Presentation
A case reporting fatal chlordane ingestion with residue levels in various body tissues is presented. Analyses were performed by gas-liquid chromatography. The highest residue levels were reported in stomach contents, liver, brain, and adipose tissue. [ncbi.nlm.nih.gov]
Clinical information is presented in a succinct narrative form to aid in understanding. [books.google.com]
Some foamy secretion was present at the mouth, but there was no sweating or lacrimation, and no fasciculations were observed. Respiration was labored, and wheezing was heard over the chest. His gaze wandered, and the pupils were pinpoint. [jamanetwork.com]
Upon initial presentation and during the recovery phase, blood and urine specimens were collected to measure the disposition and elimination of chlordane and its metabolites. [tandfonline.com]
Thomason also testified that he was present when Stephenson tested his home on October 7, 1986, and that he was then aware that the test was "[t]o see how much Chlordane was in it." [law.justia.com]
Entire Body System
- Unconsciousness
Report of a Case An unconscious 17-year-old boy was brought to the hospital at midnight from a nearby settlement with an accompanying note from a physician stating that the boy had drunk an insecticide (a 2% solution of chlordane in kerosene [Flit]). [jamanetwork.com]
Never give anything by mouth to an unconscious person. (P331) Store in a tightly closed container. (P404) Do not breathe vapor. (P260) Do not get in eyes, on skin or clothing. [accustandard.com]
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. [cameochemicals.noaa.gov]
[…] onset, are the primary clinical effects of acute organochlorine toxicity; therefore, patients may present with any of the following: Initial euphoria with auditory or visual hallucinations and perceptual disturbances Seizures Agitation, lethargy, or unconsciousness [emedicine.medscape.com]
- Anemia
Symptoms of chronic poisoning with this type of compound may include headache, loss of appetite, muscular weakness, fine tremors, apprehensive mental state, aplastic anemia and acute leukemia. [cameochemicals.noaa.gov]
In addition, chronic exposure to these agents may be associated with the development of blood dyscrasias, including aplastic anemia and leukemia in humans (inconclusive). [emedicine.medscape.com]
- Weakness
These results prompt us to conclude that, during the initial step of intoxication, an increase of the oxygen consumption occurs under weak poisoning conditions, while higher concentrations of insecticide give rise to a decrease in metabolism. [link.springer.com]
Symptoms of chronic poisoning with this type of compound may include headache, loss of appetite, muscular weakness, fine tremors, apprehensive mental state, aplastic anemia and acute leukemia. [cameochemicals.noaa.gov]
- Fatigue
Symptoms of acute poisoning with this type of compound include vomiting, diarrhea, paraesthesia, excitement, giddiness, fatigue, tremors, convulsions, coma, possibly pulmonary edema; liver, kidney and myocardial toxicity and hypothermia. [cameochemicals.noaa.gov]
[…] produces the following manifestations: Ear, nose, and throat irritation Blurred vision Cough Acute lung injury Dermatitis Long-term occupational exposure to organochlorine pesticides may result in various nonspecific symptoms, including headaches, nausea, fatigue [emedicine.medscape.com]
Gastrointestinal
- Vomiting
الصفحة 11 - Anorexia, nausea, vomiting, abdominal cramps, epigastric and substernal tightness (cardiospasm) with "heartburn" and eructation, diarrhea, tenesmus, involuntary defecation. Increased sweating. Increased salivation. [books.google.com]
The patient experienced multiple acute clinical sequellae attributable to his acute intoxication, including vomiting, diarrhea, seizures, coma and respiratory failure. [tandfonline.com]
DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. [cameochemicals.noaa.gov]
(P360) Ingestion: Do NOT induce vomiting. Call a physician or poison control center immediately. Never give anything by mouth to an unconscious person. (P331) Store in a tightly closed container. (P404) Do not breathe vapor. [accustandard.com]
- Nausea
الصفحة 11 - Anorexia, nausea, vomiting, abdominal cramps, epigastric and substernal tightness (cardiospasm) with "heartburn" and eructation, diarrhea, tenesmus, involuntary defecation. Increased sweating. Increased salivation. [books.google.com]
Below are a few of the symptoms linked to chlordane exposure: Confusion Nausea Cardiac problems Dizziness and tremors Current Status of Chlordane Manufacturing of Chlordane has stopped since the late 1980's, but there are still large stocks of the chemical [legalmatch.com]
