Edit concept Question Editor Create issue ticket

Childhood Celiac Disease

Nontropical Sprue


Presentation

  • OBJECTIVE: The goal was to evaluate the impact of immunoglobulin A endomysial antibody testing on the incidence and clinical presentation of childhood celiac disease.[ncbi.nlm.nih.gov]
  • Anemia was present alone in 19 (86.3%) patients, and leukopenia coexisted with anemia in 2 (9%) patients. Thrombocytopenia was found alone in 1 (4.5%) patient. Twelve patients had an iron deficiency anemia.[ncbi.nlm.nih.gov]
  • Abstract The aims of the study were to analyze the trends and characteristics of the incidence and clinical presentation of childhood celiac disease (CD) from 1976 to 2010 in Estonia.[ncbi.nlm.nih.gov]
  • Pica as a presenting symptom in childhood celiac disease.[sciepub.com]
  • Our findings suggest that the present infant feeding recommendation to gradually introduce gluten-containing foods from 4 months of age, preferably during ongoing breastfeeding, is favorable.[ncbi.nlm.nih.gov]
Anemia
  • Anemia was present alone in 19 (86.3%) patients, and leukopenia coexisted with anemia in 2 (9%) patients. Thrombocytopenia was found alone in 1 (4.5%) patient. Twelve patients had an iron deficiency anemia.[ncbi.nlm.nih.gov]
  • […] of iron deficiency anemia.[sciepub.com]
  • Children with pica and anemia should be evaluated for celiac disease, particularly if they are growing poorly. (Consumer Summary produced by Reliance Medical Information, Inc.) Publisher: American Society for Clinical Nutrition, Inc.[readabstracts.com]
  • Three children are described with long-standing pica and iron-deficiency anemia and in whom total villous atrophy consistent with celiac disease was found on jejunal biopsy.[hero.epa.gov]
  • In older children, the disease has fewer symptoms, limited to isolated indications such as small size, late onset of puberty, chronic anemia, tooth enamel defects and joint pain.[sports.yahoo.com]
Fatigue
  • Heather came in to the office with “fatigue.” She has felt tired for years. She has been to other doctors and found to have normal thyroid and other hormones. No cause of her fatigue had been found.[homecuresthatwork.com]
  • In undiagnosed, untreated coeliac disease there is a greater risk of complications including impaired weight gain and growth problems, delayed puberty, iron deficiency anaemia, chronic fatigue and osteoporosis.[coeliac.org.uk]
  • Other Symptoms Can Include: Chronic diarrhea or constipation Abdominal pain Vomiting Bloating and gas Fatigue Damaged or discolored tooth enamel Skin rashes (known as dermatitis herpetiformis) Iron deficiency anemia Decreased appetite Delayed growth or[beyondceliac.org]
  • Recently, it has been recognized that celiac disease may cause a variety of atypical symptoms, such as: Diarrhea Abdominal pain Weight loss (or failure to gain weight appropriately in childhood) Delayed puberty Short stature Chronic fatigue Dermatitis[lifespan.org]
  • Gariepy had noticed some unusual but seemingly unrelated symptoms in Alyson for many months, like crankiness, constipation, insatiable hunger and relentless fatigue.[todaysparent.com]
Weight Loss
  • Although iron deficiency anemia may be the sole presenting clinical manifestation of occult celiac disease without other typical symptoms, such as diarrhea or weight loss, a very thorough gastrointestinal assessment is essential to exclude other causes[sciepub.com]
  • However, this study by Dhroove, et al. was limited in that children with chronic diarrhea, weight loss, and abdominal pain in particular locations were excluded.[bmcgastroenterol.biomedcentral.com]
  • "Celiac disease presentations are highly variable and should be at least considered with many different symptoms, including abdominal pain, failure to thrive/weight loss and diarrhea, constipation, anemia, canker sores, arthritis, tooth enamel defects[foxnews.com]
  • The most recognized symptoms of celiac disease are diarrhea, abdominal pain, and weight loss.[lifespan.org]
  • Other children have more severe symptoms that can result in an earlier diagnosis, including failure to thrive, weight loss, and vomiting. Fortunately, children and adolescents typically respond well to treatment with the gluten-free diet.[celiac.org]
Diarrhea
  • In young children, it can lead to chronic diarrhea, as well as tiredness, listlessness and sadness. Young children may also have a swollen abdomen and slender limbs, and growth in weight and height can slow.[sports.yahoo.com]
  • However, this study by Dhroove, et al. was limited in that children with chronic diarrhea, weight loss, and abdominal pain in particular locations were excluded.[bmcgastroenterol.biomedcentral.com]
  • Although iron deficiency anemia may be the sole presenting clinical manifestation of occult celiac disease without other typical symptoms, such as diarrhea or weight loss, a very thorough gastrointestinal assessment is essential to exclude other causes[sciepub.com]
  • "Celiac disease presentations are highly variable and should be at least considered with many different symptoms, including abdominal pain, failure to thrive/weight loss and diarrhea, constipation, anemia, canker sores, arthritis, tooth enamel defects[foxnews.com]
  • Before celiac disease is diagnosed, patients may suffer from severe diarrhea, malabsorption and intestinal bleeding.[readabstracts.com]
Vomiting
