Painless jaundice (yellow/orange coloring of the skin and eyes) may be the only initial clue. The history often includes reviewing alcohol use, drug use, or recent illnesses that may be associated with hepatitis, or inflammation of the liver. [medicinenet.com]

Distal cholangiocarcinomas, which can mimic pancreatic cancer with regards to presentation (painless jaundice with a distal common bile duct stricture), can be treated via pancreaticoduodenectomy (Whipple procedure). [healio.com]

They fall into two broad categories based on the origin of tumor growth: intrahepatic cholangiocarcinoma and extrahepatic cholangiocarcinoma. 1 Intrahepatic cholangiocarcinoma arises from tumors that grow in the small ducts within the liver and extrahepatic [cancerquest.org]

D espite the need for cumulative evidence, clinical practice can fall short of that ideal. “Sometimes all you have is just one of these,” Dr. Izzy says—imaging suggesting a malignant stricture, but nothing else. [captodayonline.com]

Thus, although multiple studies report rising incidence rates of iCCA and falling rates of extrahepatic CCA, we do not know what is happening with incidence/mortality rates of pCCA, the commonest form of CCA, which could have been incorrectly coded as [onlinelibrary.wiley.com]

Symptoms: Yellowing of your skin and whites of your eyes Weight loss Abdominal pain or discomfort Nausea Itchy skin Treatment Options Treatment depends on the size and location of the tumor, whether the cancer has spread, and the person’s overall health [bostonscientific.com]

Nausea and vomiting. Weight loss for an unknown reason. Check with your physician if you have any of these symptoms. [mysouthernhealth.com]

[…] virus Diabetes Obesity Genetic factors Symptoms of bile duct cancer Symptoms of bile duct cancer include jaundice (yellowing of the skin and the whites of the eyes), pain in the abdomen, dark urine, light or ‘clay’ colored stool, fever, itchy skin, nausea [publichealth.va.gov]

Fever, nausea, and vomiting 4 : These are not typical symptoms of bile duct cancer but may develop as a result of an infection caused by blockage of the bile duct. [cancerquest.org]

Symptoms may differ according to the location, but they usually include: Jaundice Pain in your belly or sides Nausea and vomiting Fever Loss of appetite/ weight loss Weakness Itching Light-colored stools Dark urine Getting a Diagnosis Your doctor will [webmd.com]

Nausea and vomiting. Weight loss for an unknown reason. Check with your physician if you have any of these symptoms. [mysouthernhealth.com]

Diabetes Obesity Genetic factors Symptoms of bile duct cancer Symptoms of bile duct cancer include jaundice (yellowing of the skin and the whites of the eyes), pain in the abdomen, dark urine, light or ‘clay’ colored stool, fever, itchy skin, nausea and vomiting [publichealth.va.gov]

Fever, nausea, and vomiting 4 : These are not typical symptoms of bile duct cancer but may develop as a result of an infection caused by blockage of the bile duct. [cancerquest.org]

Symptoms may differ according to the location, but they usually include: Jaundice Pain in your belly or sides Nausea and vomiting Fever Loss of appetite/ weight loss Weakness Itching Light-colored stools Dark urine Getting a Diagnosis Your doctor will [webmd.com]

Side effects of chemotherapy can include: nausea vomiting fatigue hair loss However, these side effects should stop once the course of treatment has finished. Chemotherapy can also weaken your immune system, making you more vulnerable to infection. [nhsinform.scot]

Right upper quadrant pain, fever, and rigors suggest cholangitis (this is unusual without drainage attempts). Cholangiocarcinoma usually presents after the disease is advanced. [gut.bmj.com]

Many factors that influence oral medication, such as unable to swallow; chronic diarrhea; intestinal obstruction; the situations which significantly affect the use and absorption of drugs 9. [clinicaltrials.gov]

Symptoms include post-hepatic jaundice and pruritus, with pale stools and dark urine. Other less common features include RUQ pain, early satiety, weight loss, anorexia and malaise. On examination, jaundice and cachexia are often evident. [teachmesurgery.com]

Extra-hepatic CCA manifests with signs of cholestasis (jaundice, pale stools, dark urine, pruritus), malaise, weight loss and/or progressive weakness. [orpha.net]

jaundice, dark urine, pruritus ) and a painless, enlarged gallbladder ( Courvoisier sign ). [amboss.com]

Palliative therapy Relief of biliary obstruction is warranted when symptoms such as pruritus and hepatic dysfunction outweigh other symptoms of the cancer. [healthy.kaiserpermanente.org]

[…] the permission of the Centre for Evidence-based Medicine. 3.0 DIAGNOSIS 3.1 Clinical features 5, 17 Most common presenting clinical features of perihilar or extrahepatic tumours are those of biliary obstruction: jaundice, pale stool, dark urine, and pruritus [gut.bmj.com]

Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. [ebi.ac.uk]

[…] tables Images hosted on other servers: Morphologic classification Clinical features Asymptomatic in early stages (19 - 40% incidentally identified) ( J Am Coll Surg 2001;193:384 ) Nonspecific symptoms in late stages, such as abdominal pain, malaise, night [pathologyoutlines.com]

Patients may have non-specific symptoms including weight loss, abdominal pain, fevers, night sweats and fatigue. [rarediseases.org]