None of the osseous lesions showed adjacent periosteal reaction or associated soft-tissue mass. View larger version (49K) Fig. 2A. — Cherubism in 9-year-old boy. Lateral CT scout scan shows extensive involvement of maxilla and mandible. [doi.org]

There is a narrow zone of transition and no periosteal reaction or soft tissue mass. Sometimes there is focal thinning of the overlying cortex, called "scalloping from within". [ijps.org]

This can happen after there has already been less severe pain for a time, or it may happen suddenly with no prior pain. Tooth may loosen and fall off. [ijps.org]

Massive enlargement of the jaws is common and can also be associated with severe pain [ Battaglia et al 2000, Timoşca et al 2000, Silva et al 2002, Gomes et al 2005, Wang et al 2006 ]. [ncbi.nlm.nih.gov]

Ophthalmologic examination Assessment of respiratory status including determining the presence or absence of mouth breathing, snoring, chronic nasal infection, and obstructive sleep apnea. [ncbi.nlm.nih.gov]

Clinical course and progression were also assessed using a 4-point scale (improvement, no changes, modest progression, and marked progression). The patients were followed up for an average of 8.5 years. [ncbi.nlm.nih.gov]

Ophthalmologic examination Assessment of respiratory status including determining the presence or absence of mouth breathing, snoring, chronic nasal infection, and obstructive sleep apnea. [ncbi.nlm.nih.gov]

To our knowledge, lower lid skin discoloration in Cases 2 and 3 and anisometropic amblyopia in case 3 were not described elsewhere in cherubism cases. [ncbi.nlm.nih.gov]

A knock-in mouse model with the most common pathogenic variant in human 3BP-2 (p.Pro418Arg) develops severe osteoporosis associated with highly activated osteoclasts, demonstrating that pathogenic variants within this peptide sequence result in a gain-of-function [ncbi.nlm.nih.gov]

A mouse model carrying a Pro416Arg mutation in SH3BP2 develops osteopenia and expansile lytic lesions in bone and some soft tissue organs. [ncbi.nlm.nih.gov]

Cranial asymmetry and limb length differences remained unchanged. An increase in bone density was also reported. Elevated levels of alkaline phosphatase and urine hydroxyproline were reduced by the treatment. Long term implications are unknown. [fibrousdysplasia.org]