Incidence Affects males and females equally Usually more than 50 years Increased incidence with increased age 3 - 5% of population have CPPD deposition in the knee at autopsy Seen in 40% of patients with haemochromatosis or hyperparathyroidism Clinically Presents [orthopaedicsone.com]

The breakdown of collagen cells has been proposed to be the source of the inorganic pyrophosphate. [2, 3, 4] Presentation Following are the 4 separate and distinct manifestations of this disease: Pseudogout An acute presentation appears very similar to [thehealthscience.com]

Patients demonstrated several clinical presentations including acute monarthritis (pseudogout), premature generalized osteoarthritis, and polyarticular rheumatoid-like presentations. [cags.org.ae]

[…] septic arthritis; - chondrocalcinosis of the meniscus occurs not only in otherwise healthy individuals in older age groups but also in definite association w/ several distinct metabolic disorders; - references: - Monoarticular pseudogout of the hip presenting [wheelessonline.com]

The most common presentation is acute monoarthritis but patients may present mimicking OA and rheumatoid arthritis. Metabolic and endocrine disorders can be associated with CPPD arthritis. [omagdigital.com]

(See Etiology, Presentation, and Workup .) Calcium pyrophosphate deposition disease. Radiograph of the knee showing chondrocalcinosis involving the meniscal cartilage, as well as evidence of osteoarthritis. Calcium pyrophosphate deposition disease. [emedicine.medscape.com]

Indeed, as the experts at MedlinePlus indicated, "careful workup, with analysis of crystals found in the joints, should ultimately lead to the correct diagnosis." Treatment There are a variety of treatment options. [medical-dictionary.thefreedictionary.com]

Calcium pyrophosphate crystal deposition disease: diagnosis and treatment. Open Access Rheumatology : Research and Reviews. 2014;6:39-47. doi:10.2147/OARRR.S39039 MacMullan P, McCarthy G. [rarediseases.org]

Recent research demonstrated the effective role of ethylene diamine tetra acetic acid (EDTA) for the treatment of CCAL2, however, due to the significant adverse effects EDTA is still under massive examination. [cags.org.ae]

Rest Anti-inflammatory therapy (NSAIDs, corticosteroid injection) Chronic chondrocalcinosis appears to be irreversible Treatment for secondary OA [orthopaedicsone.com]

Treatment Treatment of CPPD disease includes treatment of acute attacks, prophylaxis against recurrent acute attacks, and management of chronic symptoms12 (See Table 3). This treatment includes both pharmacological and non-pharmacological options. [omagdigital.com]

SLIDESHOW Gout Attack Symptoms, Causes, Treatment, and Diet See Slideshow What are treatments for pseudogout? The treatment of pseudogout is directed toward stopping the inflammation in the joints. Local ice applications and resting can help. [medicinenet.com]

One would think the task of estimating prognosis impossible. [books.google.com]

Prognosis of Pseudogout (Calcium pyrophosphate deposition disease) Prognosis is good for acute episodes of psuedogout, which usually improve over a period of 10 days or so. [myvmc.com]

Chondrocalcinosis Prognosis As aforesaid, Chondrocalcinosis is often left untreated if there is no pain. In case a patient is experiencing pain, certain medications are used to relieve painful sensations. This may, however, cause damage to organs. [hxbenefit.com]

Prognosis With regard to an acute attack of pseudogout, the prognosis is usually very good. The symptoms usually go away within two weeks. However, over time, joint degeneration can occur. [medical-dictionary.thefreedictionary.com]

They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]

Etiology Although the exact mechanism for the development of CPDD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. [emedicine.medscape.com]

Etiology See Pathophysiology. Pathophysiology The exact physiologic dysfunction is not clear, but studies appear to implicate the chondrocyte and surrounding matrix as the responsible agents. [thehealthscience.com]

Etiology: The cause of CPPD crystal deposition disease is unknown. Formation of CPPD crystals in cartilage may be related to matrix changes or result from elevated levels of calcium or inorganic pyrophosphate. [rheumaknowledgy.com]

In the present study the specific involvement of this cotransporter in the etiology of this disorder is further substantiated by the finding that the proband is homozygous for the S615L variation. [omicsonline.org]

The book also provides updated epidemiologic and statistical data throughout and includes a section on biostatistics in physical medicine and rehabilitation. [books.google.com]

[…] author={Josep Ausi and Josep Brugulat and Miquel Casadevall and Teresa Esquerra and Josep Fontarnau and Alejandro Ganiko and Vicenc Grenzner}, year={2004} } Josep Ausi, Josep Brugulat, +4 authors Vicenc Grenzner Published 2004 Objectives-To undertake an epidemiological [semanticscholar.org]

Epidemiology Frequency Estimates on the frequency of CPPD disease in the United States vary widely. Rates range from 4% to more than 25% of the population by age 80 years. [thehealthscience.com]

Chondrocalcinosis Epidemiology Chondrocalcinosis is known to affect people from all cultural and ethnic backgrounds. In United States, nearly 50% of people over the age of 85 are estimated to be suffering from the disorder. [hxbenefit.com]

Presents in 4th decade Pain & stiffness In spine & larger joints XR shows calcification of intervertebral discs Progressing to obliteration of the disc space And bony ankylosis Excretion of homogentisic acid Causes the urine to turn dark on standing Epidemiology [orthofracs.com]

Etiology See Pathophysiology. Pathophysiology The exact physiologic dysfunction is not clear, but studies appear to implicate the chondrocyte and surrounding matrix as the responsible agents. [thehealthscience.com]

Definition / general Also called pseudogout, chondrocalcinosis Common finding in arthritic joints Pathophysiology Calcium pyrophosphate dehydrate (CPPD) crystals develop first in menisci and intervertebral discs, may seed the joint and elicit neutrophilic [pathologyoutlines.com]

Further studies are needed in order to enlighten the pathophysiology and prevalence of CC in patients with GS. [omicsonline.org]

Subsequent messenger RNA expression analysis of the relevant genes in this pathway, in articular cartilage of independent patients undergoing joint replacement surgery for osteoarthritis, showed that upregulation of TNFRSF11B is a general phenomenon in the pathophysiological [emedicine.medscape.com]

Hemochromatosis: Genetics, Pathophysiology, diagnosis, and treatment. [physio-pedia.com]

Prevention There are not specific techniques applicable to every patient to prevent the formulation of the crystals; however, some patients with certain diseases are at greater risk of developing them. [medical-dictionary.thefreedictionary.com]

These problems are preventable if hemochromatosis is recognized in time. [orthop.washington.edu]

Drainage of joint fluid and injection of a corticosteroid Nonsteroidal anti-inflammatory drugs Colchicine to help prevent attacks Physical therapy Usually, treatment can stop acute attacks and prevent new attacks but cannot reverse changes in already [msdmanuals.com]

While you can’t prevent the disease, you can find treatments to reduce the inflammation and relieve the pain. Treating the underlying condition that causes pseudogout may slow its development and lessen the severity of symptoms. [healthline.com]

For the purpose of preventing further attacks, low doses of Colcrys (colchicine) and NSAIDs are typically prescribed, along with recommendations for proper hydration. [verywell.com]