  • Chronic abdominal pain was accompanied by constipation in 69 (43.1%), nausea in 39 (24.4%), vomiting in 38 (23.8%), diarrhea in 34 (21.3%), flatus in 19 (11.9%), bloating in 17 (10.6%), 10% weight loss in 16 (10%), and eructation in 6 (3.8%).[bmcgastroenterol.biomedcentral.com]
  • Other children have more severe symptoms that can result in an earlier diagnosis, including failure to thrive, weight loss, and vomiting. Fortunately, children and adolescents typically respond well to treatment with the gluten-free diet.[celiac.org]
  • Here’s what they recommend: CD should be an early consideration in differential diagnosis for children who demonstrate symptoms of failure to thrive (FTT), persistent diarrhea, recurrent belly pain, constipation and vomiting.[glutenfreetherapeutics.com]
  • Celiac disease can manifest in a child in many ways, including Poor growth Weight gain Gastrointestinal symptoms including pain, diarrhea, vomiting, bloating, and constipation Abnormal blood tests showing anemia or increased liver enzymes There may be[columbiadoctors.org]
  • Other Symptoms Can Include: Chronic diarrhea or constipation Abdominal pain Vomiting Bloating and gas Fatigue Damaged or discolored tooth enamel Skin rashes (known as dermatitis herpetiformis) Iron deficiency anemia Decreased appetite Delayed growth or[beyondceliac.org]
Abdominal Pain
  • […] at a tertiary care medical center for abdominal pain [ 10 ].[bmcgastroenterol.biomedcentral.com]
  • In the testing group, 13 previously unrecognized clinical presentations were observed in 98 children, including 35 with family history, 18 with abdominal pain, and 14 with type 1 diabetes mellitus.[ncbi.nlm.nih.gov]
  • To prevent symptoms such as stomach aches, diarrhea and abdominal pain, sufferers must follow a strict diet. The study identified two factors influencing the development of celiac disease: season and region of birth.[sports.yahoo.com]
  • "Celiac disease presentations are highly variable and should be at least considered with many different symptoms, including abdominal pain, failure to thrive/weight loss and diarrhea, constipation, anemia, canker sores, arthritis, tooth enamel defects[foxnews.com]
Failure to Thrive
  • "Celiac disease presentations are highly variable and should be at least considered with many different symptoms, including abdominal pain, failure to thrive/weight loss and diarrhea, constipation, anemia, canker sores, arthritis, tooth enamel defects[foxnews.com]
  • Failure to thrive/delayed growth or puberty - Failure to thrive is a term used to describe children who are far behind their peers in height and weight. Children who fail to thrive are usually much shorter or smaller than other kids their age.[beyondceliac.org]
  • Other children have more severe symptoms that can result in an earlier diagnosis, including failure to thrive, weight loss, and vomiting. Fortunately, children and adolescents typically respond well to treatment with the gluten-free diet.[celiac.org]
  • […] to thrive Short stature By the time these symptoms have appeared, some reversible damage to the child’s small intestine has already occurred.[beyondceliac.org]
  • Here’s what they recommend: CD should be an early consideration in differential diagnosis for children who demonstrate symptoms of failure to thrive (FTT), persistent diarrhea, recurrent belly pain, constipation and vomiting.[glutenfreetherapeutics.com]
Chronic Diarrhea
  • In young children, it can lead to chronic diarrhea, as well as tiredness, listlessness and sadness. Young children may also have a swollen abdomen and slender limbs, and growth in weight and height can slow.[sports.yahoo.com]
  • Other Symptoms Can Include: Chronic diarrhea or constipation Abdominal pain Vomiting Bloating and gas Fatigue Damaged or discolored tooth enamel Skin rashes (known as dermatitis herpetiformis) Iron deficiency anemia Decreased appetite Delayed growth or[beyondceliac.org]
  • A study from researchers at the University of Maryland defines “classic” CD as disease that typically begins between six and 24 months of age, resulting in chronic diarrhea, abdominal bloating, poor appetite and irritability or moodiness, followed by[glutenfreetherapeutics.com]
  • Other symptoms can include: Anemia Bloating and gas Chronic diarrhea or constipation Damaged or discolored tooth enamel Fatigue Itchy skin rash (known as dermatitis herpetiformis) Poor weight gain Vomiting It is important to note that nearly 75% of children[beyondceliac.org]
Aphthous Stomatitis
  • stomatitis – canker sores Multiple Sclerosis Systemic Lupus Erythematosis Reynaud’s Syndrome – constriction of blood vessels of hands, feet, fingers and toes Behavioral/Psychiatric Depression – bulk of serotonin found in the intestine, not the brain[childrensnational.org]
  • stomatitis defects in dental enamel vitamin deficiencies osteoporosis other autoimmune endocrine disorders, such as thyroiditis neurological symptoms, including ataxia and peripheral neuropathy [ Hadjivassiliou: 2003 ] [ Hadjivassiliou: 2003 ] [ Hadjivassiliou[medicalhomeportal.org]
Muscle Cramp
  • cramps Fatigue Chronic Fatigue Syndrome Swelling and inflammation Night Blindness Chronic infections Little or no nail growth A patient with celiac disease may experience fairly immediate problems such as abdominal pain, bloating or diarrhea after eating[childrensnational.org]

