prove the affect of this drug on mouth sores. [news.cancerconnect.com]

  More than a sore mouth: patients’ experience of oral mucositis. Oncol Nurs Forum. 2002;29:1051-1057. 5. Elting LS, Cooksley C, Chambers M, et al. The burdens of cancer therapy: clinical and economic outcomes of chemotherapy-induced mucositis. [theoncologypharmacist.com]

• Dental Caries

  The pre-existence or development of xerostomia is associated with an increased bacterial colonization on dental surfaces and prostheses and, therefore, a higher incidence of oral mucositis and dental caries during the course of antineoplastic therapy. [ahcmedia.com]

  Also, the progression of dental caries is accelerated by the reduction in antimicrobial proteins normally contained in saliva. [cancer.gov]

  Patients with pulpal disease from dental caries or trauma, periodontal disease, and low-grade soft-tissue infections (especially those associated with partially erupted third molars) are at increased risk for bacteremia due to oral viridans streptococci [emedicine.medscape.com]

• Ulcer

  During the fifth and final healing phase, cell proliferation occurs with reepithelialization of ulcers. Signals from the extracellular matrix induce epithelial cells to migrate underneath the pseudomembrane (fibrin clot) of the ulcer. [emedicine.medscape.com]

  So when the mucous membrane is damaged (e.g., inflamed), ulceration can easily occur. Mucositis is a potential complication of chemotherapy, especially for patients receiving oral and throat treatments. [5pointacupuncture.com]

  Symptoms include mouth pain and ulceration, esophagitis, abdominal pain, bloating, and diarrhea. It is associated with increased infections and occasional mortality, and its palliation is very expensive. [ncbi.nlm.nih.gov]

• Eruptions

  Patients with pulpal disease from dental caries or trauma, periodontal disease, and low-grade soft-tissue infections (especially those associated with partially erupted third molars) are at increased risk for bacteremia due to oral viridans streptococci [emedicine.medscape.com]

  Eruption of teeth can be delayed, including increased frequency of impacted maxillary canines. Shortened root length is associated with diminished alveolar processes, leading to decreased occlusal vertical dimension. [cancer.gov]

• Irritability

  Purified or deionized water can reduce irritation. [verywell.com]

  […] stomach from irritants. [chemocare.com]

  Chronic irritation from ill-fitting prostheses or faulty restorations can predispose patients to the development of oral mucositis due to local irritation and trauma. [oralcancerfoundation.org]

  […] ice lollies eat soft, moist foods (try adding gravy or sauces to meals) drink plenty of water chew sugar-free gum (this can help keep your mouth moist) do not use mouthwashes from shops without speaking to a pharmacist, nurse or doctor – they might irritate [nhs.uk]

[…] oral mucositis are the following: World Health Organization (WHO) Oral Toxicity Scale: Combines both objective and functional elements into a single score National Cancer Institute Common Toxicity Criteria (NCI CTC): Scores functional elements only See Workup [emedicine.medscape.com]

Accurate and early diagnostic workup. Effective preventative and therapeutic strategies. An individual approach geared to unique patient characteristics. [cancer.gov]

Although treatment is available for a small subset of patients suffering from mucositis, the majority rely on pain relief as their only treatment option. [ncbi.nlm.nih.gov]

The compliance of TJ-14-treatment was good and side effects from TJ-14 were not observed. [wjon.org]

Utilización del láser para la prevención y el tratamiento de la mucositis oral inducida por quimioterapia y radioterapia de cabeza y cuello [Use of laser for the prevention and treatment of oral mucositis induced by radiotherapy and chemotherapy for head [crd.york.ac.uk]

Prognosis Chemotherapy-induced oral mucositis is a self-limiting condition. [emedicine.medscape.com]

Although breast cancer prognosis has improved dramatically in the last 20 years, a significant number of patients will present the evolution of the disease and most of them will die of this malignancy. [medichub.ro]

Dentition that exhibits poor prognosis and is within high-dose fields should be extracted before radiation therapy begins. [cancer.gov]

Incomplete outcome data Only two studies were at high risk of attrition bias (Askarifar 2015; Sorensen 2008), both due to differential attrition between groups, which may have been linked to prognosis. [cochranelibrary.com]

Cranial Irradiation /adverse effects; Double-Blind Method; Head and Neck Neoplasms /complications /drug therapy /radiotherapy; Humans; Low-Level Light Therapy /methods /utilization; Prospective Studies; Randomized Controlled Trials as Topic; Stomatitis /etiology [crd.york.ac.uk]

GELCLAIR is a bioadherent oral gel that provides effective pain relief by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies, including: Oral mucositis (OM)/stomatitis Irritation due to oral surgery Traumatic ulcers [gelclair.com]

Oral mucositis occurs independently of oral mucosal infections of viral and fungal etiology, but it may be exacerbated by such concomitant infections. [emedicine.medscape.com]

In 2011, the FDA cleared episil oral liquid for the management and relief of pain of oral lesions with various etiologies, including oral mucositis/stomatitis which may be caused by chemotherapy or radiation therapy. [en.wikipedia.org]

Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(suppl 9):1995-2025. Peterson DE, Bensadoun R-J, Roila F. [gelclair.com]

Epidemiology Frequency Some degree of oral mucositis occurs in approximately 40% of patients who receive cancer chemotherapy. [emedicine.medscape.com]

Sonis ST, Elting LS, Keefe D, et al.: Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100 (9 Suppl): 1995-2025, 2004. [cancer.gov]

Therefore, the question arises if the currently used 5-phase pathophysiological model is correct for gastrointestinal mucositis. [rug.nl]

According to this five-phase model, the intestinal microbiota plays no role in the pathophysiology of mucositis. [ncbi.nlm.nih.gov]

Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient’s optimal cancer treatment plan and consequentially decreasing their chances of survival. [4] Pathophysiology [ edit ] The pathophysiology of mucositis is complex and multifactorial [en.wikipedia.org]

Because this toxicity clusters with dermatologic toxicities, rather than GI (as is the case with conventional mucositis) toxicities, this suggests that the underlying pathophysiology is likely very different. [emedicine.medscape.com]

Utilización del láser para la prevención y el tratamiento de la mucositis oral inducida por quimioterapia y radioterapia de cabeza y cuello [Use of laser for the prevention and treatment of oral mucositis induced by radiotherapy and chemotherapy for head [crd.york.ac.uk]

The pathobiology of mucositis is complex, and agents that target mechanisms to prevent mucositis or accelerate healing are in high demand. [ncbi.nlm.nih.gov]

Prevention and care of chemotherapy-induced gastrointestinal mucositis. [Groningen]: Rijksuniversiteit Groningen. Author Kuiken, Nicoline Sipke Sophia. / Prevention and care of chemotherapy-induced gastrointestinal mucositis. [rug.nl]