Initial euphoria with auditory or visual hallucinations and perceptual disturbances Seizures Agitation, lethargy, or unconsciousness Other symptoms include the following: Pulmonary - Cough, shortness of breath Dermatologic - Skin rash Gastrointestinal - Nausea [emedicine.medscape.com]
Then the children, suffering from periodic dizziness and nausea, were tested and found to have possible liver ailments. [people.com]
(NTP, 1992) Health Hazard SYMPTOMS: Symptoms of exposure to this compound include blurred vision, confusion, ataxia, delirium, coughing, abdominal pain, nausea, irritability and anuria. [cameochemicals.noaa.gov]
- Diarrhea
الصفحة 11 - Anorexia, nausea, vomiting, abdominal cramps, epigastric and substernal tightness (cardiospasm) with "heartburn" and eructation, diarrhea, tenesmus, involuntary defecation. Increased sweating. Increased salivation. [books.google.com]
The patient experienced multiple acute clinical sequellae attributable to his acute intoxication, including vomiting, diarrhea, seizures, coma and respiratory failure. [tandfonline.com]
(d) Plaintiff Vicki Mae Thomason Pressley gave deposition testimony that she resided with her parents (plaintiffs Mary Ellen Thomason and Richard Thomason) until her marriage in 1984; that she started having recurrent physical problems (dizziness, diarrhea [law.justia.com]
Symptoms of acute poisoning with this type of compound include vomiting, diarrhea, paraesthesia, excitement, giddiness, fatigue, tremors, convulsions, coma, possibly pulmonary edema; liver, kidney and myocardial toxicity and hypothermia. [cameochemicals.noaa.gov]
- Abdominal Pain
(NTP, 1992) Health Hazard SYMPTOMS: Symptoms of exposure to this compound include blurred vision, confusion, ataxia, delirium, coughing, abdominal pain, nausea, irritability and anuria. [cameochemicals.noaa.gov]
pain Nervous system - Headache, dizziness, or paresthesias of the face, tongue, and extremities Ingestion produces the following manifestations: Nausea and vomiting Confusion, tremor, myoclonus, coma, and seizures Respiratory depression or failure Unusual [emedicine.medscape.com]
- Abdominal Cramps
الصفحة 11 - Anorexia, nausea, vomiting, abdominal cramps, epigastric and substernal tightness (cardiospasm) with "heartburn" and eructation, diarrhea, tenesmus, involuntary defecation. Increased sweating. Increased salivation. [books.google.com]
Skin
- Increased Sweating
Increased sweating. Increased salivation. Increased lacrimination. [books.google.com]
Neurologic
- Convulsions
In experimental animals the characteristic signs of acute toxicity are hypothermia, hyperexcitability, tremors and convulsions. In human, signs of acute chlordane toxicity are tremors and convulsions. [pubmed.ncbi.nlm.nih.gov]
Muscular rigidity and opisthotonos alternating with generalized clonic convulsions were seen at intervals. Some foamy secretion was present at the mouth, but there was no sweating or lacrimation, and no fasciculations were observed. [jamanetwork.com]
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. [cameochemicals.noaa.gov]
Symptoms of acute poisoning are vomiting, dizziness, tremors, disturbances of balance and convulsions. [wgbis.ces.iisc.ernet.in]
High exposure can cause convulsions and death. Low exposure may cause headaches, confusion, vomiting, stomach cramps, vision problems, and general malaise. [globalhealingcenter.com]
- Tremor
In experimental animals the characteristic signs of acute toxicity are hypothermia, hyperexcitability, tremors and convulsions. In human, signs of acute chlordane toxicity are tremors and convulsions. [pubmed.ncbi.nlm.nih.gov]
Below are a few of the symptoms linked to chlordane exposure: Confusion Nausea Cardiac problems Dizziness and tremors Current Status of Chlordane Manufacturing of Chlordane has stopped since the late 1980's, but there are still large stocks of the chemical [legalmatch.com]
Symptoms of chronic poisoning with this type of compound may include headache, loss of appetite, muscular weakness, fine tremors, apprehensive mental state, aplastic anemia and acute leukemia. [cameochemicals.noaa.gov]
Symptoms of acute poisoning are vomiting, dizziness, tremors, disturbances of balance and convulsions. [wgbis.ces.iisc.ernet.in]
Skin rash Gastrointestinal - Nausea, vomiting, diarrhea, and abdominal pain Nervous system - Headache, dizziness, or paresthesias of the face, tongue, and extremities Ingestion produces the following manifestations: Nausea and vomiting Confusion, tremor [emedicine.medscape.com]
- Headache
(b) Plaintiff Richard Thomason gave deposition testimony that his health started deteriorating (headaches, rash, dizziness, excessive perspiration, cramping feet and sinus problems) after 1982; that he suspected Chlordane to be the cause of his problems [law.justia.com]
