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Chlamydophila Pneumoniae

Chlamydia Pneumoniae


Presentation

  • Of the 295 subjects presenting with dry cough, 122 (41.4%) had positive tests for Chlamydia.[ncbi.nlm.nih.gov]
  • The boy, previously healthy, presented with fever, rash, constitutional symptoms, elevated acute phase reactants, elevated cardiac enzymes, and high brain natriuretic peptide levels.[ncbi.nlm.nih.gov]
  • In valve group, same pathogens were present in AVR and MVR patients as follows: 24.2% vs. 21.4% (p 0.773), 9.1% vs. 7.1% (p 0.758), and 21.2% vs. 11.9% (p 0.275).[ncbi.nlm.nih.gov]
  • Main Article Content Stefania Cazzavillan * Affiliation not present. Chiara Segala Affiliation not present. Emanuela Bonoldi Affiliation not present. Stefania Manfro Affiliation not present. Emanuele D’Amore Affiliation not present.[pagepressjournals.org]
  • In the present study, peritoneal macrophages harvested from green fluorescent protein (GFP) transgenic mice were used to analyze how Chlamydia pneumoniae infection affects the adherence of GFP-macrophages to mouse endothelial cells in vitro and to the[ncbi.nlm.nih.gov]
Fever
  • A 63-year-old man had a week-long history of intermittent high fever and rapidly progressive jaundice with atypical erythema. The results of liver function tests were recorded.[ncbi.nlm.nih.gov]
  • A previously healthy 29-year-old man was admitted to our hospital, with a 4-day history of fever ( 39 C), rigours, diaphoresis, fatigue and retro-orbital headache. On examination, he was febrile (37.8 C) and tachycardic (110 bpm).[ncbi.nlm.nih.gov]
  • After treatment with Doxyciclin the patient had no more fever, hepatosplenomegaly resolved and blood testes normalized.[ncbi.nlm.nih.gov]
  • After exacerbations of atopic eczema or rhinitis, both patients presented a nocturnal fever with persistent cough for more than two weeks.[ncbi.nlm.nih.gov]
  • The boy, previously healthy, presented with fever, rash, constitutional symptoms, elevated acute phase reactants, elevated cardiac enzymes, and high brain natriuretic peptide levels.[ncbi.nlm.nih.gov]
Malaise
  • The incubation period of C pneumoniae infection is around 21 days, and such symptoms as cough and malaise show a gradual onset, yet may persist for several weeks or months despite appropriate antibiotic therapy.[ncbi.nlm.nih.gov]
  • Symptoms due to C. pneumoniae respiratory infections may be of prolonged duration, with persistence of cough and malaise for several weeks or months despite appropriate antibiotic therapy.[novatec-id.com]
  • She had been well until one week before admission when she noted myalgias, malaise and a rash on the abdomen.[ncbi.nlm.nih.gov]
  • Clinical Syndrome Symptoms include a pharyngitis, bronchitis, a persistent cough and malaise. More severe infections can result in pneumonia, usually of a single lobe. D. Laboratory diagnosis Culture is difficult so serological test are most common.[web.archive.org]
  • Mycoplasma pneumoniae is known to produce a gradual tracheobronchitis with malaise and nonproductive cough, which can progress to pneumonia and extra pulmonary manifestations [ 7 , 11 ].[journals.plos.org]
Cough
  • A total of 214 outpatients aged from 2 to 94 years (110 women, 64 men, and 40 children) with chronic cough were studied.[ncbi.nlm.nih.gov]
  • Of the 295 subjects presenting with dry cough, 122 (41.4%) had positive tests for Chlamydia.[ncbi.nlm.nih.gov]
  • There also were decreases in Chl. pneumoniae detection rate in cases stratified due to the presenting symptom: dry cough, productive cough, or in asymptomatic cases.[ncbi.nlm.nih.gov]
  • Abstract The aim of this study was to analyze the rate of Chlamydophila pneumoniae infection in adults with symptoms of chronic cough. The study was conducted in 83 hospitalized patients aged 18-67 suffering of chronic cough.[ncbi.nlm.nih.gov]
  • In the group of patients with dry cough, as the most common presenting clinical symptom of respiratory infection, the positive IFA test results for C. pneumoniae occurred in 32 out of 94 (34.0%) of girls and in 34 out of 117 (29.1%) of boys.[ncbi.nlm.nih.gov]
Dyspnea
  • A Chlamydia pneumoniae infection may cause a person to experience dyspnea, or labored breathing symptoms, according to Merck Manuals Online Medical Library.[livestrong.com]
  • […] pharyngitis Dermatologic – erythema nodosum Neurologic – meningitis (uncommon) Cardiac – endocarditis , myocarditis (uncommon) C. psittaci Incubation – 5-19 days Constitutional – fever, chills, headache, myalgias Pulmonary – dry cough, pleural rub, rales, dyspnea[arupconsult.com]
