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Childhood Thymoma

Presentation

CASE REPORT An 8-year-old boy presented to the pediatric clinic with a 3-month history of intermittent cough and occasional pain in the right upper chest. There was no history of dysphagia or dyspnea. [ncbi.nlm.nih.gov]

Thymic hyperplasia may present as an emergency with symptoms of respiratory stridor, dysphagia, cyanosis and dyspnoea (13). [med.amegroups.com]

Hypertrophic pulmonary os-teoarthropathy in child with carcinoma: An unusual presentation in childhood. Med Pediatr Oncol 1994;23:140-143. [ Links ] 19. Di-Cataldo A, Villari L, Milone P, et al. [scielo.org.mx]

Cardiovascular

  • Chest Pain

    They are less likely to present with MG or other PNS as compared to thymomas (31) and have other constitutional symptoms as well including chest pain, weight loss, fatigue, night sweats, symptoms of superior vena caval compression and recurrent lower [med.amegroups.com]

Workup

X-Ray

  • Mediastinal Mass

    Computed tomography chest showing a large, lobulated, homogenous soft tissue anterior mediastinal mass (marked T). [ncbi.nlm.nih.gov]

    Thymic cysts Thymic cysts (Figure 1A,B) are uncommon among the paediatric population forming less than 1% of all mediastinal masses and may be congenital or acquired. [med.amegroups.com]

Treatment

Long-term outcome after multimodality treatment for stage III thymic tumors. Ann Thorac Surg 2003;76:1866-1872. [ Links ] 29. Rajan A, Giaccone G. Treatment of advanced thymoma and thymic carcinoma. [scielo.org.mx]

Surgical resection is the mainstay of treatment for epithelial lesions of the thymus. Radiation and chemotherapy are reserved for treatment of invasive and malignant disease. [ncbi.nlm.nih.gov]

Post-operative radiotherapy is the recommended adjuvant treatment in incompletely resected cases. [med.amegroups.com]

Prognosis

Paraneoplastic syndromes, of which around 70% are myasthenia gravis, correlate with poor prognosis. [ncbi.nlm.nih.gov]

New WHO histologic classification predicts prognosis of thymic epithelial tumors: A clinicopathologic study of 200 thymoma cases from China. Cancer 2002;95:420-429. [ Links ] 9. [scielo.org.mx]

The rarity of the disease has caused difficulty in ascertaining prognosis or formulating treatment strategies of this entity in children and adolescents (7). [med.amegroups.com]

Etiology

Thymic lesions of the paediatric age group: a comprehensive review of non-neoplastic and neoplastic etiologies. Mediastinum 2019;3:24. [med.amegroups.com]

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