Workup

  • However, because 50% of patients were neither short nor underweight, normal height and weight should not preclude workup of a patient with symptoms suggestive of CCD.[ncbi.nlm.nih.gov]
  • The researchers conclude that their study “underscores the importance of both mental health surveillance in children with celiac disease and a medical workup in children with psychiatric symptoms.”[psychiatryadvisor.com]
Delayed Bone Age
  • Additional findings included short stature, delayed bone age, and impaired xylose absorption. A dramatic growth spurt and complete resolution of pica were observed after a gluten-free diet.[hero.epa.gov]
Thrombocytosis
  • […] be confused with Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), ulcerative colitis and Crohn’s Disease Hematologic Leukopenia – low white blood cell count Anemia – iron, folate, B12 deficiency Bruising Vitamin K deficiency Bleeding Thrombocytosis[childrensnational.org]
Giardia Lamblia
  • The string test is used primarily for detection of Giardia lamblia, a parasite. Other parasites have been successfully diagnosed as well. Salmonella typhi has been isolated from string cultures when other procedures failed to diagnose the problem.[readabstracts.com]
  • Giardiasis - due to infection with Giardia lamblia, a flagellated protozoan parasite. Diagnosed by stool sample.[medicalhomeportal.org]
HLA-DQ2
  • All successfully genotyped screening-detected cases (99%) carried the HLA-DQ2/DQ8 haplotype ( Table 2 ).[pediatrics.aappublications.org]
  • Children with typical symptoms of CD, who have a tissue transglutaminase antibody level 10 times the upper limit of normal together with a positive endomysium antibody and are HLA-DQ2 and or HLA-DQ8 heterodimer positive, can be presumed to have CD and[journals.lww.com]
  • HLA-DQ2 and HLA-DQ8 Genes 95% of people with celiac disease have either or both of the HLA-DQ2 or HLA-DQ8 genes. Having one or both of these genes does not mean that you will definitely develop celiac disease.[beyondceliac.org]
  • Ninety percent of affected individuals carry the HLADQ2 haplotype, 5% the DQ8 haplotype, and the remaining 5% carry at least one of the two DQ2 alleles [ 1, 2 ].[intechopen.com]
  • Methods We performed a multicenter, randomized, double-blind, placebo-controlled dietary-intervention study involving 944 children who were positive for HLA-DQ2 or HLA-DQ8 and had at least one first-degree relative with celiac disease.[drschaer-institute.com]
HLA-DR3
  • Kaplan–Meier Estimates of CDA in HLA-DR3–DQ2 Homozygotes, According to Country. The proportion of children with persistently increased levels of tTG antibodies was highest among those who were homozygous for the DR3–DQ2 HLA haplotype.[nejm.org]

