It typically presents with pain, swelling, and tenderness to palpation. The lesion has a predilection for the metaphysis of long bones of the lower extremity, most commonly in the proximal tibial metaphysis.[ncbi.nlm.nih.gov]
In an effort to further define the aberrant 6q13 breakpoint and identify the molecular consequences, a fluorescence in situ hybridization (FISH)-based positional cloning strategy on chondromyxoid fibroma abnormal metaphase and interphase cells using a[ncbi.nlm.nih.gov]
., D.d.J. and K.S. performed FISH analyses. K.H.N. prepared the manuscript with contributions from all other authors. Competing interests The authors declare no competing financial interests. Corresponding author Correspondence to Karolin H Nord.[nature.com]
However, this is very non-specific and can be found in a plethora of other bone lesions. They are benign lesions and malignant degeneration is rare. They are usually treated with curettage which however have a high recurrence rate of 25%.[en.wikipedia.org]
We report a case of a 7-year-old white female who presented with acute, progressive bilateral lower extremity weakness over 48 h.[ncbi.nlm.nih.gov]
There was an over-all rate of recurrence of 27 per cent. With curettage alone there was an 80 per cent recurrence rate, but when curettage was combined with corticocancellous bone-grafting the recurrence rate decreased to 7 per cent.[moh-it.pure.elsevier.com]
We found a novel unbalanced translocation between the longarms of chromosomes 1 and 9, resulting in loss of 1p. In addition, rearrangements involving the 6q23 and 9q22 regions were also observed.[ncbi.nlm.nih.gov]
Using single-nucleotide polymorphism arrays, the authors first found—in tumors from two different patients—deletions in the longarm of chromosome 6, with a distal breakpoint immediately upstream of the gene that encodes metabotropic glutamate receptor[stm.sciencemag.org]
In particular, rearrangement of the longarm of chromosome 6 at bands q13 and q25 was most frequent [ 29 – 38 ].[doi.org]
A 45-year-old female was admitted with painless bonyswelling in the forehead. Computerized tomography demonstrated a well-defined expansive lesion with a sclerotic margin measuring approximately 3 cm in diameter in the right frontal bone.[ncbi.nlm.nih.gov]
Typically people present with progressive pain, often long standing and/or bonyswelling and restricted range of movement in affected limb 3,12.[en.wikipedia.org]
swelling and restricted range of movement in affected limb 3,12 .[radiopaedia.org]
The common clinical presentation in cases of skull-bone involvement are headache with bonyswelling as in our case, others include neuralgia, facial pain, exophthalmos, convulsions, and diplopia. [6] The imaging features of these lesions are characteristic[pediatricneurosciences.com]
Patients can suffer from bonyswelling, dysarthria, neuralgia, diplopia, facial pain, exophthalmos, headache, polyuria, and polydipsia. [5,6,10] In our case, the patient presented with diplopia, occasional headaches, and dizziness, which is consistent[journals.lww.com]
The patient has had excellent clinical and radiographic resolution of the prior instability with no neckpain, instability, or local recurrence.[ncbi.nlm.nih.gov]
The most common clinical manifestation reported was neckpain 12-13 . Radiologically CMF appears as a well-defined lytic lesion with lobulated margins, a sclerotic ring, and septations.[scielo.br]
Chondromyxoid fibroma is a rare benign bony tumor classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and smallfoot bones.[ncbi.nlm.nih.gov]
Classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and smallfoot bones.[2] It accounts for less than 1% of all the primary bone tumors[surgicalcasesjournal.com]
Abstract Chondromyxoid fibroma is a rare benign bony tumor classically occurring in the metaphyseal region of the long bones surrounding the knee, but also found with relative frequency in other long bones, the pelvis, ribs, and smallfoot bones.[healio.com]
Eighteen cells showed an abnormal pseudodiploid clone with a clonal translocation between the shortarms of chromosomes 1 and 5 [46,XX,t(1;5)(p13;p13)] (Figure 6 ). Four of these eighteen cells had additional non-clonal single cell abnormalities.[doi.org]
A 55-year-old male was admitted with polyuria and headache. A CT scan showed a well-defined expansive lesion with a sclerotic margin measuring approximately 2 cm in diameter in the sellar region.[ncbi.nlm.nih.gov]
Patients can suffer from bony swelling, dysarthria, neuralgia, diplopia, facial pain, exophthalmos, headache, polyuria, and polydipsia. [5,6,10] In our case, the patient presented with diplopia, occasional headaches, and dizziness, which is consistent[journals.lww.com]
A 16-year-old Asian male presented to the hospital 12 months ago with bilateral diplopia involving right visual fields, intermittent headaches, and dizziness.[ncbi.nlm.nih.gov]
