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Chinese Restaurant Syndrome
Moodium Glutamate Reaction

Images

WIKIDATA, CC BY-SA 3.0

Presentation

The glutamate in MSG is chemically indistinguishable from glutamate present in food proteins. Our bodies ultimately metabolize both sources of glutamate in the same way. [fda.gov]

MSG is most often confused as a preservative, however, it is actually a salt that rounds and balances the flavors already present in food. [tripsavvy.com]

Glutamate is naturally present in most foods, such as meat, seafood and vegetables. Two kinds of nucleotides that contribute most to the umami taste, inosinate and guanylate, are also present in many foods. [umamiinfo.com]

[…] when it is not, or that implies an ingredient is not present when it is present. [inspection.gc.ca]

Entire Body System

  • Fatigue

    It also causes headache, fatigue, sweating, chest pain, and difficulty in breathing. This usually happens two hours after eating. [atimes.com]

    Common symptoms include headaches, sweating, skin flushing, numbness, burning in the mouth and fatigue. The celebrity chef went on to discuss his latest book, Historic Heston. [dailymail.co.uk]

    […] etiology that apparently originated in mainland China in 2003; characterized by fever and coughing or difficulty breathing or hypoxia; can be fatal Lambert-Eaton syndrome a disease seen in patients with lung cancer and characterized by weakness and fatigue [vocabulary.com]

    Some of the more common symptoms associated with salicylate sensitivities include unexplained rashes, headaches, digestive symptoms of all kinds, depression, hyperactivity, persistent cough, and chronic fatigue. [pharmacistben.com]

  • Malaise

    Nobody wants MSG in their food—the protest goes—it causes headaches, stomachaches, dizziness and general malaise. It’s unhealthy and, maybe even worse, unsexy, used by lazy chefs as an excuse for flavor, not an enhancement. [smithsonianmag.com]

    Also, I had a murderous thirst and had sunk into what I can only describe as a deep malaise (which, considering these other symptoms, really isn't much of a surprise)." Wow. Sounds pretty intense. [businessinsider.com]

  • Inflammation

    The prominent symptoms of MSG allergy include, Skin reactions such as dermatitis (skin inflammation), hives, rash and redness Flushing and sweating Swelling of face Heart palpitations Nausea and vomiting Diarrhea Shortness of breath Anaphylaxis How do [medindia.net]

    On the following day, there was a gradual reduction in the size of the uvula and surrounding inflammation. 2 days from admission, the uvula and surrounding structures including the palate returned to normal and he could swallow solids [ Figure 2 ]. [ncbi.nlm.nih.gov]

    What could possibly be causing widespread reports of non-coeliac gluten intolerance, commonly blamed for a raft of symptoms including gas, bloating, diarrhoea, constipation, fatigue, goose bumps, dizziness, infertility, migraines, joint inflammation and [newscientist.com]

Respiratoric

  • Dyspnea

    On 17 August 1996 (in the southern hemisphere winter) several children and then adults among 100 customers in a chinese restaurant suddenly presented dyspnea, nausea, vomiting, headache, confusion and clumsiness. [ccforum.biomedcentral.com]

Gastrointestinal

  • Overeating

    The debate over MSG's safety has been raging for decades, making it one of the most studied food additives in history. [tripsavvy.com]

    […] monosodium glutamate [ mon″o-so´de-um ] Chi·nese res·tau·rant syn·drome development of chest pain, feelings of facial pressure, and sensation of burning over variable portions of the body surface after ingestion of food containing monosodium l -glutamate [medical-dictionary.thefreedictionary.com]

    Chinese restaurant in Manhattan, New York, United States Patrick GUEDJ/Gamma-Rapho/Getty Monosodium glutamate has accumulated quite an undeserving reputation over the years, forcing many an Asian restaurant to post “No MSG” signs lest customers run in [stufftoblowyourmind.com]

    Work over the past 17 years has consistently failed to reveal any objective sign accompanying the transient sensations that some individuals experience after the experimental ingestion of monosodium glutamate and it is questionable whether the term 'Chinese [ncbi.nlm.nih.gov]

