Presentation
Cerebrotendinous xanthomatosis (CTX) is a rare inborn disorder of sterol storage with autosomal recessive inheritance and a variable clinical presentation. [ncbi.nlm.nih.gov]
However, it should be understood that the following examples are intended to illustrate the present invention, and cannot limit the scope of the present invention in any manner. [google.com]
HPLC Analysis of Bile Acids on Ascentis® Express C18 Keywords: Chromatography, Clinical, High performance liquid chromatography LC/MS Analysis of Bile Acids and Their Conjugates on Ascentis® Express C18 From our library of Articles, Sigma-Aldrich presents [sigmaaldrich.com]
Gastrointestinal
- Diarrhea
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Diarrhea Less Common Abdominal or stomach pain acid or sour stomach belching bloated cramps difficulty [drugs.com]
Diarrhea occurred significantly more often in group B than in group A (p less than 0.001) and was the main reason for withdrawal of randomized medication. Severe adverse effects of the bile acids were not observed. [ncbi.nlm.nih.gov]
[…] dissolve gallstones.Chenodeoxycholic acid can be used in the treatment of cerebrotendineous xanthomatosis.The Australian biotechnology company Giaconda has tested a treatment for Hepatitis C infection that combines chenodeoxycholic acid with bezafibrate.As diarrhea [en.wikipedia.org]
No side effects were observed with UDCA, while with CDCA diarrhea occurred in 28% and a transient increase in SGOT in a single patient. 1 patient on UDCA required emergency cholecystectomy for acute cholecystitis. [karger.com]
Call your doctor at once if you have: worsening or no improvement of your gallstone symptoms; severe or ongoing diarrhea; or liver problems --loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, clay-colored stools, [peacehealth.org]
- Delayed Gastric Emptying
Compared with colesevelam, CDCA + colesevelam and placebo, respectively, CDCA increased glucagon and delayed gastric emptying in both groups. CONCLUSIONS: CDCA increased GLP-1 and glucagon secretion, and delayed gastric emptying. [ncbi.nlm.nih.gov]
Psychiatrical
- Suggestibility
As a result, it has been suggested that UDCA or one of its conjugates could have a direct protective effect on hepatocyte structure and function. [ncbi.nlm.nih.gov]
Neurologic
- Pyramidal Tract Signs
After treatment for one year, the serum levels of these sterols were decreased and some neurologic improvements in the pyramidal tract signs and cerebellar signs were noted. The electroencephalographic findings were markedly changed and normalized. [ncbi.nlm.nih.gov]
Before treatment, all subjects were symptomatic, with Achilles tendon xanthomas (in 15 of 17), cataracts (in 12 of 17), dementia (in 13 of 17), pyramidal-tract signs (in all 17), cerebellar dysfunction (in 13 of 17), mild peripheral neuropathy (in 7 of [doi.org]
Workup
We present a two-week old girl who was diagnosed with cerebrotendinous xanthomatosis (CTX), an inborn error of bile acid synthesis, after a diagnostic workup for convulsions which were shown to be caused by a parechovirus encephalitis. [ncbi.nlm.nih.gov]
Treatment
We studied effects of oral chenodeoxycholic acid treatment. SRD5B1 gene analysis used peripheral lymphocyte genomic DNA. Diagnosis and treatment of these two patients were investigated retrospectively and prospectively investigated. [ncbi.nlm.nih.gov]
Prognosis
In PSC patients with less favorable prognosis, baseline C4 levels were drastically suppressed and did not further decline. [ncbi.nlm.nih.gov]
Etiology
Skin biopsy was performed and histological examination suggested a drug etiology. [ncbi.nlm.nih.gov]
Epidemiology
Epidemiological and experimental studies suggest that bile acids may play a role in CRC etiology. [ncbi.nlm.nih.gov]
Pathophysiology
The pathophysiological implications of bile acids at the macromolecular level is highlighted by a chapter on the influence of bile salts on the activity of various enzymes. [books.google.com]
RESULTS: We observed that pathophysiological levels (< or = 150 micromolar) of CDCA competitively inhibited 3H-fMLP binding to human monocytes, FPR and FPRL1 transfected cells. [ncbi.nlm.nih.gov]
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Bile acids are formed in the liver from cholesterol, conjugated primarily to glycine and taurine, stored and concentrated in [mayomedicallaboratories.com]
Prevention
Distinctly from CDCA, MG132 prevented SHP and an exogenous FXR agonist, GW4064 from reducing HIF-1α protein. Furthermore a FXR antagonist, guggulsterone failed to prevent CDCA from decreasing HIF-1α protein. [ncbi.nlm.nih.gov]