[…] or inhalation produces the following manifestations: Ear, nose, and throat irritation Blurred vision Cough Acute lung injury Dermatitis Long-term occupational exposure to organochlorine pesticides may result in various nonspecific symptoms, including headaches [emedicine.medscape.com]
Low exposure may cause headaches, confusion, vomiting, stomach cramps, vision problems, and general malaise. [globalhealingcenter.com]
Symptoms of chronic poisoning with this type of compound may include headache, loss of appetite, muscular weakness, fine tremors, apprehensive mental state, aplastic anemia and acute leukemia. [cameochemicals.noaa.gov]
Convincing medical and epidemiological evidence links pesticide poisoning with long-term neurological illnesses such as depression, headaches, reduced concentration and decision- making abilities, visual disturbances, memory impairment, neurobehavioral [tldp.com]
- Seizure
The patient experienced multiple acute clinical sequellae attributable to his acute intoxication, including vomiting, diarrhea, seizures, coma and respiratory failure. [tandfonline.com]
These changes can result in agitation, confusion, and seizures. Cardiac effects have been attributed to sensitization of the myocardium to circulating catecholamines. [emedicine.medscape.com]
Elsewhere we learn she is a manic-depressive who has been treated with lithium, has a seizure disorder and is a recovered drug addict. What Antonetta has written is something new—a postpsychological memoir. [michaelpollan.com]
- Fine Tremor
Symptoms of chronic poisoning with this type of compound may include headache, loss of appetite, muscular weakness, fine tremors, apprehensive mental state, aplastic anemia and acute leukemia. [cameochemicals.noaa.gov]
Workup
[…] prolongation, nonspecific ST-segment changes Gastrointestinal - Transaminitis and hyperbilirubinemia Hematologic - Leukocytosis and prolonged activated partial thromboplastin time (aPTT) Renal - Acidemia, azotemia, creatinine elevation, hyperkalemia See Workup [emedicine.medscape.com]
Treatment
Back to top Controlling Termites - liquid barrier termite treatments Pre Treatment: Pre Construction Termite Treatment of Structures Homes and other buildings can be pretreated to protect them against termite attack at the time of construction. [doityourselftermitecontrol.com]
Current results implicate the hazards associated with chlordane treatment of residential homes and the continued need for further studies. This content is only available as a PDF. © 1995 National Academy of Neuropsychologists [academic.oup.com]
To the researchers' surprise, the measurable residues of chlorpyrifos continued to increase for a week after the initial treatment. [rainforestinfo.org.au]
Journal of the Food Hygienic Society of Japan 30(6): 526-533, 1989 Adsorption of atmospheric chlordane on polished rice in homes after termite treatment studies on the route of chlordane contamination to humans 3rd report. [eurekamag.com]
And each month without medical treatment increases the probability that our immune system damage will be permanent. Conclusions and Questions The realtor committed a material breach of the purchase/sale contract. [tldp.com]
Prognosis
The prognosis in patients exposed to organochlorine compounds depends on the amount and type of exposure. [emedicine.medscape.com]
Epidemiology
Convincing medical and epidemiological evidence links pesticide poisoning with long-term neurological illnesses such as depression, headaches, reduced concentration and decision- making abilities, visual disturbances, memory impairment, neurobehavioral [tldp.com]
Highly toxic organochlorines include: Aldrin Dieldrin [12] Endrin [13] Endosulfan [14, 15] Moderately toxic organochlorines include: Chlordane DDT Heptachlor Kepone Lindane Mirex Toxaphene Epidemiology United States statistics Organochlorine pesticides [emedicine.medscape.com]
Pathophysiology
Pathophysiology Organochlorines are well absorbed orally and by inhalation. Transdermal absorption is variable. [emedicine.medscape.com]
Prevention
الصفحة 1 - Pesticide means any substance or mixture of substances intended for preventing, destroying or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals causing harm during or otherwise interfering [books.google.com]
Protective gloves must be worn to prevent skin contact. (P280) Shipping Class Shp Class 3 [accustandard.com]
The pest control company committed the tort of negligence by spraying the home top-to-bottom with more than 758 gallons of highly neurotoxic chemicals, and failing to take prudent and reasonable precautions to prevent these poisons from contaminating [tldp.com]
Decontamination may be indicated to prevent continued absorption, as well as exposure of health care personnel. For dermal decontamination, remove clothing and wash skin with soap and water. This is best performed in the field. [emedicine.medscape.com]