An unusual presentation of chlorpropamide toxicity, presenting as a mixed hepatocanalicular reaction, is reported, along with a review of the literature. [ncbi.nlm.nih.gov]

Our patient is presented as the third case of fatal agranulocytosis due to chlorpropamide. [jamanetwork.com]

• Swelling

  However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing. [webmd.com]

  Tell your doctor if you have serious side effects of Diabinese including: skin changes (such as darkening, thickening), unusual fatigue, fast or pounding heartbeat, easy bruising or bleeding, mental/mood changes, sudden weight gain, swelling of the hands [rxlist.com]

  Tell your doctor about the allergy and what signs you had, like rash; hives ; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. [drugs.com]

  Tell your doctor right away if you have any serious side effects, including: skin changes (such as darkening, thickening) unusual fatigue fast/pounding heartbeat easy bruising/bleeding mental/mood changes sudden weight gain swelling of the hands/feet [healthlinkbc.ca]

• Acute Intermittent Porphyria

  Chlorpropamide is dangerous in patients suffering from acute forms of porphyria, especially variegate porphyria, and to a lesser extent acute intermittent porphyria and hereditary coproporphyria. [home.intekom.com]

  Clorpropamida is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. Clorpropamida may also be used for purposes not listed in this medication guide. [ndrugs.com]

  Clorpropamida is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. Clorpropamida may also be used for purposes not listed in Clorpropamida guide. [gmedication.com]

• Congestive Heart Failure

  Alcohol even in moderation Alcohol intoxication Cardiovascular disease predisposing to tissue hypoxia Carry a reliable source of sugar along with you Congestive heart failure Do not drink alcohol Do not drive or operate heavy machinery Exercise caution [tabletwise.com]

• Camping

  Twenty-four-hour Chlorpropamide exposure (100 μM) upregulates the ADH receptors without affecting affinity, which lowers Ka and increases basal AC activity and maximal response (1.86 vs. 1.35 and 14.9 vs. 10.6 fmol cAMP/min/1000 cells). [selleckchem.com]

• Nausea

  Signs include throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, palpitations, tachycardia, hypotension, syncope, agitation, confusion, weakness, vertigo, and blurred vision. [fadavispt.mhmedical.com]

  Gastrointestinal: Gastrointestinal disturbances are the most common reactions; nausea has been reported in less than 5% of patients, and diarrhea, vomiting, anorexia, and hunger in less than 2%. [rxlist.com]

  Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, and feeling shaky. [everydayhealth.com]

  Side Effects Nausea, loss of appetite, diarrhea, vomiting, and weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [webmd.com]

• Abdominal Cramps

  GI disturbances (e.g. anorexia, nausea, vomiting, epigastric discomfort, abdominal cramps, constipation, diarrhoea), vague neurologic symptoms (e.g. headache, weakness, paraesthesia), syndrome of inappropriate secretion of antidiuretic hormone, jaundice [mims.com]

• Skin Rash

  skin rash that spreads and causes blistering and peeling). [rxlist.com]

  Get emergency medical help if you have signs of an allergic reaction ( hives, difficult breathing, swelling in your face or throat) or a severe skin reaction ( fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and [emedicinehealth.com]

  Check with your doctor as soon as possible if any of the following side effects occur: severe skin rash or blistering, peeling skin skin rash or itchy skin symptoms of low blood sugar dizziness drowsiness headache lack of energy nervousness numbness or [medbroadcast.com]

• Photosensitivity

  Adverse Reactions: Hypoglycemia, cholestatic jaundice, GI disturbances, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria. Note: Formerly known under the brand name Diabinese. How Supplied: Contact supplier [empr.com]

  Body as a Whole: Flushing, photosensitivity, alcohol intolerance. GI: GI distress, anorexia, nausea, diarrhea, constipation, cholestatic jaundice. Hematologic: Leukopenia, thrombocytopenia, agranulocytosis. [robholland.com]

  Photosensitizing agents (topical): (Moderate) Additive photosensitization may be seen with concurrent administration of sulfonylureas and other photosensitizing agents. [pdr.net]

  Derm: photosensitivity, rash, pruritus, urticaria. Endo: hypoglycemia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion. F and E: hyponatremia. [fadavispt.mhmedical.com]

• Paresthesia

  CNS: Drowsiness, muscle cramps, weakness, paresthesias. Skin: Rash, pruritus. [robholland.com]

  Adverse reactions CNS: paresthesia, fatigue, dizziness, vertigo, malaise, headache. GI: nausea, heartburn, epigastric distress. GU: tea-colored urine, altered urine phenyl ketone level. [glowm.com]

• Renal Insufficiency

  Petitpierre B, Perrin L, Rudhardt M, Herrera A, Fabre J (1972) Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy. Int J Clin Pharmacol 6: 120–124 Google Scholar 15. [link.springer.com]

  Renal Impairment Use conservative initial and maintenance dosages to avoid hypoglycemia. 189 (See Renal Impairment under Cautions.) [drugs.com]

• Hyponatremia

  Abstract The incidence and risk factors of chlorpropamide-induced hyponatremia were assessed in diabetic outpatients. [ncbi.nlm.nih.gov]

  Chlorpropamide administration was associated with hyponatremia and serum hypoosmolality, continued sodium excretion despite hyponatremia and an impaired ability to dilute urine maximally and to excrete a water load. [nejm.org]

The effects of the three meals were investigated by administering each of the meals alone, without the medicinal drug (Treatment I); in Treatment II each meal was administered 30 min following the administration of 250 mg chlorpropamide; in Treatment [ncbi.nlm.nih.gov]

Uses antidiabetic Uses For treatment of NIDDM in conjunction with diet and exercise. [chemicalbook.com]

Abstract An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after [ncbi.nlm.nih.gov]

In: Mann JI, Pyorala K, Teuscher A (eds) Diabetes and epidemiological perspectives. Churchill Livingstone, Edinburgh and London, pp 147–153 Google Scholar 40. [link.springer.com]

By suspecting and identifying neuroglycopenia, disabling residual deficits and even death could eventually be prevented. [ncbi.nlm.nih.gov]

[…] to prevent bedsores, according to a new study. [mynetmeds.comprar-medicina.com]

Treatment & Diagnosis Medications & Supplements Prevention & Wellness QUESTION ______________ is another term for type 2 diabetes. [medicinenet.com]