Fatigue: About 70% to 80% patients with chronic fatigue suffer from fatigue. Underlying abnormal serotonergic neurotransmission or neuroendocrine defects in the corticotrophin hormone axis are believed to be underlying etiology. [ncbi.nlm.nih.gov]

Hepaticojejunostomy was performed and pathologic analysis of the conglomerated soft-tissue mass revealed chronic granulomatous inflammation with caseation of the lymph nodes. [ncbi.nlm.nih.gov]

Some of these effects include : Steatorrhea (‘fatty stools’) Unintentional weight loss Softening of the bones (osteomalacia) Bleeding disorders Muscle pain and weakness Abnormal sensations like numbness and tingling Other late features of obstructive [healthhype.com]

[…] products in the skin Tiredness, loss of appetite, nausea due to liver disease Pale-coloured stools (since bile and associated pigment does not reach the intestine) Deficiency of fat-soluble vitamins (since bile is needed to absorb fat soluble vitamins) Steatorrhea [medindia.net]

References:[10][8] Clinical features In addition to jaundice, the following signs may also indicate cholestasis: Pale, clay-colored (acholic) stool Darkening of urine Pruritus Fat malabsorption (steatorrhea, weight loss) References:[10][8][11][12] Diagnostics [amboss.com]

Liver biopsy CT Ultrasound MRI Doppler flow Endoscopic cholangiography PTC ( percutaneous transhepatic cholangiography) ERCP (endoscopic retrograde cholangiopancretography) /cytology/biopsy Chronic bile stasis Pruritus - bile salts Steatorrhea - malabsorption [meddean.luc.edu]

Clay colored stool, weight loss and palpable abdominal mass were more common in malignant obstructive jaundice, whereas right upper abdominal pain was more common in benign obstructive jaundice. [bmcresnotes.biomedcentral.com]

Regarding the symptoms, clinical jaundice was most common, seen in 97 (88%) patients followed by right upper quadrant pain in 75(66.2%) patients, dark urine in 64 (55.2%), pruritius in 60 (54.5%), clay colored stools in 54(49.1%), weight loss in 48( 43.6% [ispub.com]

INTRODUCTION: Patients with metastatic colorectal cancer can develop jaundice from intrahepatic or extrahepatic causes. Currently, there is little data on the underlying causes and overall survival after onset of jaundice. [ncbi.nlm.nih.gov]

Hard & nodular hepatomegaly – ? metastatic malignancy. 6. [slideshare.net]

Abdominal Pain Gallstones – stones are in the common bile duct Choledochal cysts (congenital anomalies of the bile duct) Pancreatitis Fever with Abdominal Pain Gallstones Choledochal cyst Stricture Abdominal Mass Pancreatitis Choledochal cyst Liver cancer Hepatomegaly [healthhype.com]

Abdominal examination showed a tender hepatomegaly 3 cm below the costal margin with a smooth surface. There was no shifting dullness. Investigations revealed conjugated hyperbilirubinaemia with total bilirubin 10 mg% and direct 4.2 mg%. [termedia.pl]

Primary systemic amyloidosis with giant hepatomegaly and a swiftly progressive course. J Clin Gastroenterol. 1997;24:173–175. [PubMed] [Google Scholar] 15. Chang HC, Nguyen B, Regan F. Hepatomegaly and multiple liver lesions. [ncbi.nlm.nih.gov]

He also had scleral icterus. The remainder of his physical exam including the abdominal exam was normal. [hindawi.com]

[…] carotenemia. carotenemia does not cause scleral icterus Hyperbilirubinemia per se has no patho-physiologic effect. [meddean.luc.edu]

Definition Jaundice: yellowish discoloration of the skin, sclerae, and mucous membranes due to the deposition of bilirubin Scleral icterus: discoloration of the whites of the eyes, starting at serum bilirubin levels 2–3 mg/dL Jaundice: discoloration of [amboss.com]

He had marked scleral icterus; proptosis was noted. On thyroid examination, he had a large symmetrical, non‐tender goiter with audible bruit. Heartbeat was irregularly irregular. [onlinelibrary.wiley.com]

icterus is unacceptable to a patient et Võimaldamaks tõhusat ja ametlikku järelevalvet artikli # lõikes # osutatud sööda üle, rakendatakse järgmisi sätteid en It should not be used in patients with myasthenia gravis (a disease of the nerves causing muscle [et.glosbe.com]

Prominent features of cholestasis are pruritus and malabsorption of fat and fat-soluble vitamins. [ncbi.nlm.nih.gov]

Bile acid resins (cholestyramine or colestipol) are the first line agents in moderate to severe pruritus particularly when associated with excoriations and disturbed sleep. Our patient was started on cholestyramine with symptom improvement. [hindawi.com]

Pruritus - manifest by scratch marks (excoriation). This is a common but not universal feature (ranging from absent to severely disabling), the exact pathophysiology of which is not clearly understood. [patient.info]

• Excoriations suggest prolonged cholestasis or high-grade biliary obstruction 23. [slideshare.net]

Excoriations suggest prolonged cholestasis or high-grade biliary obstruction. Center SA. Diseases of the gallbladder and biliary tree. Vet Clin North Am Small Anim Pract. 2009 May. 39(3):543-98. [Medline]. Marrelli D, Caruso S, Pedrazzani C, et al. [emedicine.medscape.com]

Symptoms of obstructive jaundice include the typical yellowing of jaundice as well as dark urine, pale feces, and itching. Also known as post-hepatic jaundice. [medicinenet.com]

Symptoms & Effects of obstructive jaundice may include: Dark Urine Pale Faeces Itching Compare obstructive jaundice with hepatocellular jaundice and haemolytic jaundice. Click for pages about Digestion [ivyroses.com]

Patients with medical jaundice will have yellowing of the skin, without dark urine or light-coloured stools. [healthxchange.sg]

‘Two thirds of pancreatic cancers develop in the head of the pancreas, and most patients present with progressive, obstructive jaundice with dark urine and pale stools.’ [en.oxforddictionaries.com]

Engelsk definition Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. [mesh.kib.ki.se]