    Patrons' growing concerns over possible health problems and the flavor enhancer's high sodium content have led many restaurateurs to stop including MSG in stir-fry and other Asian dishes. [articles.latimes.com]

  • Nausea

    Chinese restaurant syndrome Headache, nausea, a tight or burning sensation in the face, head and chest and sometimes dizziness and diarrhoea coming on one to two hours after a meal containing a large amount of MONOSODIUM GLUTAMATE. [medical-dictionary.thefreedictionary.com]

    Sufferers complain of symptoms including headaches, nausea, vomiting, arthritic pain, asthma attacks and heart palpitations. [articles.chicagotribune.com]

    A substantial minority of people experience an array of symptoms after ingesting MSG including tightness over the scalp, tingling of extremities, flushing, chest pressure, palpitations, thirst, headache, nausea, abdominal discomfort and bladder urgency [westerdrug.com]

    Some of the subjects reported weakness, warmth, tingling, nausea, headache, lightheadedness or gastric problems. But the frequency of these complaints was the same in the MSG and placebo groups. Most subjects reported no symptoms at all. [mcgill.ca]

    Over the years, FDA has received reports of symptoms such as headache and nausea after eating foods containing MSG. However, we were never able to confirm that the MSG caused the reported effects. [fda.gov]

  • Abdominal Pain

    Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia Bridging the Gap Challenge Yourself [nejm.org]

    A sensitive individual may suffer from headache, giddiness, sweating, abdominal pain, and urticaria within a few hours of consumption of MSG. [ncbi.nlm.nih.gov]

Cardiovascular

  • Chest Pain

    Chinese restaurant syndrome - chest pain, facial pressure, and burning sensation that develops after persons sensitive to monosodium glutamate ingest this food additive. Synonym(s): Kwok quease [medical-dictionary.thefreedictionary.com]

    National Library of Medicine, many people report symptoms that include chest pain, flushing, headaches, sweating, and numbness around the mouth. In rare cases, these symptoms even include shortness of the breath, chest pains, and heart palpitations. [thescientificstudent.com]

    Calling your health care provider If you experience any symptoms such as shortness of breath, heart palpitations, chest pain, or swelling of the lips or throat, go to the nearest emergency room immediately. [coordinatedhealth.com]

Musculoskeletal

  • Arthritis

    Aquatics Compression Diet and Nutrition Exercise Equipment Hearing Devices Independent Living Low Vision Aids Medical Supplies Pain Relief Parkinsons Pediatrics & Maternity Physical Therapy Skin Care Winter Products Oxygen Hospital Supplies Shop by Topic Arthritis [activeforever.com]

Skin

  • Flushing

    CONCLUSIONS: MSG has a widespread reputation for eliciting a variety of symptoms, ranging from headache to dry mouth to flushing. [ncbi.nlm.nih.gov]

    […] glutamate–MSG, a seasoning used in Chinese restaurants and in soy sauce Clinical Abrupt onset of severe headaches, heartburn, numbness, palpitations, vertigo–especially with chronic MSG exposure, thirst, abdominal and chest pains/heartburn, sweating, and flushing [medical-dictionary.thefreedictionary.com]

    Most, such as headache or flushing, need no treatment. Life-threatening symptoms require immediate medical attention. [coordinatedhealth.com]

  • Eczema

    People with asthma, childhood allergies, eczema, or prior severe food allergies are especially at risk for having an anaphylactic reaction. MSG reaction can be mistaken for an allergic reaction. [emedicinehealth.com]

Psychiatrical

  • Hunger

    Well Photo Credit Illustration by Celia Jacobs Outrunning Hunger Intense exercise may change the way certain neurons influence our appetite and metabolism. [nytimes.com]

    Neurotransmitters stimulate the nerve cells; stimulate the sense of smell, taste and can even stimulate hunger. It's just like alcohol or caffeine that has different effects on different people. [buzzle.com]

