Bullough, MB, ChB, presents a unique, lavishly illustrated account of the pathology of arthritic disorders, metabolic disturbances, and soft tissue and bone tumors. [books.google.com]

The breakdown of collagen cells has been proposed to be the source of the inorganic pyrophosphate. [2, 3, 4] Presentation Following are the 4 separate and distinct manifestations of this disease: Pseudogout An acute presentation appears very similar to [thehealthscience.com]

Incidence Affects males and females equally Usually more than 50 years Increased incidence with increased age 3 - 5% of population have CPPD deposition in the knee at autopsy Seen in 40% of patients with haemochromatosis or hyperparathyroidism Clinically Presents [orthopaedicsone.com]

Patients demonstrated several clinical presentations including acute monarthritis (pseudogout), premature generalized osteoarthritis, and polyarticular rheumatoid-like presentations. [cags.org.ae]

[…] septic arthritis; - chondrocalcinosis of the meniscus occurs not only in otherwise healthy individuals in older age groups but also in definite association w/ several distinct metabolic disorders; - references: - Monoarticular pseudogout of the hip presenting [wheelessonline.com]

(See Etiology, Presentation, and Workup .) Calcium pyrophosphate deposition disease. Radiograph of the knee showing chondrocalcinosis involving the meniscal cartilage, as well as evidence of osteoarthritis. Calcium pyrophosphate deposition disease. [emedicine.medscape.com]

Indeed, as the experts at MedlinePlus indicated, "careful workup, with analysis of crystals found in the joints, should ultimately lead to the correct diagnosis." Treatment There are a variety of treatment options. [medical-dictionary.thefreedictionary.com]

Calcium pyrophosphate crystal deposition disease: diagnosis and treatment. Open Access Rheumatology : Research and Reviews. 2014;6:39-47. doi:10.2147/OARRR.S39039 MacMullan P, McCarthy G. [rarediseases.org]

Recent research demonstrated the effective role of ethylene diamine tetra acetic acid (EDTA) for the treatment of CCAL2, however, due to the significant adverse effects EDTA is still under massive examination. [cags.org.ae]

Rest Anti-inflammatory therapy (NSAIDs, corticosteroid injection) Chronic chondrocalcinosis appears to be irreversible Treatment for secondary OA [orthopaedicsone.com]

Although treatment is not always required, proper medical attention allows keeping a close watch on the symptoms of the disorder. [hxbenefit.com]

This has been brought on by the need to improve our knowledge of all aspects of the disease, especially with regard to its etiopathogenesis and treatment. [books.google.de]

One would think the task of estimating prognosis impossible. [books.google.com]

Chondrocalcinosis Prognosis As aforesaid, Chondrocalcinosis is often left untreated if there is no pain. In case a patient is experiencing pain, certain medications are used to relieve painful sensations. This may, however, cause damage to organs. [hxbenefit.com]

It tends to be more aggressive, with a more ominous long-term prognosis. The longevity of satisfactory joint function is reduced in these individuals. Genetic studies have implicated a responsible gene with an autosomal dominant mode of inheritance. [thehealthscience.com]

Prognosis of Pseudogout (Calcium pyrophosphate deposition disease) Prognosis is good for acute episodes of psuedogout, which usually improve over a period of 10 days or so. [myvmc.com]

Etiology See Pathophysiology. Pathophysiology The exact physiologic dysfunction is not clear, but studies appear to implicate the chondrocyte and surrounding matrix as the responsible agents. [thehealthscience.com]

They are organised into groups, and further divided into clinical, etiological or histopathological sub-types. [orpha.net]

Etiology Although the exact mechanism for the development of CPDD remains unknown, increased adenosine triphosphate breakdown with resultant increased inorganic pyrophosphate in the joints results from aging, genetic factors, or both. [emedicine.medscape.com]

In the present study the specific involvement of this cotransporter in the etiology of this disorder is further substantiated by the finding that the proband is homozygous for the S615L variation. [omicsonline.org]

Etiology: The cause of CPPD crystal deposition disease is unknown. Formation of CPPD crystals in cartilage may be related to matrix changes or result from elevated levels of calcium or inorganic pyrophosphate. [rheumaknowledgy.com]

The book also provides updated epidemiologic and statistical data throughout and includes a section on biostatistics in physical medicine and rehabilitation. [books.google.com]

[…] author {Josep Ausi and Josep Brugulat and Miquel Casadevall and Teresa Esquerra and Josep Fontarnau and Alejandro Ganiko and Vicenc Grenzner}, year {2004} } Josep Ausi, Josep Brugulat, 4 authors Vicenc Grenzner Published 2004 Objectives-To undertake an epidemiological [semanticscholar.org]

Epidemiology Frequency Estimates on the frequency of CPPD disease in the United States vary widely. Rates range from 4% to more than 25% of the population by age 80 years. [thehealthscience.com]

Chondrocalcinosis Epidemiology Chondrocalcinosis is known to affect people from all cultural and ethnic backgrounds. In United States, nearly 50% of people over the age of 85 are estimated to be suffering from the disorder. [hxbenefit.com]

Abstract OBJECTIVES--To undertake an epidemiological survey of the prevalence of radiological chondrocalcinosis in the elderly population of Osona, a rural area of Catalonia, north east Spain. [ncbi.nlm.nih.gov]

Etiology See Pathophysiology. Pathophysiology The exact physiologic dysfunction is not clear, but studies appear to implicate the chondrocyte and surrounding matrix as the responsible agents. [thehealthscience.com]

Further studies are needed in order to enlighten the pathophysiology and prevalence of CC in patients with GS. [omicsonline.org]

Definition / general Also called pseudogout, chondrocalcinosis Common finding in arthritic joints Pathophysiology Calcium pyrophosphate dehydrate (CPPD) crystals develop first in menisci and intervertebral discs, may seed the joint and elicit neutrophilic [pathologyoutlines.com]

Hemochromatosis: Genetics, Pathophysiology, diagnosis, and treatment. Cambridge: Cambridge University Press, 2000. 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 Hemochromatosis: Clinical Features of Hemochromatosis. [physio-pedia.com]

Subsequent messenger RNA expression analysis of the relevant genes in this pathway, in articular cartilage of independent patients undergoing joint replacement surgery for osteoarthritis, showed that upregulation of TNFRSF11B is a general phenomenon in the pathophysiological [emedicine.medscape.com]

Acute pseudogout symptoms are treated with: Intra-articular corticosteroid injection NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) Systemic corticosteroids High-dose colchicine (occasionally) NSAIDs are commonly administered in low amounts to prevent [hxbenefit.com]

Moreover, patients experiencing re-current episodes are provided with NSAIDS and colchicines for further prevention. [cags.org.ae]

Prevention There are not specific techniques applicable to every patient to prevent the formulation of the crystals; however, some patients with certain diseases are at greater risk of developing them. [medical-dictionary.thefreedictionary.com]

These problems are preventable if hemochromatosis is recognized in time. [orthop.washington.edu]

Drainage of joint fluid and injection of a corticosteroid Nonsteroidal anti-inflammatory drugs Colchicine to help prevent attacks Physical therapy Usually, treatment can stop acute attacks and prevent new attacks but cannot reverse changes in already [msdmanuals.com]