Presentation
An unusual presentation of chlorpropamide toxicity, presenting as a mixed hepatocanalicular reaction, is reported, along with a review of the literature. [ncbi.nlm.nih.gov]
Our patient is presented as the third case of fatal agranulocytosis due to chlorpropamide. [jamanetwork.com]
Entire Body System
- Acute Intermittent Porphyria
Chlorpropamide is dangerous in patients suffering from acute forms of porphyria, especially variegate porphyria, and to a lesser extent acute intermittent porphyria and hereditary coproporphyria. [home.intekom.com]
Clorpropamida is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. Clorpropamida may also be used for purposes not listed in this medication guide. [ndrugs.com]
Clorpropamida is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. Clorpropamida may also be used for purposes not listed in Clorpropamida guide. [gmedication.com]
- Congestive Heart Failure
Alcohol even in moderation Alcohol intoxication Cardiovascular disease predisposing to tissue hypoxia Carry a reliable source of sugar along with you Congestive heart failure Do not drink alcohol Do not drive or operate heavy machinery Exercise caution [tabletwise.com]
Gastrointestinal
- Nausea
Gastrointestinal: Gastrointestinal disturbances are the most common reactions; nausea has been reported in less than 5% of patients, and diarrhea, vomiting, anorexia, and hunger in less than 2%. [rxlist.com]
Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, and feeling shaky. [everydayhealth.com]
Side Effects Nausea, loss of appetite, diarrhea, vomiting, and weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. [webmd.com]
Alcohol also interacts with the medication and can cause discomfort and unwanted side effects such as stomach pain, nausea, facial flushing and dizziness. [medicalook.com]
Skin
- Skin Rash
skin rash that spreads and causes blistering and peeling). [rxlist.com]
Get emergency medical help if you have signs of an allergic reaction ( hives, difficult breathing, swelling in your face or throat) or a severe skin reaction ( fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and [emedicinehealth.com]
Workup
Serum
- Hyponatremia
Abstract The incidence and risk factors of chlorpropamide-induced hyponatremia were assessed in diabetic outpatients. [ncbi.nlm.nih.gov]
Monitor I&O ratio and pattern: Infrequently, chlorpropamide produces an antidiuretic effect, with resulting severe hyponatremia, edema, and water intoxication. [robholland.com]
Colonoscopy
- Colitis
One similar case of chlorpropamide toxicity manifested by jaundice and colitis has been previously reported. It is possible that the sulfonamide moiety of the chlorpropamide was implicated in the development of the colitis. [ncbi.nlm.nih.gov]
Treatment
The effects of the three meals were investigated by administering each of the meals alone, without the medicinal drug (Treatment I); in Treatment II each meal was administered 30 min following the administration of 250 mg chlorpropamide; in Treatment [ncbi.nlm.nih.gov]
Uses antidiabetic Uses For treatment of NIDDM in conjunction with diet and exercise. [chemicalbook.com]
Epidemiology
Abstract An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after [ncbi.nlm.nih.gov]
In: Mann JI, Pyorala K, Teuscher A (eds) Diabetes and epidemiological perspectives. Churchill Livingstone, Edinburgh and London, pp 147–153 Google Scholar 40. [link.springer.com]
Prevention
By suspecting and identifying neuroglycopenia, disabling residual deficits and even death could eventually be prevented. [ncbi.nlm.nih.gov]
[…] to prevent bedsores, according to a new study. [mynetmeds.comprar-medicina.com]
Treatment & Diagnosis Medications & Supplements Prevention & Wellness QUESTION ______________ is another term for type 2 diabetes. [medicinenet.com]
To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. [healthlinkbc.ca]