However, this case represents the first example, to our knowledge, of a chondromyxoid fibroma invading the transverse-sigmoid junction, resulting in intracranialhemorrhage.[ncbi.nlm.nih.gov]
Preoperative tumor workup was performed for our patients. We reviewed and recorded demographic data and the sign and symptoms of patients at presentation to our center.[ncbi.nlm.nih.gov]
An extensive infection workup was negative. (click for larger image) Figure 1: CT scan of the chest with three sagittal sections revealing no evidence of interstitial lung disease or air trapping.[the-rheumatologist.org]
To describe the use of RFA as a definitive treatment and an alternative to traditional open surgery for the treatment of chondromyxoid fibroma (CMF), a benign but locally aggressive bone tumor.[ncbi.nlm.nih.gov]
[…] macrophages and monocytes No bone osteoid No matrix calcification Treatment Extra-capsular marginal excision yields almost no recurrence In rare occasions of soft tissue invasion, wide excision is necessary If skeletally immature, wait until maturity Prognosis[orthopaedicsone.com]
This shall facilitate better treatment approaches and prognosis. This case is the first reported case of involvement of the zygomatic arch in a pediatric patient.[jomfp.in]
[…] this highly lauded three-volume reference provides an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, including the incidence, etiology, clinical presentation, pathology, differential diagnosis, and prognosis[books.google.com]
Prognosis The prognosis is excellent. Cytogenetics Morphological Karyotypes of 12 cases are reported in the literature. Complex cytogenic abnormalities are reported.[atlasgeneticsoncology.org]
Treatment and prognosis They are benign lesions and malignant degeneration is rare. There is a high rate of reported recurrence (up to 80%) with curettage alone, with lower rate ( 20%) with bone grafting.[radiopaedia.org]
Updated, reorganized, and revised throughout, this highly lauded three-volume reference provides an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, including the incidence, etiology, clinical presentation[books.google.com]
To date, no definite etiologies have been documented. It is known that approximately 75% of the total cases of CMF affect the bones of the lower extremities. In particular, it occurs most frequently in the tibia and femur around the knee joint [3].[surgicalcasesjournal.com]
A study by Romeo et al examined the DNA microarray of chondromyxoid fibroma and demonstrated that CMFs could be differentiated from other cartilaginous tumors. [8] Etiology As is the case with most bone tumors, no specific cause is known for CMF.[emedicine.medscape.com]
Patient Population: Prevalence and Epidemiology Knee // Shoulder & Elbow // Hip // Spine // Foot & Ankle // Hand & Wrist Fragility Fractures: Diagnosis and Treatment Shoulder & Elbow The Characteristics of Surgeons Performing Total Shoulder Arthroplasty[mdedge.com]
As with all rare lesions, reported epidemiology varies: age: most commonly diagnosed before 30 years of age ( 75%), mostly during second and third decades 1,12-15 full reported range from 3 to 70 years of age gender: conflicting data 2, 12,18 some series[radiopaedia.org]
Introduction A rare and benign chondrogenic lesion characterized by variable amounts of chondroid, fibromatoid and myxoid elements Epidemiology demographics more common in males most common in second and third decades of life may affect patients up to[orthobullets.com]
Epidemiology Chondromyxoid fibroma is a very rare neoplasm accounting for less than 1% of all bone tumours , and less of 2% of all benign bone tumours.[atlasgeneticsoncology.org]
Epidemiology CMFs account for fewer than 1% of primary bone tumors in the United States. CMFs are becoming less frequently diagnosed, and thus, the current frequency is much lower than 1%.[emedicine.medscape.com]
Epidemiology demographics more common in males most common in second and third decades of life may affect patients up to 75 years old location long bones (ie. tibia, distal femur) often affects metaphyseal (proximal tibia) regions pelvis feet or hands Pathophysiology[orthobullets.com]
Pathophysiology Grossly, CMFs are firm, grayish-white masses that are sharply demarcated; they are lobulated or pseudolobulated. Their appearance can mimic that of fibrous tissue or hyaline cartilage.[emedicine.medscape.com]
A quick and accurate diagnosis of chondromyxoid fibroma can prevent unnecessary treatment that could be harmful to the patient.[ncbi.nlm.nih.gov]
This will prevent amputation of the toe and will give cosmetic success to the patient No References No Citations No Supplementary Data No Article Media No Metrics Document Type: Research Article Affiliations: 1: Department of Orthopedics, Kasturba Medical[ingentaconnect.com]