Neurologic

  • Headache

    Chinese restaurant syndrome Headache, nausea, a tight or burning sensation in the face, head and chest and sometimes dizziness and diarrhoea coming on one to two hours after a meal containing a large amount of MONOSODIUM GLUTAMATE. [medical-dictionary.thefreedictionary.com]

    Home About Donate Support Us Donation Headache What Is Headache Adults and Headache Children and Headache History of Headache Headache Types Headache Management Headache & Migraine Diaries Headache and Pain Clinics Personal Management Precipitating Factors [headacheaustralia.org.au]

    Definition of Chinese restaurant syndrome : a group of symptoms (such as numbness of the neck, arms, and back with headache, dizziness, and palpitations) that is held to affect susceptible persons eating food and especially Chinese food heavily seasoned [merriam-webster.com]

    CONCLUSIONS: MSG has a widespread reputation for eliciting a variety of symptoms, ranging from headache to dry mouth to flushing. [ncbi.nlm.nih.gov]

    […] fermented bean paste, and cheese, and is also a component of hydrolyzed protein such as yeast ... (40 of 3283 words, 1 image) en.wikipedia.org/wiki/Glutamic acid (flavor) Collins Dictionary: Chinese restaurant syndrome a group of symptoms such as dizziness, headache [memidex.com]

  • Dizziness

    Definition of Chinese restaurant syndrome : a group of symptoms (such as numbness of the neck, arms, and back with headache, dizziness, and palpitations) that is held to affect susceptible persons eating food and especially Chinese food heavily seasoned [merriam-webster.com]

    […] sauce, fermented bean paste, and cheese, and is also a component of hydrolyzed protein such as yeast ... (40 of 3283 words, 1 image) en.wikipedia.org/wiki/Glutamic acid (flavor) Collins Dictionary: Chinese restaurant syndrome a group of symptoms such as dizziness [memidex.com]

    Chinese restaurant syndrome Headache, nausea, a tight or burning sensation in the face, head and chest and sometimes dizziness and diarrhoea coming on one to two hours after a meal containing a large amount of MONOSODIUM GLUTAMATE. [medical-dictionary.thefreedictionary.com]

    Definitions Chinese restaurant syndrome the dizziness, headache, etc. experienced by some people as a reaction to monosodium glutamate, often used to intensify the flavor of Chinese food Webster's New World College Dictionary, Fifth Edition Copyright [yourdictionary.com]

    English Word Lists Latest Word Submissions Easy Learning English Grammar COBUILD Grammar Patterns Word Lover's Blog Online Scrabble Checker The Paul Noble Method the dizziness, headache, etc. experienced by some people as a reaction to monosodium glutamate [collinsdictionary.com]

  • Excitement

    Carl Clarke, the brains behind the chicken joint is opening a place below, Chinese Restaurant Syndrome and we are pretty damn excited. [londontheinside.com]

    So when we heard that he's opening a new bar, planning to serve a whimsical take on Chinese comfort food, UNDER Chick 'n' Sours, we were naturally pretty darned excited. [hot-dinners.com]

    Enter a word (“newspaper”), a word combination (“exciting trip”) or a phrase (“with all good wishes”) into the search box. [en.pons.com]

  • Stroke

    Feet Carpal Tunnel Syndrome Diet and Nutrition Emergency Supplies Fall Prevention Fibromyalgia Fitness and Health Hearing Loss Home Health Care and Safety Industrial and Public Health Safety Occupational Health Safety Sight Impaired Sleeping - COPD Stroke [activeforever.com]

    […] it might be the seasoning of MSG used by the restaurant. (1) The next month ten letters responded – one didn’t think it was MSG, one noted it didn’t happen in all Chinese restaurants – and might be placebo, and another reported a patient developing a stroke [yourdoctorsorders.com]

    […] increased; (2) Glial and neuronal GLU transporters ( Goldsmith, 2000 ; Meldrum, 2000 ) would also presumably remain functional under conditions of increased BBB permeability (except if the brain is ischemic, and thus oxygen deprived, such as during a stroke [doi.org]