  • The patient was hospitalized with 3 days of fever (temperature, 40 C), dry cough, and progressive dyspnea. Her admission medications included furosemide, olmesartan, hydrocodone, methotrexate, and infliximab.[journals.lww.com]
  • A nonproductive cough began two days before admission and 24 h later was followed by progressively worsening dyspnea. The patient’s family had also noted that she was mildly confused.[ncbi.nlm.nih.gov]
Asthmatic Bronchitis
  • Repeated or prolonged exposure to C pneumoniae may have a causal association with wheezing, asthmatic bronchitis, and asthma.[ncbi.nlm.nih.gov]
  • bronchitis, and adult-onset asthma in 1991.[en.wikipedia.org]
  • Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA. 1991; 266 :225–30. [ PubMed ] [ Google Scholar ] 20. Thom DH, Grayston JT, Wang S-P, Kuo C-C, Altman J.[ncbi.nlm.nih.gov]
  • Later diagnoses of asthmatic bronchitis were made within six months of the presenting illness in 29.6% of patients with antibody titres of 64 at recruitment, and in only 7% of matched controls (p 15 Several other groups have also shown a serological association[thorax.bmj.com]
  • Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis and adult onset asthma. JAMA 1991 ; 266 : 225 –230. Emre U, Roblin PM, Gelling M, et al.[erj.ersjournals.com]
Dry Cough
  • Of the 295 subjects presenting with dry cough, 122 (41.4%) had positive tests for Chlamydia.[ncbi.nlm.nih.gov]
  • There also were decreases in Chl. pneumoniae detection rate in cases stratified due to the presenting symptom: dry cough, productive cough, or in asymptomatic cases.[ncbi.nlm.nih.gov]
  • In the group of patients with dry cough, as the most common presenting clinical symptom of respiratory infection, the positive IFA test results for C. pneumoniae occurred in 32 out of 94 (34.0%) of girls and in 34 out of 117 (29.1%) of boys.[ncbi.nlm.nih.gov]
  • cough, pleural rub, rales, dyspnea, pneumonia Gastrointestinal – diarrhea , nausea, anorexia, abdominal pain Hepatitic – hepatitis Dermatologic – faint macular rash may occur (Horder spots), erythema multiforme, erythema nodosum Neurologic – cranial[arupconsult.com]
  • Sometimes there is a biphasic illness, with initial upper respiratory tract infection symptoms that resolve and give rise to a dry cough and low-grade fever.[www2.health.vic.gov.au]
Hoarseness
  • Upper respiratory signs and symptoms, such as rhinitis, sore throat, or hoarseness, may be reported initially.[novatec-id.com]
  • Symptoms: Cough, slight throat pain, hoarseness, sinusitis, atypical pneumonia, meningoencephalitis, bronchiolitis obliterans, myocarditis, Guillain-Barre-Syndrom After infection (4-6 weeks): arthritis (reactive, undifferentiated), tendovaginitis Associations[arminlabs.com]
  • When Chlamydia pneumoniae bacteria cause the infection, the infected person may also experience concurrent hoarseness. Dr.[livestrong.com]
  • Common symptoms are: A blocked or runny nose Tiredness A mild fever Sore throat or hoarseness A bad cough Headaches An upper respiratory tract infection (like ear or sinus infections) Serious lung infections (like bronchitis or pneumonia) – these can[onlinedoctor.superdrug.com]
Venous Insufficiency
  • Abstract Objective Chronic cerebrospinal venous insufficiency (CCSVI) is a condition associated with multiple sclerosis (MS).[ncbi.nlm.nih.gov]
Skin Lesion
  • Further, reddening of the throat, rhinitis, shortness of breath, fever, enlarged lymph nodes, skin lesions and dyspepsia were also observed. The frequency of specific clinical features in both groups was similar.[ncbi.nlm.nih.gov]
Headache
  • A previously healthy 29-year-old man was admitted to our hospital, with a 4-day history of fever ( 39 C), rigours, diaphoresis, fatigue and retro-orbital headache. On examination, he was febrile (37.8 C) and tachycardic (110 bpm).[ncbi.nlm.nih.gov]
  • The disease usually starts as influenza like syndrome with fever, illness, headache, scratchy sore throat and cough as the predominant symptoms. Chlamydophila pneumoniae has been associated with pharyngitis, sinusitis and bronchitis.[mikrogen.de]
  • Headache, another typical pharyngitis symptom, may accompany the sore throat symptoms. A Chlamydia pneumoniae infection may cause a person to experience dyspnea, or labored breathing symptoms, according to Merck Manuals Online Medical Library.[livestrong.com]

