In an effort to further define the aberrant 6q13 breakpoint and identify the molecular consequences, a fluorescence in situ hybridization (FISH)-based positional cloning strategy on chondromyxoid fibroma abnormal metaphase and interphase cells using a [ncbi.nlm.nih.gov]

D.d.J. and K.S. performed FISH analyses. K.H.N. prepared the manuscript with contributions from all other authors. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Karolin H Nord. [nature.com]

However, this is very non-specific and can be found in a plethora of other bone lesions. They are benign lesions and malignant degeneration is rare. They are usually treated with curettage which however have a high recurrence rate of 25%. [en.wikipedia.org]

We report a case of a 7-year-old white female who presented with acute, progressive bilateral lower extremity weakness over 48 h. [ncbi.nlm.nih.gov]

There was an over-all rate of recurrence of 27 per cent. With curettage alone there was an 80 per cent recurrence rate, but when curettage was combined with corticocancellous bone-grafting the recurrence rate decreased to 7 per cent. [moh-it.pure.elsevier.com]

We found a novel unbalanced translocation between the long arms of chromosomes 1 and 9, resulting in loss of 1p. In addition, rearrangements involving the 6q23 and 9q22 regions were also observed. [ncbi.nlm.nih.gov]

Using single-nucleotide polymorphism arrays, the authors first found—in tumors from two different patients—deletions in the long arm of chromosome 6, with a distal breakpoint immediately upstream of the gene that encodes metabotropic glutamate receptor [stm.sciencemag.org]

In particular, rearrangement of the long arm of chromosome 6 at bands q13 and q25 was most frequent [ 29 – 38 ]. [doi.org]

A 45-year-old female was admitted with painless bony swelling in the forehead. Computerized tomography demonstrated a well-defined expansive lesion with a sclerotic margin measuring approximately 3 cm in diameter in the right frontal bone. [ncbi.nlm.nih.gov]

Typically people present with progressive pain, often long standing and/or bony swelling and restricted range of movement in affected limb 3,12. [en.wikipedia.org]

swelling and restricted range of movement in affected limb 3,12. [radiopaedia.org]

The common clinical presentation in cases of skull-bone involvement are headache with bony swelling as in our case, others include neuralgia, facial pain, exophthalmos, convulsions, and diplopia. [6] The imaging features of these lesions are characteristic [pediatricneurosciences.com]

Patients can suffer from bony swelling, dysarthria, neuralgia, diplopia, facial pain, exophthalmos, headache, polyuria, and polydipsia. [5,6,10] In our case, the patient presented with diplopia, occasional headaches, and dizziness, which is consistent [journals.lww.com]

The patient has had excellent clinical and radiographic resolution of the prior instability with no neck pain, instability, or local recurrence. [ncbi.nlm.nih.gov]

The most common clinical manifestation reported was neck pain 12-13. Radiologically CMF appears as a well-defined lytic lesion with lobulated margins, a sclerotic ring, and septations. [scielo.br]

Chondromyxoid fibroma is a rare benign bony tumor classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and small foot bones. [ncbi.nlm.nih.gov]

Classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and small foot bones.[2] It accounts for less than 1% of all the primary bone tumors [surgicalcasesjournal.com]

Abstract Chondromyxoid fibroma is a rare benign bony tumor classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and small foot bones. [healio.com]

Eighteen cells showed an abnormal pseudodiploid clone with a clonal translocation between the short arms of chromosomes 1 and 5 [46,XX,t(1;5)(p13;p13)] (Figure 6 ). Four of these eighteen cells had additional non-clonal single cell abnormalities. [doi.org]

A 16-year-old Asian male presented to the hospital 12 months ago with bilateral diplopia involving right visual fields, intermittent headaches, and dizziness. [ncbi.nlm.nih.gov]

However, this case represents the first example, to our knowledge, of a chondromyxoid fibroma invading the transverse-sigmoid junction, resulting in intracranial hemorrhage. [ncbi.nlm.nih.gov]