  • Paresthesia

    […] muscles and an aching back; caused by antibodies directed against the neuromuscular junctions cervical root syndrome an abnormal condition resulting from compression of spinal nerve roots in the neck region; involves neck pains and muscular weakness and paresthesia [vocabulary.com]

    The range of symptoms described in these reports included numbness, headache, migraine, palpitations, tightness, weakness, aching, flushing, sweating, fasciculation, lacrimation, syncope, dizziness, shudder attacks, paresthesias, arrhythmias and tachycardia [academic.oup.com]

Treatment

Treatment & Monitoring What are the treatments for the disease? With symptoms so similar to an allergic reaction, treatment is sometimes given before the diagnosis is made. Antihistamines are the most frequently used medication. [medicineonline.com]

The following signs may also be used to aid in diagnosis: Abnormal heart rhythm observed on an electrocardiogram Decreased air entry into the lungs Rapid heart rate Treatment Treatment depends on the symptoms. [coordinatedhealth.com]

Prognosis

They may be similar to any other severe allergic reaction and include: Chest pain Heart palpitations Shortness of breath Expectations (prognosis) Most people recover from mild cases of Chinese restaurant syndrome without treatment and with no lasting [coordinatedhealth.com]

They may be similar to any other severe allergic reaction and include: Chest pain Heart palpitations Shortness of breath Swelling of the throat Outlook (Prognosis) Most people recover from mild cases of Chinese restaurant syndrome without treatment and [medicalgeek.com]

They may be similar to other severe allergic reactions and include: Chest pain Heart palpitations Shortness of breath Swelling of the throat Outlook (Prognosis) Most people recover from mild cases of Chinese restaurant syndrome without treatment and have [ufhealth.org]

Etiology

Nurse practitioners should therefore concentrate their efforts on advising patients of the nutritional pitfalls of some Chinese restaurant meals and to seek more consistently documented etiologies for symptoms such as headache, xerostomia, or flushing [ncbi.nlm.nih.gov]

[…] on eating binges and then feel guilt and depression and self-condemnation premenstrual syndrome a syndrome that occurs in many women from 2 to 14 days before the onset of menstruation severe acute respiratory syndrome a respiratory disease of unknown etiology [vocabulary.com]

Epidemiology

Epidemiologic surveys of reactions to MSG. An epidemiologic survey of ∼5000 MSG users and nonusers in Hawaii found no increased recall of neurologic symptoms among MSG users. [academic.oup.com]

Am J Clin Nutr 2011;93:1328–36. (8)A lack of epidemiologic evidence to link consumption of monosodium L-glutamate and obesity in China.vBursey RG, Watson L, Smriga M.Am J Clin Nutr. 2011 Sep;94(3):958-60; author reply 960-1. doi: 10.3945/ajcn.111.020727 [yourdoctorsorders.com]

Pathophysiology

Helen Nonye Henry-Unaeze, Update on food safety of monosodium l -glutamate (MSG), Pathophysiology, 10.1016/j.pathophys.2017.08.001, 24, 4, (243-249), (2017). [doi.org]

Prevention

Prevention & Expectations What can be done to prevent the disease? People with CRS should avoid foods containing high amounts of MSG. Symptoms of CRS can sometimes be avoided by eating food prior to eating MSG. [medicineonline.com]

If these ideas are correct, then inhibitors of the NO-MNP and/or temporary reduction of the plasma level of arginine may be useful in preventing at least some of the symptoms of these disorders. [ncbi.nlm.nih.gov]

Nevertheless, the only way to surely prevent a reaction is to avoid MSG altogether. This is good practice especially for those who know they have reactions to MSG. [thescientificstudent.com]

Food Allergy Prevention The only sure way to prevent future food allergies is to avoid eating a trigger food. Take care because a trigger can be present in many different foods; only a trace amount can cause a reaction. [emedicinehealth.com]

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