Workup

  • There clearly were fewer patients each next year submitted for Chl. pneumoniae detection procedure, which stemmed from the declining severity of respiratory infections noted in children and thus less demanding diagnostic workup commissioned by physicians[ncbi.nlm.nih.gov]
Pulmonary Infiltrate
Bicytopenia
  • Laboratory work up revealed bicytopenia (white cell count 1.37 10(9)/L, platelets 60 10(9)/L) and an increase in C reactive protein (9 mg/dL). The ECG showed ST segment elevation in V1, V2 and V3 leads.[ncbi.nlm.nih.gov]
Chlamydia
  • RESULTS: Overall, Chlamydia infection was detected in the respiratory tract in 43.1% (276/ 641) of the children, with no clear gender differences. Of the 295 subjects presenting with dry cough, 122 (41.4%) had positive tests for Chlamydia.[ncbi.nlm.nih.gov]
  • Chlamydia pneumoniae sp. nov. for Chlamydia strain TWAR. Int. J. Syst. Bacteriol. 39 , 88 ( 1989). 2. Kuo, C.C. , Jackson, L.A. , Campbell, L.A. & Grayston, J.T. Chlamydia pneumoniae (TWAR). Clin. Microbiol. Rev. 8 , 451–461 (1995). 3.[doi.org]
  • Da Wikimedia Commons, l'archivio di file multimediali liberi Jump to navigation Jump to search Regnum : Bacteria • Phylum : Chlamydiae • Classis : Chlamydiae • Ordo : Chlamydiales • Familia : Chlamydiaceae • Genus : Chlamydophila • Species: Chlamydophila[commons.wikimedia.org]
  • Bacteriol. 49::432 Classification kingdom Bacteria phylum Chlamydiae class Chlamydiae order Chlamydiales family Chlamydiaceae genus Chlamydophila species Chlamydophila pneumoniae Name Synonyms Chlamydia pneumoniae Grayston & al., 1989 Homonyms Chlamydophila[gbif.org]
  • Hahn , Role of Chlamydia pneumoniae as an Inducer of Asthma , Chlamydia pneumoniae Infection and Disease , 10.1007/0-306-48741-1_17 , (239-262) , (2005) .[doi.org]

Treatment

  • Post-treatment pulmonary function and asthma symptoms were compared with baseline values. Follow-up was an average of 6 months (range 1.5 to 36) post-treatment.[ncbi.nlm.nih.gov]
  • Post-treatment pulmonary function and asthma symptoms were compared with baseline values. Follow-up was an average of 6 months (range 1.5 to 36) post-treatment. Results.[go.galegroup.com]
  • Our results indicated that RU486 treatment produced growth inhibition and an absence of C. pneumoniae gene expression in normal HEp-2 cells and that this treatment failed to inhibit C. pneumoniae growth in HEp-2 cells stimulated with IFNγ.[ncbi.nlm.nih.gov]
  • Our suggestion is to read the forums and comments after you have gotten a basic understanding of Cpn and the treatment process.[cpnhelp.org]
  • We were not able to confirm which factor was responsible for the occurrence of the skin changes as treatment of both infections was effective and all skin changes later disappeared completely.[ncbi.nlm.nih.gov]

