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Chloroform Poisoning


Presentation

  • Presented is a case of a double homicide involving a 29-year-old male and his 23-year-old fiance. Gas chromatographic methodology and tissue concentrations of chloroform are presented.[ncbi.nlm.nih.gov]
  • The two cases presented here involve deaths that were due to dichloromethane or chloroform poisoning. The dichloromethane and chloroform were determined in biological specimens by headspace gas chromatography with mass spectrometric detector.[ncbi.nlm.nih.gov]
  • "I'm impressed by the presentation by the defense team," Rudloff said. Referring to Semel, he added, "however, she's not a miracle person. She can't work miracles."[articles.latimes.com]
  • Phosgene can form in chloroform as it is exposed to oxygen and amounts of UV light (although UV light is not always necessary if catalytic contaminants are present). Phosgene has a characteristic odor of cut hay.[earlham.edu]
  • Although FANA titer was positive, this finding is not usually present alone in auto-immune hepatitis; It usually presents with other auto-immune antibodies and anti-smooth muscle antibody [ 6 ].[aoemj.biomedcentral.com]
Fever
  • […] stimuli to living protoplasm, and that respiratory activity and growth may be accelerated by chloroform, ether and even powerful mineral poisons, such as mercuric chloride, in minimal doses, offers some explanation of these phenomena of hypertrophy, wound fever[sentence.yourdictionary.com]
  • Mary now had a new lover, a man called Natrass, but he died too of Gastric Fever, according to Mary. The local doctor, Dr. Kilburn, became suspicious and in 1873 Mary was brought to Durham Assizes. She was found guilty and hanged at Durham Jail.[historic-uk.com]
Ecchymosis
  • […] place at the Assizes, some years since, a surgeon, in giving his evidence, informed the court that on examining the prosecutor, he found him suffering from a severe contusion of the integuments under the left orbit, with great extravasation of blood and ecchymosis[books.google.com]
Asymptomatic
  • Google Scholar Hay JE, Czaja AJ, Rakela J, Ludwig J: The nature of unexplained chronic aminotransferase elevations of a mild to moderate degree in asymptomatic patients.[aoemj.biomedcentral.com]
Camping
  • The couple had spent several days last August at Dubria's family home in Glendale, using it as a base camp to play Southern California tourist.[articles.latimes.com]
Vomiting
  • Acute poisoning is associated with headache, altered consciousness, convulsions, respiratory paralysis and disturbances of the autonomic nervous system: dizziness, nausea, and vomiting are common.[cargohandbook.com]
  • Gastrointestinal signs and symptoms include nausea, vomiting, salivation, anorexia, and gastrointestinal irritation. Cardiac arrhythmias and cardiac arrest have been reported.[cameochemicals.noaa.gov]
  • High concentrations of the chemical may produce headaches, dizziness, and gastrointestinal problems such as nausea and vomiting. In addition, chloroform has been classified as a probable carcinogen—a chemical that can cause cancer.[owlcation.com]
  • Case presentation Case 1 A 34-year-old woman who had been working in a medical endoscopic device factory for approximately 40 days developed nausea, vomiting, and jaundice.[aoemj.biomedcentral.com]
  • The central part of Adelaide’s defence at her trial was the mystery of how the chloroform got into the stomach, as it is almost impossible to swallow as the unpleasant taste causes vomiting and if it had been poured down his throat while unconscious,[historic-uk.com]
Nausea
  • Acute poisoning is associated with headache, altered consciousness, convulsions, respiratory paralysis and disturbances of the autonomic nervous system: dizziness, nausea, and vomiting are common.[cargohandbook.com]
  • --More likely effects of inhaling chloroform are dizziness, nausea, disorientation, headache and possible drunken-like behavior. Longer-term exposure can lead to hallucinations and psychotic episodes.[answers.google.com]
  • High concentrations of the chemical may produce headaches, dizziness, and gastrointestinal problems such as nausea and vomiting. In addition, chloroform has been classified as a probable carcinogen—a chemical that can cause cancer.[owlcation.com]
  • Case presentation Case 1 A 34-year-old woman who had been working in a medical endoscopic device factory for approximately 40 days developed nausea, vomiting, and jaundice.[aoemj.biomedcentral.com]
  • Gastrointestinal signs and symptoms include nausea, vomiting, salivation, anorexia, and gastrointestinal irritation. Cardiac arrhythmias and cardiac arrest have been reported.[cameochemicals.noaa.gov]
Jaundice
  • The effects observed in the women included jaundice, liver enlargement and tenderness, delirium, coma, and death. Neurological Effects The central nervous system is a major target for chloroform toxicity in humans and in animals.[answers.google.com]
  • There is another case series of 13 jaundice patients exposed to chloroform (400 ppm) inhalation at their workplaces [ 20 ].[aoemj.biomedcentral.com]
Flushing
  • If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 30 minutes. 5. Wash exposed skin areas thoroughly with water. 6.[cameochemicals.noaa.gov]
Contusion
  • الصفحة 60 - On a trial for an assault which took place at the Assizes, some years since, a surgeon, in giving his evidence, informed the court that on examining the prosecutor, he found him suffering from a severe contusion of the integuments under the[books.google.com]
Osteoporosis
  • Regarding medical history, she underwent a routine health examination 4 months ago and was diagnosed with reflux esophagitis and osteoporosis; she did not take medications for either.[aoemj.biomedcentral.com]
Myalgia
  • 1) 179/309(3) * 46/83 (11) † Case 2 AST/ALT 767/1420(0) 312/739(3) 140/341(7) * 40/98 (14) † Case 2 A 41-year-old woman who had been working in a medical endoscopic device factory for 45 days visited the Department of Gastroenterology complaining of myalgia[aoemj.biomedcentral.com]
Anger
  • Monday's revelations are fueling doubt and anger at the authorities, but Vice-Governor Kazanzhy doubts they will spark more violence.[voanews.com]
Headache
  • Acute poisoning is associated with headache, altered consciousness, convulsions, respiratory paralysis and disturbances of the autonomic nervous system: dizziness, nausea, and vomiting are common.[cargohandbook.com]
  • Intial exposure to chloroform can cause headaches, dizziness, and fatigue (as an anesthetic, chloroform depresses the central nervous system).[websleuths.com]
  • --More likely effects of inhaling chloroform are dizziness, nausea, disorientation, headache and possible drunken-like behavior. Longer-term exposure can lead to hallucinations and psychotic episodes.[answers.google.com]
  • High concentrations of the chemical may produce headaches, dizziness, and gastrointestinal problems such as nausea and vomiting. In addition, chloroform has been classified as a probable carcinogen—a chemical that can cause cancer.[owlcation.com]
  • Acute exposure may also lead to respiratory depression, chemical pneumonitis, pulmonary edema, metabolic acidosis, central nervous system depression, headache, fatigue, and dizziness.[cameochemicals.noaa.gov]
Neglect
  • Cleanroom manufactures may neglect to maintain adequate ventilation amounts of outside air to lessen the associated costs.[aoemj.biomedcentral.com]