Treatment

  • In a research setting, delaying treatment for children without symptoms seems to be an option after a positive screening test.[ncbi.nlm.nih.gov]
  • Home » Colon And Digestive » Childhood celiac disease discovery offers new potential treatments, new risk factors also found Written by Published on April 11, 2016 Childhood celiac disease discovery offers new potential treatments.[belmarrahealth.com]
  • The children with celiac disease were studied before dietary treatment, during gluten-free diet, and during gluten challenge.[ncbi.nlm.nih.gov]
  • Treatment with a gluten-free diet was evaluated in 20 children with celiac disease who were followed up for 6 months from diagnosis.[ncbi.nlm.nih.gov]
  • Conclusions An alternative treatment that can improve CD patients’ quality of life may lie in probiotics.[intechopen.com]

Prognosis

  • Symptomatic first-degree relatives of those with CD have a 1 in 22 risk of having CD. [ Fasano: 2003 ] Prognosis Complete gluten restriction should result in complete cessation of the inflammatory response and subsequent normal reproductive capability[medicalhomeportal.org]

Etiology

  • Therefore, diagnostic procedures related to CCD appear justified in all children with short stature of unknown etiology.[ncbi.nlm.nih.gov]
  • Children who were subsequently diagnosed with an (potential) organic etiology (e.g. inflammatory bowel disease) as determined by the primary gastroenterologist, had any laboratory abnormalities suggesting an organic etiology, or who had resolution of[bmcgastroenterol.biomedcentral.com]
  • To date, human microbiota and mucosal barrier function are the key players in etiology of many inflammatory and autoimmune diseases [ 37 ].[intechopen.com]
  • The increased risk of neurodevelopmental disorders also suggests a “biological etiology of psychiatric comorbidity in celiac disease.” In addition, psychological aspects of celiac disease and chronic symptoms may contribute to the effect.[psychiatryadvisor.com]
  • The increased prevalence of type I diabetes mellitus, osteoporosis, intestinal lymphoma, autoimmune disease, miscarriage, and infertility in patients with untreated CD and their families suggests common immunogenetic etiologies.[medicalhomeportal.org]

Epidemiology

  • The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted.[ncbi.nlm.nih.gov]
  • Norsk Epidemiologi, 24 (1-2). Copyright (c) 2015 Norsk epidemiologi This work is licensed under a Creative Commons Attribution 4.0 International License.[ntnu.no]
  • […] substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC[bioportfolio.com]
  • The study, published in the American Journal of Epidemiology, found that the risk of developing celiac disease was particularly high in the case of repeated gastrointestinal infections in the first year of life.[zeenews.india.com]
  • They are variously affilated with the Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; the Department of Paediatrics, the Department of Immunology, and the Department of Epidemiology, Erasmus MC, University[celiac.com]
Sex distribution
Age distribution

Pathophysiology

  • The epidemiology, pathophysiology, diagnosis, and clinical spectrum of CD in children are highlighted.[ncbi.nlm.nih.gov]
  • View Article PubMed PubMed Central Google Scholar Tack J, Jones MP, Karamanolis G, Coulie B, Dubois D: Symptom pattern and pathophysiological correlates of weight loss in tertiary-referred functional dyspepsia.[bmcgastroenterol.biomedcentral.com]

Prevention

  • CONCLUSIONS: A significantly reduced prevalence of celiac disease in 12-year-olds indicates an option for disease prevention.[ncbi.nlm.nih.gov]
  • The health status improved in 66% of the treated children: in 41% by early treatment and in 25% by prevention of the gluten-dependent symptoms that they developed after diagnosis.[ncbi.nlm.nih.gov]
  • الصفحة 225 - Dietary products used in infants for treatment and prevention of food allergy.[books.google.com]
  • Socioeconomic position, daycare attendance and CMV seropositivity partly explained these differences, and may serve as targets for prevention strategies for CDA. Source: BMJ Publishing Group Limited[celiac.com]
  • To prevent symptoms such as stomach aches, diarrhea and abdominal pain, sufferers must follow a strict diet. The study identified two factors influencing the development of celiac disease: season and region of birth.[sports.yahoo.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!