Prognosis

  • Specific therapy may play role in the management and prognosis of this disorder.[ncbi.nlm.nih.gov]
  • Prognosis of chlamydia Treatment of chlamydia Chlamydia prevention References What is chlamydia? Chlamydia is a sexually transmitted infection caused by bacteria.[myvmc.com]
  • Previous severe disability or poor prognosis due to underlying disease constitutes the other main contraindication for ECMO initiation.[jmedicalcasereports.biomedcentral.com]
  • Because asthma prognosis is generally worse for severe asthma, this disparity could have diminished contrasts (ie, tendency to bias the OL results toward a null effect).[doi.org]

Etiology

  • We present a case of erythema nodosum caused by Ascaris lumbricoides infection as well as by an early Chlamydophila pneumoniae infection, whose etiology has rarely been described in the literature.[ncbi.nlm.nih.gov]
  • RESULTS: Over 2003-2009 period there were 1870 children hospitalized due to pneumonia, of which in 332 (17.8%) the Mycoplasma pneumoniae and/or Chlamydophila pneumoniae etiology was confirmed.[ncbi.nlm.nih.gov]
  • In 19 patients out of 37 (51.35%) etiological diagnosis were established and in 18 patients (48.65%) no pathogens were found. 11 patients (29.72%) had either CP or MP and 8 patients (21.62%) had RSV.[ncbi.nlm.nih.gov]
  • Since it is difficult to detect C. pneumoniae in clinical practice, specific etiological diagnosis is established only in a minority of cases.[ncbi.nlm.nih.gov]
  • Abstract High affinity to the epithelial lining of the airways makes Chlamydophila pneumoniae a common etiological agent of respiratory tract infections (RTI).[ncbi.nlm.nih.gov]

Epidemiology

  • BACKGROUND: No recent Austrian data are available on the epidemiology and morbidity of Chlamydophila pneumoniae (C. pneumoniae) as causative agent in youths and children hospitalized with community-acquired pneumonia (CAP).[ncbi.nlm.nih.gov]
  • In the central area of Argentina, the epidemiological and molecular characteristics of Chlamydophila pneumoniae infections in reptiles are still unknown.[ncbi.nlm.nih.gov]
  • Current deficits and goals in standardisation of diagnostic tools, basic and applied research, design of epidemiological and monitoring of therapy studies were identified.[books.google.ro]
  • This study investigated the epidemiology of M. pneumoniae and C. pneumoniae infections among children hospitalized with acute respiratory infections in Suzhou, China in the year 2006, and associations between incidence rates and climatic conditions.[ncbi.nlm.nih.gov]
  • Although epidemiological studies have found an association between Chlamydia pneumoniae infection and severe asthma, the causality and underlying mechanism are largely unknown.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Author information 1 Department of Pathophysiology, Basic Medical School of Tianjin Medical University, Tianjin, 300070, P. R. China.[ncbi.nlm.nih.gov]
  • ." : Overview, Pathophysiology, Epidemiology. 2 Nov. 2013. Available at: . 6. Kuo CC, Jackson LA, Campbell LA, Grayston JT. Chlamydia pneumoniae (TWAR). Clinical Microbiology Reviews. 1995;8(4):451-461. 7. Casadevall A, Pirofski L. 2003.[microbewiki.kenyon.edu]
  • Correspondence to: Dr S J Furrows Microbiology Department, University College London Hospitals, Cecil Fleming House, London WC1E 6DB, UK; SFurrowsaol.com Abstract Background: Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology[jnnp.bmj.com]
  • The pathophysiology of this immunodeficiency is probably multifactorial.[imedpub.com]

Prevention

  • Author information 1 Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.[ncbi.nlm.nih.gov]
  • Author information 1 Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.[ncbi.nlm.nih.gov]
  • Author information 1 Respiratory Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.[ncbi.nlm.nih.gov]
  • Nevertheless, the infection still reduced base line and prevented IFN gamma-inducible MHC-class II expression. Similar results were obtained with heat-inactivated C. pneumoniae.[ncbi.nlm.nih.gov]
  • Unraveling the presence of Chlamydia infection in chronic cough patients enables to introduce a timely implementation of effective therapy and thus can prevent distant complications.[ncbi.nlm.nih.gov]

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