Treatment

  • Treatment requires an emetic at once (see Aconite, Treatment) ; and then, as there is no chemical antidote, dashing cold water on the face and chest, and, if it can be obtained, the galvanic battery ; as a last resort, artificial respiration.[chestofbooks.com]
  • Previous reports describe survival after treatment with orally administered NAC, we report the first use of intravenously administered NAC for chloroform ingestion. Acute oral ingestion of chloroform is extremely rare.[ncbi.nlm.nih.gov]
  • This latter compound may be chlorinated to perchloracetoacrylic chloride (9), from which the corresponding acid (to) is obtained by treatment with water; alkalis hydrolyse the acid to chloroform and dichlormaleic acid (I I).[sentence.yourdictionary.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia Bridging the Gap Challenge Yourself[nejm.org]
  • Treatment: Hypodermic injection of strychnine, whiskey, or ammonia: enema of strong coffee and whiskey; artificial respiration and oxygen; when swallowed, use stomach lavage. Poisons & Antidotes - Index Botanical.com Home Page[botanical.com]

Prognosis

  • This content is accurate and true to the best of the author’s knowledge and does not substitute for diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed health professional.[owlcation.com]

Epidemiology

  • Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria — An epidemiological investigation. ‏ الصفحة 283 - Bressac, B., Kew, M., Wands, J., and Ozturk, M. 1991.[books.google.com]
  • However, it is also very unpredictable, making epidemiological analysis very difficult. Therefore, it is still important to focus on individual cases.[aoemj.biomedcentral.com]
Sex distribution
Age distribution

Pathophysiology

  • Third pathophysiology of prenatal cocaine exposure. Dev Neurosci. 2009;31:23-35. [ Links ] 52. Bigsby R, LaGasse LL, Lester B, Shankaran S, Bada H, Bauer C, et al. Prenatal cocaine exposure and motor performance at 4 months.[scielo.isciii.es]

Prevention

  • (ERG, 2016) Protective Clothing Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact.[cameochemicals.noaa.gov]
  • Every bottle of chloroform should be treated as if it contains phosgene to help prevent exposure, however, testing is possible using test strips or sampling tubes.[earlham.edu]
  • Again, the fear of dangerous results was preventing a development that would have benefitted many.[rcsedlibraryandarchive.wordpress.com]
  • If it be rubbed in or evaporation be prevented, it acts, like alcohol and chloroform, as an irritant. That quinine, chloroform, glycerin, alcohol, with others, had no attractive influence on them - negative chemiotaxis.[sentence.yourdictionary.com]
  • They knew the chloroform in their adhesive was regulated chemical but did not realize the regulation aimed to prevent human toxicity.[aoemj.biomedcentral.com]

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