Presentation
The present study was undertaken to evaluate the effect of low-power laser on the prevention of mucositis, xerostomia and pain as a result of chemotherapy. [ncbi.nlm.nih.gov]
Unfortunately, we can conclude that the interventions presented in this thesis did not lead to a decrease in the severity of mucositis in rats. [rug.nl]
In patients undergoing chemotherapy at standard doses, oral mucositis generally presents as grades 1 and 2 rather than grades 3 and 4. [touchoncology.com]
Jaw & Teeth
- Sore Mouth
Mucositis is when your mouth or gut is sore and inflamed. It's a common side effect of chemotherapy and radiotherapy for cancer. It can be very unpleasant, but usually stops in a few weeks. [nhs.uk]
Clinical trials have demonstrated that Ethyol® can reduce dry mouth and may prevent mouth sores; however, more research is needed to prove the affect of this drug on mouth sores. [news.cancerconnect.com]
More than a sore mouth: patients’ experience of oral mucositis. Oncol Nurs Forum. 2002;29:1051-1057. 5. Elting LS, Cooksley C, Chambers M, et al. The burdens of cancer therapy: clinical and economic outcomes of chemotherapy-induced mucositis. [theoncologypharmacist.com]
- Aphthous Stomatitis
stomatitis in otherwise healthy patients. [emedicine.medscape.com]
- Hairy Tongue
Hairy tongue. Multiple mucoceles on the hard palate. Erythematous oral mucositis lesion on the buccal mucosa. Ulcerative oral mucositis lesion on the buccal mucosa. Ulcerative oral mucositis lesion on the lateral and ventral surfaces of the tongue. [emedicine.medscape.com]
Workup
[…] oral mucositis are the following: World Health Organization (WHO) Oral Toxicity Scale: Combines both objective and functional elements into a single score National Cancer Institute Common Toxicity Criteria (NCI CTC): Scores functional elements only See Workup [emedicine.medscape.com]
Accurate and early diagnostic workup. Effective preventative and therapeutic strategies. An individual approach geared to unique patient characteristics. [cancer.gov]
Treatment
Although treatment is available for a small subset of patients suffering from mucositis, the majority rely on pain relief as their only treatment option. [ncbi.nlm.nih.gov]
The compliance of TJ-14-treatment was good and side effects from TJ-14 were not observed. [wjon.org]
Prognosis
Prognosis Chemotherapy-induced oral mucositis is a self-limiting condition. [emedicine.medscape.com]
Although breast cancer prognosis has improved dramatically in the last 20 years, a significant number of patients will present the evolution of the disease and most of them will die of this malignancy. [medichub.ro]
Dentition that exhibits poor prognosis and is within high-dose fields should be extracted before radiation therapy begins. [cancer.gov]
Etiology
Cranial Irradiation /adverse effects; Double-Blind Method; Head and Neck Neoplasms /complications /drug therapy /radiotherapy; Humans; Low-Level Light Therapy /methods /utilization; Prospective Studies; Randomized Controlled Trials as Topic; Stomatitis /etiology [crd.york.ac.uk]
GELCLAIR is a bioadherent oral gel that provides effective pain relief by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies, including: Oral mucositis (OM)/stomatitis Irritation due to oral surgery Traumatic ulcers [gelclair.com]
Oral mucositis occurs independently of oral mucosal infections of viral and fungal etiology, but it may be exacerbated by such concomitant infections. [emedicine.medscape.com]
In 2011, the FDA cleared episil oral liquid for the management and relief of pain of oral lesions with various etiologies, including oral mucositis/stomatitis which may be caused by chemotherapy or radiation therapy. [en.wikipedia.org]
Epidemiology
Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer. 2004;100(suppl 9):1995-2025. Peterson DE, Bensadoun R-J, Roila F. [gelclair.com]
Epidemiology Frequency Some degree of oral mucositis occurs in approximately 40% of patients who receive cancer chemotherapy. [emedicine.medscape.com]
Sonis ST, Elting LS, Keefe D, et al.: Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100 (9 Suppl): 1995-2025, 2004. [cancer.gov]
Pathophysiology
Therefore, the question arises if the currently used 5-phase pathophysiological model is correct for gastrointestinal mucositis. [rug.nl]
According to this five-phase model, the intestinal microbiota plays no role in the pathophysiology of mucositis. [ncbi.nlm.nih.gov]
Therefore, oral mucositis can be a dose-limiting condition, disrupting a patient’s optimal cancer treatment plan and consequentially decreasing their chances of survival. [4] Pathophysiology [ edit ] The pathophysiology of mucositis is complex and multifactorial [en.wikipedia.org]
Because this toxicity clusters with dermatologic toxicities, rather than GI (as is the case with conventional mucositis) toxicities, this suggests that the underlying pathophysiology is likely very different. [emedicine.medscape.com]
Prevention
The pathobiology of mucositis is complex, and agents that target mechanisms to prevent mucositis or accelerate healing are in high demand. [ncbi.nlm.nih.gov]
Utilización del láser para la prevención y el tratamiento de la mucositis oral inducida por quimioterapia y radioterapia de cabeza y cuello [Use of laser for the prevention and treatment of oral mucositis induced by radiotherapy and chemotherapy for head [crd.york.ac.uk]